Negishi cross-couplings of unsaturated halides bearing relatively acidic hydrogen atoms with organozinc reagents

Organic Letters

Volumn 10, Issue 13, 2008, Pages 2765-2768

  Manolikakes, Georg ^a   Schade, Matthias A ^a   Hernandez, Carmen Muñoz ^a   Mayr, Herbert ^a   Knochel, Paul ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 55249105544     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol8009013     Document Type: Article

References (28)

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26. However, for the coupling of 5-bromoindole (2j), the zinc reagents 1a and 1b had to be prepared by transmetalation from the corresponding magnesium reagents. Control experiments have revealed accelerated cross-coupling reactions in the presence of magnesium salts. For the preparation of organomagnesium reagents, see:(a) Knochel, P.; Gommermann, N.; Kneisel, F.; Kopp, F.; Korn, T.; Sapountzis, I.; Vu, V. A. Angew. Chem., Int. Ed. 2003, 42, 4302.
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