Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells

American Journal of Physiology - Cell Physiology

Volumn 292, Issue 4, 2007, Pages

  Li, Sheng ^a   Whorton, A Richard ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Endothelial cells; Nitric oxide; Nitrosothiols; Red blood cells; Smooth muscle cells; System L transporter

Indexed keywords

2 AMINOBIOCYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; AMINO ACID TRANSPORTER; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; GROWTH FACTOR; I KAPPA B; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITROSO DERIVATIVE; S NITROSOALBUMIN; S NITROSOCYSTEINE; SERUM ALBUMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; HEAVY CHAIN; HUMAN; HUMAN CELL; LIGHT CHAIN; NITROSYLATION; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; XENOPUS LAEVIS;

AMINO ACID TRANSPORT SYSTEM L; AMINO ACIDS, CYCLIC; AMINO ACIDS, NEUTRAL; ANIMALS; ANTIGENS, CD98 HEAVY CHAIN; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; CYSTEINE; ENDOTHELIUM, VASCULAR; ERYTHROCYTES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; I-KAPPA B PROTEINS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; OOCYTES; PHOSPHORYLATION; S-NITROSOTHIOLS; TUMOR NECROSIS FACTOR-ALPHA; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 34247357710     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00382.2006     Document Type: Article

References (41)

1. Andersson A, Lindgren A, Arnadottir M, Prytz H, Hultberg B. Thiols as a measure of plasma redox status in healthy subjects and in patients with renal or liver failure. Clin Chem 45: 1084-1086, 1999.
2. Bisseling TM, Maria Roes E, Raijmakers MT, Steegers EA, Peters WH, Smits P. N-acetylcysteine restores nitric oxide-mediated effects in the fetoplacental circulation of preeclamptic patients. Am J Obstet Gynecol 191: 328-333, 2004.
3. Chang EY, Barbosa E, Paintlia MK, Singh A, Singh I. The use of N-acetylcysteine for the prevention of hypertension in the reduced uterine perfusion pressure model for preeclampsia in Sprague-Dawley rats. Am J Obstet Gynecol 193: 952-956, 2005.
4. Crane MS, Ollosson R, Moore KP, Rossi AG, Megson IL. Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function. J Biol Chem 277: 46858-46863, 2002.
5. Davisson RL, Travis MD, Bates JN, Lewis SJ. Hemodynamic effects of L- and D-S-nitrosocysteine in the rat. Stereoselective S-nitrosothiol recognition sites. Circ Res 79: 256-262, 1996.
6. 2 gradients. Proc Natl Acad Sci USA 102: 5709-5714, 2005.
7. Foster MW, Pawloski JR, Singel DJ, Stamler JS. Role of circulating S-nitrosothiols in control of blood pressure. Hypertension 45: 15-17, 2005.
8. Gandley RE, Tyurin VA, Huang W, Arroyo A, Daftary A, Harger G, Jiang J, Pitt B, Taylor RN, Hubel CA, Kagan VE. S-nitrosoalbuminmediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma. Hypertension 45: 21-27, 2005.
9. Gaston BM, Carver J, Doctor A, Palmer LA. S-nitrosylation signaling in cell biology. Mol Interv 3: 253-263, 2003.
10. Goldman RK, Vlessis AA, Trunkey DD. Nitrosothiol quantification in human plasma. Anal Biochem 259: 98-103, 1998.
11. Ignarro LJ. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol 53: 503-514, 2002.
12. Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380: 221-226, 1996.
13. Keaney JF Jr, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest 91: 1582-1589, 1993.
14. Li S, Whorton AR. Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols. J Biol Chem 280: 20102-20110, 2005.
15. Li S, Whorton AR. Regulation of protein tyrosine phosphatase 1B in intact cells by S-nitrosothiols. Arch Biochem Biophys 410: 269-279, 2003.
16. Lipton AJ, Johnson MA, Macdonald T, Lieberman MW, Gozal D, Gaston B. S-nitrosothiols signal the ventilatory response to hypoxia. Nature 413: 171-174, 2001.
17. Marley R, Patel RP, Orie N, Ceaser E, Darley-Usmar V, Moore K. Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide. Free Radic Biol Med 31: 688-696, 2001.
18. Massy ZA, Fumeron C, Borderie D, Tuppin P, Nguyen-Khoa T, Benoit MO, Jacquot C, Buisson C, Drueke TB, Ekindjian OG, Lacour B, Iliou MC. Increased plasma S-nitrosothiol concentrations predict cardiovascular outcomes among patients with end-stage renal disease: a prospective study. J Am Soc Nephrol 15: 470-476, 2004.
19. Murad F. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep 19: 133-154, 1999.
20. Nemoto T, Shimma N, Horie S, Saito T, Okuma Y, Nomura Y, Murayama T. Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells. Eur J Pharmacol 458: 17-24, 2003.
21. Padgett CM, Whorton AR. S-nitrosoglutathione reversibly inhibits GAPDH by S-nitrosylation. Am J Physiol Cell Physiol 269: C739-C749, 1995.
22. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M. Identification of a membrane protein, LAT-2, that coexpresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274: 19738-19744, 1999.
23. Rafikova O, Rafikov R, Nudler E. Catalysis of S- nitrosothiols formation by serum albumin: the mechanism and implication in vascular control. Proc Natl Acad Sci USA 99: 5913-5918, 2002.
24. Raijmakers MT, Zusterzeel PL, Roes EM, Steegers EA, Mulder TP, Peters WH. Oxidized and free whole blood thiols in preeclampsia. Obstet Gynecol 97: 272-276, 2001.
25. Reynaert NL, Ckless K, Korn SH, Vos N, Guala AS, Wouters EF, van der Vliet A, Janssen-Heininger YM. Nitric oxide represses inhibitory κB kinase through S-nitrosylation. Proc Natl Acad Sci USA 101: 8945-8950, 2004.
26. Ricciardolo FL, Sterk PJ, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol Rev 84: 731-765, 2004.
27. Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kuhn LC. LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274: 34948-34954, 1999.
28. Sandmann J, Schwedhelm KS, Tsikas D. Specific transport of Snitrosocysteine in human red blood cells: implications for formation of S-nitrosothiols and transport of NO bioactivity within the vasculature. FEBS Lett 579: 4119-4124, 2005.
29. Scharfstein JS, Keaney JF Jr, Slivka A, Welch GN, Vita JA, Stamler JS, Loscalzo J. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J Clin Invest 94: 1432-1439, 1994.
30. + -independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274: 19745-19751, 1999.
31. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel DJ, Valeri CR, Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S- nitroso adduct of serum albumin. Proc Natl Acad Sci USA 89: 7674-7677, 1992.
32. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA 89: 444-448, 1992.
33. Tsikas D, Sandmann J, Rossa S, Gutzki FM, Frolich JC. Investigations of S-transnitrosylation reactions between low- and high-molecular-weight S-nitroso compounds and their thiols by high-performance liquid chromatography and gas chromatography-mass spectrometry. Anal Biochem 270: 231-241, 1999.
34. 15N]nitrosoalbumin in human blood in vitro. J Chromatogr B Biomed Sci Appl 726: 1-12, 1999.
35. Tyurin VA, Liu SX, Tyurina YY, Sussman NB, Hubel CA, Roberts JM, Taylor RN, Kagan VE. Elevated levels of S-nitrosoalbumin in preeclampsia plasma. Circ Res 88: 1210-1215, 2001.
36. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H. Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol 61: 729-737, 2002.
37. Vadgama JV, Castro M, Christensen HN. Characterization of amino acid transport during erythroid cell differentiation. J Biol Chem 262: 13273-13284, 1987.
38. Verrey F. System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pflügers Arch 445: 529-533, 2003.
39. Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT. Biological activity of nitric oxide in the plasmatic compartment. Proc Natl Acad Sci USA 101: 11477-11482, 2004.
40. Yang BK, Vivas EX, Reiter CD, Gladwin MT. Methodologies for the sensitive and specific measurement of S-nitrosothiols, iron-nitrosyls, and nitrite in biological samples. Free Radic Res 37: 1-10, 2003.
41. Zhang Y, Hogg N. The mechanism of transmembrane S-nitrosothiol transport. Proc Natl Acad Sci USA 101: 7891-7896, 2004.