May genetic factors in fibromyalgia help to identify patients with differentially altered frequencies of immune cells?

Clinical and Experimental Immunology

Volumn 154, Issue 3, 2008, Pages 346-352

  Carvalho, L S C ^a   Correa, H ^a   Silva, G C ^a   Campos, F S ^a   Baiao F R ^b   Ribeiro, L S ^c   Faria, A M ^a   D'Avila Reis, D ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Hospital da Baleia   (Brazil)

^c Hospital Governador Israel Pinheiro   (Brazil)

Author keywords

5 HTTLPR; Fibromyalgia; Genetic; Lymphocytes; Salivary cortisol

Indexed keywords

HYDROCORTISONE; SEROTONIN TRANSPORTER;

ADULT; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL SUBPOPULATION; CONTROLLED STUDY; FEMALE; FIBROMYALGIA; GENE EXPRESSION; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER T CELL; PRIORITY JOURNAL; PROMOTER REGION; SALIVA ANALYSIS; T LYMPHOCYTE ACTIVATION;

ADULT; B-LYMPHOCYTE SUBSETS; CASE-CONTROL STUDIES; FEMALE; FIBROMYALGIA; GENOTYPE; HUMANS; HYDROCORTISONE; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; SALIVA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; T-LYMPHOCYTE SUBSETS;

EID: 55449126901     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03787.x     Document Type: Article

References (48)

1. Wolfe F, Smythe HA, Yunus MB et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990 33 : 160 72.
2. Crofford LJ, Demitrack MA. Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am 1996 22 : 267 84.
3. Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH. Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology (Oxf) 2001 40 : 743 9.
4. Russell IJ, Vipraio GA, Michalek JE, Craig FE, Kang YK, Richards AB. Lymphocyte markers and natural killer cell activity in fibromyalgia syndrome: effects of low-dose, sublingual use of human interferon-alpha. J Interferon Cytokine Res 1999 19 : 969 78.
5. Nishikai M, Tomomatsu S, Hankins RW et al. Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders. Rheumatology (Oxf) 2001 40 : 806 10.
6. Pamuk ON, Cakir N. The frequency of thyroid antibodies in fibromyalgia patients and their relationship with symptoms. Clin Rheumatol 2007 26 : 55 9.
7. Amel Kashipaz MR, Swinden D, Todd I, Powell RJ. Normal production of inflammatory cytokines in chronic fatigue and fibromyalgia syndromes determined by intracellular cytokine staining in short-term cultured blood mononuclear cells. Clin Exp Immunol 2003 132 : 360 5.
8. Hernanz W, Valenzuela A, Quijada J et al. Lymphocyte subpopulations in patients with primary fibromyalgia. J Rheumatol 1994 21 : 2122 4.
9. Ribeiro LS, Proietti FA. Interrelations between fibromyalgia, thyroid autoantibodies, and depression. J Rheumatol 2004 31 : 2036 40.
10. Staines DR. Is fibromyalgia an autoimmune disorder of endogenous vasoactive neuropeptides? Med Hypotheses 2004 62 : 665 9.
11. McCain GA, Tilbe KS. Diurnal hormone variation in fibromyalgia syndrome: a comparison with rheumatoid arthritis. J Rheumatol Suppl. 1989 19 : 154 7.
12. Griep EN, Boersma JW, Lentjes EG, Prins AP, van der Korst JK, de Kloet ER. Function of the hypothalamic-pituitary-adrenal axis in patients with fibromyalgia and low back pain. J Rheumatol 1998 25 : 1374 81.
13. Crofford LJ, Pillemer SR, Kalogeras KT et al. Hypothalamic-pituitary- adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 1994 37 : 1583 92.
14. Gur A, Cevik R, Sarac AJ, Colpan L, Em S. Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism. Ann Rheum Dis 2004 63 : 1504 6.
15. Demitrack MA, Dale JK, Straus SE et al. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab 1991 73 : 1224 34.
16. Catley D, Kaell AT, Kirschbaum C, Stone AA. A naturalistic evaluation of cortisol secretion in persons with fibromyalgia and rheumatoid arthritis. Arthritis Care Res 2000 13 : 51 61.
17. Riedel W, Layka H, Neeck G. Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Z Rheumatol 1998 57 (Suppl. 2 81 7.
18. McLean SA, Williams DA, Harris RE et al. Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis Rheum 2005 52 : 3660 9.
19. Buskila D, Sarzi-Puttini P. Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther 2006 8 : 218.
20. Buskila D, Neumann L, Hazanov I, Carmi R. Familial aggregation in the fibromyalgia syndrome. Semin Arthritis Rheum 1996 26 : 605 11.
21. Pellegrino MJ, Waylonis GW, Sommer A. Familial occurrence of primary fibromyalgia. Arch Phys Med Rehabil 1989 70 : 61 3.
22. Stormorken H, Brosstad F. Fibromyalgia: family clustering and sensory urgency with early onset indicate genetic predisposition and thus a 'true' disease. Scand J Rheumatol 1992 21 : 207.
23. Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P. Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm Gen Sect 1993 91 : 67 72.
24. Lesch KP, Bengel D, Heils A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996 274 : 1527 31.
25. Bazzichi L, Giannaccini G, Betti L et al. Alteration of serotonin transporter density and activity in fibromyalgia. Arthritis Res Ther 2006 8 : R99.
26. Heils A, Teufel A, Petri S et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996 66 : 2621 4.
27. Offenbaecher M, Bondy B, de Jonge S et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999 42 : 2482 8.
28. Cohen H, Buskila D, Neumann L, Ebstein RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum 2002 46 : 845 7.
29. Neves FS, Silveira G, Romano-Silva MA et al. Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients? Am J Med Genet B Neuropsychiatr Genet 2008 147B : 114 16.
30. Spielberg CD, Gorsush RL, Lushene RE. The state trait anxiety inventory: test manual form X. Palo Alto, CA : Consulting Psychologist Press, 1970.
31. Zola H. Markers of cell lineage, differentiation and activation. J Biol Regul Homeost Agents 2000 14 : 218 19.
32. Rea IM, McNerlan SE, Alexander HD. CD69, CD25, and HLA-DR activation antigen expression on CD3+ lymphocytes and relationship to serum TNF-alpha, IFN-gamma, and sIL-2R levels in aging. Exp Gerontol 1999 34 : 79 93.
33. Parra F, Amado R, Lambertucci J, Rocha J, Antunes C, Pena S. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci USA 2003 100 : 177 82.
34. Bennett RM, Cook DM, Clark SR, Burckhardt CS, Campbell SM. Hypothalamic-pituitary-insulin-like growth factor-I axis dysfunction in patients with fibromyalgia. J Rheumatol 1997 24 : 1384 9.
35. Fries E, Hesse J, Hellhammer J, Hellhammer DH. A new view on hypocortisolism. Psychoneuroendocrinology 2005 30 : 1010 16.
36. Januszkiewicz A, Essén P, McNurlan M, Ringdén O, Garlick P, Wernerman J. A combined stress hormone infusion decreases in vivo protein synthesis in human T lymphocytes in healthy volunteers. Metabolism 2001 50 : 1308 14.
37. Hoetzenecker W, Meingassner J, Ecker R, Stingl G, Stuetz A, Elbe-Bürger A. Corticosteroids but not pimecrolimus affect viability, maturation and immune function of murine epidermal Langerhans cells. J Invest Dermatol 2004 122 : 673 84.
38. Macedo JA, Hesse J, Turner JD et al. Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils. J Neuroimmunol 2007 188 : 159 66.
39. Alciati A, Gallo L, Monforte AD, Brambilla F, Mellado C. Major depression-related immunological changes and combination antiretroviral therapy in HIV-seropositive patients. Hum Psychopharmacol 2007 22 : 33 40.
40. Schleifer SJ, Keller SE, Bartlett JA. Depression and immunity: clinical factors and therapeutic course. Psychiatry Res 1999 85 : 63 9.
41. Irwin M, Gillin JC. Impaired natural killer cell activity among depressed patients. Psychiatry Res 1987 20 : 181 2.
42. Schleifer SJ, Keller SE, Czaja S. Major depression and immunity in alcohol-dependent persons. Brain Behav Immun 2006 20 : 80 91.
43. Shirai T, Hirose S, Okada T, Nishimura H. CD5+ B cells in autoimmune disease and lymphoid malignancy. Clin Immunol Immunopathol 1991 59 : 173 86.
44. Hayakawa K, Hardy RR, Parks DR, Herzenberg LA. The 'Ly-1 B' cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med 1983 157 : 202 18.
45. Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985 161 : 72 87.
46. Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001 193 : 1311 18.
47. Kingsley CI, Karim M, Bushell AR, Wood KJ. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002 168 : 1080 6.
48. Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000 192 : 295 302.