-
1
-
-
0037145037
-
Integrins Bidirectional, Allosteric Signaling Machines
-
Hynes RO. Integrins Bidirectional, Allosteric Signaling Machines. Cell 2002;110:673-687.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
2
-
-
0032523064
-
Integrin signalling: The platelet paradigm
-
Shattil SJ, Kashiwagi H, Pampori N. Integrin signalling: The platelet paradigm. Blood 1998;91:2645-2657.
-
(1998)
Blood
, vol.91
, pp. 2645-2657
-
-
Shattil, S.J.1
Kashiwagi, H.2
Pampori, N.3
-
3
-
-
0034698147
-
Ligand binding to integrins
-
Plow EF, Haas TA, Zhang L, Loftus J, Smith JW. Ligand binding to integrins. J Biol Chem 2000;275:21785-21788.
-
(2000)
J Biol Chem
, vol.275
, pp. 21785-21788
-
-
Plow, E.F.1
Haas, T.A.2
Zhang, L.3
Loftus, J.4
Smith, J.W.5
-
4
-
-
0028285015
-
Integrin cytoplasmic domains mediate inside-out signal transduction
-
O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ. Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 1994;124:1047-1059.
-
(1994)
J Cell Biol
, vol.124
, pp. 1047-1059
-
-
O'Toole, T.E.1
Katagiri, Y.2
Faull, R.J.3
Peter, K.4
Tamura, R.5
Quaranta, V.6
Loftus, J.C.7
Shattil, S.J.8
Ginsberg, M.H.9
-
6
-
-
0029966310
-
Breaking the integrin hinge: A defined structural constraint regulates integrin signaling
-
Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, Shattil SJ. Ginsberg MH. Breaking the integrin hinge: A defined structural constraint regulates integrin signaling. J Biol Chem 1996;271:6571-6574.
-
(1996)
J Biol Chem
, vol.271
, pp. 6571-6574
-
-
Hughes, P.E.1
Diaz-Gonzalez, F.2
Leong, L.3
Wu, C.4
McDonald, J.A.5
Shattil, S.J.6
Ginsberg, M.H.7
-
7
-
-
0035805633
-
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state
-
Lu C, Takagi J, Springer TA. Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. J Biol Chem 2001;276:14642-14648.
-
(2001)
J Biol Chem
, vol.276
, pp. 14642-14648
-
-
Lu, C.1
Takagi, J.2
Springer, T.A.3
-
8
-
-
0037031551
-
A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face
-
Vinogradova O, Velyvis A, Velyviene A, Hu B, Haas TA, Plow EF, Qin J. A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Cell 2002;110:587-597.
-
(2002)
Cell
, vol.110
, pp. 587-597
-
-
Vinogradova, O.1
Velyvis, A.2
Velyviene, A.3
Hu, B.4
Haas, T.A.5
Plow, E.F.6
Qin, J.7
-
9
-
-
0029665001
-
The cytoplasmic domain of αIIb β3: A ternary complex of the integrin α and β subunits and a divalent cation
-
Haas TA, Plow EF. The cytoplasmic domain of αIIb β3: A ternary complex of the integrin α and β subunits and a divalent cation. J Biol Chem 1996;271:6017-6026.
-
(1996)
J Biol Chem
, vol.271
, pp. 6017-6026
-
-
Haas, T.A.1
Plow, E.F.2
-
10
-
-
0042681786
-
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
-
Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003;301:1720-1725.
-
(2003)
Science
, vol.301
, pp. 1720-1725
-
-
Kim, M.1
Carman, C.V.2
Springer, T.A.3
-
11
-
-
16644368209
-
Integrin Bidirectional Signaling: A Molecular View
-
Qin J, Vinogradova O, Plow EF. Integrin Bidirectional Signaling: A Molecular View. PLoS Biol 2004;2:726-729.
-
(2004)
PLoS Biol
, vol.2
, pp. 726-729
-
-
Qin, J.1
Vinogradova, O.2
Plow, E.F.3
-
13
-
-
1442331993
-
Integrin activation
-
Calderwood DA. Integrin activation. J Cell Sci 2004;117:657-666.
-
(2004)
J Cell Sci
, vol.117
, pp. 657-666
-
-
Calderwood, D.A.1
-
14
-
-
0032493816
-
A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis
-
Stephens G, O'Luanaigh N, Reilly D, Harriott P, Walker B, Fitzgerald D, Moran N. A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis. J Biol Chem 1998;273:20317-20322.
-
(1998)
J Biol Chem
, vol.273
, pp. 20317-20322
-
-
Stephens, G.1
O'Luanaigh, N.2
Reilly, D.3
Harriott, P.4
Walker, B.5
Fitzgerald, D.6
Moran, N.7
-
15
-
-
0035933835
-
A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation
-
Ginsberg MH, Yaspan B, Forsyth J, Ulmer TS, Campbell ID, Slepak M. A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation. J Biol Chem 2001;276:22514-22521.
-
(2001)
J Biol Chem
, vol.276
, pp. 22514-22521
-
-
Ginsberg, M.H.1
Yaspan, B.2
Forsyth, J.3
Ulmer, T.S.4
Campbell, I.D.5
Slepak, M.6
-
16
-
-
0031404511
-
Development of a structural model for the cytoplasmic domain of an integrin
-
Haas TA, Plow EF. Development of a structural model for the cytoplasmic domain of an integrin. Protein Eng 1997;10:1395-1405.
-
(1997)
Protein Eng
, vol.10
, pp. 1395-1405
-
-
Haas, T.A.1
Plow, E.F.2
-
17
-
-
33746615106
-
A novel functional role for the highly conserved alpha-subunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes
-
Aylward K, Meade G, Ahrens I, Devocelle M, Moran N. A novel functional role for the highly conserved alpha-subunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes. J Thromb Haemost. 2006;4:1804-1812.
-
(2006)
J Thromb Haemost
, vol.4
, pp. 1804-1812
-
-
Aylward, K.1
Meade, G.2
Ahrens, I.3
Devocelle, M.4
Moran, N.5
-
18
-
-
0034652205
-
A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit
-
Vinogradova O, Haas T, Plow EF, Qin J. A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit. Proc Natl Acad Sci USA 2000;97:1450-1455.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1450-1455
-
-
Vinogradova, O.1
Haas, T.2
Plow, E.F.3
Qin, J.4
-
19
-
-
2342562452
-
Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail
-
Yamanouchi J, Hato T, Tamura T, Fujita S. Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail. Biochem J 2004;379:317-323.
-
(2004)
Biochem J
, vol.379
, pp. 317-323
-
-
Yamanouchi, J.1
Hato, T.2
Tamura, T.3
Fujita, S.4
-
20
-
-
0033617417
-
Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformations
-
Leisner TM, Wencel-Drake JD, Wang W, Lam SC. Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformations. J Biol Chem 1999;274:12945-12949.
-
(1999)
J Biol Chem
, vol.274
, pp. 12945-12949
-
-
Leisner, T.M.1
Wencel-Drake, J.D.2
Wang, W.3
Lam, S.C.4
-
22
-
-
0003676525
-
-
Goodman M, Felix A, Moroder L, Toniolo G, ed, Stuttgard: Thieme
-
Goodman M, Felix A, Moroder L, Toniolo G, ed. Methods of organic chemistry: synthesis of peptide and peptidomimetics. Stuttgard: Thieme, 2003.
-
(2003)
Methods of organic chemistry: Synthesis of peptide and peptidomimetics
-
-
-
23
-
-
1542544886
-
A palmitylated peptide derived from the glycoprotein Ib beta cytoplasmic tail inhibits platelet activation
-
Martin K, Meade G, Moran N, Shields DC, Kenny D. A palmitylated peptide derived from the glycoprotein Ib beta cytoplasmic tail inhibits platelet activation. J Thromb Haemost. 2003;1:2643-2652.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 2643-2652
-
-
Martin, K.1
Meade, G.2
Moran, N.3
Shields, D.C.4
Kenny, D.5
-
25
-
-
2942516211
-
Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: Role of apolipoprotein (a) and endogenous PAF-acetylhydrolase
-
Tsironis LD, Mitsios JV, Milionis HJ, Elisaf M, Tselepis AD. Effect of lipoprotein (a) on platelet activation induced by platelet-activating factor: Role of apolipoprotein (a) and endogenous PAF-acetylhydrolase. Cardiovasc Res 2004;63:130-138.
-
(2004)
Cardiovasc Res
, vol.63
, pp. 130-138
-
-
Tsironis, L.D.1
Mitsios, J.V.2
Milionis, H.J.3
Elisaf, M.4
Tselepis, A.D.5
-
27
-
-
0029587579
-
Integrin signaling: Roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK
-
Leong L, Hughes PE, Schwartz MA, Ginsberg MH, Shattil SJ. Integrin signaling: Roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. J Cell Sci 1995;108:3817-3825.
-
(1995)
J Cell Sci
, vol.108
, pp. 3817-3825
-
-
Leong, L.1
Hughes, P.E.2
Schwartz, M.A.3
Ginsberg, M.H.4
Shattil, S.J.5
-
29
-
-
34249803276
-
Regulation and functional consequences of ADP receptor-mediated ERK2 activation in platelets
-
Garcia A, Shankar H, Murugappan S, Kim S, Kunapuli S. Regulation and functional consequences of ADP receptor-mediated ERK2 activation in platelets. Biochem J 2007;404:299-308.
-
(2007)
Biochem J
, vol.404
, pp. 299-308
-
-
Garcia, A.1
Shankar, H.2
Murugappan, S.3
Kim, S.4
Kunapuli, S.5
-
30
-
-
0344549406
-
Platelet signal transduction pathways: Could we organize them into a 'hierarchy'?
-
Lévy-Toledano S. Platelet signal transduction pathways: Could we organize them into a 'hierarchy'? Haemostasis 1999;29:4-15.
-
(1999)
Haemostasis
, vol.29
, pp. 4-15
-
-
Lévy-Toledano, S.1
-
31
-
-
0037446261
-
Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human platelets
-
McNicol A, Jackson ECJ. Inhibition of the MEK/ERK pathway has no effect on agonist-induced aggregation of human platelets. Biochem Pharmacol 2003;65:1243-1250.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1243-1250
-
-
McNicol, A.1
Jackson, E.C.J.2
-
32
-
-
0037197990
-
Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits
-
Weljie AM, Hwang PM, Vogel HJ. Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits. Proc Natl Acad Sci USA 2002;99:5878-5883.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5878-5883
-
-
Weljie, A.M.1
Hwang, P.M.2
Vogel, H.J.3
-
34
-
-
0037389585
-
-
Travis MA, Humphries JD, Humphries MJ. An unraveling tale of how integrins are activated from within. Trends Pharmacol Sci 2003;24:192-197. 35. Shattil SJ, Brugge JS. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol 1991;3:869-879.
-
Travis MA, Humphries JD, Humphries MJ. An unraveling tale of how integrins are activated from within. Trends Pharmacol Sci 2003;24:192-197. 35. Shattil SJ, Brugge JS. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol 1991;3:869-879.
-
-
-
-
35
-
-
0028588079
-
Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers
-
Schoenwaelder SM, Jackson SP, Yuan Y, Teasdale MS, Salem HH, Mitchell CA. Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers. J Biol Chem 1994;269:32479-32487.
-
(1994)
J Biol Chem
, vol.269
, pp. 32479-32487
-
-
Schoenwaelder, S.M.1
Jackson, S.P.2
Yuan, Y.3
Teasdale, M.S.4
Salem, H.H.5
Mitchell, C.A.6
-
36
-
-
0031894320
-
Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure
-
Hers I, Donath J, van Willigen G, Akkerman JW. Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure. Arterioscler. Thromb Vasc Biol 1998;18:404-414.
-
(1998)
Arterioscler. Thromb Vasc Biol
, vol.18
, pp. 404-414
-
-
Hers, I.1
Donath, J.2
van Willigen, G.3
Akkerman, J.W.4
-
37
-
-
0141865705
-
Talin binding to integrin beta tails: A final common step in integrin activation
-
Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Talin binding to integrin beta tails: A final common step in integrin activation. Science 2003;302:103-106.
-
(2003)
Science
, vol.302
, pp. 103-106
-
-
Tadokoro, S.1
Shattil, S.J.2
Eto, K.3
Tai, V.4
Liddington, R.C.5
de Pereda, J.M.6
Ginsberg, M.H.7
Calderwood, D.A.8
-
38
-
-
0033213922
-
The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation
-
Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 1999;274:28071-28074.
-
(1999)
J Biol Chem
, vol.274
, pp. 28071-28074
-
-
Calderwood, D.A.1
Zent, R.2
Grant, R.3
Rees, D.J.4
Hynes, R.O.5
Ginsberg, M.H.6
-
39
-
-
0030040067
-
Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3
-
Knezevic I, Leisner TM, Lam SC. Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3. J Biol Chem 1996;271:16416-16421.
-
(1996)
J Biol Chem
, vol.271
, pp. 16416-16421
-
-
Knezevic, I.1
Leisner, T.M.2
Lam, S.C.3
-
40
-
-
0037783291
-
Integrin alphaIIbbeta3 and its antagonism
-
Quinn MJ, Byzova TV, Qin J, Topol EF, Plow EF. Integrin alphaIIbbeta3 and its antagonism. Arterioscler Thromb Vasc Biol 2003;23:945-952.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 945-952
-
-
Quinn, M.J.1
Byzova, T.V.2
Qin, J.3
Topol, E.F.4
Plow, E.F.5
-
41
-
-
0029062761
-
Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine
-
Lefkovits J, Plow EF, Topol EJ. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. N Engl J Med 1995;332:1553-1559.
-
(1995)
N Engl J Med
, vol.332
, pp. 1553-1559
-
-
Lefkovits, J.1
Plow, E.F.2
Topol, E.J.3
-
42
-
-
0034332785
-
Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes
-
Cox D, Smith R, Quinn M, Theroux P, Crean P, Fitzgerald DJ. Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes. J Am Coll Cardiol 2000;36:1514-1519.
-
(2000)
J Am Coll Cardiol
, vol.36
, pp. 1514-1519
-
-
Cox, D.1
Smith, R.2
Quinn, M.3
Theroux, P.4
Crean, P.5
Fitzgerald, D.J.6
-
43
-
-
0033954363
-
Increased platelet reactivity in patients given orbofiban after an acute coronary syndrome: An OPUSTIMI 16 substudy. Orbofiban in Patients with Unstable coronary syndromes. Thrombolysis in Myocardial Infarction
-
Holmes MB, Sobel BE, Cannon CP, Schneider DJ. Increased platelet reactivity in patients given orbofiban after an acute coronary syndrome: An OPUSTIMI 16 substudy. Orbofiban in Patients with Unstable coronary syndromes. Thrombolysis in Myocardial Infarction. Am J Cardiol 2000;85:491-493.
-
(2000)
Am J Cardiol
, vol.85
, pp. 491-493
-
-
Holmes, M.B.1
Sobel, B.E.2
Cannon, C.P.3
Schneider, D.J.4
|