The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Cav2.1) calcium channels expressed in human embryonic kidney cells

Journal of Physiology

Volumn 546, Issue 2, 2003, Pages 337-347

  Melliti, Karim ^a   Grabner, Manfred ^b   Seabrook, Guy R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; DOPAMINE 2 RECEPTOR; GLUTAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PROTEIN SUBUNIT; QUINPIROLE; VOLTAGE GATED CHANNEL FORMING PROTEIN; CALCIUM CHANNEL CAV2.1; CALCIUM ION; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

BINDING AFFINITY; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; EMBRYO; EMBRYO CELL; FACILITATION; FAMILIAL HEMIPLEGIC MIGRAINE; GENE MUTATION; HUMAN; HUMAN CELL; KIDNEY CELL; MIGRAINE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; WILD TYPE; ARTICLE; CHANNEL GATING; MUTANT; NERVE CELL EXCITABILITY;

CALCIUM CHANNELS, N-TYPE; CELL LINE; ELECTRIC CONDUCTIVITY; EMBRYO; GTP-BINDING PROTEINS; HUMANS; KIDNEY; KINETICS; MIGRAINE WITH AURA; MUTATION; PATCH-CLAMP TECHNIQUES; RECEPTORS, DOPAMINE D2;

EID: 1642267233     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.026716     Document Type: Review

References (61)

1. Armstrong CM & Hille B (1998). Voltage-gated ion channels and electrical excitability. Neuron 20, 371-380.
2. Arnot MI, Stotz SC, Jarvis SE & Zamponi GW (2000). Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G-protein subunit isoforms. J Physiol 527, 203-212.
3. Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL & Moskowitz MA (2000). Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the α1A subunit of P/Q type calcium channels. Neuroscience 95, 639-645.
4. Battistini S, Stenirri S, Piatti M, Gelfi C, Righetti PG, Rocchi R, Giannini F, Battistini N, Guazzi GC, Ferrari M & Carrera P (1999). A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia. Neurology 53, 38-43.
5. Bean BP (1989). Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340, 153-156.
6. Boland LM & Bean BP (1993). Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone: kinetics and voltage dependence. J Neurosci 13, 516-533.
7. Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA & Moskowitz MA (2002). Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8, 136-142.
8. Bourinet E, Soong TW, Stea A & Snutch TP (1996). Determinants of the G protein-dependent opioid modulation of neuronal calcium channels. Proc Natl Acad Sci U S A 93, 1486-1491.
9. Bourinet E, Soong TW, Sutton K, Slaymaker S, Mathews E, Monteil A, Zamponi GW, Nargeot J & Snutch TP (1999). Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci 2, 407-415.
10. 2+ channels in HEK 293 cells. J Physiol 499, 637-644.
11. Brody DL & Yue DT (2000). Relief of G-protein inhibition of calcium channels and short-term synaptic facilitation in cultured hippocampal neurons. J Neurosci 20, 889-898.
12. Brown NA & Seabrook GR (1995). Phosphorylation- and voltage-dependent inhibition of neuronal calcium currents by activation of human D2 (short) dopamine receptors. Br J Pharmacol 115, 459-466.
13. Carrera P, Piatti M, Stenirri S, Grimaldi LM, Marchioni E, Curcio M, Righetti PG, Ferrari M & Gelfi C (1999). Genetic heterogeneity in Italian families with familial hemiplegic migraine. Neurology 53, 26-33.
14. Colecraft HM, Patil PG & Yue DT (2000). Differential occurrence of reluctant openings in G-protein-inhibited N- and P/Q-type calcium channels. J Gen Physiol 115, 175-192.
15. Currie KP & Fox AP (1997). Comparison of N- and P/Q-type voltage-gated calcium channel current inhibition. J Neurosci 17, 4570-4579.
16. Currie KP & Fox AP (2002). Differential facilitation of N- and P/Q-type calcium channels during trains of action potential-like waveforms. J Physiol 539, 419-431.
17. De Waard M, Liu H, Walker D, Scott VE, Gurnett CA & Campbell KP (1997). Direct binding of G-protein βγ complex to voltage-dependent calcium channels. Nature 385, 446-450.
18. Ducros A, Denier C, Joutel A, Vahedi K, Michel A, Darcel F, Madigand M, Guerouaou D, Tison F, Julien J, Hirsch E, Chedru F, Bisgard C, Lucotte G, Despres P, Billard C, Barthez MA, Ponsot G, Bousser MG & Tournier-Lasserve E (1999). Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia. Am J Hum Genet 64, 89-98.
19. 2+ channels in mammalian central neurons. Trends Neurosci 18, 89-98.
20. Elmslie KS & Jones SW (1994). Concentration dependence of neurotransmitter effects on calcium current kinetics in frog sympathetic neurones. J Physiol 481, 35-46.
21. Elmslie KS, Zhou W & Jones SW (1990). LHRH and GTP-γ-S modify calcium current activation in bullfrog sympathetic neurons. Neuron 5, 75-80.
22. Fanciullacci M, Alessandri M & Del Rosso A (2000). Dopamine involvement in the migraine attack. Funct Neurol 15, 171-181.
23. Goadsby PJ, Lipton RB & Ferrari MD (2002). Migraine, current understanding and treatment. N Engl J Med 346, 257-270.
24. 2+ channels expressed in dysgenic myotubes. Proc Natl Acad Sci U S A 95, 1903-1908.
25. Hamill OP, Marty A, Neher E, Sakmann B & Sigworth FJ (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100.
26. Hans M, Luvisetto S, Williams ME, Spagnolo M, Urrutia A, Tottene A, Brust PF, Johnson EC, Harpold MM, Stauderman KA & Pietrobon D (1999a). Functional consequences of mutations in the human α1A calcium channel subunit linked to familial hemiplegic migraine. J Neurosci 19, 1610-1619.
27. Hans M, Urrutia A, Deal C, Brust PF, Stauderman K, Ellis SB, Harpold MM, Johnson EC & Williams ME (1999b). Structural elements in domain IV that influence biophysical and pharmacological properties of human α1A-containing high-voltage-activated calcium channels. Biophys J 76, 1384-1400.
28. 2+ channels by G-protein βγ subunits. Nature 380, 258-262.
29. 2+ channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)β subunits. Proc Natl Acad Sci U S A 98, 4699-4704.
30. Hullin R, Singer-Lahat D, Freichel M, Biel M, Dascal N, Hofmann F & Flockerzi V (1992). Calcium channelβ subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J 11, 885-890.
31. Ikeda SR (1991). Double-pulse calcium channel current facilitation in adult rat sympathetic neurones. J Physiol 439, 181-214.
32. Ikeda SR (1996). Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits. Nature 380, 255-258.
33. Jones LP, Patil PG, Snutch TP & Yue DT (1997). G-protein modulation of N-type calcium channel gating current in human embryonic kidney cells (HEK 293). J Physiol 498, 601-610.
34. Jones SW (1991). Time course of receptor-channel coupling in frog sympathetic neurons. Biophys J 60, 502-507.
35. 2+ channels. J Biol Chem 276, 28731-28738.
36. Koh DS & Hille B (1997). Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. Proc Natl Acad Sci U S A 94, 1506-1511.
37. 2+ channel kinetics. J Biol Chem 273, 5586-5590.
38. Lipscombe D, Kongsamut S & Tsien RW (1989). α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating. Nature 340, 639-642.
39. 2+ currents in rat anterior pituitary cells. Neuron 8, 455-463.
40. McAllister G, Knowles MR, Patel S, Marwood R, Emms F, Seabrook GR, Graziano M, Borkowski D, Hey PJ & Freedman SB (1993). Characterisation of a chimeric hD3/D2 dopamine receptor expressed in CHO cells. FEBS Lett 324, 81-86.
41. 2+ channel gene CACNL1A4. Cell 87, 543-552.
42. Page KM, Stephens GJ, Berrow NS & Dolphin AC (1997). The intracellular loop between domains I and II of the B-type calcium channel confers aspects of G-protein sensitivity to the E-type calcium channel. J Neurosci 17, 1330-1338.
43. Park D & Dunlap K (1998). Dynamic regulation of calcium influx by G-proteins, action potential waveform, and neuronal firing frequency. J Neurosci 18, 6757-6766.
44. Patil PG, Brody DL & Yue DT (1998). Preferential closed-state inactivation of neuronal calcium channels. Neuron 20, 1027-1038.
45. Patil PG, De Leon M, Reed RR, Dubel S, Snutch TP & Yue DT (1996). Elementary events underlying voltage-dependent G-protein inhibition of N-type calcium channels. Biophys J 71, 2509-2521.
46. Peroutka SJ (1997). Dopamine and migraine. Neurology 49, 650-656.
47. Pietrobon D (2002). Calcium channels and channelopathies of the central nervous system. Mol Neurobiol 25, 31-50.
48. Ptacek LJ (1998). The place of migraine as a channelopathy. Curr Opin Neurol 11, 217-226.
49. 2+ channel α1 subunit is responsible for channel inhibition by G protein-coupled receptors. Proc Natl Acad Sci U S A 94, 8866-8871.
50. Simen AA & Miller RJ (1998). Structural features determining differential receptor regulation of neuronal Ca channels. J Neurosci 18, 3689-3698.
51. 2+ channels. Mol Pharmacol 57, 1064-1074.
52. Welch KM (1998). Current opinions in headache pathogenesis: introduction and synthesis. Curr Opin Neurol 11, 193-197.
53. 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. J Neurosci 18, 6319-6330.
54. Westenbroek RE, Sakurai T, Elliott EM, Hell JW, Starr TV, Snutch TP & Catterall WA (1995). Immunochemical identification and subcellular distribution of the α1A subunits of brain calcium channels. J Neurosci 15, 6403-6418.
55. Williams ME, Feldman DH, McCue AF, Brenner R, Velicelebi G, Ellis SB & Harpold MM (1992). Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype. Neuron 8, 71-84.
56. Wolfe SE & Morris SJ (1999). Dopamine D2 receptor isoforms expressed in AtT20 cells differentially couple to G proteins to acutely inhibit high voltage-activated calcium channels. J Neurochem 73, 2375-2382.
57. Wu LG & Saggau P (1997). Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci 20, 204-212.
58. Zamponi GW, Bourinet E, Nelson D, Nargeot J & Snutch TP (1997). Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit. Nature 385, 442-446.
59. 2+ channels support their inhibition by G proteins. Neuron 17, 991-1003.
60. 2+ channel. Proc Natl Acad Sci U S A 98, 4705-4709.
61. 2+ channel modulation by neurotransmitters in rat sympathetic neurons. J Neurophysiol 77, 2040-2048.