Host immune response and differential survival of the sexes in Drosophila

Fly

Volumn 1, Issue 4, 2007, Pages 197-204

  Taylor, Katherine ^a   Kimbrell, Deborah A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimicrobial genes; Bacteria; Beauveria bassiana; E. coli; Female; Fungus; Host immune response; Innate immunity; Male; Post infection survival

Indexed keywords

BACTERIA (MICROORGANISMS); CORDYCEPS BASSIANA; ESCHERICHIA COLI; FUNGI;

TOLL LIKE RECEPTOR 4;

ANIMAL; ARTICLE; BEAUVERIA; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FEMALE; IMMUNOLOGY; INNATE IMMUNITY; MALE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT; SIGNAL TRANSDUCTION;

ANIMALS; BEAUVERIA; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FEMALE; IMMUNITY, NATURAL; MALE; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 55249092550     PISSN: 19336934     EISSN: 19336942     Source Type: Journal    
DOI: 10.4161/fly.5082     Document Type: Article

References (27)

1. Wang L, Ligoxygakis P. Pathogen recognition and signalling in the Drosophila innate immune response. Immunobiology 2006; 211:251-61.
2. Hultmark D. Drosophila immunity: Paths and patterns. Curr Opin Immunol 2003; 15:12-9.
3. Kimbrell DA, Beutler B. The evolution and genetics of innate immunity. Nat Rev Genet 2001; 2:256-67.
4. Lemaitre B, Hoffmann J. The host defense of Drosophila melanogaster. Annu Rev Immunol 2007; 25:697-743.
5. Marriott I, Huet-Hudson YM. Sexual dimorphism in innate immune responses to infectious organisms. Immunol Res 2006; 34:177-92.
6. Whitacre CC, Reingold SC, O'Looney PA. A gender gap in autoimmunity. Science 1999; 283:1277-8.
7. Marriott I, Bost KL, Huet-Hudson YM. Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: A possible mechanism for gender-based differences in endotoxic shock susceptibility. J Reprod Immunol 2006; 71:12-27.
8. Shames RS. Gender differences in the development and function of the immune system. J Adolesc Health 2002; 30:59-70.
9. Bouman A, Heineman MJ, Faas MM. Sex hormones and the immune response in humans. Hum Reprod Update 2005; 11:411-23.
10. McKean KA, Nunney L. Bateman's principle and immunity: Phenotypically plastic reproductive strategies predict changes in immunological sex differences. Evolution Int J Org Evolution 2005; 59:1510-7.
11. Peng J, Zipperlen P, Kubli E. Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Curr Biol 2005; 15:1690-4.
12. De Gregorio E, Spellman PT, Rubin GM, Lemaitre B. Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc Natl Acad Sci USA 2001; 98:12590-5.
13. Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann J., Hetru C. A genome-wide analysis of immune responses in Drosophila. Proc Natl Acad Sci USA 2001; 98:15119-24.
14. Roxstrom-Lindquist K, Terenius O, Faye I. Parasite-specific immune response in adult Drosophila melanogaster: A genomic study. EMBO Rep 2004; 5:207-12.
15. Bernal A, Kimbrell DA. Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc Natl Acad Sci USA 2000; 97:6019-24.
16. De Gregorio E, Spellman PT, Tzou P, Rubin GM, Lemaitre B. The Toll and Imd pathways are the major regulators of the immune response in Drosophila. Embo J 2002; 21:2568-79.
17. Tanji T, Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol 2005; 26:193-8.
18. Rutschmann S, Kilinc A, Ferrandon D. Cutting edge: The toll pathway is required for resistance to gram-positive bacterial infections in Drosophila. J Immunol 2002; 168:1542-6.
19. Georgel P, Naitza S, Kappler C, Ferrandon D, Zachary D, Swimmer C, Kopczynski C, Duyk G, Reichhart JM, Hoffmann JA. Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell 2001; 1:503-14.
20. Tinsley MC, Blanford S, Jiggin FM. Genetic variation in Drosophila melanogaster pathogen susceptibility. Parasitology 2006; 132:767-73.
21. Hedengren-Olcott M, Olcott MC, Mooney DT, Ekengren S, Geller BL, Taylor BJ. Differential activation of the NF-kB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria. J Biol Chem 2004; 279:21121-7.
22. Tanji T, Hu X, Weber AN, Ip YT. Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster. Mol Cell Biol 2007; 27:4578-88.
23. Tzou P, Ohresser S, Ferrandon D, Capovilla M, Reichhart JM, Lemaitre B, Hoffmann J., Imler JL. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 2000; 13:737-48.
24. Ryu JH, Nam KB, Oh CT, Nam HJ, Kim SH, Yoon JH, Seong JK, Yoo MA, Jang IH, Brey PT, Lee WJ. The homeobox gene Caudal regulates constitutive local expression of antimicrobial peptide genes in Drosophila epithelia. Mol Cell Biol 2004; 24:172-85.
25. Tzou P, Reichhart JM, Lemaitre B. Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proc Natl Acad Sci USA 2002; 99:2152-7.
26. Dionne MS, Pham LN, Shirasu-Hiza M, Schneider DS. Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol 2006; 16:1977-85.
27. Libert S, Chao Y, Chu X, Pletcher SD. Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkB signaling. Aging Cell 2006; 5:533-43.