A rapid spectrofluorimetric technique for determining drug-serum protein binding suitable for high-throughput screening

Pharmaceutical Research

Volumn 17, Issue 5, 2000, Pages 632-637

  Parikh, Hemanshu H ^a   McElwain, Kate ^a   Balasubramanian, Vandana ^a   Leung, Winsy ^a   Wong, Diane ^a   Morris, Marilyn E ^a   Ramanathan, Murali ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Combinatorial pharmaceutics; Fraction bound; High throughput screen; Intrinsic fluorescence; Serum albumin; 1 acid glycoprotein

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA1 GLYCOPROTEIN; CHLORAMPHENICOL; CHLORPROMAZINE; DIAZEPAM; DRUG; HUMAN SERUM ALBUMIN; IMIPRAMINE; IOPHENOXIC ACID; LITHIUM CHLORIDE; PARACETAMOL; PHENYLBUTAZONE; SULFINPYRAZONE; THEOPHYLLINE; WARFARIN;

ARTICLE; BINDING SITE; CALCULATION; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SCREENING; FLUORESCENCE; PRIORITY JOURNAL; SPECTROFLUOROMETRY;

ANTICOAGULANTS; BINDING SITES; BLOOD PROTEINS; HUMANS; OROSOMUCOID; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; RECEPTORS, GABA-A; SERUM ALBUMIN; SPECTROMETRY, FLUORESCENCE; WARFARIN;

EID: 0034086186     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007537520620     Document Type: Article

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