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Volumn 480, Issue 1, 2008, Pages 41-50
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Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential
a
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Author keywords
Anti thrombosis; Cyclooxygenase; Prostacyclin; Prostacyclin synthase; Prostaglandin I2; Protein engineering; Vascular protector
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Indexed keywords
15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID;
ARACHIDONIC ACID;
BACULOVIRUS VECTOR;
COMPLEMENTARY DNA;
CYCLOOXYGENASE 2;
IBUPROFEN;
PROSTACYCLIN;
PROSTACYCLIN SYNTHASE;
PROTEIN SYNTHESIZING ENZYME;
TRICAT ENZYME;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ANTIINFLAMMATORY ACTIVITY;
ARTICLE;
BINDING AFFINITY;
CONTROLLED STUDY;
ENZYME ENGINEERING;
ENZYME SUBSTRATE;
HUMAN;
HUMAN CELL;
MOLECULAR CLONING;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
PRIORITY JOURNAL;
PROTEIN EXPRESSION;
PROTEIN FOLDING;
PROTEIN PURIFICATION;
THROMBOCYTE AGGREGATION;
THROMBOCYTE AGGREGATION INHIBITION;
WESTERN BLOTTING;
ANIMALS;
ARACHIDONIC ACID;
BACULOVIRIDAE;
CELL LINE;
CERCOPITHECUS AETHIOPS;
COS CELLS;
CYCLOOXYGENASE 2;
CYTOCHROME P-450 ENZYME SYSTEM;
DNA, COMPLEMENTARY;
DRUG DESIGN;
EPOPROSTENOL;
GENETIC VECTORS;
HUMANS;
INTRAMOLECULAR OXIDOREDUCTASES;
KINETICS;
NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;
PLATELET AGGREGATION;
PROTEIN ENGINEERING;
RECOMBINANT FUSION PROTEINS;
SPODOPTERA;
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EID: 55549088189
PISSN: 00039861
EISSN: 10960384
Source Type: Journal
DOI: 10.1016/j.abb.2008.09.010 Document Type: Article |
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Times cited : (9)
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References (27)
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