Total synthesis as a resource in drug discovery: The first in vivo evaluation of panaxytriol and its derivatives

Journal of Organic Chemistry

Volumn 70, Issue 25, 2005, Pages 10375-10380

  Yun, Heedong ^a   Chou, Ting Chao ^b   Dong, Huajin ^b   Tian, Yuan ^b   Li, Yue Ming ^b   Danishefsky, Samuel J ^a,b  

^a Columbia University ^*  (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYLATION; SYNTHESIS (CHEMICAL); TUMORS;

BIOLOGICAL ACTIVITY; CYTOTOXIXITY; NATURAL PRODUCTS; PANAXYTRIOL;

DRUG PRODUCTS;

HYDROXYL GROUP; NATURAL PRODUCT; PANAXYTRIOL; PANAXYTRIOL ACETONIDE; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROTROPISM; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; ENEDIYNES; FATTY ALCOHOLS; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28744434817     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0515475     Document Type: Article

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