Cytogenetic characterisation in Chinese patients with chronic lymphocytic leukemia: A prospective, multicenter study on 143 cases analysed with interphase fluorescence in situ hybridisation

Leukemia and Lymphoma

Volumn 49, Issue 10, 2008, Pages 1887-1892

  Qiu, Hong Xia ^a   Xu, Wei ^a   Cao, Xiang Shan ^b   Zhou, Min ^c   Shen, Yun Feng ^d   Xu, Yan Li ^e   Sun, Xue Mei ^f   Liu, Qiong ^a   Wang, Rong ^a   Qiu, Hai Rong ^a   Wang, Ji Shi ^g   Li, Jian Yong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE THIRD AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c THE AFFILIATED CHANGZHOU NO 2 PEOPLE S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d Wuxi Hospital   (China)

^e NANJING MEDICAL UNIVERSITY   (China)

^f THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^g GUIZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Chromosome; Chronic lymphocytic leukemia; Fluorescence in situ hybridisation

Indexed keywords

ADULT; AGED; CANCER PATIENT; CANCER STAGING; CENTROMERE; CHINESE; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 14Q; CHROMOSOME 17P; CHROMOSOME 6Q; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION 14; CHRONIC LYMPHATIC LEUKEMIA; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; INTERPHASE; MAJOR CLINICAL STUDY; MALE; MITOSIS; MOLECULAR PROBE; PRIORITY JOURNAL; TRISOMY 12;

ASIAN CONTINENTAL ANCESTRY GROUP; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOMES, HUMAN; CYTOGENETIC ANALYSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; TRANSLOCATION, GENETIC; TRISOMY;

EID: 55049107939     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190802308710     Document Type: Conference Paper

References (30)

1. Rai, K. R., Sawitsky, A., Cronkite, E. P., Chanana, A. D., Levy, R. N. and Pasternack, B. S. (1975) Clinical staging of chronic lymphocytic leukemia. Blood, 46, pp. 219-234.
2. Binet, J. L., Lepoprier, M., Dighiero, G., Charron, D., D'Athis, P. Vaugier, G. et al. (1977) A clinical staging system for chronic lymphocytic leukemia: Prognostic significance. Cancer, 40, pp. 855-864.
3. Juliusson, G., Oscier, D. G., Fitchett, M., Ross, F. M., Stockdill, G. Mackie, M. J. et al. (1990) Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med, 323, pp. 720-724.
4. Dohner, H., Stilgenbauer, S., Dohner, K., Bentz, M. and Lichter, P. (1999) Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis. J Mol Med, 77, pp. 266-281.
5. Sindelarova, L., Michalova, K., Zemanova, Z., Ransdorfova, S., Brezinova, J. Pekova, S. et al. (2005) Incidence of chromosomal anomalies detected with FISH and their clinical correlations in B-chronic lymphocytic leukemia. Cancer Genet Cytogenet, 160, pp. 27-34.
6. Dohner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Krober, A. Bullinger, L. et al. (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med, 343, pp. 1910-1916.
7. Dewald, G. W., Brockman, S. R., Paternoster, S. F., Bone, N. D., O'Fallon, J. R. Allmer, C. et al. (2003) Chromosome anomalies detected by interphase fluorescence in situ hybridization: Correlation with significant biological features of B-cell chronic lymphocytic leukaemia. Br J Haematol, 121, pp. 287-295.
8. Xu, W., Li, J. Y., Pan, J. L., Qiu, H. R., Shen, Y. F. Li, L. et al. (2007) Interphase fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia. Int J Hematol, 85, pp. 430-436.
9. Xu, W., Li, J. Y., Wu, Y. J., Yu, H., Shen, Q. D. Li, L. et al. (2007) Prognostic significance of ATM and TP53 deletions in Chinese patients with chronic lymphocytic leukemia. Leuk Res, 32, pp. 1071-1077.
10. Cheson, B. D., Bennett, J. M., Grever, M., Kay, N., Keating, M. J. O'Brien, S. et al. (1996) National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment. Blood, 87, pp. 4990-4997.
11. Zenz, T., Mertens, D., Dohner, H. and Stilgenbauer, S. (2008) Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications. Leuk Lymphoma, 49, pp. 864-873.
12. Mittal, A. K., Hegde, G. V., Aoun, P., Bociek, R. G., Dave, B. J. Joshi, A. D. et al. (2007) Molecular basis of aggressive disease in chronic lymphocytic leukemia patients with 11q deletion and trisomy 12 chromosomal abnormalities. Int J Mol Med, 20, pp. 461-469.
13. Athanasiadou, A., Stamatopoulos, K., Tsompanakou, A., Gaitatzi, M., Kalogiannidis, P. Anagnostopoulos, A. et al. (2006) Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis. Cancer Genet Cytogenet, 168, pp. 109-119.
14. Ripolles, L., Ortega, M., Ortuno, F., Gonzalez, A., Losada, J. Ojanguren, J. et al. (2006) Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia. Cancer Genet Cytogenet, 171, pp. 57-64.
15. Aoun, P., Blair, H. E., Smith, L. M., Dave, B. J., Lynch, J. Weisenburger, D. D. et al. (2004) Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma, 45, pp. 1595-1603.
16. Watanabe, T., Hotta, T., Ichikawa, A., Kinoshita, T., Nagai, H. Uchida, T. et al. (1994) The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood, 84, pp. 3158-3165.
17. Mould, S., Gardiner, A., Corcoran, M. and Oscier, D. G. (1996) Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia. Br J Haematol, 92, pp. 389-392.
18. Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S. Noch, E. et al. (2002) Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA, 99, pp. 15524-15529.
19. Calin, G. A., Pekarsky, Y. and Croce, C. M. (2007) The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. Best Pract Res Clin Haematol, 20, pp. 425-437.
20. Dyer, M. J. and Oscier, D. G. (2002) The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia. Leukemia, 16, pp. 973-984.
21. Mayr, C., Speicher, M. R., Kofler, D. M., Buhmann, R., Strehl, J. Busch, R. et al. (2006) Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood, 107, pp. 742-751.
22. Zenz, T., Dohner, H. and Stilgenbauer, S. (2007) Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia. Best Pract Res Clin Haematol, 20, pp. 439-453.
23. Zhong, Y., Bakke, A. C., Fan, G., Braziel, R. M., Gatter, K. M. Leis, J. F. et al. (2007) Drug resistance in B-cell chronic lymphocytic leukemia: predictable by in vitro evaluation with a multiparameter flow cytometric cytotoxicity assay. Cytometry B Clin Cytom, 72, pp. 189-195.
24. Cuneo, A., Bigoni, R., Rigolin, G. M., Roberti, M. G., Bardi, A. Cavazzini, F. et al. (2002) Late appearance of the 11q22.3-23.1 deletion involving the ATM locus in B-cell chronic lymphocytic leukemia and related disorders. Clinico-biological significance. Haematologica, 87, pp. 44-51.
25. Reddy, K. S. (2006) Chronic lymphocytic leukaemia profiled for prognosis using a fluorescence in situ hybridisation panel. Br J Haematol, 132, pp. 705-722.
26. Dohner, H., Stilgenbauer, S., James, M. R., Benner, A., Weilguni, T. Bentz, M. et al. (1997) 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood, 89, pp. 2516-2522.
27. Eclache, V., Caulet-Maugendre, S., Poirel, H. A., Djemai, M., Robert, J. Lejeune, F. et al. (2004) Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell chronic lymphocytic leukemia and related disorders. Cancer Genet Cytogenet, 152, pp. 72-76.
28. Stilgenbauer, S., Bullinger, L., Benner, A., Wildenberger, K., Bentz, M. Dohner, K. et al. (1999) Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia. Leukemia, 13, pp. 1331-1334.
29. Cuneo, A., Rigolin, G. M., Bigoni, R., De Angeli, C., Veronese, A. Cavazzini, F. et al. (2004) Chronic lymphocytic leukemia with 6q- shows distinct hematological features and intermediate prognosis. Leukemia, 18, pp. 476-483.
30. Chang, Y. H., Park, J., Kim, H. C., Chun, H. K., Kim, Y. R. Kim, M. et al. (2006) Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America. Leuk Res, 30, pp. 695-699.