Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia

Neuropsychopharmacology

Volumn 31, Issue 12, 2006, Pages 2767-2775

  D'Souza, Deepak C ^a,b,c   Gil, Roberto B ^a,c,d   Madonick, Steven ^a,c,e   Perry, Edward B ^a,c   Forselius Bielen, Kimberlee ^a,b,c   Braley, Gabriel ^a,c   Donahue, Lia ^a,c   Tellioglu, Tahir ^a,c   Zimolo, Zoran ^a,c   Gueorguieva, Ralitza ^b,c   Krystal, John H ^a,b,c  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b Yale University School of Medicine   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d College of Physicians and Surgeons ^*  (United States)

^e INSTITUTE OF LIVING   (United States)

Author keywords

Alcohol; Euphoria; Memory; Psychosis; Schizophrenia; Vulnerability

Indexed keywords

ALCOHOL; ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; FLUPHENAZINE; FLUPHENAZINE DECANOATE; HALOPERIDOL; HALOPERIDOL DECANOATE; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; QUETIAPINE; RISPERIDONE; TIOTIXENE;

ADULT; AKATHISIA; ALCOHOL ABUSE; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALERTNESS; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISTRACTIBILITY; DRUG ALCOHOL INTERACTION; DYSKINESIA; EDUCATION; EUPHORIA; FEMALE; GENDER; GROUPS BY AGE; HUMAN; HYPOTHESIS; LABORATORY; LEARNING; LIFESPAN; MALE; MEASUREMENT; MOTOR PERFORMANCE; PERCEPTION; PRIORITY JOURNAL; PSYCHOSIS; RISK ASSESSMENT; SCHIZOPHRENIA; STANDARD; SYMPTOMATOLOGY; VERBAL MEMORY;

ADOLESCENT; ADULT; AGED; ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; AROUSAL; BRAIN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOUBLE-BLIND METHOD; ETHANOL; EUPHORIA; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PLACEBO EFFECT; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 33751086141     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301207     Document Type: Article

References (32)

1. Benes FM, Berretta S (2001). GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 25: 1-27.
2. Brandt J, Corwin J, Krafft L (1992). Is verbal recognition memory really different in Huntington's and Alzheimer's disease. J Clin Exp Neuropsychol 14: 773-784.
3. Bremner JD, Krystal JH, Putnam FW, Southwick SM, Marmar C, Charney DS et al (1998). Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS). J Traumatic Stress 11: 125-136.
4. Brunner EDS, Langer F (2002). Nonparametric Analysis of Longitudinal Data in Factorial Experiments. John Wiley and Sons: New York.
5. Chambers RA, Krystal JH, Self DW (2001). A neurobiological basis for substance abuse comorbidity in schizophrenia. Biol Psychiatry 50: 71-83.
6. Chutuape MA, de Wit H (1994). Relationship between subjective effects and drug preferences: ethanol and diazepam. Drug Alcohol Depend 34: 243-251.
7. Cuffel BJ, Chase P (1994). Remission and relapse of substance use disorders in schizophrenia. Results from a one-year prospective study. J Nerv Mental Dis 182: 342-348.
8. D'Souza DC, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G et al (2005). Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biol Psychiatry 57: 594-608.
9. de Wit H, Uhlenhuth EH, Pierri J, Johanson CE (1987). Individual differences in behavioral and subjective responses to alcohol. Alcohol Clin Exp Res 11: 52-59.
10. Drake RE, Mueser KT, Clark RE, Wallach MA (1996). The course, treatment, and outcome of substance disorder in persons with severe mental illness. Am J Orthopsychiatry 66: 42-51.
11. Drake RE, Osher FC, Wallach MA (1989). Alcohol use and abuse in schizophrenia. A prospective community study. J Nerv Mental Dis 177: 408-414.
12. Drake RE, Xie H, McHugo GJ, Green AI (2000). The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia. Schizophr Bull 26: 441-449.
13. Duka T, Tasker R, Stephens DN (1998). Alcohol choice and outcome expectancies in social drinkers. Behav Pharmacol 9: 643-653.
14. Erblich J, Earleywine M, Erblich B (2001). Positive and negative associations with alcohol and familial risk for alcoholism. Psychol Addict Behav 15: 204-209.
15. Gordon M (1986). Microprocessor-based assessment of attention deficit disorders (ADD). Psychopharmacol Bull 22: 288-290.
16. Green AI (2005). Schizophrenia and comorbid substance use disorder: effects of antipsychotics. J Clin Psychiatry 66(Suppl 6): 21-26.
17. Green AI, Burgess ES, Dawson R, Zimmet SV, Strous RD (2003). Alcohol and cannabis use in schizophrenia: effects of clozapine vs risperidone. Schizophr Res 60: 81-85.
18. Holdstock L, de Wit H (1998). Individual differences in the biphasic effects of ethanol. Alcohol Clin Exp Res 22: 1903-1911.
19. Khantzian EJ (1997). The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. Harv Rev Psychiatry 4: 231-244.
20. Krystal JH, D'Souza DC, Mathalon D, Perry E, Belger A, Hoffman R (2003). NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology (Berlin) 169: 215-233.
21. Krystal JH, Tabakoff B (2002). Ethanol Abuse, Dependence, and Withdrawal: Neurobiology and Clinical Implications. Lippincott Williams and Wilkins: Philadelphia.
22. Laruelle M, Abi-Dargham A, van Dyck CH, Rosenblatt W, Zea-Ponce Y, Zoghbi SS et al (1995). SPECT imaging of striatal dopamine release after amphetamine challenge. J Nucl Med 36: 1182-1190.
23. Lawson DM, Nathan PE, Lipscomb TR (1980). Guidelines for the administration of alcohol to human subjects in behavioral research. J Stud Alcohol 41: 871-881.
24. Madden PA, Bucholz KK, Martin NG, Heath AC (2000). Smoking and the genetic contribution to alcohol-dependence risk. Alcohol Res Health 24: 209-214.
25. Madden PA, Heath AC, Starmer GA, Whitfield JB, Martin NG (1995). Alcohol sensitivity and smoking history in men and women. Alcohol Clin Exp Res 19: 1111-1120.
26. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993). Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res 17: 140-146.
27. Newlin DB, Thomson JB (1990). Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull 108: 383-402.
28. Noordsy DL, Drake RE, Teague GB, Osher FC, Hurlbut SC, Beaudett MS et al (1991). Subjective experiences related to alcohol use among schizophrenics (comment). J Nerv Mental Dis 179: 410-414.
29. Overall JE, Gorham DR (1962). The Brief Psychiatric Rating Scale: a comprehensive review. Psychol Reprints 10: 799-812.
30. Schuckit MA, Tsuang JW, Anthenelli RM, Tipp JE, Nurnberger Jr JI (1996). Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. J Stud Alcohol 57: 368-377.
31. Sobell LC, Toneatto T, Sobell MB, Leo GI, Johnson L (1992). Alcohol abusers' perceptions of the accuracy of their self-reports of drinking: implications for treatment. Addict Behav 17: 507-511.
32. Spitzer RL, Williams JBW, Gibbon M, First MB (1990). Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P, Version 1.0). American Psychiatric Press: Washington, DC.