Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6088-6092

  Mente, Scot ^a   Gallaschun, Randall ^a   Schmidt, Anne ^a   Lebel, Lorrie ^a   Vanase Frawley, Michelle ^a   Fliri, Anton ^a  

^a PFIZER INC   (United States)

Author keywords

5HT2A; Conformation; Depression; HERG; QSAR; SERT

Indexed keywords

BENZENE DERIVATIVE; METHYLAMINE; POTASSIUM CHANNEL HERG; SEROTONIN 2A RECEPTOR; SEROTONIN TRANSPORTER;

ARTICLE; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; HYDROGEN BOND; IC 50; MOLECULAR SIZE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOSPECIFICITY;

COMBINATORIAL CHEMISTRY TECHNIQUES; DEPRESSION; DRUG DESIGN; ETHER-A-GO-GO POTASSIUM CHANNELS; METHYLAMINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55549094036     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.028     Document Type: Article

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