Individualised aminoglycoside dosage based on pharmacokinetic analysis is superior to dosage based on physician intuition at achieving target plasma drug concentrations [see comments]

British Journal of Clinical Pharmacology

Volumn 28, Issue 2, 1989, Pages 137-141

  Begg, EJ ^a   Atkinson, HC ^a   Jeffery, GM ^a   Taylor, NW ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN; TOBRAMYCIN;

ADULT; AGED; CLINICAL ARTICLE; COMPARTMENT MODEL; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; DOSE CALCULATION; FEMALE; FORECASTING; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; METHODOLOGY; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ANTIBIOTICS, AMINOGLYCOSIDE; COMPARATIVE STUDY; FEMALE; HUMAN; MALE; MIDDLE AGE; RANDOM ALLOCATION;

EID: 0024375583     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1989.tb05405.x     Document Type: Article

References (11)

1. Comparison of dosing methods
2. Prediction of creatine clearance from serum creatinine
3. A model for dosing gentamicin in children and adolescents that adjusts for tissue accumulation with continuous dosing
4. The association of aminoglycoside plama levels with mortality in patients with gram‐negative bacteremia
5. Association of aminoglycoside plasma levels with therapeutic outcome in gram‐negative pneumonia
6. Clinical response to aminoglycoside therapy: Importance of ratio of peak concentration to minimal inhibitory concentration
7. Experience in monitoring gentamicin therapy during treatment of serious gram‐negative sepsis
8. Kinetic model for gentamicin dosing with the use of individual patient parameters
9. Initial aminoglycoside levels in the critically ill
10. Gentamicin dosage requirements: Wide interpatient variations in 242 surgery patients with normal renal function
11. Gentamicin pharmacokinetics in 1640 patients: Method for control of serum concentrations