메뉴 건너뛰기




Volumn 7, Issue 2, 2005, Pages

Population pharmacokinetics/pharmacodynamics of anesthetics

Author keywords

Anesthetics; NONMEM; PK PD modeling

Indexed keywords

ALFENTANIL; ANALGESIC AGENT; ANESTHETIC AGENT; DESFLURANE; HYPNOTIC AGENT; MIDAZOLAM; MORPHINE; MORPHINE 6 GLUCURONIDE; OPIATE; PROPOFOL; REMIFENTANIL; ROCURONIUM; SEVOFLURANE; THIOPENTAL;

EID: 30544450901     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj070239     Document Type: Review
Times cited : (11)

References (63)
  • 1
    • 0003747347 scopus 로고    scopus 로고
    • NONMEM Project Group. San Francisco, CA: University of California
    • NONMEM Project Group. NONMEM User's Guide. San Francisco, CA: University of California; 1999.
    • (1999) NONMEM User's Guide
  • 2
    • 0031691162 scopus 로고    scopus 로고
    • Expanding clinical applications of population pharmacodynamic modeling
    • Minto CF, Schnider TW. Expanding clinical applications of population pharmacodynamic modeling. Br J Clin Pharmacol. 1998;46:321-333.
    • (1998) Br J Clin Pharmacol. , vol.46 , pp. 321-333
    • Minto, C.F.1    Schnider, T.W.2
  • 3
    • 0031891137 scopus 로고    scopus 로고
    • Population based pharmacokinetic analysis: Why do we need it; what is it; and what has it told us about anaesthetics
    • Wright PMC. Population based pharmacokinetic analysis: why do we need it; what is it; and what has it told us about anaesthetics. Br J Anaesth. 1998;80:488-501.
    • (1998) Br J Anaesth. , vol.80 , pp. 488-501
    • Wright, P.M.C.1
  • 4
    • 0022489531 scopus 로고
    • Population pharmacokinetics. Theory and clinical application
    • Whiting B, Kelman AW, Grevel J. Population pharmacokinetics. Theory and clinical application. Clin Pharmacokinet. 1986;11:387-401.
    • (1986) Clin Pharmacokinet. , vol.11 , pp. 387-401
    • Whiting, B.1    Kelman, A.W.2    Grevel, J.3
  • 5
    • 0023280963 scopus 로고
    • Population pharmacokinetics of alfentanil: The average dose-plasma concentration relationship and interindividual variability in patients
    • Maitre PO, Vozeh S, Heykants J, Thomson DA, Stanski DR. Population pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients. Anesthesiology. 1987;66:3-12.
    • (1987) Anesthesiology , vol.66 , pp. 3-12
    • Maitre, P.O.1    Vozeh, S.2    Heykants, J.3    Thomson, D.A.4    Stanski, D.R.5
  • 6
    • 0023231783 scopus 로고
    • The relevance of pharmacokinetics to optimal intravenous anesthesia
    • Grevel J, Whiting B. The relevance of pharmacokinetics to optimal intravenous anesthesia. Anesthesiology. 1987;66:1-2.
    • (1987) Anesthesiology , vol.66 , pp. 1-2
    • Grevel, J.1    Whiting, B.2
  • 7
    • 0028057553 scopus 로고
    • The pharmacokinetics of propofol in children using three different data analysis approaches
    • Kataria BK, Ved SA, Nicodemus HF, et al. The pharmacokinetics of propofol in children using three different data analysis approaches. Anesthesiology. 1994;80:104-122.
    • (1994) Anesthesiology , vol.80 , pp. 104-122
    • Kataria, B.K.1    Ved, S.A.2    Nicodemus, H.F.3
  • 8
    • 0028115967 scopus 로고
    • Propofol in pediatrics. Lessons in pharmacokinetic modeling
    • Fisher DM. Propofol in pediatrics. Lessons in pharmacokinetic modeling. Anesthesiology. 1994;80:2-5.
    • (1994) Anesthesiology , vol.80 , pp. 2-5
    • Fisher, D.M.1
  • 9
    • 17544387018 scopus 로고    scopus 로고
    • Population pharmacokinetics of propofol: A multicenter study
    • Schüttler J, Ihmsen H. Population pharmacokinetics of propofol: a multicenter study. Anesthesiology. 2000;92:727-738.
    • (2000) Anesthesiology , vol.92 , pp. 727-738
    • Schüttler, J.1    Ihmsen, H.2
  • 10
    • 0031955972 scopus 로고    scopus 로고
    • The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers
    • Schnider TW, Minto CF, Gambus PL, et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998;88:1170-1182.
    • (1998) Anesthesiology , vol.88 , pp. 1170-1182
    • Schnider, T.W.1    Minto, C.F.2    Gambus, P.L.3
  • 11
    • 0025217527 scopus 로고
    • How far can we go with compartmental models?
    • Hull CJ. How far can we go with compartmental models? Anesthesiology. 1990;72:399-402.
    • (1990) Anesthesiology , vol.72 , pp. 399-402
    • Hull, C.J.1
  • 12
    • 0038781326 scopus 로고    scopus 로고
    • Drug handling by the lungs
    • Boer F. Drug handling by the lungs. Br J Anaesth. 2003;91:50-60.
    • (2003) Br J Anaesth. , vol.91 , pp. 50-60
    • Boer, F.1
  • 13
    • 0028234741 scopus 로고
    • A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs
    • Krejcie TC, Henthorn TK, Shanks CA, Avram MJ. A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs. J Pharm Exp Ther. 1994;269:609-616.
    • (1994) J Pharm Exp Ther. , vol.269 , pp. 609-616
    • Krejcie, T.C.1    Henthorn, T.K.2    Shanks, C.A.3    Avram, M.J.4
  • 14
    • 0035166906 scopus 로고    scopus 로고
    • Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients - The influence of cardiac output
    • Kuipers JA, Boer F, Olofsen E, Bovill JG, Burm AGL. Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients - the influence of cardiac output. Anesthesiology. 2001;94:47-55.
    • (2001) Anesthesiology , vol.94 , pp. 47-55
    • Kuipers, J.A.1    Boer, F.2    Olofsen, E.3    Bovill, J.G.4    Burm, A.G.L.5
  • 15
    • 0018394195 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tabocurarine
    • Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tabocurarine. Clin Pharmacol Ther. 1979;25:358-371.
    • (1979) Clin Pharmacol Ther. , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 16
    • 0025232491 scopus 로고
    • Population pharmacokinetics and pharmacodynamics of thiopental: The effect of age revisited
    • Stanski DR, Maitre PO. Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited. Anesthesiology. 1990;72:412-422.
    • (1990) Anesthesiology , vol.72 , pp. 412-422
    • Stanski, D.R.1    Maitre, P.O.2
  • 17
    • 0032407028 scopus 로고    scopus 로고
    • Population pharmacodynamics of midazolam administered by target controlled infusion in SICU patients after CABG surgery
    • Somma J, Donner A, Zomorodi K, et al. Population pharmacodynamics of midazolam administered by target controlled infusion in SICU patients after CABG surgery. Anesthesiology. 1998;89:1430-1443.
    • (1998) Anesthesiology , vol.89 , pp. 1430-1443
    • Somma, J.1    Donner, A.2    Zomorodi, K.3
  • 18
    • 18744368748 scopus 로고    scopus 로고
    • Modeling of the sedative and airway obstruction effects of propofol in patients with Parkinson disease undergoing stereotactic surgery
    • Fábregas N, Rapado J, Gambús PL, et al. Modeling of the sedative and airway obstruction effects of propofol in patients with Parkinson disease undergoing stereotactic surgery. Anesthesiology. 2002;97:1378-1386.
    • (2002) Anesthesiology , vol.97 , pp. 1378-1386
    • Fábregas, N.1    Rapado, J.2    Gambús, P.L.3
  • 19
    • 0036917793 scopus 로고    scopus 로고
    • Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: A comparison between propofol 6% and propofol 1%
    • Knibbe CAJ, Zuideveld KP, DeJongh J, Kuks PFM, Aarts LPHJ, Danhof M. Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%. Clin Pharmacol Ther. 2002;72:670-684.
    • (2002) Clin Pharmacol Ther. , vol.72 , pp. 670-684
    • Knibbe, C.A.J.1    Zuideveld, K.P.2    DeJongh, J.3    Kuks, P.F.M.4    Aarts, L.P.H.J.5    Danhof, M.6
  • 21
    • 0031030419 scopus 로고    scopus 로고
    • Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development
    • Minto CF, Schnider TW, Egan TD, et al. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology. 1997;86:10-23.
    • (1997) Anesthesiology , vol.86 , pp. 10-23
    • Minto, C.F.1    Schnider, T.W.2    Egan, T.D.3
  • 23
    • 2442615930 scopus 로고    scopus 로고
    • Comparison of the concentration-dependent effect of sevoflurane on the spinal H-reflex and the EEG in humans
    • Rehberg B, Bouillon T, Grünewald M, et al. Comparison of the concentration-dependent effect of sevoflurane on the spinal H-reflex and the EEG in humans. Acta Anaesthesiol Scand. 2004;48:569-576.
    • (2004) Acta Anaesthesiol Scand. , vol.48 , pp. 569-576
    • Rehberg, B.1    Bouillon, T.2    Grünewald, M.3
  • 24
    • 0033756899 scopus 로고    scopus 로고
    • Development and clinical application of electroencephalographic bispectrum monitoring
    • Johansen JW, Sebel PS. Development and clinical application of electroencephalographic bispectrum monitoring. Anesthesiology. 2000;93:1336-1344.
    • (2000) Anesthesiology , vol.93 , pp. 1336-1344
    • Johansen, J.W.1    Sebel, P.S.2
  • 26
    • 0033756927 scopus 로고    scopus 로고
    • Sex differences in morphine analgesia: An experimental study in healthy volunteers
    • Sarton E, Olofsen E, Romberg R, et al. Sex differences in morphine analgesia: an experimental study in healthy volunteers. Anesthesiology. 2000;93:1245-1254.
    • (2000) Anesthesiology , vol.93 , pp. 1245-1254
    • Sarton, E.1    Olofsen, E.2    Romberg, R.3
  • 28
    • 21744446440 scopus 로고    scopus 로고
    • Alfentanil and placebo analgesia: No sex differences detected in models of experimental pain
    • Olofsen E, Romberg R, Bijl H, et al. Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain. Anesthesiology. 2005;103:130-139.
    • (2005) Anesthesiology , vol.103 , pp. 130-139
    • Olofsen, E.1    Romberg, R.2    Bijl, H.3
  • 29
    • 14644441712 scopus 로고    scopus 로고
    • Polymorphism of μ-opioid receptor gene (OPRM1:c. 118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response
    • Romberg RR, Olofsen E, Bijl H, et al. Polymorphism of μ-opioid receptor gene (OPRM1:c. 118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response. Anesthesiology. 2005;102:522-530.
    • (2005) Anesthesiology , vol.102 , pp. 522-530
    • Romberg, R.R.1    Olofsen, E.2    Bijl, H.3
  • 30
    • 0141510576 scopus 로고    scopus 로고
    • Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers
    • Romberg R, Olofsen E, Sarton E, Teppema L, Dahan A. Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers. Anesthesiology. 2003;99:788-798.
    • (2003) Anesthesiology , vol.99 , pp. 788-798
    • Romberg, R.1    Olofsen, E.2    Sarton, E.3    Teppema, L.4    Dahan, A.5
  • 32
    • 7244260563 scopus 로고    scopus 로고
    • Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion
    • Dahan A, Romberg R, Teppema L, Sarton E, Bijl H, Olofsen E. Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion. Anesthesiology. 2004;101:1201-1209.
    • (2004) Anesthesiology , vol.101 , pp. 1201-1209
    • Dahan, A.1    Romberg, R.2    Teppema, L.3    Sarton, E.4    Bijl, H.5    Olofsen, E.6
  • 33
    • 0036187392 scopus 로고    scopus 로고
    • The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG
    • Olofsen E, Sleigh JW, Dahan A. The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG. Anesthesiology. 2002;96:555-564.
    • (2002) Anesthesiology , vol.96 , pp. 555-564
    • Olofsen, E.1    Sleigh, J.W.2    Dahan, A.3
  • 35
    • 2542471369 scopus 로고    scopus 로고
    • Pharmacodynamic interaction between propofol and remifentanil regarding hypnosis, tolerance of laryngoscopy, bispectral index, and electroencephalographic approximate entropy
    • Bouillon TW, Bruhn J, Radulescu L, et al. Pharmacodynamic interaction between propofol and remifentanil regarding hypnosis, tolerance of laryngoscopy, bispectral index, and electroencephalographic approximate entropy. Anesthesiology. 2004;100:1353-1372.
    • (2004) Anesthesiology , vol.100 , pp. 1353-1372
    • Bouillon, T.W.1    Bruhn, J.2    Radulescu, L.3
  • 36
    • 0034991313 scopus 로고    scopus 로고
    • Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index
    • Dahan A, Nieuwenhuijs D, Olofsen E, Sarton E, Romberg R, Teppema L. Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index. Anesthesiology. 2001;94:982-991.
    • (2001) Anesthesiology , vol.94 , pp. 982-991
    • Dahan, A.1    Nieuwenhuijs, D.2    Olofsen, E.3    Sarton, E.4    Romberg, R.5    Teppema, L.6
  • 37
    • 0037318166 scopus 로고    scopus 로고
    • Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index
    • Nieuwenhuijs DJF, Olofsen E, Romberg RR, et al. Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index. Anesthesiology. 2003;98:312-322.
    • (2003) Anesthesiology , vol.98 , pp. 312-322
    • Nieuwenhuijs, D.J.F.1    Olofsen, E.2    Romberg, R.R.3
  • 38
  • 40
    • 0030953226 scopus 로고    scopus 로고
    • Stability and performance of a population pharmacokinetic model
    • Ette EI. Stability and performance of a population pharmacokinetic model. J Clin Pharmacol. 1997;37:486-495.
    • (1997) J Clin Pharmacol. , vol.37 , pp. 486-495
    • Ette, E.I.1
  • 41
    • 63549134340 scopus 로고    scopus 로고
    • Response surface modeling of drug interactions: Model selection and multimodel inference using the bootstrap
    • Ward DS, Dahan A, Teppema LJSM, eds. New York: Marcel Dekker
    • Olofsen E, Dahan A. Response surface modeling of drug interactions: model selection and multimodel inference using the bootstrap. In: Ward DS, Dahan A, Teppema LJSM, eds. Pharmacology and Pathophysiology of the Control of Breathing. New York: Marcel Dekker; 2005.
    • (2005) Pharmacology and Pathophysiology of the Control of Breathing
    • Olofsen, E.1    Dahan, A.2
  • 42
    • 0032949248 scopus 로고    scopus 로고
    • The effect of collinearity on parameter estimates in nonlinear mixed effects models
    • Bonate PL. The effect of collinearity on parameter estimates in nonlinear mixed effects models. Pharm Res. 1999;16:709-717.
    • (1999) Pharm Res. , vol.16 , pp. 709-717
    • Bonate, P.L.1
  • 43
    • 3142724653 scopus 로고    scopus 로고
    • Power, selection bias and predictive performance of the population pharmacokinetic covariate model
    • Ribbing J, Jonsson EN. Power, selection bias and predictive performance of the population pharmacokinetic covariate model. J Pharmacokinet Pharmacodyn. 2004;31:109-134.
    • (2004) J Pharmacokinet Pharmacodyn. , vol.31 , pp. 109-134
    • Ribbing, J.1    Jonsson, E.N.2
  • 44
    • 0034954242 scopus 로고    scopus 로고
    • Assessment of actual significance levels for covariate effects in NONMEM
    • Wählby U, Jonsson EN, Karlsson MO. Assessment of actual significance levels for covariate effects in NONMEM. J Pharmacokinet Pharmacodyn. 2001;28:231-252.
    • (2001) J Pharmacokinet Pharmacodyn. , vol.28 , pp. 231-252
    • Wählby, U.1    Jonsson, E.N.2    Karlsson, M.O.3
  • 45
    • 0032934909 scopus 로고    scopus 로고
    • Analyzing rich data using different methods provided by NONMEM: Pharmacokinetics of telmisartan following intravenous infusion to healthy volunteers
    • Wallenstein GC, Stangier J, Ludden TM. Analyzing rich data using different methods provided by NONMEM: pharmacokinetics of telmisartan following intravenous infusion to healthy volunteers. Pharm Res. 1999;16:772-776.
    • (1999) Pharm Res. , vol.16 , pp. 772-776
    • Wallenstein, G.C.1    Stangier, J.2    Ludden, T.M.3
  • 46
    • 18044401499 scopus 로고    scopus 로고
    • Nonlinearity detection: Advantages of nonlinear mixed-effects modeling
    • Jonsson EN, Karlsson MO. Nonlinearity detection: advantages of nonlinear mixed-effects modeling. AAPS PharmSci. 2000;2:E32.
    • (2000) AAPS PharmSci. , vol.2 , Issue.E32
    • Jonsson, E.N.1    Karlsson, M.O.2
  • 47
    • 0035884238 scopus 로고    scopus 로고
    • Some statistical issues in modelling pharmacokinetic data
    • Lindsey JK, Jones B, Jarvis P. Some statistical issues in modelling pharmacokinetic data. Stat Med. 2001;20:2775-2783.
    • (2001) Stat Med. , vol.20 , pp. 2775-2783
    • Lindsey, J.K.1    Jones, B.2    Jarvis, P.3
  • 48
    • 0025743320 scopus 로고
    • The intellectual health of clinical drug evaluation
    • Sheiner LB. The intellectual health of clinical drug evaluation. Clin Pharmacol Ther. 1991;50:4-9.
    • (1991) Clin Pharmacol Ther. , vol.50 , pp. 4-9
    • Sheiner, L.B.1
  • 50
    • 0016355478 scopus 로고
    • A new look at the statistical model identification
    • Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr. 1974;19:716-723.
    • (1974) IEEE Trans Automat Contr. , vol.19 , pp. 716-723
    • Akaike, H.1
  • 51
    • 0035094883 scopus 로고    scopus 로고
    • Modeling population pharmacokinetics of lidocaine: Should cardiac output be included as a patient factor?
    • Kuipers JA, Boer F, DeRoode A, Olofsen E, Bovill JG, Burm AGL. Modeling population pharmacokinetics of lidocaine: should cardiac output be included as a patient factor? Anesthesiology. 2001;94:566-573.
    • (2001) Anesthesiology , vol.94 , pp. 566-573
    • Kuipers, J.A.1    Boer, F.2    DeRoode, A.3    Olofsen, E.4    Bovill, J.G.5    Burm, A.G.L.6
  • 52
    • 0030641551 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of remifentanil II. Model application
    • Minto CF, Schnider TW, Shafer SL. Pharmacokinetics and pharmacodynamics of remifentanil. II. Model application. Anesthesiology. 1997;86:24-33.
    • (1997) Anesthesiology , vol.86 , pp. 24-33
    • Minto, C.F.1    Schnider, T.W.2    Shafer, S.L.3
  • 53
    • 0036164333 scopus 로고    scopus 로고
    • Efficient trial design for eliciting a pharmacokinetic-pharmacodynamic model-based response surface describing the interaction between two intravenous anesthetic drugs
    • Short TG, Ho TY, Minto CF, Schnider TW, Shafer SL. Efficient trial design for eliciting a pharmacokinetic-pharmacodynamic model-based response surface describing the interaction between two intravenous anesthetic drugs. Anesthesiology. 2002;96:400-408.
    • (2002) Anesthesiology , vol.96 , pp. 400-408
    • Short, T.G.1    Ho, T.Y.2    Minto, C.F.3    Schnider, T.W.4    Shafer, S.L.5
  • 54
    • 30544442979 scopus 로고    scopus 로고
    • A pragmatic approach to the design of population pharmacokinetic studies
    • In press
    • Roy A, Ette EI. A pragmatic approach to the design of population pharmacokinetic studies. AAPSJ PharmSciTech. In press.
    • AAPSJ PharmSciTech.
    • Roy, A.1    Ette, E.I.2
  • 55
    • 0034111171 scopus 로고    scopus 로고
    • Reliability of pharmacodynamic analysis by logistic regression - A simulation study
    • Lu W, Bailey JM. Reliability of pharmacodynamic analysis by logistic regression - a simulation study. Anesthesiology. 2000;92:985-992.
    • (2000) Anesthesiology , vol.92 , pp. 985-992
    • Lu, W.1    Bailey, J.M.2
  • 56
    • 4644304156 scopus 로고    scopus 로고
    • Estimating bias in population parameters for some models for repeated measures ordinal data using NONMEM and NLMIXED
    • Jönsson S, Kjellson MC, Karlsson MO. Estimating bias in population parameters for some models for repeated measures ordinal data using NONMEM and NLMIXED. J Pharmacokinet Pharmacodyn. 2004;31:299-320.
    • (2004) J Pharmacokinet Pharmacodyn. , vol.31 , pp. 299-320
    • Jönsson, S.1    Kjellson, M.C.2    Karlsson, M.O.3
  • 57
    • 0034764915 scopus 로고    scopus 로고
    • Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check
    • Yano Y, Beal SL, Sheiner LB. Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check. J Pharmacokinet Pharmacodyn. 2001;28:171-192.
    • (2001) J Pharmacokinet Pharmacodyn. , vol.28 , pp. 171-192
    • Yano, Y.1    Beal, S.L.2    Sheiner, L.B.3
  • 58
    • 0023692294 scopus 로고
    • Bayesian forecasting improves the prediction of intraoperative plasma concentrations of alfentanil
    • Maitre PO, Stanski DR. Bayesian forecasting improves the prediction of intraoperative plasma concentrations of alfentanil. Anesthesiology. 1988;69:652-659.
    • (1988) Anesthesiology , vol.69 , pp. 652-659
    • Maitre, P.O.1    Stanski, D.R.2
  • 59
    • 0023698648 scopus 로고
    • Bayesian dosing of anesthetic agents: Esoteric or practical
    • Brater DC. Bayesian dosing of anesthetic agents: esoteric or practical. Anesthesiology. 1988;69:641-462.
    • (1988) Anesthesiology , vol.69 , pp. 462-641
    • Brater, D.C.1
  • 60
    • 0029742435 scopus 로고    scopus 로고
    • Population pharmacodynamic modeling and covariate detection for central neural blockade
    • Schnider TW, Minto CF, Bruckett H, Mandema JW. Population pharmacodynamic modeling and covariate detection for central neural blockade. Anesthesiology. 1996;85:502-512.
    • (1996) Anesthesiology , vol.85 , pp. 502-512
    • Schnider, T.W.1    Minto, C.F.2    Bruckett, H.3    Mandema, J.W.4
  • 63
    • 0030894412 scopus 로고    scopus 로고
    • Are plasma concentration values necessary for pharmacodynamic modeling of muscle relaxants?
    • Fisher DM, Wright PMC. Are plasma concentration values necessary for pharmacodynamic modeling of muscle relaxants? Anesthesiology. 1997;86:567-575.
    • (1997) Anesthesiology , vol.86 , pp. 567-575
    • Fisher, D.M.1    Wright, P.M.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.