Effects of chronic ethanol administration on serotonin metabolism in the various regions of the rat brain

Neurochemical Research

Volumn 25, Issue 2, 2000, Pages 257-262

  Uzbay, I Tayfun ^a   Usanmaz, S E ^b   Akarsu, E S ^b  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

5 hydroxy indole acetic acid; Chronic ethanol administration; Ethanol; Ethanol dependence; Rat brain regions; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ALCOHOL; SEROTONIN;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN METABOLISM; TISSUE DISTRIBUTION;

ANIMALS; CEREBRAL CORTEX; CORPUS STRIATUM; ETHANOL; HYDROXYINDOLEACETIC ACID; RATS; RATS, WISTAR; SEROTONIN;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0034040627     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007579705230     Document Type: Article

References (36)

1. O'Brien, C. P., 1996. Drug addiction and drug abuse. Pages 557-575, in Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., and Gilman, A. G. (eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics., McGraw-Hill, New York.
2. Cloninger, C. R. 1987. Neurogenetic and adaptive mechanisms in alcoholism. Science 236:410-416.
3. McBride, W. J., Murphy, J. M., Gatto, G. J., Levy, A. D., Lumeng, L., and Li, T.-K. 1991. Serotonin and dopamine systems regulating alcohol intake. Alcohol Alcohol. Suppl. 1:411-416.
4. Sellers, E. M., Higgins, G. A., and Sobel, M. B. 1992. 5-HT and alcohol abuse. Trends Pharmacol. Sci. 13:69-75.
5. Wallis, C., Rezazadeh, M., and Lal, H. 1993. Role of serotonin in ethanol abuse. Drug Dev. Res. 30:178-188.
6. Ferreria, L., and Soares-DaSilva, P. 1991.5-hydroxytryptamine and alcoholism. Hum. Psychopharmacol. Suppl.6:S21-S24.
7. Yoshimoto, K., McBride, W. J., Lumeng, L., and Li, T.-K. 1991. Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol 9:17-22.
8. LeMarquand, D., Pihl, R. O., and Benkelfat, C. 1994. Serotonin and alcohol intake, abuse, and dependence:findings of animal studies. Biol. Psychiatr. 36:395-421.
9. Weiss, F., Parsons, L. H., Schulteis, G., Hyytia, P., Lorang, M. T., Bloom, F. E., and Koob, G. F. 1996. Ethanol self-administration restores withdrawal associated deficiencies in accumbal dopamine and 5-Hydroxytryptamine release in dependent rats. J. Neurosci., 16:3474-3485.
10. Buydens-Branchey, L., Branchey, M., Fergeson, P., Hudson, J., and McKernin, C. 1997. Hormonal, psychological, and alcohol craving changes after m-chlorphenylpiperazine administration in alcoholics. Alcohol. Clin. Exp. Res. 21:220-226.
11. Rezvani, A. H., Overstreet, D. H., and Janowsky, D. S. 1990. Genetic serotonin deficiency and alcohol preference in the fawn hooded rats. Alcohol Alcohol. 25:573-575.
12. Koob, G. F., and Bloom, F. E. 1988. Cellular and molecular mechanisms of drug dependence. Science 242:715-723.
13. Koob, G. F. 1992. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13:177-184.
14. Samson, H. H., and Harris, R. A. 1992. Neurobiology of alcohol abuse. Trends Pharmacol. Sci. 13:206-211, 1992.
15. Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytiä, P., Merlo-Pich, E., and Weiss, F. 1998. Neurocircuity targets in ethanol reward and dependence. Alcohol. Clin. Exp. Res. 22:3-9.
16. Uzbay, İ. T., Usanmaz, S., Tapanyigit, E. E. Aynacioglu, S., and Akarsu, E. S. 1998. Dopaminergic and serotonergic alterations in the rat brain during ethanol withdrawal: association with behavioral signs. Drug Alcohol Depend. 53:39-47.
17. Uzbay, İ. T., and Kayaalp, S. O. 1995. A modified liquid diet of chronic ethanol administration: Validation by ethanol withdrawal syndrome in rats. Pharmacol. Res. 31:37-42.
18. Uzbay, İ. T., and Kayaalp, S. O. 1995. Heterogeneity of tolerance developed to effects of ethanol on rotarod and accelerod performances in rats. Alcohol, 12:593-595.
19. Uzbay İ. T., Erden, B. F., Tapanyigit, E. E., and Kayaalp, S. O. 1997. Nitric oxide synthase inhibition attenuates signs of ethanol withdrawal in rats. Life Sci. 61:2197-2209.
20. Jolley, M. E. 1981. Fluorescence polarization immunoassay for the determination of therapeutic drug levels in human plasma. J. Anal. Toxicol. 5:236-240.
21. Jussofie, A., Lojewski, J., and Hiemke, C. 1993. Simultaneous automated determination of catecolamines, serotonin, and their metabolites in brain tissue by HPLC and electrochemical detection. J. Liquid Chromatog. 16:447-463.
22. Uzbay, İ. T., Akarsu, E. S., and Kayaalp, S. O. 1994. Effects of bromocriptine and haloperidol on ethanol withdrawal syndrome in rats. Pharmacol. Biochem. Behav. 49:969-974.
23. Uzbay, İ. T., Akarsu, E. S., and Kayaalp, S. O. 1995. Effects of flumazenil on ethanol withdrawal syndrome in rats. Arzneim. Forsch-Drug Res. 45:120-124.
24. Uzbay, İ. T., Sever, B., Celik, T., and Ayhan, I. H. 1995. Investigation of the effects of moclobemide in chronic ethanol feeding rats. Pharmacol. Res. 32:287-292.
25. Uzbay, İ. T. and Wallis, C. J. 1999. Lack of tolerance to ethanol-induced motor impairment on accelerod performance in rats. Pharmacol. Biochem. Behav. 63:607-611.
26. Mirowsky, Y., Wagner, G. C., Sekowski, A., Goldberg, M., and Fisher, H. 1995. Simultaneous changes in striatal dopamine, serotonin, and their metabolites after withdrawal seizures in rats from dependence on alcohol. Alcohol 12:251-256.
27. Frankel, D., Khanna, J. M., Kalant, H., and LeBlanc, A. E. 1974. Effect of acute and chronic ethanol administration on serotonin turnover in rat brain. Psychopharmacologia 37:91-100.
28. Murphy, J. M., McBridge, W. J., Lumeng, L., and Li, T.-K. 1987. Contents of monoamines in forebrain regions of alcohol-preferring and non-preferring lines of rats. Pharmacol. Biochem. Behav. 26:389-392.
29. Roy, A., Virkunnen, M., and Linnolia, M. 1987. Reduced central serotonin turnover in subgroup of alcoholics. Biol. Psychiatr. 11:173-177.
30. Myers, R. D. and Quarfordt, S.D. 1991. Alcohol drinking attenuated by sertraline in rats with 6-OHDA or 5,7-DHT lesions of N. accumbens: a caloric response? Pharmacol. Biochem. Behav. 40:923-929.
31. Myers, R. D. 1994. New drugs for the treatment of experimental alcoholism. Alcohol 11:439-451.
32. Badawy, A. A.-B., Evans, M., and Punjani, N. F. 1980. Enhancement of rat brain metabolism of a tryptophan load by chronic ethanol administration. Br. J. Pharmacol. 68:22-24.
33. Badawy, A. A.-B., and Evans, M. 1983. Opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on the metabolism and disposition of endogenous and exogenous tryptophan in the rat. Alcohol Alcohol. 18:369-387.
34. Mena, M. A. and Herrera, E. 1980. Monoamine metabolism in rat brain regions following long-term alcohol treatment. J. Neural Transm. 41:227-236.
35. Pohorecky, L. A., Newman, B., Sun, J., and Bailey, W. H. Acute and chronic ethanol ingestion and serotonin metabolism in rat brain. J. Pharmacol. Exp. Ther. 204:424-432.
36. Wu, P. H., Naranjo, C. A., and Fan, T. 1986. Chronic ethanol inhibits rat hippocampal "stimulus secretion" coupling mechanism for 5-HT in vitro. Neurochem. Res. 47:801-812.