Computerized advice on drug dosage to improve prescribing practice

Cochrane Database of Systematic Reviews

Volumn , Issue 3, 2008, Pages

  Durieux, Pierre ^a   Trinquart, Ludovic ^b   Colombet, Isabelle ^b   Niès, Julie ^b   Walton, R T ^c   Rajeswaran, Anand ^d   Walther, Myriam Rège ^d   Harvey, Emma ^e   Burnand, Bernard ^d  

^a Hôpital Cochin ^*  (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e SaltaSustainable   (United Kingdom)

Author keywords

*Drug therapy, computer assisted; *Physician's practice patterns; Humans; Randomized controlled trials as topic

Indexed keywords

ACENOCOUMAROL; AMINOGLYCOSIDE; AMINOPHYLLINE; ANTICOAGULANT AGENT; FENTANYL; GENTAMICIN; HEPARIN; LIDOCAINE; MIDAZOLAM; NITROPRUSSIDE SODIUM; THEOPHYLLINE; TOBRAMYCIN; WARFARIN;

ASTHMA; AUTOMATION; BEHAVIOR CHANGE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; COMPUTER SYSTEM; CONTINUOUS INFUSION; COST EFFECTIVENESS ANALYSIS; DATA BASE; DECISION SUPPORT SYSTEM; DOSE CALCULATION; DRUG BLOOD LEVEL; DRUG DOSE; DRUG DOSE INCREASE; EMBASE; FEMALE INFERTILITY; HEALTH CARE; HEALTH CARE COST; HEALTH CARE ORGANIZATION; HEALTH CARE QUALITY; HEALTH PERSONNEL ATTITUDE; HEALTH PRACTITIONER; HEART INFARCTION; HEART VALVE REPLACEMENT; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INFECTION; INFORMATION PROCESSING; INFORMATION RETRIEVAL; KIDNEY FAILURE; LENGTH OF STAY; LONG TERM CARE; MAINTENANCE DRUG DOSE; MEDICAL PRACTICE; MEDLINE; META ANALYSIS; NURSE; OPTIMAL DRUG DOSE; OUTCOME ASSESSMENT; OUTPATIENT DEPARTMENT; PATIENT CARE; PHARMACEUTICAL CARE; PHARMACIST; PHYSICIAN; PRESCRIPTION; REVIEW; RISK BENEFIT ANALYSIS; RISK REDUCTION; SYSTEMATIC REVIEW; THROMBOEMBOLISM; TREATMENT OUTCOME; VALVULAR HEART DISEASE;

EID: 55049138657     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD002894.pub2     Document Type: Review

References (69)

1. Ageno 1998 {published data only} Ageno W, Turpie AG. A randomized comparison of a computer-based dosing program with a manual system to monitor oral anticoagulant therapy. Thrombosis Research 1998;91(5):237-40.
2. Begg 1989 {published data only} Begg EJ, Atkinson HC, Jeffery GM, Taylor NW. Individualised aminoglycoside dosage based on pharmacokinetic analysis is superior to dosage based on physician intuition at achieving target plasma drug concentrations. British Journal of Clinical Pharmacology 1989;28(2):137-41.
3. Burton 1991 {published data only} Burton ME, Ash CL, Hill DP Jr, Handy T, Shepherd MD, Vasko MR. A controlled trial of the cost benefit of computerized bayesian aminoglycoside administration. Clinical Pharmacology and Therapeutics 1991;49(6):685-94.
4. Carter 1987 {published data only} Carter BL, Taylor JW, Becker A. Evaluation of three dosage-prediction methods for initial in-hospital stabilization of warfarin therapy. Clinical Pharmacy 1987;6(1):37- 45.
5. Casner 1993 {published data only} Casner PR, Reilly R, Ho H. A randomized controlled trial of computerized pharmacokinetic theophylline dosing versus empiric physician dosing. Clinical Pharmacology and Therapeutics 1993;53(6):684-90.
6. Chertow 2001 {published data only} Chertow GM, Lee J, Kuperman GJ, Burdick E, Horsky J, Seger DL, et al.Guided medication dosing for inpatients with renal insufficiency. JAMA 2001;286(22):2839-44.
7. Destache 1990 {published data only} Destache CJ, Meyer SK, Bittner MJ, Hermann KG. Impact of a clinical pharmacokinetic service on patients treated with aminoglycosides: a cost-benefit analysis. Therapetic Drug Monitoring 1990;12(5):419-26.
8. Fitzmaurice 2000 {published data only} Fitzmaurice DA, Hobbs FD, Murray ET, Holder RL, Allan TF, Rose PE. Oral anticoagulation management in primary care with the use of computerized decision support and near-patient testing: a randomized, controlled trial. Archives of Internal Medicine 2000;160(15):2343-8.
9. Gonzalez 1989 {published data only} Gonzalez ER, Vanderheyden BA, Ornato JP, Comstock TG. Computer-assisted optimization of aminophylline therapy in the emergency department. American Journal of Emergency Medicine 1989;7(4):395-401.
10. Hickling 1989 {published data only} Hickling K, Begg E, Moore ML. A prospective randomised trial comparing individualised pharmacokinetic dosage prediction for aminoglycosides with prediction based on estimated creatinine clearance in critically ill patients. Intensive Care Medicine 1989;15(4):233-7.
11. Hurley 1986 {published data only} Hurley SF, Dziukas LJ, McNeil JJ, Brignell MJ. A randomized controlled clinical trial of pharmacokinetic theophylline dosing. American Review of Respiratory Disease 1986;134(6):1219-24.
12. Lesourd 2002 {published data only} Lesourd F, Avril C, Boujennah A, Parinaud J. A computerized decision support system for ovarian stimulation by gonadotropins. Fertility and Sterility 2002;77(3):456-60.
13. Manotti 2001 {published data only} Manotti C, Moia M, Palareti G, Pengo V, Ria L, Dettori AG. Effect of computer-aided management on the quality of treatment in anticoagulated patients : a prospective, randomized, multicenter trial of APROAT (Automated Program for Oral Anticoagulant Treatment). Haematologica 2001;86(10):1060-70.
14. Mungall 1994 {published data only} Mungall DR, Anbe D, Forrester PL, Luoma T, Genovese R, Mahan J, et al.A prospective randomized comparison of the accuracy of computer-assisted versus GUSTO nomogram - directed heparin therapy. Clinical Pharmacology and Therapeutics 1994;55(5):591-6.
15. Poller 1998 {published data only} Poller L, Shiach CR, MacCallum PK, Johansen AM, Munster AM, Magalhaes A, et al.Multicentre randomised study of computerised anticoagulant dosage. European Concerted Action on Anticoagulation. Lancet 1998;352(9139):1505-9.
16. Poller 1998a {published data only} Poller L, Shiach CR, MacCallum PK, Johansen AM, Munster AM, Magalhaes A, et al.Multicentre randomised study of computerised anticoagulant dosage. European Concerted Action on Anticoagulation. Lancet 1998;352(9139):1505-9.
17. Rodman 1984 {published data only} Rodman JH, Jelliffe RW, Kolb E, Tuey DB, de Guzman MF, Wagers PW, et al.Clinical studies with computer-assisted initial lidocaine therapy. Archives of Internal Medicine 1984;144(4):703-9.
18. Ruiz 1993 {published data only} Ruiz R, Borches D, Gonzalez A, Corral J. A new sodium-nitroprusside-infusion controller for the regulation of arterial blood pressure. Biomedical Instrumentation & Technology 1993;27(3):244-51.
19. Theil 1993 fentanyl {published data only} Theil DR, Stanley TE 3rd, White WD, Goodman DK, Glass PS, Bai SA, et al.Midazolam and fentanyl continuous infusion anesthesia for cardiac surgery: a comparison of computer-assisted versus manual infusion systems. Journal of Cardiothoracic and Vascular Anesthesia 1993;7(3):300-6.
20. Theil 1993 midazolam {published data only} Theil DR, Stanley TE 3rd, White WD, Goodman DK, Glass PS, Bai SA, et al.Midazolam and fentanyl continuous infusion anesthesia for cardiac surgery: a comparison of computer-assisted versus manual infusion systems. Journal of Cardiothoracic and Vascular Anesthesia 1993;7(3):300-6.
21. Vadher 1997 {published data only} Vadher B, Patterson DL, Leaning M. Evaluation of a decision support system for initiation and control of oral anticoagulation in a randomised trial. BMJ 1997;314(7089): 1252-6.
22. Vadher 1997 pop 1 {published data only} Vadher BD, Patterson DL, Leaning M. Comparison of oral anticoagulant control by a nurse-practitioner using a computer decision-support system with that by clinicians. Clinical and Laboratory Haematology 1997;19(3):203-7.
23. Vadher 1997 pop2 {published data only} Vadher BD, Patterson DL, Leaning M. Comparison of oral anticoagulant control by a nurse-practitioner using a computer decision-support system with that by clinicians. Clinical and Laboratory Haematology 1997;19(3):203-7.
24. Verner 1992 {published data only} Verner D, Seligmann H, Platt S, Dany S, Almog S, Zulty L, et al.Computer assisted design of a theophylline dosing regimen in acute bronchospasm: serum concentrations and clinical outcome. European Journal of Clinical Pharmacology 1992;43(1):29-33.
25. White 1987 {published data only} White RH, Hong R, Venook AP, Daschbach MM, Murray W, Mungall DR, et al.Initiation of warfarin therapy: comparison of physician dosing with computer-assisted dosing. Journal of General Internal Medicine 1987;2(3):141-8.
26. White 1991 {published data only} White RH, Mungall D. Outpatient management of warfarin therapy: comparison of computer-predicted dosage adjustment to skilled professional care. Therapeutic Drug Monitoring 1991;13(1):46-50.
27. Abbrecht 1982 {published data only} Abbrecht PH, O'Leary TJ, Behrendt DM. Evaluation of a computer-assisted method for individualized anticoagulation: retrospective and prospective studies with a pharmacodynamic model. Clinical Pharmacology and Therapeutics 1982;32(1):129-36.
28. Alvis 1985 {published data only} Alvis JM, Reves JG, Govier AV, Menkhaus PG, Henling CE, Spain JA, et al.Computer-assisted continuous infusions of fentanyl during cardiac anesthesia: comparison with a manual method. Anesthesiology 1985;63(1):41-9.
29. Bury 2005 {published data only} Bury J, Hurt C, Roy A, Cheesman L, Bradburn M, Cross S, et al.LISA: a web-based decision-support system for trial management of childhood acute lymphoblastic leukaemia. British Journal of Haematology 2005;129(6):746-54.
30. Carter 1987 linear {published data only} Carter BL, Taylor JW, Becker A. Evaluation of three dosage-prediction methods for initial in-hospital stabilization of warfarin therapy. Clinical Pharmacy 1987;6(1):37-45.
31. Chiarelli 1990 {published data only} Chiarelli F, Tumini S, Morgese G, Albisser AM. Controlled study in diabetic children comparing insulin-dosage adjustment by manual and computer algorithms. Diabetes Care 1990;13(10):1080-4.
32. Collins 2004 {published data only} Collins CD, Pedersen CA, Schneider PJ, Miller AS, Sierawski SJ, Roux RK. Effect on amphotericin B lipid complex use of a clinical decision support system for computerized prescriber order entry. American Journal of Health-System Pharmacy 2004;61(13):1395-9.
33. Fihn 1994 {published data only} Fihn SD, McDonell MB, Vermes D, Henikoff JG, Martin DC, Callahan CM, et al.A computerized intervention to improve timing of outpatient follow-up: a multicenter randomized trial in patients treated with warfarin. National Consortium of Anticoagulation Clinics. Journal of General Internal Medicine 1994;9(3):131-9.
34. Fitzmaurice 1996 {published data only} Fitzmaurice DA, Hobbs FD, Murray ET, Bradley CP, Holder R. Evaluation of computerized decision support for oral anticoagulation management based in primary care. British Journal of General Practice 1996;46(410):533-5.
35. Fitzmaurice 1998 {published data only} Fitzmaurice DA, Hobbs FD, Murray ET. Primary care anticoagulant clinic management using computerized decision support and near patient International Normalized Ratio (INR) testing: routine data from a practice nurse-led clinic. Family Practice 1998;15(2):144-6.
36. Hobbs 1996 {published data only} Hobbs FD, Delaney BC, Carson A, Kenkre JE. A prospective controlled trial of computerized decision support for lipid management in primary care. Family Practice 1996;13(2):133-7.
37. Horn 2002 {published data only} Horn W, Popow C, Miksch S, Kirchner L, Seyfang A. Development and evaluation of VIE-PNN, a knowledge-based system for calculating the parenteral nutrition of newborn infants. Artificial Intelligence in Medicine 2002;24(3):217-28.
38. Hwang 2004 {published data only} Hwang HG, Chang IC, Hung WF, Sung ML, Yen D. The design and evaluation of clinical decision support systems in the area of pharmacokinetics. Medical Informatics and the Internet in Medicine 2004;29(3-4):239-51.
39. Kroese 2005 {published data only} Kroese WL, Avery AJ, Savelyich BS, Brown NS, Schers H, Howard R, et al.Assessing the accuracy of a computerized decision support system for digoxin dosing in primary care: an observational study. Journal of Clinical Pharmacy and Therapeutics 2005;30(3):279-83.
40. Manotti 2001 mainten {published data only} Manotti C, Moia M, Palareti G, Pengo V, Ria L, Dettori AG. Effect of computer-aided management on the quality of treatment in anticoagulated patients: a prospective, randomized, multicenter trial of APROAT (Automated PRogramfor Oral Anticoagulant Treatment). Haematologica 2001;86(10):1060-70.
41. McDonald 1980 {published data only} McDonald CJ, Wilson GA, McCabe GP, Jr. Physician response to computer reminders. JAMA 1980;244(14):1579-81.
42. McMichael 1993 {published data only} McMichael J, Lieberman R, Doyle H, McCauley J, Fung J, Starzl TE. An intelligent and cost-effective computer dosing system for individualizing FK506 therapy in transplantation and autoimmune disorders. Journal of Clinical Pharmacology 1993;33(7):599-605.
43. Murchie 1989 {published data only} Murchie CJ, Kenny GN. Comparison among manual, computer-assisted, and closed-loop control of blood pressure after cardiac surgery. Journal of Cardiothoracic Anesthesia 1989;3(1):16-19.
44. Nieuwenhuyze 1995 {published data only} van den Nieuwenhuyzen MC, Engbers FH, Burm AG, Vletter AA, van Kleef JW, Bovill JG. Computer-controlled infusion of alfentanil versus patient-controlled administration of morphine for postoperative analgesia: a double-blind randomized trial. Anesthesia and Analgesia 1995;81(4):671-9.
45. Nightingale 2000 {published data only} Nightingale PG, Adu D, Richards NT, Peters M. Implementation of rules based computerised bedside prescribing and administration: intervention study. BMJ 2000;320(7237):750-3.
46. Peck 1973 {published data only} Peck CC, Sheiner LB, Martin CM, Combs DT, Melmon KL. Computer-assisted digoxin therapy. New England Journal of Medicine 1973;289(9):441-6.
47. Peters 1996 {published data only} Peters A, Kerner W. Analytical design and clinical application of an intelligent control system for insulin treatment) (Analytical design and clinical application of an intelligent control system for insulin treatment [Analytisches Design und klinische Anwendung eines lernfähigen Regelsystems für die Pharmakotherapie mit Insulin]. Biomedizinische Technik 1996;41(1-2):2-13.
48. Peterson 1986 {published data only} Peterson CM, Jovanovic L, Chanoch LH. Randomized trial of computer-assisted insulin delivery in patients with type I diabetes beginning pump therapy. American Journal of Medicine 1986;81(1):69-72.
49. Peterson 2005 {published data only} Peterson JF, Kuperman GJ, Shek C, Patel M, Avorn J, Bates DW. Guided prescription of psychotropic medications for geriatric inpatients. Archives of Internal Medicine 2005;165(7):802-7.
50. Poller 1993 {published data only} Poller L, Wright D, Rowlands M. Prospective comparative study of computer programs used for management of warfarin. Journal of Clinical Pathology 1993;46(4):299-303.
51. Rood 2005 {published data only} Rood E, Bosman RJ, van der Spoel JI, Taylor P, Zandstra DF. Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. Journal of the American Medical Informatics Association 2005;12(2):172-80.
52. Rotman 1996 {published data only} Rotman BL, Sullivan AN, McDonald TW, Brown BW, DeSmedt P, Goodnature D, et al.A randomized controlled trial of a computer-based physician workstation in an outpatient setting: implementation barriers to outcome evaluation. Journal of the American Medical Informatics Association 1996;3(5):340-8.
53. Ryff-de Leche 1992 {published data only} Ryff-de Leche A, Engler H, Nutzi E, Berger M, Berger W. Clinical application of two computerized diabetes management systems: comparison with the log-book method. Diabetes Research 1992;19(3):97-105.
54. Strack 1985 {published data only} Strack T, Bergeler J, Beyer J, Hutten H. Computer assisted conventional insulin therapy. Life Support Systems 1985;3 Suppl 1:568-72.
55. Tamblyn 2003 {published data only} Tamblyn R, Huang A, Perreault R, Jacques A, Roy D, Hanley J, et al.The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. CMAJ 2003 Sep 16;169(6):549-56.
56. White 1984 {published data only} White KS, Lindsay A, Pryor TA, Brown WF, Walsh K. Application of a computerized medical decision-making process to the problem of digoxin intoxication. Journal of the American College of Cardiology 1984;4(3):571-6.
57. Willcourt 1994 {published data only} Willcourt RJ, Pager D, Wendel J, Hale RW. Induction of labor with pulsatile oxytocin by a computer-controlled pump. American Journal of Obstetrics and Gynecology 1994;170(2):603-8.
58. Baldwin 1995 Baldwin L. Calculating drug doses. British Medical Journal 1995;310(6988):1154.
59. Durieux 2005 Durieux P. Electronic medical alerts - so simple, so complex. New England Journal of Medicine 2005;352(10):1034-6.
60. Garcia 2002 Garcia JM, Martin JLR, Subirana M, Gich I. Self management for oral anticoagulation. Cochrane Database of Systematic Reviews 2002, Issue 4. Art. No.: CD003839. DOI: 10.1002/14651858.CD003839.
61. Garg 2005 Garg AX, Adhikari NK, McDonald H, Rosas-Arellano MP, Devereaux PJ, Beyene J, Sam J, Haynes RB. Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. Journal of the American Medical Association 2005;293(10):1223-38.
62. Kaushal 2006 Kaushal R, Jha AK, Franz C, Glaser J, Shetty KD, Jaggi T, Middleton B, Kuperman GJ, Khorasani R, Tanasijevic M, Bates DW, Brigham and Women's Hospital CPOE Working Group. Return on investment for a computerized physician order entry system. Journal of the American Medical Informatics Association 2006;13(3):261-3.
63. Kawamoto 2005 Kawamoto K, Houlihan CA, Balas EA, Lobach DF. Improving clinical practice using clinical decision support systems: a systematic review of trials to identify features critical to success. British medical journal 2005;330(7494):765.
64. Kuperman 2003 Kuperman GJ, Gibson RF. Computer physician order entry: benefits, costs, and issues. Annals of internal medicine 2003;139(1):31-9.
65. McDonald 1976 McDonald CJ. Protocol-based computer reminders, the quality of care and the non-perfectability of man. New England Journal of Medicine 1976;295(24):1351-5.
66. National Asthma 2002 National Asthma Education and Prevention Program Expert Panel Report: guidelines for the diagnosis and management of asthma update on selected topics-2002. J Allergy Clin Immunol 2002;110:S141-219.
67. Nies 2006 Nies J, Colombet I, Degoulet P, Durieux P. Determinants of Success for Computerized Clinical Decision Support Systems Integrated in CPOE Systems: a Systematic Review. AMIA Annual Symposium Proceedings 2006:594-8.
68. Rolfe 1995 Rolfe S, Harper NJ. Ability of hospital doctors to calculate drug doses. British Medical Journal 1995;310(6988):1173- 4.
69. Walton 2001 Walton RT, Harvey E, Dovey S, Freemantle N. Computerised advice on drug dosage to improve prescribing practice. The Cochrane Database of Systematic Reviews 2001, Issue 1. Art. No.: CD002894. DOI: 10.1002/14651858.CD002894.