Alteration of serotonin transporter density and activity in fibromyalgia

Arthritis Research and Therapy

Volumn 8, Issue 4, 2006, Pages

  Bazzichi, Laura ^a   Giannaccini, Gino ^a   Betti, Laura ^a   Mascia, Giovanni ^a   Fabbrini, Laura ^a   Italiani, Paola ^a   De Feo, Francesca ^a   Giuliano, Tiziana ^a   Giacomelli, Camillo ^a   Rossi, Alessandra ^a   Lucacchini, Antonio ^a   Bombardieri, Stefano ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PAROXETINE; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

AGED; BLOOD; CELL MEMBRANE; FEMALE; FIBROMYALGIA; HUMAN; KINETICS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; QUESTIONNAIRE; SEVERITY OF ILLNESS INDEX; SICKNESS IMPACT PROFILE; THROMBOCYTE;

AGED; BLOOD PLATELETS; CELL MEMBRANE; FEMALE; FIBROMYALGIA; HUMANS; KINETICS; MIDDLE AGED; PAROXETINE; QUESTIONNAIRES; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX; SICKNESS IMPACT PROFILE;

EID: 34247551200     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar1982     Document Type: Article

References (43)

1. Wolfe F, Smythe HA, Yunus MD, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, et al.: The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia: Report of the Multicenter Criteria Committee. Arthritis Rheum 1990, 33:160-172.
2. Wolfe F, Ross K, Anderson J, Russell IJ, Herbert L: The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995, 38:19-28.
3. Hudson JI, Goldenberg DL, Pope HG Jr, Keck PE Jr, Schlesinger L: Comorbidity of fibromyalgia with medical and psychiatric disorders. Am J Med 1992, 92:363-367.
4. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R: Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
5. Neeck G: Pathogenic mechanisms of fibromyalgia. Ageing Res Rev 2002, 1:243-255.
6. Neeck G, Rieder W: Neuromediator and hormonal perturbations in fibromyalgia syndrome: Results of chronic stress? Baillieres Clin Rheumatol 1994, 8:763-775.
7. Yunus MB, Dailey JW, Aldag JC, Masi AT, Jobe PC: Plasma tryptophan and other amino acids in primary fibromyalgia: A controlled study. J Rheumatol 1992, 19:90-94.
8. Moldofsky H, Warsh JJ: Plasma tryptophan and musculoskeletal pain in non-articular rheumatism ('fibrositis syndrome'). Pain 1978, 5:65-71.
9. Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN: Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 2001, 92 179-212.
10. Miller LJ, Kubes KL: Serotonergic agents in the treatment of fibromyalgia syndrome. Ann Pharmacother 2002, 36:707-712.
11. Gursoy S, Erdal E, Herken H, Madenci E, Alasehirli B: Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fibromyalgia syndrome. Rheumatol Int 2001, 21:58-61.
12. Stratz T, Fiebich B, Haus U, Muller W: Influence of tropisetron on the serum substance P levels in fibromyalgia patients. Scand J Rheumatol Suppl 2004, 119:41-43.
13. Stratz T, Mennet P, BenA HP, Muller W: Blocking of S2 receptors: a new treatment principle in generalized tendomyopathy (fibromyalgia)? Z Rheumatol 1991, 50:21-22.
14. Chen JX, Pan H, Rothman TP, Wade PR, Gershon MD: Guinea pig 5-HT transporter: Cloning, expression, distribution and function in intestinal sensory reception. Am J Physiol 1998, 275 G433-G438.
15. Lesch KP, Wolozin BL, Murphy DL, Reiderer P: Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter. J Neurochem 1993, 60:2319-2322.
16. Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P: Isolation of cDNA encoding the human brain serotonin transporter. J Neural Transm Gen Sect 1993, 91:67-72.
17. Goldenberg D, Mayskiy M, Mossey C, Ruthazer R, Schmid C: A randomized, double blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromylagia. Arthritis Rheum 1996, 39 1852-1859.
18. Russell IJ: Advances in fibromyalgia possible role for central neurochemicals. Am J Med Sci 1998, 315:377-384.
19. Offenbaecher M, Bondy B, De Jonge S, Glatzeder K, Kruger M, Schoeps P, Ackenheil M: Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999, 42:2482-2488.
20. Fischer AA: Pressure tolerance over muscles and bones in normal subjects. Arch Phys Med Rehabil 1986, 67:406-409.
21. Burckhardt CS, Clark SR, Bennett RM: The Fibromyalgia Impact Questionnaire: Development and validation. J Rheumatol 1991, 18:728-734.
22. First MB, Spitzer RL, Williams JBW, Gibbon M: Structured Clinical Interview for DSM-IV-Patient Edition (SCID-P). Washington, DC: American Psychiatric Press; 1995.
23. Arora RC, Meltzer HY: A modified assay method for determining serotonin uptake in human platelets. Clin Chim Acta 1981, 112:225-233.
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193 265-275.
25. 3H]paroxetine binding in obsessive-compulsive patients. Neuropsychobiology 1996, 34:184-187.
26. Stahl SM: The human platelets. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurological disorders. Arch Gen Psychiatry 1977, 34:509-516.
27. 3H]imipramine reuptake in the primary fibromyalgia syndrome. Rheumatology (Oxford) 2001, 40:290-296.
28. 3H]paroxetine binding sites in suicide attempters. Psychiatry Res 2001, 103:125-131.
29. Marazziti D, Dell'Osso L, Presta S, Pfanner C, Rossi A, Masala I, Baroni S, Giannaccini G, Lucacchini A, Cassano GB: Platelet [3H]paroxetine binding in patients with OCD-related disorders. Psychiatry Res 1999, 89:223-228.
30. Wolfe F, Russel IJ, Vipraio G, Ross K, Anderson J: Serotonin level, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol 1997, 24:555-559.
31. Ernberg M, Voog U, Alstergren P, Lundemberg T, Kopp S: Plasma and serum serotonin levels and their relationship to orofacial pain and anxiety in fibromyalgia. J Orofac Pain 2000, 14:37-46.
32. Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S: Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol 1999, 26:408-412.
33. Yamamoto S, Ouchi Y, Onoe H, Yoshikawa E, Tsukada H, Takahashi H, Iwase M, Yamaguti K, Kuratsune H, Watanabe Y: Reduction of serotonin transporters of patients with chronic fatigue syndrome. Neuroreport 2004, 15:2571-2574.
34. Kim HJ, Camilleri M, Carlson PJ, Cremonini F, Ferber I, Stephens D, McKinzie S, Zinsmeister AR, Urrutia R: Association of distinct a2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 2004, 53:829-837.
35. Lenzinger E, Neumeister A, Praschak-Rieder N, Fuchs K, Gerhard E, Willeit M, Sieghart W, Kasper SF, Hornik K, Aschauer HN: Behavioral effects of tryptofan depletation in seasonal affective disorder associated with the serotonin transporter gene. Psychiatry Res 1999, 22:241-246.
36. Ernberg M, Lundeberg T, Kopp S: Effects on muscle pain by intramuscular injection of granisetron in patients with fibromyalgia. Pain 2003, 101:275-282.
37. 3H]imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 1992, 19:104-109.
38. Kravitz HM, Katz R, Kot E, Helmke N, Fawcett J: Biochemical clues to a fibromyalgia-depression link: Imipramine binding in patients with fibromyalgia or depression and healthy controls. J Rheumatol 1992, 19:1428-1432.
39. 3H]Imipramine binding sites are decreased in platelets of chronic pain patients. Clin Neuropharmacol 1987, 10 175-177.
40. 3H]imipramine to human platelet membranes. Eur J Pharmacol 1983, 96:303-309.
41. Owens MJ, Nemeroff CB: Role of the serotonin in the pathophysiology of depression: Focus on the serotonin transporter. Clin Chem 1994, 40:288-295.
42. Gursoy S: Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients Clin Rheumatol 2002, 21:194-197.
43. Almay BG, Maggendal J, Von KL, Oreland L: 5-HIAA and HVA in CSF in patients with idiopatic pain disorders. Biol Psychiatry 1987, 22:403-412.