Cryptic chromosome rearrangement resulting in SYT-SSX2 fusion gene in a monophasic synovial sarcoma

Cancer Genetics and Cytogenetics

Volumn 187, Issue 1, 2008, Pages 45-49

  Torres, Lurdes ^a   Lisboa, Susana ^a   Cerveira, Nuno ^a   Lopes, José M ^a   Lopes, Carlos ^a,b   Teixeira, Manuel R ^a,b  

^a PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN;

ADULT; ARTICLE; CASE REPORT; CHROMOSOME 18Q; CHROMOSOME BANDING PATTERN; CHROMOSOME REARRANGEMENT; CHROMOSOME XP; COMPARATIVE GENOMIC HYBRIDIZATION; DNA SEQUENCE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE FUSION; HUMAN; MARKER CHROMOSOME; MONOSOMY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SSX2 GENE; SYNOVIAL SARCOMA; SYT GENE;

CHROMOSOME BANDING; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, X; COMBINED MODALITY THERAPY; FEMALE; GENE FUSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; TRANSLOCATION, GENETIC;

EID: 55149109459     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.07.008     Document Type: Article

References (21)

1. Fisher C., de Bruijn D.R.H., and Kessel G.v. Synovial sarcoma. In: Fletcher C.D.M., Unni K.K., and Mertens F. (Eds). World Health Organization Classification of TumoursPathology and Genetics of Tumours of Soft Tissue and Bone (2002), IARC Press, Lyon 200-204
2. Sandberg A.A., and Bridge J.A. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma. Cancer Genet Cytogenet 133 (2002) 1-23
3. Burns D.K., and Kumar V. The musculoskeletal system. In: Kumar V., Cotran R.S., and Robbins S.L. (Eds). Robbins Basic Pathology. 7th edition (2003), W.B. Saunders Co., Philadelphia 787-788
4. Subramaniam M.M., Noguera R., Piqueras M., Navarro S., Carda C., Pellin A., López-Guerrero J.A., and Llombart-Bosch A. Evaluation of genetic stability of the SYT gene rearrangement by break-apart FISH in primary and xenotransplanted synovial sarcomas. Cancer Genet Cytogenet 172 (2007) 23-28
5. dos Santos N.R., de Bruijn D.R., and van Kessel A.G. Molecular mechanisms underlying human synovial sarcoma development. Genes Chromosomes Cancer 30 (2001) 1-14
6. Ladanyi M., Antonescu C.R., Leung D.H., Woodruff J.M., Kawai A., Healey J.H., Brennan M.F., Bridge J.A., Neff J.R., Barr F.G., Goldsmith J.D., Brooks J.S., Goldblum J.R., Ali S.Z., Shipley J., Cooper C.S., Fisher C., Skytting B., and Larsson O. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 62 (2002) 135-140
7. Dei Tos A.P., and Dal Cin P. The role of cytogenetics in the classification of soft tissue tumours. Virchows Arch 431 (1997) 83-94
8. Lestou V.S., O'Connell J.X., Robichaud M., Salski C., Mathers J., Maguire J., ChudobaI, Sorensen P.H., Lam W., and Horsman D.E. Cryptic t(X;18), ins(6;18), and SYT-SSX2 gene fusion in a case of intraneural monophasic synovial sarcoma. Cancer Genet Cytogenet 138 (2002) 153-156
9. Shaffer L.G., and Tommerup N. ISCN: An International System for Human Cytogenetic Nomenclature (2005), S. Karger, Basel
10. Kallioniemi O.P., Kallioniemi A., Piper J., Isola J., Waldman F.M., Gray J.W., and Pinkel D. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer 10 (1994) 231-243
11. Teixeira M.R., Ribeiro F.R., Torres L., Pandis N., Andersen J.A., Lothe R.A., and Heim S. Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis. Br J Cancer 91 (2004) 775-782
12. Kirchhoff M., Gerdes T., Rose H., Maahr J., Ottesen A.M., and Lundsteen C. Detection of chromosomal gains and losses in comparative genomic hybridization analysis based on standard reference intervals. Cytometry 31 (1998) 163-173
13. Panagopoulos I., Mertens F., Isaksson M., Limon J., Gustafson P., Skytting B., Akerman M., Sciot R., Dal P.C., Samson I., Iliszko M., Ryoe J., Dêbiec-Rychter M., Szadowska A., Brosjö O., Larsson O., Rydholm A., and Mandahl N. Clinical impact of molecular and cytogenetic findings in synovial sarcoma. Genes Chromosomes Cancer 31 (2001) 362-372
14. Morel F., Herry A., Le Bris M.J., Morice P., Bouquard P., Abgrall J.F., Berthou C., and De Braekeleer M. Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukaemia. Cancer Genet Cytogenet 147 (2003) 115-120
15. Grimwade D., Biondi A., Mozziconacci M.J., Hagemeijer A., Berger R., Neat M., Howe K., Dastugue N., Jansen J., Radford-Weiss I., Lo Coco F., Lessard M., Hernandez J.M., Delabesse E., Head D., Liso V., Sainty D., Flandrin G., Solomon E., Birg F., and Lafage-Pochitaloff M. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies. Blood 96 (2000) 1297-1308
16. García-Casado Z., Cervera J., Valencia A., Pajuelo J.C., Mena-Duran A.V., Barragán E., Bolufer P., and Sanz M.A. A t(17;20)(q21;q12) masking a variant t(15;17)(q22;q21) in a patient with acute promyelocytic leukemia. Cancer Genet Cytogenet 168 (2006) 73-76
17. Rowe D., Cotterill S.J., Ross F.M., Bunyan D.J., Vickers S.J., Bryon J., McMullan D.J., Griffiths M.J., Reilly J.T., Vandenberghe E.A., Wilson G., Watmore A.E., and Bown N.P. Cytogenetically cryptic AML1-ETO and CBF beta-MYH11 gene rearrangements: incidence in 412 cases of acute myeloid leukaemia. Br J Haematol 111 (2000) 1051-1056
18. Batanian J.R., Bridge J.A., Wickert R., Vogler C., Gadre B., and Huang Y. EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). Cancer Genet Cytogenet 133 (2002) 72-75
19. Kaneko Y., Kobayashi H., Handa M., Satake N., and Maseki N. EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma. Genes Chromosomes Cancer 18 (1997) 228-231
20. Cerveira N., Torres L., Ribeiro F.R., Henrique R., Pinto A., Bizarro S., Ferreira A.M., Lopes C., and Teixeira M.R. Multimodal genetic diagnosis of solid variant alveolar rhabdomyosarcoma. Cancer Genet Cytogenet 163 (2005) 138-143
21. Geurts van Kessel A., de Bruijn D., Hermsen L., Janssen I., dos Santos N.R., Willems R., Makkus L., Schreuder H., and Veth R. Masked t(X;18)(p11;q11) in a biphasic synovial sarcoma revealed by FISH and RT-PCR. Genes Chromosomes Cancer 23 (1998) 198-201