Insulin resistance-reducing effect of a new thiazolidinedione derivative, pioglitazone

Folia Pharmacologica Japonica

Volumn 117, Issue 5, 2001, Pages 335-342

  Ikeda, H ^a   Sugiyama, Y ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Cellular insulin signal transduction; Inhibition of TNF production; Insulin resistance; Pioglitazone; PPAR agonist

Indexed keywords

INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; THIAZOLIDINE DERIVATIVE;

ADIPOCYTE; ANIMAL MODEL; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DOSE RESPONSE; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; NONHUMAN; OBESITY; RAT; RAT STRAIN; REVIEW; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MICE; RATS; RATS, WISTAR; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0034965564     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.117.335     Document Type: Review

References (31)

1. y mice: Models of obese non-insulin-dependent diabetes
2. Induction of diabetic alterations by goldthioglucose-obesity in KK, ICR and C57BL mice
3. Breeding of mice strains for diabetes mellitus
4. A new genetically obese-hyperglycemic rat (Wistar fatty)
5. Studies on antihyperlipidemic agents. III. Synthesis and biological activities of 2-chloro-3-arylpropionic acids containing a quarternary carbon atom
6. Studies on antidiabetic agents. I. Synthesis of 5-[4-(2-methyl-2-phenylpropoxy) benzyl] thiazolidine-2,4-dione (AL321) and related compounds
7. Studies on antidiabetic agents. II. Synthesis of 5-[4- (1-methylcyclohexylmethoxy) benzyl] thiazolidine-2,4-dione (ADD-3878) and its derivatives
8. Reduction of insulin resistance in obese and/or diabetic animals by 5-[4- (1-methylcyclohexylmethoxy) benzyl] thiazolidine-2,4-dione (ADD-3878, U-63,287, cyglitazone), a new antidiabetic agent
9. Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats
10. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals
11. Effects of pioglitazone on hepatic and peripheral insulin resistance in Wistar fatty rats
12. Pioglitazone increases insulin sensitivity by activating insulin receptor kinase
13. Pioglitazone improves insulin signaling defects in skeletal muscle from Wistar fatty (fa/fa) rats
14. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-α
15. Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
16. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
17. Pioglitazone time-dependently reduces tumor necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats
18. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
19. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
20. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone
21. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
22. PPARγ, the ultimate thrifty gene
23. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat
24. VLDL triglyceride kinetics in Wistar fatty rats, an animal model of NIDDM. Effects of dietary fructose alone or in combination with pioglitazone