Estrogen receptor α and β in uterine fibroids: a basis for altered estrogen responsiveness

Fertility and Sterility

Volumn 90, Issue 5, 2008, Pages 1878-1885

  Bakas, Panagiotis ^a   Liapis, Angelos ^a   Vlahopoulos, Spiros ^b   Giner, Maria ^a   Logotheti, Stella ^b   Creatsas, Georgios ^a   Meligova, Aggeliki K ^b   Alexis, Michael N ^b   Zoumpourlis, Vassilis ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF BIOLOGY   (Greece)

Author keywords

estrogen receptor alpha; estrogen receptor beta; fibroids; myometrium; Uterine myomas

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; DNA BINDING; DNA SYNTHESIS; ESTROGEN RESPONSIVE ELEMENT; FEMALE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; LEIOMYOMA; MYOMECTOMY; MYOMETRIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA EXTRACTION; UTERUS BIOPSY; UTERUS MYOMA;

ADULT; DIMERIZATION; DNA; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; FOLLICULAR PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEIOMYOMA; MIDDLE AGED; MYOMETRIUM; RNA, MESSENGER; UTERINE NEOPLASMS;

EID: 55149090714     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.09.019     Document Type: Article

References (37)

1. Buttram V.C., and Reiter R.C. Uterine leiomyomata: etiology, symptomatology and management. Fertil Steril 36 (1981) 433-445
2. Parker W.H. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril 87 (2007) 725-736
3. Stewart E.A. Uterine fibroids. Lancet 357 (2001) 293-298
4. Noe M., Kunz G., Herbertz M., Mall G., and Leyendecker G. The cyclic pattern of the immunocytochemical expression of estrogen and progesterone receptors in human and endometrial layers: characterization of endometrial-subendometrial unit. Hum Reprod 14 (1999) 190-197
5. Shozu M., Sumitani H., Segawa T., Yang H.J., Murakami K., and Inoue M. Inhibition of in situ expression of aromatase P450 in leiomyoma of the uterus by leuprorelin acetate. J Clin Endocrinol Metab 86 (2001) 5405-5411
6. Al-Hendy A., Lee E.J., Wang H.Q., and Copland J.A. Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice. Am J Obstet Gynecol 191 (2004) 1621-1631
7. Shang Y., and Brown M. Molecular determinants for the tissue specificity of SERMs. Science 295 (2002) 2465-2468
8. Hall J.M., and Korach K.S. Analysis of the molecular mechanisms of human estrogen receptors α and β reveals differential specificity in target promoter regulation by xenoestrogens. J Biol Chem 277 (2002) 44455-44461
9. Dahlman-Wright K., Cavailles V., Fuqua S.A., Jordan V.C., Katzenellenbogen J.A., Korach K.S., et al. International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev 58 (2006) 773-781
10. Cowley S.M., Hoare S., Mosselman S., and Parker M.G. Estrogen receptors alpha and beta form heterodimers on DNA. J Biol Chem 272 (1997) 19858-19862
11. Osborne C.K., and Schiff R. Estrogen-receptor biology: continuing progress and therapeutic implications. J Clin Oncol 23 Suppl 8 (2005) 1616-1622
12. Paech K., Webb P., Kuiper G.G., Nilsson S., Gustafsson J., Kushner P.J., et al. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277 (1997) 1508-1510
13. Mueller S.O., Clark J.A., Myers P.H., and Korach K.S. Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology 143 (2002) 2357-2365
14. Forster C., Makela S., Warri A., Kietz S., Becker D., Hultenby K., et al. Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci USA 99 (2002) 15578-15583
15. Helguero L.A., Faulds M.H., Gustafsson J.A., and Haldosen L.A. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24 (2005) 6605-6616
16. Shaaban A.M., Jarvis C., Moore F., West C., Dodson A., and Foster C.S. Prognostic significance of estrogen receptor beta in epithelial hyperplasia of usual type with known outcome. Am J Surg Pathol 29 (2005) 1593-1599
17. Chang E.C., Frasor J., Komm B., and Katzenellenbogen B.S. Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology 147 (2006) 4831-4842
18. Valladares F., Frías I., Báez D., García C., López F.J., Fraser J.D., et al. Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells. Fertil Steril 86 (2006) 1736-1743
19. Matsuzaki S., Fukaya T., Uehara S., Murakami T., Sasano H., and Yajima A. Characterization of messenger RNA expression of estrogen receptor-alpha and -beta in patients with ovarian endometriosis. Fertil Steril 73 (2000) 1219-1225
20. Jakimiuk A.J., Bogusiewicz M., Tarkowski R., Dziduch P., Adamiak A., Wrobel A., et al. Estrogen receptor alpha and beta expression in uterine leiomyomas from premenopausal women. Fertil Steril 82 Suppl 3 (2004) 1244-1249
21. Wang H., Wu X., Englund K., Blanck A., Lindblom B., and Sahlin M. Different expression of estrogen receptors α and β in human myometrium and leiomyoma during the proliferative phase of the menstrual cycle and after GnRHa treatment. Gynecol Endocrinol 15 (2001) 443-452
22. Roan C.J., Chuang J.H., Hsu T.Y., Tsai H.Y., Pan L.L., and Cheng J.T. Estrogen receptor beta is not increasingly expressed in leiomyoma nodules which show no progressive enlargement in premenopausal women. J Formos Med Assoc 104 (2005) 920-926
23. Noyes R.W., Hertig A.T., and Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol 122 (1975) 262-263
24. Gorgoulis V.G., Zacharatos P., Mariatos G., Liloglou T., Kokotas S., Kastrinakis N., et al. Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics. Cancer Res 61 (2001) 538-549
25. Karakaidos P., Taraviras S., Vassiliou L.V., Zacharatos P., Kastrinakis N.G., Kougiou D., et al. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability-evidence of E2F-1 transcriptional control over hCdt1. Am J Pathol 165 (2004) 1351-1365
26. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
27. Katsanou E.S., Halabalaki M., Aligiannis N., Mitakou S., Skaltsounis A.L., Alexi X., et al. Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: modulation by adrenal and gonadal steroids. J Steroid Biochem Mol Biol 104 (2007) 228-236
28. Alexis M.N., Stylianopoulou F., Kitraki E., and Sekeris C.E. The distribution and properties of the glucocorticoid receptor from rat brain and pituitary. J Biol Chem 258 (1983) 4710-4714
29. Stauffer S.R., Coletta C.J., Tedesco R., Nishiguchi G., Carlson K., Sun J., et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem 43 (2000) 4934-4947
30. Fokialakis N., Lambrinidis G., Mitsiou D.J., Aligiannis N., Mitakou S., Skaltsounis A.L., et al. A new class of phytoestrogens; evaluation of the estrogenic activity of deoxybenzoins. Chem Biol 11 (2004) 397-406
31. Roger P., Sahla M.E., Makela S., Gustafsson J.A., Baldet P., and Rochefort H. Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res 61 (2001) 2537-2541
32. Hall J.M., and McDonnell D.P. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140 (1999) 5566-5578
33. Liu M.M., Albanese C., Anderson C.M., Hilty K., Webb P., Uht R.M., et al. Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 277 (2002) 24353-24360
34. Kovacs K.A., Oszter A., Gocze P.M., Kornyei J.L., and Szabo L. Comparative analysis of cyclin D1 and estrogen receptor (α and β) levels in human leiomyoma and adjacent myometrium. Mol Hum Reprod 7 (2001) 1085-1091
35. Kolankaya A., and Arici A. Myomas and assisted reproductive technologies: when and how to act?. Obstet Gynecol Clin North Am 33 (2006) 145-152
36. Bradlow H.L., Michnovicz J., Telang N.T., and Osborne M.P. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12 (1991) 1571-1574
37. Sundar S.N., Kerekatte V., Equinozio C.N., Doan V.B., Bjeldanes L.F., and Firestone G.L. Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. Mol Endocrinol 20 (2006) 3070-3082