Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae

Genetics

Volumn 162, Issue 1, 2002, Pages 15-27

  Freedman, Jennifer A ^a   Jinks Robertson, Sue ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; RAD50 PROTEIN; RAD51 PROTEIN; RAD52 PROTEIN; RAD54 PROTEIN; RAD57 PROTEIN; RAD59 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; CROSSING OVER; FUNGAL GENETICS; FUNGAL STRAIN; FUNGUS MUTANT; GENE CONVERSION; GENE FUSION; GENE INDUCTION; GENETIC TRANSCRIPTION; MITOTIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE;

CROSSING OVER, GENETIC; DNA-BINDING PROTEINS; GENE CONVERSION; MITOSIS; PLASMIDS; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION, GENETIC;

FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036743426     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. Aboussekhra, A., R. Chanet, A. Adjiri and F. Fabre, 1992 Semi-dominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins. Mol. Cell. Biol. 12: 3224-3234.
2. Aguillera, A., 2001 The connection between transcription and genomic instability. EMBO J. 21: 195-201.
3. Alani, E., L. Cao and N. Kleckner, 1987 A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 116: 541-545.
4. Bai, Y., and L. S. Symington, 1996 A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae. Genes Dev. 10: 2025-2037.
5. Bartsch, S., L. E. Kang and L. S. Symington, 2000 RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates. Mol. Cell. Biol. 20: 1194-1205.
6. Boeke, J. D., J. Trueheart, G. Natsoulis and G. R., Fink, 1987 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 154: 164-175.
7. Datta, A., and S. Jinks-Robertson, 1995 Association of increased spontaneous mutation rates with high levels of transcription in yeast. Science 268: 1616-1619.
8. Davis, A. P., and L. S. Symington, 2001 The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing. Genetics 159: 515-525.
9. Dixon, W. J., and F. J. Massey, Jr., 1969 Introduction to Statistical Analysis. McGraw-Hill, New York.
10. Eisen, J. A., K. S. Sweder and P. C. Hanawalt, 1995 Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res. 23: 2715-2723.
11. Esposito, M. S., 1978 Evidence that spontaneous mitotic recombination occurs at the two-strand stage. Proc. Natl. Acad. Sci. USA 75: 4436-4440.
12. Essers, J., A. B. Houtsmuller, L. van Veelen, C. Paulusma, A. L. Nigg et al., 2002 Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J. 21: 2030-2037.
13. Fleig, U. N., R. D. Pridmore and P. Philippsen, 1986 Construction of LYS2 cartridges for use in genetic manipulations of Saccharomyces cerevisiae. Gene 46: 237-245.
14. Gietz, R. D., and R. H. Schiestl, 1995 Transforming yeast with DNA. Methods Mol. Cell. Biol. 5: 255-269.
15. Gottlieb, S., J. Wagstaff and R. E. Esposito, 1989 Evidence for two pathways of meiotic intrachromosomal recombination in yeast. Proc. Natl. Acad. Sci. USA 86: 7072-7076.
16. Haber, J. E., and M. Hearn, 1985 RAD52-independent mitotic gene conversion in Saccharomyces cerevisiae frequently results in chromosomal loss. Genetics 111: 7-22.
17. Hays, S. L., A. A. Firmenich and P. Berg, 1995 Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl. Acad. Sci. USA 92: 6925-6929.
18. Hoeijmakers, J. H., 2001 Genome maintenance mechanisms for preventing cancer. Nature 411: 366-374.
19. Ivanov, E. L., N. Sugawara, C. I. White, F. Fabre and J. E. Haber, 1994 Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 3414-3425.
20. Ivanov, E. L., N. Sugawara, J. Fishman-Lobell and J. E. Haber, 1996 Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae. Genetics 142: 693-704.
21. Jablonovich, Z., B. Liefshitz, R. Steinlauf and M. Kupiec, 1999 Characterization of the role played by the RAD59 gene of Saccharomyces cerevisiae in ectopic recombination. Curr. Genet. 36: 13-20.
22. Jinks-Robertson, S., M. Michelitch and S. Ramcharan, 1993 Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 3937-3950.
23. Johnson, R. D., and L. S. Symington, 1995 Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57. Mol. Cell. Biol. 15: 4843-4850.
24. Kang, L. E., and L. S. Symington, 2000 Aberrant double-strand break repair in rad51 mutants of Saccharomyces cerevisiae. Mol. Cell. Biol. 20: 9162-9172.
25. Keil, R. L., and G. S. Roeder, 1984 Cis-acting, recombination-stimulating activity in a fragment of the ribosomal DNA of S. cerevisiae. Cell 39: 377-386.
26. Kraus, E., W. Y. Leung and J. E. Haber, 2001 Break-induced replication: a review and an example in budding yeast. Proc. Natl. Acad. Sci. USA 98: 8255-8262.
27. Krejci, L., J. Damborsky, B. Thomsen, M. Duno and C. Bendixen, 2001 Molecular dissection of interactions between Rad51 and members of the recombination-repair group. Mol. Cell. Biol. 21: 966-976.
28. Kupiec, M., and T. D. Petes, 1988 Allelic and ectopic recombination between Ty elements in yeast. Genetics 119: 549-559.
29. Kuzminov, A., 1999 Recombinational repair of DNA damage in Escherichia coli and bacteriophage λ. Microbiol. Mol. Biol. Rev. 63: 751-813.
30. Lea, D. E., and C. A. Coulson, 1949 The distribution of the numbers of mutants in bacterial populations. J. Genet. 49: 264-285.
31. Lichten, M., R. H. Borts and J. E. Haber, 1987 Meiotic gene conversion and crossing over between dispersed homologous sequences occur frequently in Saccharomyces cerevisiae. Genetics 115: 233-246.
32. Liefshitz, B., A. Parket, R. Maya and M. Kupiec, 1995 The role of DNA repair genes in recombination between repeated sequences in yeast. Genetics 140: 1199-1211.
33. Lovett, S. T., and R. K. Mortimer, 1987 Characterization of null mutants of the RAD55 gene of Saccharomyces cerevisiae: effects of temperature, osmotic strength and mating type. Genetics 116: 547-553.
34. Malagon, F., and A. Aguilera, 2001 Yeast spt6-140 mutation, affecting chromatin and transcription, preferentially, increases recombination in which Rad51 p-mediated strand exchange is dispensable. Genetics 158: 597-611.
35. Maldonado, E., R. Shiekhattar, M. Sheldon, H. Cho, R. Drapkin et al., 1996 A human RNA polymerase 11 complex associated with SRB and DNA-repair proteins. Nature 381: 86-89.
36. Malkova, A., E. L. Ivanov and J. E. Haber, 1996 Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc. Natl. Acad. Sci. USA 93: 7131-7136.
37. Malone, R. E., and R. E. Esposito, 1981 Recombinationless meiosis in Saccharomyces cerevisiae. Mol. Cell. Biol. 1: 891-901.
38. Malone, R. E., T. Ward, S. Lin and J. Waring, 1990 The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast. Curr. Genet. 18: 111-116.
39. Mazin, A. V., C. J. Bornarth, J. A. Solinger, W. D. Heyer and S. C. Kowalczykowski, 2000 Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament. Mol. Cell 6: 583-592.
40. Morey, N. J., C. N. Greene and S. Jinks-Robertson, 2000 Genetic analysis of transcription-associated mutation in Saccharomyces cerevisiae. Genetics 154: 109-120.
41. Mortensen, U. H., C. Bendixen, I. Sunjevaric and R. Rothstein, 1996 DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. USA 93: 10729-10734.
42. Nevo-Caspi, Y., and M. Kupiec, 1994 Transcriptional induction of Ty recombination in yeast. Proc. Natl. Acad. Sci. USA 91: 12711-12715.
43. Nevo-Caspi, Y., and M. Kupiec, 1996 Induction of Ty recombination in yeast by cDNA and transcription: role of the RAD1 and RAD52 genes. Genetics 144: 947-955.
44. New, J. H., T. Sugiyama, E. Zaitseva and S. C. Kowalczykowski, 1998 Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A. Nature 391: 407-410.
45. Ogawa, T., X. Yu, A. Shinohara and E. H. Egelman, 1993 Similarity of the yeast RAD51 filament to the bacterial RecA filament. Science 259: 1896-1899.
46. Pâques, F., and J. E. Haber, 1999 Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63: 349-404.
47. Petukhova, G., S. Stratton and P. Sung, 1998 Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins. Nature 393: 91-94.
48. Petukhova, G., S. A. Stratton, and P. Sung, 1999a Single strand DNA binding and annealing activities in the yeast recombination factor Rad59. J. Biol. Chem. 274: 33839-33842.
49. Petukhova, G., S. Van Komen, S. Vergano, H. Klein and P. Sung, 1999b Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation. J. Biol. Chem. 274: 29453-29462.
50. Rattray, A. J., and L. S. Symington, 1994 Use of a chromosomal inverted repeat to demonstrate that the RAD51 and RAD52 genes of Saccharomyces cerevisiae have different roles in mitotic recombination. Genetics 138: 587-595.
51. Rattray, A. J., and L. S. Symington, 1995 Multiple pathways for homologous recombination in Saccharomyces cerevisiae. Genetics 139: 45-56.
52. Roitgrund, C., R. Steinlauf and M. Kupiec, 1993 Donation of information to the unbroken chromosome in double-strand break repair. Curr. Genet. 23: 414-422.
53. Saxe, D., A. Datta and S. Jinks-Robertson, 2000 Stimulation of mitotic recombination events by high levels of RNA polymerase II transcription in yeast. Mol. Cell. Biol. 20: 5404-5414.
54. Schild, D., B. Konforti, C. Perez, W. Gish and R. Mortimer, 1983 Isolation and characterization of yeast DNA repair genes. I. Cloning of the RAD52 gene. Curr. Genet. 7: 85-92.
55. Sherman, F., 1991 Getting started with yeast. Methods Enzymol. 194: 3-20.
56. Shinohara, A., and T. Ogawa, 1998 Stimulation by Rad52 of yeast Rad51-mediated recombination. Nature 391: 404-407.
57. Shinohara, A., H. Ogawa and T. Ogawa, 1992 Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell 69: 457-470.
58. Signon, L., A. Malkova, M. L. Naylor, H. Klein and J. E. Haber, 2001 Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break. Mol. Cell. Biol. 21: 2048-2056.
59. Solinger, J. A., and W. D. Heyer, 2001 Rad54 protein stimulates the postsynaptic phase of Rad51 protein-mediated DNA strand exchange. Proc. Natl. Acad. Sci. USA 98: 8447-8453.
60. Song, B., and P. Sung, 2000 Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in DNA strand exchange. J. Biol. Chem. 275: 15895-15904.
61. Sugawara, N., and J. E. Haber, 1992 Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation. Mol. Cell. Biol. 12: 563-575.
62. Sugawara, N., E. L. Ivanov, J. Fishman-Lobell, B. L. Ray, X. Wu et al., 1995 DNA structure-dependent requirements for yeast RAD genes in gene conversion. Nature 373: 84-86.
63. Sugiyama, T., J. H. New and S. C. Kowalczykowski, 1998 DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA. Proc. Natl. Acad. Sci. USA 95: 6049-6054.
64. Sung, P., 1994 Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265: 1241-1243.
65. Sung, P., 1997a Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase. J. Biol. Chem. 272: 28914-28917.
66. Sung, P., 1997b Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase. Genes Dev. 11: 1111-1121.
67. Sung, P., K. M. Trujillo and S. Van Komen, 2000 Recombination factors of Saccharomyces cerevisiae. Mutat. Res. 451: 257-275.
68. Thomas, B. J., and R. Rothstein, 1989a Elevated recombination rates in transcriptionally active DNA. Cell 56: 619-630.
69. Thomas, B. J., and R. Rothstein, 1989b The genetic control of direct-repeat recombination in Saccharomyces: the effect of rad52 and rad1 on mitotic recombination at GAL10, a transcriptionally regulated gene. Genetics 123: 725-738.
70. Trujillo, K. M., S. S. Yuan, E. Y. Lee and P. Sung, 1998 Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273: 21447-21450.
71. Tsubouchi, H., and H. Ogawa, 1998 A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis. Mol. Cell. Biol. 18: 260-268.
72. Usui, T., T. Ohta, H. Oshiumi, J. Tomizawa, H. Ogawa et al., 1998 Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-716.
73. Van Komen, S., G. Petukhova, S. Sigurdsson, S. Stratton and P. Sung, 2000 Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54. Mol. Cell 6: 563-572.
74. Voelkel-Meiman, K., and G. S. Roeder, 1990 A chromosome containing HOT1 preferentially receives information during mitotic interchromosomal gene conversion. Genetics 124: 561-572.
75. Voekel-Meiman, K., R. L. Keil and G. S. Roeder, 1987 Recombination-stimulating sequences in yeast ribosomal DNA correspond to sequences regulating transcription by RNA polymerase I. Cell 48: 1071-1079.
76. Wach, A., A. Brachat, R. Pohlmann and P. Philippsen, 1994 New heterologous modules for classical or PCR-based gene disruption in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
77. Zehfus, B. R., A. D. McWilliams, Y.-H. Lin, M. F. Hoekstra and R. L. Keil, 1990 Genetic control of RNA polymerase I-stimulated recombination in yeast. Genetics 126: 41-52.