Paranormal experience and the COMT dopaminergic gene: A preliminary attempt to associate phenotype with genotype using an underlying brain theory

Cortex

Volumn 44, Issue 10, 2008, Pages 1336-1341

  Raz, Amir ^a,d   Hines, Terence ^b   Fossella, John ^c   Castro, Daniella ^b  

^a VANCOUVER COASTAL HEALTH RESEARCH INSTITUTE   (Canada)

^b PACE UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

COMT; Genetics; Genotype; Paranormal; Phenotype

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADULT; ARTICLE; BEHAVIOR GENETICS; COGNITION; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN EXPERIMENT; HUMAN GENOME; MALE; NORMAL HUMAN; PARAPSYCHOLOGY; PREFRONTAL CORTEX; SOCIAL BELIEF;

EID: 55349090693     PISSN: 00109452     EISSN: 00109452     Source Type: Journal    
DOI: 10.1016/j.cortex.2007.07.011     Document Type: Article

References (70)

1. Avramopoulos D., Stefanis N.C., Hantoumi I., Smyrnis N., Evdokimidis I., and Stefanis C.N. Higher scores of self reported schizotypy in healthy young males carrying the comt high activity allele. Molecular Psychiatry 7 (2002) 706-711
2. Blackmore S. Belief in the paranormal: probability judgements, illusory control, and the chance baseline shift. British Journal of Psychology (1985) 459-468
3. Braffman W., and Kirsch I. Imaginative suggestibility and hypnotizability: an empirical analysis. Journal of Personality and Social Psychology 77 (1999) 578-587
4. Brugger P. From haunted brain to haunted science: A cognitive neuroscience view of paranormal and pseudoscientific thought. In: Houran J., and Lange R. (Eds). Hauntings and poltergeists: multidisciplinary perspectives (2001), McFarland & Company, Jefferson, NC 195-213
5. Brugger P., Dowdy M.A., and Graves R.E. From superstitious behavior to delusional thinking: the role of the hippocampus in misattributions of causality. Medical Hypotheses 43 (1994) 397-402
6. Brugger P., and Taylor K. Esp: Extrasensory perception or effect of subjective probability?. In: Alcock J.E., Burns J.E., and Freeman A. (Eds). Psi wars: getting to grips with the paranormal (2003), Imprint Academis, Essex, UK 221-246
7. Cooper J.R., Bloom F.E., and Roth R.H. Biochemical basis of neuropharmacology (2002), Oxford University Press, New York
8. Craddock N., Owen M.J., and O'Donovan M.C. The catechol-o-methyl transferase (comt) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 11 (2006) 446-458
9. Diamond A., Briand L., Fossella J., and Gehlbach L. Genetic and neurochemical modulation of prefrontal cognitive functions in children. American Journal of Psychiatry 161 (2004) 125-132
10. Dixon M., Brunet A., and Laurence J.R. Hypnotic susceptibility and verbal automatic and strategic processing differences in the stroop color-naming task. Journal of Abnormal Psychology 99 (1990) 336-343
11. Dixon M., Brunet A., and Laurence J.R. Hypnotizability and automaticity: toward a parallel distributed processing model of hypnotic responding. Journal of Abnormal Psychology 99 (1990) 336-343
12. Dixon M., Labelle L., and Laurence J.R. A multivariate approach to the prediction of hypnotic susceptibility. International Journal of Clinical and Experimental Hypnosis 44 (1996) 250-264
13. Dixon M., and Laurence J.R. Hypnotic susceptibility and verbal automaticity: automatic and strategic processing differences in the stroop color-naming task. Journal of Abnormal Psychology 101 (1992) 344-347
14. Eckblad M., and Chapman L.J. Magical ideation as an indicator of schizotypy. Journal of Consulting and Clinical Psychology 51 (1983) 215-225
15. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzanti C.M., Straub R.E., Goldman D., and Weinberger D.R. Effect of comt val108/158 met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences USA 98 (2001) 6917-6922
16. Fan J., Fossella J., Sommer T., Wu Y., and Posner M.I. Mapping the genetic variation of executive attention onto brain activity. Proceedings of the National Academy of Sciences USA 100 (2003) 7406-7411
17. Fan J., McCandliss B.D., Sommer T., Raz A., and Posner M.I. Testing the efficiency and independence of attentional networks. Journal of Cognitive Neuroscience 14 (2002) 340-347
18. Fan J., Wu Y., Fossella J.A., and Posner M.I. Assessing the heritability of attentional networks. BMC Neuroscience 2 (2001) 14
19. Fanous A., Gardner C., Walsh D., and Kendler K.S. Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives. Archives of General Psychiatry 58 (2001) 669-673
20. Fanous A.H., and Kendler K.S. The genetic relationship of personality to major depression and schizophrenia. Neurotoxicity Research 6 (2004) 43-50
21. Fossella J., Posner M.I., Fan J., Swanson J.M., and Pfaff D.W. Attentional phenotypes for the analysis of higher mental function. The Scientific World 2 (2002) 217-223
22. Fossella J., Sommer T., Fan J., Wu Y., Swanson J.M., Pfaff D.W., and Posner M.I. Assessing the molecular genetics of attention networks. BMC Neuroscience 3 (2002) 14
23. Fossella J.A., Sommer T., Fan J., Pfaff D., and Posner M.I. Synaptogenesis and heritable aspects of executive attention. Mental Retardation and Developmental Disabilities Research Reviews 9 (2003) 178-183
24. Gallagher C., Kumar V., and Pekala R. The anomalous experiences inventory: reliability and validity. Journal of Parapsychology 58 (1994) 402-428
25. Garety P., and Wessely S. The assessment of positive symptoms. In: Barnes R., and Nelson H. (Eds). The assessment of psychoses (1994), Chapman & Hall, London 21-39
26. Geschwind N. Interictal behavioral changes in epilepsy. Epilepsia 24 (1983) S23-S30
27. Grandy D.K., and Kruzich P.J. A molecular genetic approach to the neurobiology of attnetion utilizing dopamine receptor-deficient mice. In: Posner M.I. (Ed). Cognitive neuroscience of attention (2004), Guilford Press, New York 260-268
28. Greenwood P.M., and Parasuraman R. Normal genetic variation, cognition, and aging. Behavioral and Cognitive Neuroscience Reviews 2 (2003) 278-306
29. Hamer D.H. The god gene: how faith is hardwired into our genes (2004), Doubleday, New York
30. Hariri A.R., and Weinberger D.R. Imaging genomics. British Medical Bulletin 65 (2003) 259-270
31. Hines T. Pseudoscience and the paranormal (2003), Prometheus, Amherst, NY
32. Huettel S.A., Mack P.B., and McCarthy G. Perceiving patterns in random series: dynamic processing of sequence in prefrontal cortex. Nature Neuroscience 5 (2002) 485-490
33. Kirsch I. Hypnotic suggestion: a musical mathaphor. American Journal of Clinical Hypnosis 39 (1997) 271-277 (Discussion 277-281)
34. Kirsch I. How expectancies shape experience (1999), American Psychological Association, Washington, DC
35. Kirsch I., and Braffman W. Imaginative suggestibility and hypnotizability. Current Directions in Psychological Science 10 (2001) 57-61
36. Kirsch I., Burgess C.A., and Braffman W. Attentional resources in hypnotic responding. International Journal of Clinical and Experimental Hypnosis 47 (1999) 175-191
37. Kirsch I., Wickless C., and Moffitt K.H. Expectancy and suggestibility: are the effects of environmental enhancement due to detection?. International Journal of Clinical and Experimental Hypnosis 47 (1999) 40-45
38. Krummenacher P, Brugger P, Fahti M, Mohr C. Dopamine, paranormal ideation, and the detection of meaningful stimuli. Poster; presented at the 3rd Forum of European Neuroscience, Paris, France 2002.
39. Lichtenberg P., Bachner-Melman R., Gritsenko I., and Ebstein R.P. Exploratory association study between catechol-o-methyltransferase (COMT) high/low enzyme activity polymorphism and hypnotizability. American Journal of Medical Genetics - Neuropsychiatric Genetics 96 (2000) 771-774
40. Liu Y., and Nakamura S. Stress-induced plasticity of monoamine axons. Frontiers in Bioscience 11 (2006) 1794-1801
41. Mandell A. Toward a psychobiology of transcendence: god in the brain. In: Davidson J., and Davidson R. (Eds). Psychobiology of consciousness (1980), Plenum, New York 379-464
42. McClay J.L., Fanous A., van den Oord E.J., Webb B.T., Walsh D., O'Neill F.A., Kendler K.S., and Chen X. Catechol-o-methyltransferase and the clinical features of psychosis. American Journal of Medical Genetics B, Neuropsychiatric Genetics 141 (2006) 935-938
43. Mohr C., Krummenacher P., Landis T., Sandor P.S., Fathi M., and Brugger P. Psychometric schizotypy modulates levodopa effects on lateralized lexical decision performance. Journal of Psychiatric Research 39 (2005) 241-250
44. Mohr C., Landis T., Bracha H.S., Fathi M., and Brugger P. Levodopa reverses gait asymmetries related to anhedonia and magical ideation. European Archives of Psychiatry and Clinical Neuroscience 255 (2005) 33-39
45. Mohr C., Landis T., Sandor P.S., Fathi M., and Brugger P. Nonstereotyped responding in positive schizotypy after a single dose of levodopa. Neuropsychopharmacology 29 (2004) 1741-1751
46. Oldfield R.C. The assessment and analysis of handedness: the edinburgh inventory. Neuropsychologia 9 (1971) 97-113
47. Parasuraman R., and Greenwood P.M. Molecular genetics of visuospatial attention and working memory. In: Posner M.I. (Ed). Cognitive neuroscience of attention (2004), Guilford Press, New York 245-259
48. Parasuraman R., Greenwood P.M., Kumar R., and Fossella J. Beyond heritability: neurotransmitter genes differentially modulate visuospatial attention and working memory. Psychological Science 16 (2005) 200-207
49. Persinger M.A. Propensity to report paranormal experiences is correlated with temporal lobe signs. Perceptual and Motor Skills 59 (1984) 583-586
50. Persinger M.A., and Makarec K. Temporal lobe epileptic signs and correlative behaviors displayed by normal populations. Journal of General Psychology 114 (1987) 179-195
51. Raz A. Anatomy of attentional networks. Anatomical record. Part B. New Anatomist 281 (2004) 21-36
52. Raz A. Attention and hypnosis: neural substrates and genetic associations of two converging processes. International Journal of Clinical and Experimental Hypnosis 53 (2005) 237-258
53. Raz A. Individual differences and attentional varieties. Europa Medicophysica 42 (2006) 53-58
54. Raz A. Suggestibility and hypnotizability: mind the gap. American Journal of Clinical Hypnosis 49 (2007) 205-210
55. Raz A., and Buhle J. Typologies of attentional networks. Nature reviews. Neuroscience 7 (2006) 367-379
56. Raz A., Fan J., and Posner M.I. Neuroimaging and genetic associations of attentional and hypnotic processes. Journal of Physiology, Paris 99 (2006) 483-491
57. Raz A., Fossella J.A., McGuiness P., Zephrani Z.R., and Posner M.I. Neural correlates and exploratory genetic associations of attentional and hypnotic phenomena. Hypnose und Kognition 21 (2005) 79-92
58. Raz A., Moreno-Iniguez M., Martin L., and Zhu H. Suggestion overrides the stroop effect in highly hypnotizable individuals. Consciousness and Cognition 16 (2007) 331-338
59. Shaner A. Delusions, superstitious conditioning and chaotic dopamine neurodynamics. Medical Hypotheses 52 (1999) 119-123
60. Smyrnis N., Avramopoulos D., Evdokimidis I., Stefanis C.N., Tsekou H., and Stefanis N.C. Effect of schizotypy on cognitive performance and its tuning by comt val158 met genotype variations in a large population of young men. Biological Psychiatry 61 (2007) 845-853
61. Sommer T, Fossella JA, Fan J, Posner MI. Inhibitory control: cognitive subfunctions, individual differences and variation in dopaminergic genes. In: Proceedings of the Hanse Wissenschaftskolleg; 2003: 27-44.
62. Stefanis N.C., Van Os J., Avramopoulos D., Smyrnis N., Evdokimidis I., Hantoumi I., and Stefanis C.N. Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men. Biological Psychiatry 56 (2004) 510-515
63. Stefanis N.C., Van Os J., Avramopoulos D., Smyrnis N., Evdokimidis I., and Stefanis C.N. Effect of comt val158met polymorphism on the continuous performance test, identical pairs version: tuning rather than improving performance. American Journal of Psychiatry 162 (2005) 1752-1754
64. Tellegen A., and Atkinson G. Openness to absorbing and self-altering experiences ("Absorption"), a trait related to hypnotic susceptibility. Journal of Abnormal Psychology 83 (1974) 268-277
65. Tunbridge E.M., Harrison P.J., and Weinberger D.R. Catechol-o-methyltransferase, cognition, and psychosis: Val158met and beyond. Biological Psychiatry 60 (2006) 141-151
66. Tunbridge E.M., Lane T.A., and Harrison P.J. Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain. American Journal of Medical Genetics B, Neuropsychiatric Genetics 144B (2007) 834-839
67. Winterer G., Egan M.F., Kolachana B.S., Goldberg T.E., Coppola R., and Weinberger D.R. Prefrontal electrophysiologic "noise" and catechol-o-methyltransferase genotype in schizophrenia. Biological Psychiatry 60 (2006) 578-584
68. Winterer G., Musso F., Vucurevic G., Stoeter P., Konrad A., Seker B., Gallinat J., Dahmen N., and Weinberger D.R. Comt genotype predicts bold signal and noise characteristics in prefrontal circuits. NeuroImage 32 (2006) 1722-1732
69. Wolfsberg T.G., Wetterstrand K.A., Guyer M.S., Collins F.S., and Baxevanis A.D. A user's guide to the human genome. Nature Genetics 32 (2002) 1-79
70. Zubieta J.K., Heitzeg M.M., Smith Y.R., Bueller J.A., Xu K., Xu Y., Koeppe R.A., Stohler C.S., and Goldman D. Comt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 299 (2003) 1240-1243