Nitric oxide and the clinical manifestations of acute porphyria

Internal Medicine Journal

Volumn 38, Issue 9, 2008, Pages 732-735

  Thachil, J ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Diabetes; Lead toxicity; Nitric oxide; Porphyria; Sickle cell disease

Indexed keywords

AMINOLEVULINIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HEME; HEMOGLOBIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PORPHYRIN;

ABDOMINAL PAIN; ACUTE INTERMITTENT PORPHYRIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BACKACHE; CONSTIPATION; DIABETIC KETOACIDOSIS; DYSTONIA; ERYTHROCYTE DISORDER; ESOPHAGUS SPASM; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HYPERTENSION; INAPPROPRIATE VASOPRESSIN SECRETION; INSOMNIA; LEAD POISONING; LIMB PAIN; MOUSE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; RESTLESSNESS; SEIZURE; SENSORIMOTOR NEUROPATHY; SICKLE CELL ANEMIA; TACHYCARDIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; VASCULAR DISEASE; VOMITING;

HUMANS; NITRIC OXIDE; PORPHYRIA, ACUTE INTERMITTENT;

EID: 54949104980     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2008.01778.x     Document Type: Article

References (34)

1. Kauppinen R. Porphyrias. Lancet 2005 365 : 241 52.
2. Yeung Laiwah AC, Moore MR, Goldberg A. Pathogenesis of acute porphyria. Q J Med 1987 63 : 377 92.
3. Moore MR, Goldberg A, Yeung-Laiwah AA. Lead effects on the heme biosynthetic pathway. Relationship to toxicity. Ann N Y Acad Sci 1987 514 : 191 203.
4. White KA, Marletta MA. Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry 1992 31 : 6627 31.
5. Klatt P, Pfeiffer S, List BM, Lehner D, Glatter O, Bächinger HP et al. Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. J Biol Chem 1996 271 : 7336 42.
6. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990 347 : 768 70.
7. Desai KM, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 1991 351 : 477 9.
8. Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev 2007 21 : 37 47.
9. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 2005 293 : 1653 62.
10. George JN. Clinical practice. Thrombotic thrombocytopenic purpura. N Engl J Med 2006 354 : 1927 35.
11. Thachil J. Thrombotic thrombocytopenic purpura: is there more than ADAMTS-13? J Thromb Haemost 2007 5 : 634 5.
12. Umpierrez G, Freire AX. Abdominal pain in patients with hyperglycemic crises. J Crit Care 2002 17 : 63 7.
13. Surendran S, Kondapaka SB. Altered expression of neuronal nitric oxide synthase in the duodenum longitudinal muscle-myenteric plexus of obesity induced diabetes mouse: implications on enteric neurodegeneration. Biochem Biophys Res Commun 2005 338 : 919 22.
14. Pitei DL, Watkins PJ, Edmonds ME. NO-dependent smooth muscle vasodilation is reduced in NIDDM patients with peripheral sensory neuropathy. Diabet Med 1997 14 : 284 90.
15. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes 1998 47 : 457 63.
16. Meyer UA, Schuurmans MM, Lindberg RL. Acute porphyrias: pathogenesis of neurological manifestations. Semin Liver Dis 1998 18 : 43 52.
17. Kato GJ, Hsieh M, Machado R, Taylor J 6th, Little J, Butman JA et al. Cerebrovascular disease associated with sickle cell pulmonary hypertension. Am J Hematol 2006 81 : 503 10.
18. Kupferschmidt H, Bont A, Schnorf H, Landis T, Walter E, Peter J et al. Transient cortical blindness and bioccipital brain lesions in two patients with acute intermittent porphyria. Ann Intern Med 1995 123 : 598 600.
19. Lindberg RLP, Martini R, Baumgartner M, Erne B, Borg J, Zielasek J et al. Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria. J Clin Invest 1999 103 : 1127 34.
20. Jover R, Hoffmann F, Scheffler-Koch V, Lindberg RL. Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital. Eur J Biochem 2000 267 : 7128 37.
21. Toda N, Okamura T. The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacol Rev 2003 55 : 271 324.
22. Salazar FJ, Llinas MT, Gonzalez JD, Quesada T, Pinilla JM. Role of prostaglandins and nitric oxide in mediating renal response to volume expansion. Am J Physiol 1995 268 : R1442 8.
23. Thadani H, Deacon A, Peters T. Diagnosis and management of porphyria. BMJ 2000 320 : 1647 51.
24. Bonthius DJ, Karacay B, Dai D, Pantazis NJ. FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures. Dev Brain Res 2003 140 : 15 28.
25. Kehrberg AMH, Pantazis NJ, McKim RA, Bonthius DJ. A nitric oxide signalling pathway protects the developing brain against alcohol-induced neuronal death. In : Preedy V, ed. Comprehensive Handbook of Alcohol Related Pathology, Vol. 2. London : Elsevier 2005 873 87.
26. Kim YM, Lee JY, Choi SH, Kim DG, Jahng JW. RU486 blocks fasting-induced decrease of neuronal nitric oxide synthase in the rat paraventricular nucleus. Brain Res 2004 1018 : 221 6.
27. Maul H, Longo M, Saade GR, Garfield RE. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr Pharm Des 2003 9 : 359 80.
28. Wang JG, Guarnaccia M, Weiss SF, Sauer MV, Choi JM. Initial presentation of undiagnosed acute intermittent porphyria as a rare complication of ovulation induction. Fertil Steril 2006 86 : 462.e1 3.
29. Cherney DZ, Scholey JW, Cattran DC, Kang AK, Zimpelmann J, Kennedy C et al. The effect of oral contraceptives on the nitric oxide system and renal function. Am J Physiol Renal Physiol 2007 293 : F1539 44.
30. Cosentino F, Hishikawa K, Katusic ZS, Luscher TF. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 1997 96 : 25 8.
31. Tenhunen R, Mustajoki P. Acute porphyria: treatment with heme. Semin Liver Dis 1998 18 : 53 5.
32. Barbosa F Jr., Sertorio JT, Gerlach RF, Tanus-Santos JE. Clinical evidence for lead-induced inhibition of nitric oxide formation. Arch Toxicol 2006 80 : 811 16.
33. Wolff DJ, Naddelman RA, Lubeskie A, Saks DA. Inhibition of nitric oxide synthase isoforms by porphyrins. Arch Biochem Biophys 1996 333 : 27 34.
34. Akiyama K, Suzuki H, Grant P, Bing RJ. Oxidation products of nitric oxide, NO2 and NO3, in plasma after experimental myocardial infarction. J Mol Cell Cardiol 1997 29 : 1 9.