The involvement of cellular oxidative damage in the apoptotic death induced in γ-irradiated mouse thymocytes

International Journal of Low Radiation

Volumn 5, Issue 4, 2008, Pages 356-367

  Pandey, B N ^a   Kumar, Amit ^a   Rastogi, Lori ^a   Mishra, K P ^b  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Eugenol; Mitochondrial membrane potential; Reactive oxygen species; ROS; Thymocytes

Indexed keywords

DICHLORODIHYDROFLUORESCEIN DIACETATE; EUGENOL; FLUORESCENT DYE; LIPOCORTIN 5; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL POPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; FEMALE; GAMMA IRRADIATION; LOW ENERGY RADIATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; RADIATION EXPOSURE; RADIOSENSITIVITY; THYMOCYTE;

EID: 55249100821     PISSN: 14776545     EISSN: 17419190     Source Type: Journal    
DOI: 10.1504/IJLR.2008.020979     Document Type: Article

References (24)

1. Azzam, E.I., de Toledo, S.M. and Little, J.B. (2003) 'Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect', Oncogene, Vol. 22, pp.7050-7057.
2. Azzam, E.I. and Little, J.B. (2004) 'The radiation-induced bystander effect: evidence and significance', Hum Exp Toxicol, Vol. 23, pp.61-65.
3. Bauer, V. and Bauer, F. (1999) 'Reactive oxygen species as mediators of tissue protection and injury', Gen Physiol Biophys, Vol. 18, Spec no. 7-14.
4. Belka, C. and Budach, W. (2002) 'Anti-apoptotic Bcl-2 proteins: structure, function and relevance for radiation biology', Int J Radiat Biol, Vol. 78, pp.643-658.
5. Carmody, R.J. and Cotter, T.G. (2001) 'Signalling apoptosis: a radical approach', Redox Rep, Vol. 6, pp.77-90.
6. Das, U. (2002) 'A radical approach to cancer', Med Sci Monit, Vol. 8, pp.RA79-92.
7. Green, D. and Kroemer, G. (1998) 'The central executioners of apoptosis: caspases or mitochondria?', Trends Cell Biol, Vol. 8, pp.267-271.
8. Green, D.R. (2005) 'Apoptotic pathways: ten minutes to dead', Cell, Vol. 121, pp.671-674.
9. Green, D.R. and Reed, J.C. (1998) 'Mitochondria and apoptosis', Science, Vol. 281, pp.1309-1312.
10. Hall, E.J. (2001) Radiobiology for Radiobiologists, Philadephia: Lippincott Williams and Wilkins.
11. Halliwell, B. and Gutteridge, J.M.C. (1989) Free Radicals in Biology and Medicine, Oxford: Cleardon Press.
12. Kerr, J.F., Wyllie, A.H. and Currie, A.R. (1972) 'Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics', Br J Cancer, Vol. 26, pp.239-257.
13. Mates, J.M. (2000) 'Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology', Toxicology, Vol. 153, pp.83-104.
14. Mishra, K.P. (2004) 'Cell membrane oxidative damage induced by gamma-radiation and apoptotic sensitivity', J Environ Pathol Toxicol Oncol, Vol. 23, pp.61-66.
15. Morgan, W.F. (2003a) 'Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?', Oncogene, Vol. 22, pp.7094-7099.
16. Morgan, W.F. (2003b) 'Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro', Radiat Res, Vol. 159, pp.567-580.
17. Nicoletti, I., Milgiorati, G., Pagliacci, M.C.M., Grigani, F. and Riccardi, C. (1991) 'A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry', J Immuonol Meth, Vol. 139, pp.271-279.
18. Pandey, B.N., Gordon, D.M., De Toledo, S.M., Pain, D. and Azzam, E.I. (2006a) 'Normal human fibroblasts exposed to high- or low-dose ionizing radiation: differential effects on mitochondrial protein import and membrane potential', Antioxid Redox Signal, Vol. 8, pp.1253-1261.
19. Pandey, B.N. and Mishra, K.P. (1999) 'Radiation biology for cancer radiotherapy', in H.C. Goel (Ed.) Advances in Radiation Biology and Peace, New Delhi: CBS Publishers, Vol. Suppl. 2, pp.45-51.
20. Pandey, B.N. and Mishra, K.P. (2003) 'In vitro studied on radiation induced membrane oxidative damage in apoptotic death in mouse thymocytes', Int J Low Radiat, Vol. 1, pp.113-119.
21. Pandey, B.N. and Mishra, K.P. (2004) 'Modification of thymocytes membrane radiooxidative damage and apoptosis by eugenol', J Environ Pathol Toxicol Oncol, Vol. 23, pp.117-122.
22. Pandey, B.N., Sarma, H.D., Shukla, D. and Mishra, K.P. (2006b) 'Low dose radiation induced modification of ROS and apoptosis in thymocytes of whole body irradiated mice', Int J Low Radiat, Vols. 1-2, pp.111-118.
23. Pandey, B.N., Venkatachalam, P., de Toledo, S.M. and Azzam, E.I. (2006c) 'The ionizing radiation-induced bystander effect: mechanisms and relevance to radiation protection and radiotherapy', Ind J Radiat Res, Vol. 2, pp.13-29.
24. Spitz, D.R., Azzam, E.I., Li, J.J. and Gius, D. (2004) 'Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology', Cancer Metastasis Rev, Vol. 23, pp.311-322.