Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation

Journal of Cellular Biochemistry

Volumn 105, Issue 3, 2008, Pages 922-930

  Cheng, Ya Shan ^a   Lee, Tzong Shyuan ^a   Hsu, Hui Chi ^a,b   Yu, Ru Kou ^a   Wu, Yuh Lin ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

3T3 L1 preadipocytes; Adipocyte differentiation; RGS2

Indexed keywords

RGS2 PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CLONING, MOLECULAR; CYCLIC AMP; GENE EXPRESSION REGULATION; MICE; PROMOTER REGIONS, GENETIC; RGS PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 54849429139     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21893     Document Type: Article

References (55)

1. Anger T, Zhang W, Mende U. 2004. Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo. J Biol Chem 279:3906-3915.
2. Barth N, Langmann T, Scholmerich J, Schmitz G, Schaffler A. 2002. Identification of regulatory elements in the human adipose most abundant gene transcript-1 (apM-1) promoter: Role of SP1/SP3 and TNF-alpha as regulatory pathways. Diabetologia 45:1425-1433.
3. Betuing S, Valet P, Lapalu S, Peyroulan D, Hickson G, Daviaud D, Lafontan M, Saulnier-Blache JS. 1997. Functional consequences of constitutively active alpha2A-adrenergic receptor expression in 3T3F442A preadipocytes and adipocytes. Biochem Biophys Res Commun 235:765-773.
4. Bost F, Aouadi M, Caron L, Binetruy B. 2005. The role of MAPKs in adipocyte differentiation and obesity. Biochimie 87:51-56.
5. Bouwman P, Philipsen S. 2002. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol 195:27-38.
6. Collins S, Surwit RS. 2001. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog Horm Res 56:309-328.
7. Denis-Henriot D, de Mazancourt P, Goldsmith PK, Giudicelli Y. 1996a. G proteins in adipocytes and preadipocytes: Characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation. Cell Signal 8:225-234.
8. Denis-Henriot D, Lacasa D, Goldsmith PK, de Mazancourt P, Giudicelli Y. 1996b. Site-related differences in G-protein alpha subunit expression during adipogenesis in vitro: Possible key role for Gq/11 alpha in the control of preadipocyte differentiation. Biochem Biophys Res Commun 220:443-448.
9. Denis-Henriot D, de Mazancourt P, Morot M, Giudicelli Y. 1998. Mutant alpha-subunit of the G protein G12 activates proliferation and inhibits differentiation of 3T3-F442A preadipocytes. Endocrinology 139:2892-2899.
10. Freson K, Stolarz K, Aerts R, Brand E, Brand-Herrmann SM, Kawecka-Jaszcz K, Kuznetsova T, Tikhonoff V, Thijs L, Vermylen J, Staessen JA, Van GC. 2007. -391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: Consistency between molecular and epidemiological studies. J Hypertens 25:117-125.
11. Gold SJ, Han MH, Herman AE, Ni YG, Pudiak CM, Aghajanian GK, Liu RJ, Potts BW, Mumby SM, Nestler EJ. 2003. Regulation of RGS proteins by chronic morphine in rat locus coeruleus. Eur J Neurosci 17:971-980.
12. Gordeladze JO, Hovik KE, Merendino JJ, Hermouet S, Gutkind S, Accili D. 1997. Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes. J Cell Biochem 64:242-257.
13. Gotoh C, Hong YH, Iga T, Hishikawa D, Suzuki Y, Song SH, Choi KC, Adachi T, Hirasawa A, Tsujimoto G, Sasaki S, Roh SG. 2007. The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun 354:591-597.
14. Gu L, Findley HW, Zhou M. 2002. MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: A novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia. Blood 99:3367-3375.
15. Guest SJ, Hadcock JR, Watkins DC, Malbon CC. 1990. Beta 1- and beta 2-adrenergic receptor expression in differentiating 3T3-L1 cells. Independent regulation at the level of mRNA. J Biol Chem 265:5370-5375.
16. Hollinger S, Hepler JR. 2002. Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling. Pharmacol Rev 54:527-559.
17. Imagawa M, Tsuchiya T, Nishihara T. 1999. Identification of inducible genes at the early stage of adipocyte differentiation of 3T3-L1 cells. Biochem Biophys Res Commun 254:299-305.
18. Jiang MS, Lane MD. 2000. Sequential repression and activation of the CCAAT enhancer-binding protein-alpha (C/EBPalpha) gene during adipogenesis. Proc Natl Acad Sci USA 7:12519-12523.
19. Kahn SE, Hull RL, Utzschneider KM. 2006. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-846.
20. Kim SD, Lee WM, Suk K, Park SC, Kim SK, Cho JY, Rhee MH. 2006. Mechanism of isoproterenol-induced RGS2 up-regulation in astrocytes. Biochem Biophys Res Commun 349:408-415.
21. Ko JK, Choi KH, Kim IS, Jung EK, Park DH. 2001. Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells. Biochem Biophys Res Commun 287:1025-1033.
22. Lane MD, Tang QQ, Jiang MS. 1999. Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. Biochem Biophys Res Commun 266:677-683.
23. Lania L, Majello B, de Luca P. 1997. Transcriptional regulation by the Sp family proteins. Int J Biochem Cell Biol 29:1313-1323.
24. Lehrke M, Lazar MA. 2005. The many faces of PPARgamma. Cell 123:993-999.
25. Letovsky J, Dynan WS. 1989. Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence. Nucleic Acids Res 17:2639-2653.
26. Liu L, Clipstone NA. 2007. Prostaglandin F2alpha inhibits adipocyte differentiation via a G alpha q-calcium-calcineurin-dependent signaling pathway. J Cell Biochem 100:161-173.
27. MacDougald OA, Mandrup S. 2002. Adipogenesis: Forces that tip the scales. Trends Endocrinol Metab 13:5-11.
28. Monjo M, Pujol E, Roca P. 2005. alpha2- to beta3-Adrenoceptor switch in 3T3-L1 preadipocytes and adipocytes: Modulation by testosterone, 17beta-estradiol, and progesterone. Am J Physiol Endocrinol Metab 289:E145-E150.
29. Nishizuka M, Honda K, Tsuchiya T, Nishihara T, Imagawa M. 2001. RGS2 promotes adipocyte differentiation in the presence of ligand for peroxisome proliferator-activated receptor gamma. J Biol Chem 276:29625-29627.
30. Ntambi JM, Young-Cheul K. 2000. Adipocyte differentiation and gene expression. J Nutr 130:3122S-3126S.
31. Otto TC, Lane MD. 2005. Adipose development: From stem cell to adipocyte. Crit Rev Biochem Mol Biol 40:229-242.
32. Pi-Sunyer FX. 2006. The relation of adipose tissue to cardiometabolic risk. Clin Cornerstone 8 (Suppl 4): S14-S23.
33. Quarles LD, Haupt DM, Davidai G, Middleton JP. 1993. Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: Role of protein kinase-C-mediated tyrosine phosphorylation. Endocrinology 132:1505-1513.
34. Reusch JE, Colton LA, Klemm DJ. 2000. CREB activation induces adipogenesis in 3T3-L1 cells. Mol Cell Biol 20:1008-1020.
35. Rosen ED. 2005. The transcriptional basis of adipocyte development. Prostaglandins Leukot Essent Fatty Acids 73:31-34.
36. Rosen ED, Spiegelman BM. 2000. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16:145-171.
37. Rosen ED, Spiegelman BM. 2006. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444:847-853.
38. Schaffler A, Ehling A, Neumann E, Herfarth H, Paul G, Tarner I, Gay S, Buechler C, Scholmerich J, Muller-Ladner U. 2004. Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter. Biochim Biophys Acta 1678:150-156.
39. Shimba S, Wada T, Hara S, Tezuka M. 2004. EPAS1 promotes adipose differentiation in 3T3-L1 cells. J Biol Chem 279:40946-40953.
40. Siderovski DP, Willard FS. 2005. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci 1:51-66.
41. Simon MF, Daviaud D, Pradere JP, Gres S, Guigne C, Wabitsch M, Chun J, Valet P, Saulnier-Blache JS. 2005. Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent downregulation of peroxisome proliferator-activated receptor gamma2. J Biol Chem 280:14656-14662.
42. Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS. 1988. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem 263:9402-9408.
43. Soderling SH, Beavo JA. 2000. Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions. Curr Opin Cell Biol 12:174-179.
44. Student AK, Hsu RY, Lane MD. 1980. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. J Biol Chem 255:4745-4750.
45. Tang QQ, Jiang MS, Lane MD. 1999. Repressive effect of Sp1 on the C/EBPalpha gene promoter: Role in adipocyte differentiation. Mol Cell Biol 19:4855-4865.
46. Taylor SM, Jones PA. 1979. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 17:771-779.
47. Thirunavukkarasu K, Halladay DL, Miles RR, Geringer CD, Onyia JE. 2002. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J Cell Biochem 85:837-850.
48. Tsingotjidou A, Nervina JM, Pham L, Bezouglaia O, Tetradis S. 2002. Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3′,5′-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone 30:677-684.
49. Van Gaal LF, Mertens IL, de Block CE. 2006. Mechanisms linking obesity with cardiovascular disease. Nature 444:875-880.
50. Wada T. 2007. Transcription factor EPAS1 regulates insulin signaling pathway. Yakugaku Zasshi 127:143-151.
51. Watanabe T, Waga I, Honda Z, Kurokawa K, Shimizu T. 1995. Prostaglandin F2 alpha stimulates formation of p21ras-GTP complex and mitogen-activated protein kinase in NIH-3T3 cells via Gq-protein-coupled pathway. J Biol Chem 270:8984-8990.
52. Willars GB. 2006. Mammalian RGS proteins: Multifunctional regulators of cellular signalling. Semin Cell Dev Biol 17:363-376.
53. Wu YL, Chuang HH, Kou YR, Lee TS, Lu SH, Huang YC, Nishi Y, Yanase T. 2008. Regulation of LH receptor and PGF2a receptor signaling by the regulator of G protein signaling 2 (RGS2) in human and mouse granulosa cells. Chin J Physiol 51:1-10.
54. Xia X, Serrero G. 1999. Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors. J Cell Physiol 178:9-16.
55. Zhu Q, Liao K. 2000. Differential expression of the adipocyte amino acid transporter is transactivated by SP1 and SP3 during the 3T3-L1 preadipocyte differentiation process. Biochem Biophys Res Commun 271:100-106.