Identification of regulatory elements in the human adipose most abundant gene transcript-1 (apM-1) promoter: Role of SP1/SP3 and TNF-α as regulatory pathways

Diabetologia

Volumn 45, Issue 10, 2002, Pages 1425-1433

  Barth, N ^a   Langmann, T ^a   Scholmerich J ^a   Schmitz, G ^a   Schaffler A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adipocyte; apM 1; Diabetes; Differentiation; Obesity; Promoter; SP1; SP3; TNF ; Transcription

Indexed keywords

TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ELECTROPHORETIC MOBILITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; LUCIFERASE REPORTER GENE ASSAY; MOLECULAR CLONING; PRIORITY JOURNAL; PROMOTER REGION; REDUCTION; SIGNAL TRANSDUCTION;

3T3 CELLS; ADIPOCYTES; ADIPONECTIN; ANIMALS; CELL DIFFERENTIATION; CLONING, MOLECULAR; DNA-BINDING PROTEINS; HOMEOSTASIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; MICE; PROMOTER REGIONS (GENETICS); PROTEINS; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, RIBONUCLEIC ACID; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036034966     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0895-5     Document Type: Article

References (48)

1. Shimomura I, Funahashi T, Takahashi M et al. (1996) Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 2:800-803
2. Hu E, Liang P, Spiegelman BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271:10697-10703
3. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749
4. Maeda K, Okubo K, Shimomura I, Mizuno K, Matsuzawa Y, Matsubara K (1997) Analysis of an expression profile of genes in the human adipose tissue. Gene 190:227-235
5. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996) cDNA cloning and expression of a novel adipose collagen-like factor, apM1. Biochem Biophys Res Commun 221:286-289
6. Shapiro L, Scherer PE (1998) The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 8:335-338
7. Schäffler A, Orsó E, Palitzsch K-D et al. (1999) The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for Familial Combined Hyperlipidaemia (FCH). Biochem Biophys Res Commun 260:416-425
8. Arita Y, Shinhi K, Ouchi N et al. (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83
9. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M (1996) Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem 120:803-812
10. Statnick MA, Beavers LS, Conner LJ et al. (2000) Decreased expression of apM-1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes. Int J Exp Diabetes Res 1:81-88
11. Hotta K, Funahashi T, Arita Y et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599
12. Hotta K, Funahashi T, Bodkin NL et al. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133
13. Weyer C, Funahashi T, Tanaka S et al. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935
14. Zietz B, Barth N, Schölmerich J, Schmitz G, Schäffler A (2001) Gly15Gly polymorphism within the human adipocyte-specific apM-1 gene but not Tyr111His polymorphism is associated with higher levels of cholesterol and LDL-cholesterol in caucasian patients with type 2 diabetes. Exp Clin Endocrinol Diabetes 109:320-325
15. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947-953
16. Yamauchi T, Kamon J, Waki H et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946
17. Kappes A, Loffle G (2000) Influences of ionomycin, dibutyryl-cycloAMP and tumor necrosis factor-alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes. Horm Metab Res 32:548-554
18. Maeda N, Takahashi M, Funahashi T et al. (2001) PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50:2094-2099
19. Bogan JS, Lodish HF (1999) Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol 146:609-620
20. Saito K, Tobe T, Yoda M, Nakano Y, Choi-Miura NH, Tomita M (1999) Regulation of gelatine-binding protein 28 (GBP28) gene expression by C/EBP. Biol Pharm Bull 22:1158-1162
21. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R (2001) Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett 507:142-146
22. Schäffler A, Langmann T, Palitzsch K-D, Schölmerich J, Schmitz G (1998) Identification and Characterization of the human adipocyte apM-1 promoter. Biochim Biophys Acta 1399:187-197
23. Zaitsu H, Serrero G (1990) Pedersen fetuin contains three adipogenic factors with distinct biochemical characteristics. J Cell Physiol 144:485-491
24. Bachmeier M, Löffler G (1994) Adipogenic activities in commercial preparations of fetuin. Horm Metab Res 26:92-96
25. Green H, Kehinde O (1979) Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line. J Cell Physiol 101:169-172
26. Green H, Kehinde O (1976) Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 7:105-113
27. Green H, Kehinde O (1975) An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5:19-27
28. Green H, Meuth M (1974) An established pre-adipose cell line and its differentiation in culture. Cell 3:127-133
29. Cornelius P, MacDougald OA, Lane MD (1994) Regulation of adipocyte development. Annu Rev Nutr 14:99-129
30. MacDougald OA, Lane MD (1995) Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 64:345-373
31. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
32. Courey A, Tjian R (1992) Transcriptional regulation. In: McKnight S, Yamamoto K (eds) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 743-769
33. Hagen G, Muller S, Beato M, Suske G (1992) Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res 20:5519-5525
34. Stephens JM, Pekala PH (1991) Transcriptional repression of the Glut-4 and C/BP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J Biol Chem 266:21839-21845
35. Zhang B, Berger J, Hu E et al. (1996) Negative regulation of peroxisome proliferator-activated receptor-gamma gene expresssion contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol 10:1457-1466
36. Szalkowski D, White-Carrington S, Berger J, Zhang B (1995) Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology 136:1474-1481
37. Torti FM, Dieckmann B, Beutler B, Cerami A, Ringold GM (1985) A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science 229:1867-1869
38. Denson LA, Menon RK, Shaufl A, Bajwa HS, Williams CR, Karpen SJ (2001) TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting SP1 and SP3 binding. J Clin Invest 107:1451-1458
39. Kadonaga JT, Carner KR, Masiarz FR, Tjian R (1987) Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079-1090
40. Hagen G, Muller S, Beato M, Suske G (1994) SP-1-mediated transcriptional activation is repressed by SP-3. EMBO J 13:3843-3851
41. Birnbaum MJ, Wijnen AJ van, Odgren PR et al. (1995) Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3. Biochemistry 34:16503-16508
42. De Luca P, Majello B, Lania L (1996) Sp3 represses transcription when tethered to promoter DNA or targeted to promoter proximal RNA. J Biol Chem 271:8533-8536
43. Dennig J, Beato M, Suske G (1996) An inhibitor domain in Sp3 regulates its glutamine-rich activation domains. EMBO J 15:5659-5667
44. Liang Y, Robinson D, Dennig J, Suske G, Fahl W (1996) Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. J Biol Chem 271:11792-11797
45. Majello M, DeLuca P, Suske G, Lania L (1995) Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins. Oncogene 10:1841-1848
46. Majello B, DeLuca P, Lania L (1997) Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J Biol Chem 272:4021-4026
47. Ding H, Benotmane AM, Suske G, Collen D, Belayew A (1999) Functional interactions between SP-1 or SP-3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. J Biol Chem 274:19573-19580
48. Bethea JR, Ohmori Y, Hamilton TA (1997) A tandem GC box motif is necessary for lipopolysaccharide induced transcription of the type II TNF receptor gene. J Immunol 158:5815-5823