Dendritic cells pulsed with keyhole limpet hemocyanin and cryopreserved maintain anti-tumor activity in a murine melanoma model

Clinical Immunology

Volumn 129, Issue 3, 2008, Pages 482-491

  Teitz Tennenbaum, Seagal ^a   Li, Qiao ^a   Davis, Mary A ^a   Chang, Alfred E ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Cancer vaccines; ; Cellular immunotherapy; ; Cryopreservation; Dendritic cells; ; Keyhole limpet hemocyanin;

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; DENDRITIC CELL VACCINE; KEYHOLE LIMPET HEMOCYANIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNIZATION; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL FUNCTION; CELL MATURATION; CELL STIMULATION; CELL THERAPY; CELL VIABILITY; CONTROLLED STUDY; CRYOPRESERVATION; DENDRITIC CELL; ENDOCYTOSIS; FEMALE; IMMUNE RESPONSE; MELANOMA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELL SURVIVAL; CRYOPRESERVATION; DENDRITIC CELLS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HEMOCYANIN; IMMUNOPHENOTYPING; IMMUNOTHERAPY, ADOPTIVE; LYMPHOCYTE CULTURE TEST, MIXED; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 55249091808     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.08.022     Document Type: Article

References (42)

1. Harris J.R., and Markl J. Keyhole limpet hemocyanin (KLH): a biomedical review. Micron 30 (1999) 597-623
2. Harris J.R., and Markl J. Keyhole limpet hemocyanin: molecular structure of a potent marine immunoactivator. A review. Eur. Urol. 37 Suppl 3 (2000) 24-33
3. Schlienger K., Craighead N., Lee K.P., Levine B.L., and June C.H. Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells. Blood 96 (2000) 3490-3498
4. Mehta-Damani A., Markowicz S., and Engleman E.G. Generation of antigen-specific CD4+ T cell lines from naive precursors. Eur. J. Immunol. 25 (1995) 1206-1211
5. Mittelman A., Chen Z.J., Liu C.C., Hirai S., and Ferrone S. Kinetics of the immune response and regression of metastatic lesions following development of humoral anti-high molecular weight-melanoma associated antigen immunity in three patients with advanced malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23. Cancer Res. 54 (1994) 415-421
6. Foon K.A., John W.J., Chakraborty M., Sherratt A., Garrison J., Flett M., and Bhattacharya-Chatterjee M. Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. Clin. Cancer Res. 3 (1997) 1267-1276
7. Birebent B., Koido T., Mitchell E., Li W., Somasundaram R., Purev E., Hoey D., Mastrangelo M., Maguire H., Harris D.T., Nair S., Cai E., and Herlyn D. Anti-idiotypic antibody (ab2) vaccines: coupling of Ab2 BR3E4 to KLH increases humoral and/or cellular immune responses in animals and colorectal cancer patients. J. Cancer Res. Clin. Oncol. 127 Suppl 2 (2001) R27-R33
8. Timmerman J.M., and Levy R. Linkage of foreign carrier protein to a self-tumor antigen enhances the immunogenicity of a pulsed dendritic cell vaccine. J. Immunol. 164 (2000) 4797-4803
9. Shimizu K., Thomas E.K., Giedlin M., and Mule J.J. Enhancement of tumor lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein. Cancer Res. 61 (2001) 2618-2624
10. Redman B.G., Chang A.E., Whitfield J., Esper P., Jiang G., Braun T., Roessler B., and Mule J.J. Phase Ib trial assessing autologous, tumor-pulsed dendritic cells as a vaccine administered with or without IL-2 in patients with metastatic melanoma. J. Immunother. 31 (2008) 591-598
11. Chang A.E., Redman B.G., Whitfield J.R., Nickoloff B.J., Braun T.M., Lee P.P., Geiger J.D., and Mule J.J. A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer. Clin. Cancer Res. 8 (2002) 1021-1032
12. Geiger J.D., Hutchinson R.J., Hohenkirk L.F., McKenna E.A., Yanik G.A., Levine J.E., Chang A.E., Braun T.M., and Mule J.J. Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression. Cancer Res. 61 (2001) 8513-8519
13. Nestle F.O., Alijagic S., Gilliet M., Sun Y., Grabbe S., Dummer R., Burg G., and Schadendorf D. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med. 4 (1998) 328-332
14. Banchereau J., Palucka A.K., Dhodapkar M., Burkeholder S., Taquet N., Rolland A., Taquet S., Coquery S., Wittkowski K.M., Bhardwaj N., Pineiro L., Steinman R., and Fay J. Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res. 61 (2001) 6451-6458
15. Hsu F.J., Benike C., Fagnoni F., Liles T.M., Czerwinski D., Taidi B., Engleman E.G., and Levy R. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2 (1996) 52-58
16. Teitz-Tennenbaum S., Li Q., Rynkiewicz S., Ito F., Davis M.A., McGinn C.J., and Chang A.E. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 63 (2003) 8466-8475
17. Huang J., Wang Y., Guo J., Lu H., Lin X., Ma L., Teitz-Tennenbaum S., Chang A.E., and Li Q. Radiation-induced apoptosis along with local and systemic cytokine elaboration is associated with DC plus radiotherapy-mediated renal cell tumor regression. Clin. Immunol. 123 (2007) 298-310
18. Teitz-Tennenbaum S., Li Q., Okuyama R., Davis M.A., Sun R., Whitfield J., Knibbs R.N., Stoolman L.M., and Chang A.E. Mechanisms involved in radiation enhancement of intratumoral dendritic cell therapy. J. Immunother. 31 (2008) 345-358
19. Chi K.H., Liu S.J., Li C.P., Kuo H.P., Wang Y.S., Chao Y., and Hsieh S.L. Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J. Immunother. 28 (2005) 129-135
20. Lewalle P., Rouas R., Lehmann F., and Martiat P. Freezing of dendritic cells, generated from cryopreserved leukaphereses, does not influence their ability to induce antigen-specific immune responses or functionally react to maturation stimuli. J. Immunol. Methods 240 (2000) 69-78
21. Feuerstein B., Berger T.G., Maczek C., Roder C., Schreiner D., Hirsch U., Haendle I., Leisgang W., Glaser A., Kuss O., Diepgen T.L., Schuler G., and Schuler-Thurner B. A method for the production of cryopreserved aliquots of antigen-preloaded, mature dendritic cells ready for clinical use. J. Immunol. Methods 245 (2000) 15-29
22. Garderet L., Cao H., Salamero J., Verge V., Tisserand E., Scholl S., Gorin N.C., and Lopez M. In vitro production of dendritic cells from human blood monocytes for therapeutic use. J. Hematother. Stem Cell Res. 10 (2001) 553-567
23. Pecher G., Schirrmann T., Kaiser L., and Schenk J.A. Efficient cryopreservation of dendritic cells transfected with cDNA of a tumour antigen for clinical application. Biotechnol. Appl. Biochem. 34 (2001) 161-166
24. Tuyaerts S., Noppe S.M., Corthals J., Breckpot K., Heirman C., De Greef C., Van Riet I., and Thielemans K. Generation of large numbers of dendritic cells in a closed system using Cell Factories. J. Immunol. Methods 264 (2002) 135-151
25. John J., Hutchinson J., Dalgleish A., and Pandha H. Cryopreservation of immature monocyte-derived dendritic cells results in enhanced cell maturation but reduced endocytic activity and efficiency of adenoviral transduction. J. Immunol. Methods 272 (2003) 35-48
26. Westermann J., Korner I.J., Kopp J., Kurz S., Zenke M., Dorken B., and Pezzutto A. Cryopreservation of mature monocyte-derived human dendritic cells for vaccination: influence on phenotype and functional properties. Cancer Immunol. Immunother. 52 (2003) 194-198
27. Celluzzi C.M., and Welbon C. A simple cryopreservation method for dendritic cells and cells used in their derivation and functional assessment. Transfusion 43 (2003) 488-494
28. Hori S., Heike Y., Takei M., Maruyama M., Inoue Y., Lee J.J., Kim H.J., Harada Y., Kawai H., Shimosaka A., Kami M., Tanosaki M.D., Wakasugi H., Saito S., Takaue Y., and Kakizoe T. Freeze-thawing procedures have no influence on the phenotypic and functional development of dendritic cells generated from peripheral blood CD14+ monocytes. J. Immunother. 27 (2004) 27-35
29. Arca M.J., Krauss J.C., Aruga A., Cameron M.J., Shu S., and Chang A.E. Therapeutic efficacy of T cells derived from lymph nodes draining a poorly immunogenic tumor transduced to secrete granulocyte-macrophage colony-stimulating factor. Cancer Gene Ther. 3 (1996) 39-47
30. Nestle F.O., Farkas A., and Conrad C. Dendritic-cell-based therapeutic vaccination against cancer. Curr. Opin. Immunol. 17 (2005) 163-169
31. Gilboa E. DC-based cancer vaccines. J. Clin. Invest. 117 (2007) 1195-1203
32. Kim K.W., Kim S.H., Shin J.G., Kim G.S., Son Y.O., Park S.W., Kwon B.H., Kim D.W., Lee C.H., Sol M.Y., Jeong M.H., Chung B.S., and Kang C.D. Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity. Int. J. Cancer 109 (2004) 685-690
33. Chen Z., Xia D., Bi X., Saxena A., Sidhu N., El-Gayed A., and Xiang J. Combined radiation therapy and dendritic cell vaccine for treating solid tumors with liver micro-metastasis. J. Gene Med. 7 (2005) 506-517
34. Akutsu Y., Matsubara H., Urashima T., Komatsu A., Sakata H., Nishimori T., Yoneyama Y., Hoshino I., Murakami K., Usui A., Kano M., and Ochiai T. Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice. Int. J. Oncol. 31 (2007) 509-515
35. Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5 (2005) 263-274
36. Ganss R., Ryschich E., Klar E., Arnold B., and Hammerling G.J. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62 (2002) 1462-1470
37. Lugade A.A., Moran J.P., Gerber S.A., Rose R.C., Frelinger J.G., and Lord E.M. Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor. J. Immunol. 174 (2005) 7516-7523
38. Chakraborty M., Abrams S.I., Camphausen K., Liu K., Scott T., Coleman C.N., and Hodge J.W. Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J. Immunol. 170 (2003) 6338-6347
39. Strome S.E., Voss S., Wilcox R., Wakefield T.L., Tamada K., Flies D., Chapoval A., Lu J., Kasperbauer J.L., Padley D., Vile R., Gastineau D., Wettstein P., and Chen L. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res. 62 (2002) 1884-1889
40. Apetoh L., Ghiringhelli F., Tesniere A., Obeid M., Ortiz C., Criollo A., Mignot G., Maiuri M.C., Ullrich E., Saulnier P., Yang H., Amigorena S., Ryffel B., Barrat F.J., Saftig P., Levi F., Lidereau R., Nogues C., Mira J.P., Chompret A., Joulin V., Clavel-Chapelon F., Bourhis J., Andre F., Delaloge S., Tursz T., Kroemer G., and Zitvogel L. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 13 (2007) 1050-1059
41. Yang D., Chen Q., Yang H., Tracey K.J., Bustin M., and Oppenheim J.J. High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin. J. Leukoc. Biol. 81 (2007) 59-66
42. Sai T., Milling S.W., and Mintz B. Freezing and thawing of bone marrow-derived murine dendritic cells with subsequent retention of immunophenotype and of antigen processing and presentation characteristics. J. Immunol. Methods 264 (2002) 153-162