메뉴 건너뛰기




Volumn 323, Issue 2, 2008, Pages 166-176

Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3

Author keywords

GAP; GTPase; Ras; Suppressor; Tumor

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN GAP 3; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 54849418152     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ydbio.2008.08.026     Document Type: Article
Times cited : (12)

References (53)
  • 1
    • 0025605344 scopus 로고
    • The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
    • Aroian R.V., Koga M., Mendel J.E., Ohshima Y., and Sternberg P.W. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348 (1990) 693-699
    • (1990) Nature , vol.348 , pp. 693-699
    • Aroian, R.V.1    Koga, M.2    Mendel, J.E.3    Ohshima, Y.4    Sternberg, P.W.5
  • 2
    • 0027160919 scopus 로고
    • Odorant-selective genes and neurons mediate olfaction in C. elegans
    • Bargmann C.I., Hartwieg E., and Horvitz H.R. Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell 74 (1993) 515-527
    • (1993) Cell , vol.74 , pp. 515-527
    • Bargmann, C.I.1    Hartwieg, E.2    Horvitz, H.R.3
  • 3
    • 0025226084 scopus 로고
    • Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction
    • Beitel G.J., Clark S.G., and Horvitz H.R. Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 348 (1990) 503-509
    • (1990) Nature , vol.348 , pp. 503-509
    • Beitel, G.J.1    Clark, S.G.2    Horvitz, H.R.3
  • 4
    • 0037451803 scopus 로고    scopus 로고
    • GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila
    • Bernards A. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta 1603 (2003) 47-82
    • (2003) Biochim. Biophys. Acta , vol.1603 , pp. 47-82
    • Bernards, A.1
  • 5
    • 24944582633 scopus 로고    scopus 로고
    • GAPs in growth factor signalling
    • Bernards A., and Settleman J. GAPs in growth factor signalling. Growth Factors 23 (2005) 143-149
    • (2005) Growth Factors , vol.23 , pp. 143-149
    • Bernards, A.1    Settleman, J.2
  • 6
    • 0035137910 scopus 로고    scopus 로고
    • Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development
    • Berset T., Hoier E.F., Battu G., Canevascini S., and Hajnal A. Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science 291 (2001) 1055-1058
    • (2001) Science , vol.291 , pp. 1055-1058
    • Berset, T.1    Hoier, E.F.2    Battu, G.3    Canevascini, S.4    Hajnal, A.5
  • 7
    • 22344439386 scopus 로고    scopus 로고
    • The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions
    • Berset T.A., Hoier E.F., and Hajnal A. The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions. Genes Dev. 19 (2005) 1328-1340
    • (2005) Genes Dev. , vol.19 , pp. 1328-1340
    • Berset, T.A.1    Hoier, E.F.2    Hajnal, A.3
  • 8
    • 19444387096 scopus 로고    scopus 로고
    • RASA1: variable phenotype with capillary and arteriovenous malformations
    • Boon L.M., Mulliken J.B., and Vikkula M. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr. Opin. Genet. Dev. 15 (2005) 265-269
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 265-269
    • Boon, L.M.1    Mulliken, J.B.2    Vikkula, M.3
  • 9
    • 0037240419 scopus 로고    scopus 로고
    • Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
    • Botella J.A., Kretzschmar D., Kiermayer C., Feldmann P., Hughes D.A., and Schneuwly S. Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Mol. Biol. Cell 14 (2003) 241-250
    • (2003) Mol. Biol. Cell , vol.14 , pp. 241-250
    • Botella, J.A.1    Kretzschmar, D.2    Kiermayer, C.3    Feldmann, P.4    Hughes, D.A.5    Schneuwly, S.6
  • 10
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S. The genetics of Caenorhabditis elegans. Genetics 77 (1974) 71-94
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 11
    • 28544436811 scopus 로고    scopus 로고
    • The Caenorhabditis elegans-oncogene ect-2 positively regulates RAS signalling during vulval development
    • Canevascini S., Marti M., Frohli E., and Hajnal A. The Caenorhabditis elegans-oncogene ect-2 positively regulates RAS signalling during vulval development. EMBO Rep. 6 (2005) 1169-1175
    • (2005) EMBO Rep. , vol.6 , pp. 1169-1175
    • Canevascini, S.1    Marti, M.2    Frohli, E.3    Hajnal, A.4
  • 12
    • 0027937835 scopus 로고
    • The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans
    • Chamberlin H.M., and Sternberg P.W. The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Development 120 (1994) 2713-2721
    • (1994) Development , vol.120 , pp. 2713-2721
    • Chamberlin, H.M.1    Sternberg, P.W.2
  • 13
    • 0034601059 scopus 로고    scopus 로고
    • Caenorhabditis elegans-1 is necessary for multiple RAS-mediated developmental signals
    • Chang C., Hopper N.A., and Sternberg P.W. Caenorhabditis elegans-1 is necessary for multiple RAS-mediated developmental signals. Embo J. 19 (2000) 3283-3294
    • (2000) Embo J. , vol.19 , pp. 3283-3294
    • Chang, C.1    Hopper, N.A.2    Sternberg, P.W.3
  • 14
    • 0029021421 scopus 로고
    • Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans
    • Church D.L., Guan K.L., and Lambie E.J. Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans. Development 121 (1995) 2525-2535
    • (1995) Development , vol.121 , pp. 2525-2535
    • Church, D.L.1    Guan, K.L.2    Lambie, E.J.3
  • 15
    • 0026608178 scopus 로고
    • C. elegans-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
    • Clark S.G., Stern M.J., and Horvitz H.R. C. elegans-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature 356 (1992) 340-344
    • (1992) Nature , vol.356 , pp. 340-344
    • Clark, S.G.1    Stern, M.J.2    Horvitz, H.R.3
  • 16
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon A.S., Hagan S., Rath O., and Kolch W. MAP kinase signalling pathways in cancer. Oncogene 26 (2007) 3279-3290
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 17
    • 0030904503 scopus 로고    scopus 로고
    • Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 -sensitive, gain-of-function mutation
    • Eisenmann D.M., and Kim S.K. Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 -sensitive, gain-of-function mutation. Genetics 146 (1997) 553-565
    • (1997) Genetics , vol.146 , pp. 553-565
    • Eisenmann, D.M.1    Kim, S.K.2
  • 18
    • 0026588783 scopus 로고
    • A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    • Gaul U., Mardon G., and Rubin G.M. A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68 (1992) 1007-1019
    • (1992) Cell , vol.68 , pp. 1007-1019
    • Gaul, U.1    Mardon, G.2    Rubin, G.M.3
  • 19
    • 0030774790 scopus 로고    scopus 로고
    • Inhibition of Caenorhabditis elegans vulval induction by GAP-1 and let-23 receptor tyrosine kinase
    • Hajnal A., Whitfield C.W., and Kim S.K. Inhibition of Caenorhabditis elegans vulval induction by GAP-1 and let-23 receptor tyrosine kinase. Genes Dev. 11 (1997) 2715-2728
    • (1997) Genes Dev. , vol.11 , pp. 2715-2728
    • Hajnal, A.1    Whitfield, C.W.2    Kim, S.K.3
  • 20
    • 0025647293 scopus 로고
    • The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans
    • Han M., Aroian R.V., and Sternberg P.W. The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans. Genetics 126 (1990) 899-913
    • (1990) Genetics , vol.126 , pp. 899-913
    • Han, M.1    Aroian, R.V.2    Sternberg, P.W.3
  • 21
    • 0027263251 scopus 로고
    • C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation
    • Han M., Golden A., Han Y., and Sternberg P.W. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature 363 (1993) 133-140
    • (1993) Nature , vol.363 , pp. 133-140
    • Han, M.1    Golden, A.2    Han, Y.3    Sternberg, P.W.4
  • 22
    • 0031902873 scopus 로고    scopus 로고
    • Characterization of the C. elegans GAP-2 -GTPase activating protein and its possible role in larval development
    • Hayashizaki S., Iino Y., and Yamamoto M. Characterization of the C. elegans GAP-2 -GTPase activating protein and its possible role in larval development. Genes Cells 3 (1998) 189-202
    • (1998) Genes Cells , vol.3 , pp. 189-202
    • Hayashizaki, S.1    Iino, Y.2    Yamamoto, M.3
  • 24
    • 0034673644 scopus 로고    scopus 로고
    • The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans
    • Hirotsu T., Saeki S., Yamamoto M., and Iino Y. The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans. Nature 404 (2000) 289-293
    • (2000) Nature , vol.404 , pp. 289-293
    • Hirotsu, T.1    Saeki, S.2    Yamamoto, M.3    Iino, Y.4
  • 25
    • 0033634782 scopus 로고    scopus 로고
    • ARK-1 inhibits EGFR signaling in C. elegans
    • Hopper N.A., Lee J., and Sternberg P.W. ARK-1 inhibits EGFR signaling in C. elegans. Mol. Cell 6 (2000) 65-75
    • (2000) Mol. Cell , vol.6 , pp. 65-75
    • Hopper, N.A.1    Lee, J.2    Sternberg, P.W.3
  • 27
    • 0031868411 scopus 로고    scopus 로고
    • Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans
    • Jiang L.I., and Sternberg P.W. Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans. Development 125 (1998) 2337-2347
    • (1998) Development , vol.125 , pp. 2337-2347
    • Jiang, L.I.1    Sternberg, P.W.2
  • 28
    • 33645769516 scopus 로고    scopus 로고
    • Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes
    • Jiang S.Y., and Ramachandran S. Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes. Physiol. Genomics 24 (2006) 235-251
    • (2006) Physiol. Genomics , vol.24 , pp. 235-251
    • Jiang, S.Y.1    Ramachandran, S.2
  • 29
    • 0035229245 scopus 로고    scopus 로고
    • Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    • RESEARCH0002
    • Kamath R.S., Martinez-Campos M., Zipperlen P., Fraser A.G., and Ahringer J. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol. 2 (2001) RESEARCH0002
    • (2001) Genome Biol. , vol.2
    • Kamath, R.S.1    Martinez-Campos, M.2    Zipperlen, P.3    Fraser, A.G.4    Ahringer, J.5
  • 30
    • 0019891530 scopus 로고
    • Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans
    • Kimble J. Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans. Dev Biol. 87 (1981) 286-300
    • (1981) Dev Biol. , vol.87 , pp. 286-300
    • Kimble, J.1
  • 31
    • 0032523935 scopus 로고    scopus 로고
    • clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
    • Kokel M., Borland C.Z., DeLong L., Horvitz H.R., and Stern M.J. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12 (1998) 1425-1437
    • (1998) Genes Dev. , vol.12 , pp. 1425-1437
    • Kokel, M.1    Borland, C.Z.2    DeLong, L.3    Horvitz, H.R.4    Stern, M.J.5
  • 32
    • 0031081140 scopus 로고    scopus 로고
    • Vulval development in Caenorhabditis elegans
    • Kornfeld K. Vulval development in Caenorhabditis elegans. Trends Genet. 13 (1997) 55-61
    • (1997) Trends Genet. , vol.13 , pp. 55-61
    • Kornfeld, K.1
  • 33
    • 0028947528 scopus 로고
    • The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK
    • Kornfeld K., Guan K.L., and Horvitz H.R. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes Dev. 9 (1995) 756-768
    • (1995) Genes Dev. , vol.9 , pp. 756-768
    • Kornfeld, K.1    Guan, K.L.2    Horvitz, H.R.3
  • 34
    • 0028107517 scopus 로고
    • A MAP kinase homolog, mpk-1-mediated induction of vulval cell fates in Caenorhabditis elegans
    • Lackner M.R., Kornfeld K., Miller L.M., Horvitz H.R., and Kim S.K. A MAP kinase homolog, mpk-1-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes Dev. 8 (1994) 160-173
    • (1994) Genes Dev. , vol.8 , pp. 160-173
    • Lackner, M.R.1    Kornfeld, K.2    Miller, L.M.3    Horvitz, H.R.4    Kim, S.K.5
  • 35
    • 0028818537 scopus 로고
    • Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system
    • Maduro M., and Pilgrim D. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141 (1995) 977-988
    • (1995) Genetics , vol.141 , pp. 977-988
    • Maduro, M.1    Pilgrim, D.2
  • 36
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences
    • Mello C.C., Kramer J.M., Stinchcomb D., and Ambros V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. Embo J. 10 (1991) 3959-3970
    • (1991) Embo J. , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 37
  • 38
    • 0029670221 scopus 로고    scopus 로고
    • Determinants of Ras proteins specifying the sensitivity to yeast Ira2p and human p120-GAP
    • Parrini M.C., Bernardi A., and Parmeggiani A. Determinants of Ras proteins specifying the sensitivity to yeast Ira2p and human p120-GAP. Embo J. 15 (1996) 1107-1111
    • (1996) Embo J. , vol.15 , pp. 1107-1111
    • Parrini, M.C.1    Bernardi, A.2    Parmeggiani, A.3
  • 40
  • 42
    • 0022500775 scopus 로고
    • Pattern formation during vulval development in C. elegans
    • Sternberg P.W., and Horvitz H.R. Pattern formation during vulval development in C. elegans. Cell 44 (1986) 761-772
    • (1986) Cell , vol.44 , pp. 761-772
    • Sternberg, P.W.1    Horvitz, H.R.2
  • 43
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • Sulston J.E., and Horvitz H.R. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56 (1977) 110-156
    • (1977) Dev. Biol. , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 44
    • 10144220631 scopus 로고    scopus 로고
    • A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans
    • Sundaram M., Yochem J., and Han M. A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans. Development 122 (1996) 2823-2833
    • (1996) Development , vol.122 , pp. 2823-2833
    • Sundaram, M.1    Yochem, J.2    Han, M.3
  • 46
    • 0023619575 scopus 로고
    • A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
    • Trahey M., and McCormick F. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238 (1987) 542-545
    • (1987) Science , vol.238 , pp. 542-545
    • Trahey, M.1    McCormick, F.2
  • 49
    • 0028180320 scopus 로고
    • Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans-1 MAP kinase in vulval differentiation
    • Wu Y., and Han M. Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans-1 MAP kinase in vulval differentiation. Genes Dev. 8 (1994) 147-159
    • (1994) Genes Dev. , vol.8 , pp. 147-159
    • Wu, Y.1    Han, M.2
  • 50
    • 0028943025 scopus 로고
    • MEK-2, a Caenorhabditis elegans-mediated vulval induction and other developmental events
    • Wu Y., Han M., and Guan K.L. MEK-2, a Caenorhabditis elegans-mediated vulval induction and other developmental events. Genes Dev. 9 (1995) 742-755
    • (1995) Genes Dev. , vol.9 , pp. 742-755
    • Wu, Y.1    Han, M.2    Guan, K.L.3
  • 51
    • 0031003117 scopus 로고    scopus 로고
    • Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans
    • Yochem J., Sundaram M., and Han M. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans. Mol. Cell. Biol. 17 (1997) 2716-2722
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2716-2722
    • Yochem, J.1    Sundaram, M.2    Han, M.3
  • 52
    • 0442272485 scopus 로고    scopus 로고
    • Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development
    • Yoo A.S., Bais C., and Greenwald I. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science 303 (2004) 663-666
    • (2004) Science , vol.303 , pp. 663-666
    • Yoo, A.S.1    Bais, C.2    Greenwald, I.3
  • 53
    • 0029124883 scopus 로고
    • Similarity of sli-1, a regulator of vulval development in C. elegans-oncogene c-cbl
    • Yoon C.H., Lee J., Jongeward G.D., and Sternberg P.W. Similarity of sli-1, a regulator of vulval development in C. elegans-oncogene c-cbl. Science 269 (1995) 1102-1105
    • (1995) Science , vol.269 , pp. 1102-1105
    • Yoon, C.H.1    Lee, J.2    Jongeward, G.D.3    Sternberg, P.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.