-
1
-
-
0028904194
-
Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms
-
Welsh DK, Logothetis DE, Meister M, Reppert SM. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 1995;14:697-706.
-
(1995)
Neuron
, vol.14
, pp. 697-706
-
-
Welsh, D.K.1
Logothetis, D.E.2
Meister, M.3
Reppert, S.M.4
-
2
-
-
33746900451
-
The circadian visual system, 2005
-
Morin LP, Allen CN. The circadian visual system, 2005. Brain Res Rev 2006;51:1-60.
-
(2006)
Brain Res Rev
, vol.51
, pp. 1-60
-
-
Morin, L.P.1
Allen, C.N.2
-
3
-
-
0030272030
-
The role of glutamate in the photic regulation of the suprachiasmatic nucleus
-
Ebling FJ. The role of glutamate in the photic regulation of the suprachiasmatic nucleus. Prog Neurobiol 1996;50:109-132.
-
(1996)
Prog Neurobiol
, vol.50
, pp. 109-132
-
-
Ebling, F.J.1
-
4
-
-
0030962604
-
Pituitary adenylate cyclase-activating peptide (PACAP) in the retinohypothalamic tract: A potential daytime regulator of the biological clock
-
Hannibal J, Ding JM, Chen D, et al. Pituitary adenylate cyclase-activating peptide (PACAP) in the retinohypothalamic tract: a potential daytime regulator of the biological clock. J Neurosci 1997;17:2637-2644.
-
(1997)
J Neurosci
, vol.17
, pp. 2637-2644
-
-
Hannibal, J.1
Ding, J.M.2
Chen, D.3
-
5
-
-
0016824822
-
Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber
-
Aschoff J, Hoffmann K, Pohl H, Wever R. Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber. Chronobiologia 1975;2:23-78.
-
(1975)
Chronobiologia
, vol.2
, pp. 23-78
-
-
Aschoff, J.1
Hoffmann, K.2
Pohl, H.3
Wever, R.4
-
6
-
-
22544456542
-
How to trick mother nature into letting you fly around or stay up all night
-
Revell VL, Eastman CI. How to trick mother nature into letting you fly around or stay up all night. J Biol Rhythms 2005;20:353-365.
-
(2005)
J Biol Rhythms
, vol.20
, pp. 353-365
-
-
Revell, V.L.1
Eastman, C.I.2
-
7
-
-
0041417804
-
Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle
-
Vansteensel MJ, Yamazaki S, Albus H, et al. Dissociation between circadian Per1 and neuronal and behavioral rhythms following a shifted environmental cycle. Curr Biol 2003;13:1538-1542.
-
(2003)
Curr Biol
, vol.13
, pp. 1538-1542
-
-
Vansteensel, M.J.1
Yamazaki, S.2
Albus, H.3
-
9
-
-
0031658863
-
Migraine chronobiology
-
Fox AW, Davis RL. Migraine chronobiology. Headache 1998;38:436-441.
-
(1998)
Headache
, vol.38
, pp. 436-441
-
-
Fox, A.W.1
Davis, R.L.2
-
11
-
-
0032872087
-
Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans
-
Jones CR, Campbell SS, Zone SE, et al. Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans. Nat Med 1999;5:1062-1065.
-
(1999)
Nat Med
, vol.5
, pp. 1062-1065
-
-
Jones, C.R.1
Campbell, S.S.2
Zone, S.E.3
-
12
-
-
15844420887
-
Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome
-
Xu Y, Padiath QS, Shapiro RE, et al. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 2005;434:640-644.
-
(2005)
Nature
, vol.434
, pp. 640-644
-
-
Xu, Y.1
Padiath, Q.S.2
Shapiro, R.E.3
-
13
-
-
54849427212
-
A novel familial syndrome of migraine with aura, flushing spells, myalgias, asthma, and the advanced sleep phase syndrome
-
Abstract
-
Shapiro RE, Waheed W, Nagle K. A novel familial syndrome of migraine with aura, flushing spells, myalgias, asthma, and the advanced sleep phase syndrome. Cephalalgia 1999;19:424 (Abstract).
-
(1999)
Cephalalgia
, vol.19
, pp. 424
-
-
Shapiro, R.E.1
Waheed, W.2
Nagle, K.3
-
14
-
-
0038583628
-
Electrophysiological studies in migraine: A comprehensive review of their interest and limitations
-
Ambrosini A, de Noordhout AM, Sándor PS, Schoenen J. Electrophysiological studies in migraine: a comprehensive review of their interest and limitations. Cephalalgia 2003;23(suppl 1):13-31.
-
(2003)
Cephalalgia
, vol.23
, Issue.SUPPL. 1
, pp. 13-31
-
-
Ambrosini, A.1
de Noordhout, A.M.2
Sándor, P.S.3
Schoenen, J.4
-
15
-
-
1442265540
-
The International Classification of Headache Disorders
-
Headache Classification Subcommittee of the International Headache Society, 2nd edition
-
Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004;24:1-160.
-
(2004)
Cephalalgia
, vol.24
, pp. 1-160
-
-
-
16
-
-
0036263926
-
A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria
-
Thomsen LL, Eriksen MK, Roemer SF, et al. A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. Brain 2002;125:1379-1391.
-
(2002)
Brain
, vol.125
, pp. 1379-1391
-
-
Thomsen, L.L.1
Eriksen, M.K.2
Roemer, S.F.3
-
17
-
-
84882473886
-
Migraine as a Cerebral Ionopathy with Impaired Central Sensory Processing
-
Waxman SG, ed, New York: Elsevier
-
Ferrari MD, van den Maagdenberg AM, Frants RR, Goadsby PJ. Migraine as a Cerebral Ionopathy with Impaired Central Sensory Processing. In: Waxman SG, ed. Molecular Neurology. New York: Elsevier, 2007:439-461.
-
(2007)
Molecular Neurology
, pp. 439-461
-
-
Ferrari, M.D.1
van den Maagdenberg, A.M.2
Frants, R.R.3
Goadsby, P.J.4
-
19
-
-
12144286750
-
A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression
-
van den Maagdenberg AM, Pietrobon D, Pizzorusso T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron 2004;41:701-710.
-
(2004)
Neuron
, vol.41
, pp. 701-710
-
-
van den Maagdenberg, A.M.1
Pietrobon, D.2
Pizzorusso, T.3
-
20
-
-
0028827658
-
Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels
-
Westenbroek RE, Sakurai T, Elliott EM, et al. Immunochemical identification and subcellular distribution of the alpha 1A subunits of brain calcium channels. J Neurosci 1995;15:6403-6418.
-
(1995)
J Neurosci
, vol.15
, pp. 6403-6418
-
-
Westenbroek, R.E.1
Sakurai, T.2
Elliott, E.M.3
-
21
-
-
0032008546
-
Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons
-
Chen G, van den Pol AN. Presynaptic GABAB autoreceptor modulation of P/Q-type calcium channels and GABA release in rat suprachiasmatic nucleus neurons. J Neurosci 1998;18:1913-1922.
-
(1998)
J Neurosci
, vol.18
, pp. 1913-1922
-
-
Chen, G.1
van den Pol, A.N.2
-
22
-
-
0037335442
-
Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus
-
Cloues RK, Sather WA. Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus. J Neurosci 2003;23:1593-1604.
-
(2003)
J Neurosci
, vol.23
, pp. 1593-1604
-
-
Cloues, R.K.1
Sather, W.A.2
-
23
-
-
27144502468
-
Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus
-
Nahm SS, Farnell YZ, Griffith W, Earnest DJ. Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus. J Neurosci 2005;25:9304-9308.
-
(2005)
J Neurosci
, vol.25
, pp. 9304-9308
-
-
Nahm, S.S.1
Farnell, Y.Z.2
Griffith, W.3
Earnest, D.J.4
-
24
-
-
0029089184
-
Calcium control of transmitter release at a cerebellar synapse
-
Mintz IM, Sabatini BL, Regehr WG. Calcium control of transmitter release at a cerebellar synapse. Neuron 1995;15:675-688.
-
(1995)
Neuron
, vol.15
, pp. 675-688
-
-
Mintz, I.M.1
Sabatini, B.L.2
Regehr, W.G.3
-
25
-
-
0033555416
-
Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses
-
Wu LG, Westenbroek RE, Borst JG, et al. Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J Neurosci 1999;19:726-736.
-
(1999)
J Neurosci
, vol.19
, pp. 726-736
-
-
Wu, L.G.1
Westenbroek, R.E.2
Borst, J.G.3
-
26
-
-
0036792027
-
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons
-
Tottene A, Fellin T, Pagnutti S, et al. Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A 2002;99:13284-13289.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 13284-13289
-
-
Tottene, A.1
Fellin, T.2
Pagnutti, S.3
-
27
-
-
0028325495
-
Pathophysiology of the migraine aura. The spreading depression theory
-
Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994;117:199-210.
-
(1994)
Brain
, vol.117
, pp. 199-210
-
-
Lauritzen, M.1
-
28
-
-
0035836628
-
Mechanisms of migraine aura revealed by functional MRI in human visual cortex
-
Hadjikhani N, Sanchez Del Rio M, Wu O, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 2001;98:4687-4692.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4687-4692
-
-
Hadjikhani, N.1
Sanchez Del Rio, M.2
Wu, O.3
-
29
-
-
0036171973
-
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
-
Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002;8:136-142.
-
(2002)
Nat Med
, vol.8
, pp. 136-142
-
-
Bolay, H.1
Reuter, U.2
Dunn, A.K.3
-
30
-
-
33645789260
-
Suppression of cortical spreading depression in migraine prophylaxis
-
Ayata C, Jin H, Kudo C, et al. Suppression of cortical spreading depression in migraine prophylaxis. Ann Neurol 2006;59:652-661.
-
(2006)
Ann Neurol
, vol.59
, pp. 652-661
-
-
Ayata, C.1
Jin, H.2
Kudo, C.3
-
31
-
-
0034724728
-
Resetting central and peripheral circadian oscillators in transgenic rats
-
Yamazaki S, Numano R, Abe M, et al. Resetting central and peripheral circadian oscillators in transgenic rats. Science 2000;288:682-685.
-
(2000)
Science
, vol.288
, pp. 682-685
-
-
Yamazaki, S.1
Numano, R.2
Abe, M.3
-
32
-
-
0033983933
-
Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: Empirical data and simulations
-
Huber R, Deboer T, Tobler I. Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations. Brain Res 2000;857:8-19.
-
(2000)
Brain Res
, vol.857
, pp. 8-19
-
-
Huber, R.1
Deboer, T.2
Tobler, I.3
-
33
-
-
0036333688
-
Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
-
Deboer T, Fontana A, Tobler I. Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG. J Neurophysiol 2002;88:839-846.
-
(2002)
J Neurophysiol
, vol.88
, pp. 839-846
-
-
Deboer, T.1
Fontana, A.2
Tobler, I.3
-
34
-
-
0018146115
-
Effects of light on sleep and activity rhythms
-
Borbely AA. Effects of light on sleep and activity rhythms. Prog Neurobiol 1978;10:1-31.
-
(1978)
Prog Neurobiol
, vol.10
, pp. 1-31
-
-
Borbely, A.A.1
-
35
-
-
0025736555
-
Short light-dark cycles influence sleep stages and EEG power spectra in the rat
-
Alfoldi P, Franken P, Tobler I, Borbely AA. Short light-dark cycles influence sleep stages and EEG power spectra in the rat. Behav Brain Res 1991;43:125-131.
-
(1991)
Behav Brain Res
, vol.43
, pp. 125-131
-
-
Alfoldi, P.1
Franken, P.2
Tobler, I.3
Borbely, A.A.4
-
36
-
-
36949015154
-
Short light-dark cycles affect sleep in mice
-
Deboer T, Ruijgrok G, Meijer JH. Short light-dark cycles affect sleep in mice. Eur J Neurosci 2007;26:3518-3523.
-
(2007)
Eur J Neurosci
, vol.26
, pp. 3518-3523
-
-
Deboer, T.1
Ruijgrok, G.2
Meijer, J.H.3
-
37
-
-
0036333826
-
Excitatory mechanisms in the suprachiasmatic nucleus: The role of AMPA/KA glutamate receptors
-
Michel S, Itri J, Colwell CS. Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors. J Neurophysiol 2002;88:817-828.
-
(2002)
J Neurophysiol
, vol.88
, pp. 817-828
-
-
Michel, S.1
Itri, J.2
Colwell, C.S.3
-
38
-
-
33644772271
-
Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus
-
Michel S, Itri J, Han JH, et al. Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus. BMC Neurosci 2006;7:15.
-
(2006)
BMC Neurosci
, vol.7
, pp. 15
-
-
Michel, S.1
Itri, J.2
Han, J.H.3
-
39
-
-
20144382764
-
A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock
-
Albus H, Vansteensel MJ, Michel S, et al. A GABAergic mechanism is necessary for coupling dissociable ventral and dorsal regional oscillators within the circadian clock. Curr Biol 2005;15:886-893.
-
(2005)
Curr Biol
, vol.15
, pp. 886-893
-
-
Albus, H.1
Vansteensel, M.J.2
Michel, S.3
-
40
-
-
0032211067
-
Light responsiveness of the suprachiasmatic nucleus: Long-term multiunit and single-unit recordings in freely moving rats
-
Meijer JH, Watanabe K, Schaap J, et al. Light responsiveness of the suprachiasmatic nucleus: long-term multiunit and single-unit recordings in freely moving rats. J Neurosci 1998;18:9078-9087.
-
(1998)
J Neurosci
, vol.18
, pp. 9078-9087
-
-
Meijer, J.H.1
Watanabe, K.2
Schaap, J.3
-
41
-
-
0346734112
-
Heterogeneity of rhythmic suprachiasmatic nucleus neurons: Implications for circadian waveform and photoperiodic encoding
-
Schaap J, Albus H, VanderLeest HT, et al. Heterogeneity of rhythmic suprachiasmatic nucleus neurons: implications for circadian waveform and photoperiodic encoding. Proc Natl Acad Sci U S A 2003;100:15994-15999.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15994-15999
-
-
Schaap, J.1
Albus, H.2
VanderLeest, H.T.3
-
42
-
-
18044370254
-
Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN)
-
Gompf HS, Moldavan MG, Irwin RP, Allen CN. Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN). Neurosci 2005;132:955-965.
-
(2005)
Neurosci
, vol.132
, pp. 955-965
-
-
Gompf, H.S.1
Moldavan, M.G.2
Irwin, R.P.3
Allen, C.N.4
-
43
-
-
23844438843
-
A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons
-
Lundkvist GB, Kwak Y, Davis EK, et al. A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons. J Neurosci 2005;25:7682-7686.
-
(2005)
J Neurosci
, vol.25
, pp. 7682-7686
-
-
Lundkvist, G.B.1
Kwak, Y.2
Davis, E.K.3
-
45
-
-
24044458609
-
Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness
-
Kaja S, van de Ven RC, Broos LA, et al. Gene dosage-dependent transmitter release changes at neuromuscular synapses of CACNA1A R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness. Neuroscience 2005;135:81-95.
-
(2005)
Neuroscience
, vol.135
, pp. 81-95
-
-
Kaja, S.1
van de Ven, R.C.2
Broos, L.A.3
-
46
-
-
0037811262
-
An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center
-
Nagano M, Adachi A, Nakahama K, et al. An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center. J Neurosci 2003;23:6141-6151.
-
(2003)
J Neurosci
, vol.23
, pp. 6141-6151
-
-
Nagano, M.1
Adachi, A.2
Nakahama, K.3
-
47
-
-
20444422860
-
Differential response of Period 1 expression within the suprachiasmatic nucleus
-
Nakamura W, Yamazaki S, Takasu NN, et al. Differential response of Period 1 expression within the suprachiasmatic nucleus. J Neurosci 2005;25:5481-5487.
-
(2005)
J Neurosci
, vol.25
, pp. 5481-5487
-
-
Nakamura, W.1
Yamazaki, S.2
Takasu, N.N.3
-
48
-
-
20244390460
-
Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock
-
Kim DY, Choi HJ, Kim JS, et al. Voltage-gated calcium channels play crucial roles in the glutamate-induced phase shifts of the rat suprachiasmatic circadian clock. Eur J Neurosci 2005;21:1215-1222.
-
(2005)
Eur J Neurosci
, vol.21
, pp. 1215-1222
-
-
Kim, D.Y.1
Choi, H.J.2
Kim, J.S.3
-
49
-
-
0036758613
-
Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag
-
Reddy AB, Field MD, Maywood ES, Hastings MH. Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag. J Neurosci 2002;22:7326-7330.
-
(2002)
J Neurosci
, vol.22
, pp. 7326-7330
-
-
Reddy, A.B.1
Field, M.D.2
Maywood, E.S.3
Hastings, M.H.4
-
50
-
-
0030910641
-
Effects of serotonin on caudal raphe neurons: Inhibition of N-and P/Q-type calcium channels and the afterhyperpolarization
-
Bayliss DA, Li YW, Talley EM. Effects of serotonin on caudal raphe neurons: inhibition of N-and P/Q-type calcium channels and the afterhyperpolarization. J Neurophysiol 1997;77:1362-1374.
-
(1997)
J Neurophysiol
, vol.77
, pp. 1362-1374
-
-
Bayliss, D.A.1
Li, Y.W.2
Talley, E.M.3
-
51
-
-
0037292262
-
Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus
-
Silva AP, Carvalho AP, Carvalho CM, Malva JO. Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus. Neuropharmacology 2003;44:282-292.
-
(2003)
Neuropharmacology
, vol.44
, pp. 282-292
-
-
Silva, A.P.1
Carvalho, A.P.2
Carvalho, C.M.3
Malva, J.O.4
-
52
-
-
33751517370
-
Direct G protein modulation of Cav2 calcium channels
-
Tedford HW, Zamponi GW. Direct G protein modulation of Cav2 calcium channels. Pharmacol Rev 2006;58:837-862.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 837-862
-
-
Tedford, H.W.1
Zamponi, G.W.2
-
53
-
-
1642267233
-
The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells
-
Melliti K, Grabner M, Seabrook GR. The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells. J Physiol 2003;546:337-347.
-
(2003)
J Physiol
, vol.546
, pp. 337-347
-
-
Melliti, K.1
Grabner, M.2
Seabrook, G.R.3
-
54
-
-
5444238568
-
Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons
-
Womack MD, Chevez C, Khodakhah K. Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons. J Neurosci 2004;4:8818-8822.
-
(2004)
J Neurosci
, vol.4
, pp. 8818-8822
-
-
Womack, M.D.1
Chevez, C.2
Khodakhah, K.3
-
55
-
-
27744490791
-
Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons
-
Goldberg JA, Wilson CJ. Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons. J Neurosci 2005;25:10230-10238.
-
(2005)
J Neurosci
, vol.25
, pp. 10230-10238
-
-
Goldberg, J.A.1
Wilson, C.J.2
-
57
-
-
33747624755
-
BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output
-
Meredith AL, Wiler SW, Miller BH, et al. BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nat Neurosci 2006;9:1041-1049.
-
(2006)
Nat Neurosci
, vol.9
, pp. 1041-1049
-
-
Meredith, A.L.1
Wiler, S.W.2
Miller, B.H.3
|