Evaluation of solvent accessibility epitopes for different dehydrogenase inhibitors

ChemMedChem

Volumn 3, Issue 9, 2008, Pages 1371-1376

  Ludwig, Christian ^a   Michiels, Paulus J A ^b   Lodi, Alessia ^a   Ride, John ^a   Bunce, Chris ^a   Günther, Ulrich L ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Epitope mapping; NMR spectroscopy; Pharmacophore mapping; Protein ligand interactions

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AKR1C3 PROTEIN, HUMAN; DIMETHYL SULFOXIDE; ENZYME INHIBITOR; EPITOPE; ESTRADIOL 17BETA DEHYDROGENASE; FLAVONOID; HSD17B1 PROTEIN, HUMAN; INDOMETACIN; LIGAND; SOLVENT; WATER;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MAGNETISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; STANDARD; SURFACE PROPERTY;

3-HYDROXYSTEROID DEHYDROGENASES; BINDING SITES; DIMETHYL SULFOXIDE; ENZYME INHIBITORS; EPITOPES; ESTRADIOL DEHYDROGENASES; FLAVONOIDS; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; INDOMETHACIN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; REFERENCE STANDARDS; SOLVENTS; SURFACE PROPERTIES; WATER;

EID: 54849432001     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800110     Document Type: Article

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