메뉴 건너뛰기




Volumn 8, Issue 8, 2008, Pages 1331-1338

Biologic therapies for advanced pancreatic cancer

Author keywords

Biologic therapy; EGF receptor; K RAS; Pancreatic cancer; VEGF

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; AXITINIB; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CGP 69846A; CISPLATIN; DOCETAXEL; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; IMATINIB; IRINOTECAN; LAPATINIB; LONAFARNIB; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; OXALIPLATIN; PEMETREXED; PLACEBO; SORAFENIB; SUNITINIB; TIPIFARNIB; VASCULOTROPIN INHIBITOR; VATALANIB; EPIDERMAL GROWTH FACTOR;

EID: 54549111166     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.8.8.1331     Document Type: Review
Times cited : (8)

References (56)
  • 1
    • 0025236629 scopus 로고
    • Survival after pancreatoduodenectomy. 118 consecutive resections without an operative mortality
    • Trede M, Schwall G, Saeger HD. Survival after pancreatoduodenectomy. 118 consecutive resections without an operative mortality. Ann. Surg. 211(4), 447-458 (1990).
    • (1990) Ann. Surg , vol.211 , Issue.4 , pp. 447-458
    • Trede, M.1    Schwall, G.2    Saeger, H.D.3
  • 2
    • 0027370407 scopus 로고
    • Prognostic indicators for survival after resection of pancreatic adenocarcinoma
    • discussion 72-73
    • Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am. J. Surg. 165(1), 68-72; discussion 72-73 (1993).
    • (1993) Am. J. Surg , vol.165 , Issue.1 , pp. 68-72
    • Geer, R.J.1    Brennan, M.F.2
  • 3
    • 0028197556 scopus 로고
    • Pylorus-preserving pancreatoduodenectomy. Is it an adequate cancer operation?
    • Tsao JI, Rossi RL, Lowell JA. Pylorus-preserving pancreatoduodenectomy. Is it an adequate cancer operation? Arch. Surg. 129(4), 405-412 (1994).
    • (1994) Arch. Surg , vol.129 , Issue.4 , pp. 405-412
    • Tsao, J.I.1    Rossi, R.L.2    Lowell, J.A.3
  • 4
    • 0029002348 scopus 로고
    • Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients
    • discussion 731-733
    • Yeo CJ, Cameron JL, Lillemoe KD et al. Pancreaticoduodenectomy for cancer of the head of the pancreas. 201 patients. Ann. Surg. 221(6), 721-731; discussion 731-733 (1995).
    • (1995) Ann. Surg , vol.221 , Issue.6 , pp. 721-731
    • Yeo, C.J.1    Cameron, J.L.2    Lillemoe, K.D.3
  • 5
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as firstline therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J et al. Improvements in survival and clinical benefit with gemcitabine as firstline therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 15(6), 2403-2413 (1997).
    • (1997) J. Clin. Oncol , vol.15 , Issue.6 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 6
    • 34548627542 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiation to convert locally advanced pancreatic body adenocarcinoma to resectable disease
    • discussion 743
    • Cunningham SC, Cusnir M, Burdick RK, Van Echo DA, Moesinger R. Neoadjuvant chemoradiation to convert locally advanced pancreatic body adenocarcinoma to resectable disease. Clin. Adv. Hematol. Oncol. 1(12), 741-742; discussion 743 (2003).
    • (2003) Clin. Adv. Hematol. Oncol , vol.1 , Issue.12 , pp. 741-742
    • Cunningham, S.C.1    Cusnir, M.2    Burdick, R.K.3    Van Echo, D.A.4    Moesinger, R.5
  • 7
    • 33748445708 scopus 로고    scopus 로고
    • Randomized Phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
    • Heinemann V, Quietzsch D, Gieseler F et al. Randomized Phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J. Clin. Oncol. 24(24), 3946-3952 (2006).
    • (2006) J. Clin. Oncol , vol.24 , Issue.24 , pp. 3946-3952
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3
  • 8
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD Phase III trial
    • Louvet C, Labianca R, Hammel P et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD Phase III trial. J. Clin. Oncol. 23(15), 3509-3516 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.15 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 9
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima CM, Green MR, Rotche R et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J. Clin. Oncol. 22(18), 3776-3783 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.18 , pp. 3776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3
  • 10
    • 27144530079 scopus 로고    scopus 로고
    • A Phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
    • Oettle H, Richards D, Ramanathan RK et al. A Phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann. Oncol. 16(10), 1639-1645 (2005).
    • (2005) Ann. Oncol , vol.16 , Issue.10 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3
  • 11
    • 33847328329 scopus 로고    scopus 로고
    • Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer
    • Büchler P, Reber HA, Roth MM, Shiroishi M, Friess H, Hines OJ. Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer. Neoplasia 9(2), 119-127 (2007).
    • (2007) Neoplasia , vol.9 , Issue.2 , pp. 119-127
    • Büchler, P.1    Reber, H.A.2    Roth, M.M.3    Shiroishi, M.4    Friess, H.5    Hines, O.J.6
  • 12
    • 0028081120 scopus 로고
    • K-ras mutations in pancreatic ductal proliferative lesions
    • Klimstra DS, Longnecker DS. K-ras mutations in pancreatic ductal proliferative lesions. Am. J. Pathol. 145(6), 1547-1550 (1994).
    • (1994) Am. J. Pathol , vol.145 , Issue.6 , pp. 1547-1550
    • Klimstra, D.S.1    Longnecker, D.S.2
  • 13
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • Rozenblum E, Schutte M, Goggins M et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57(9), 1731-1734 (1997).
    • (1997) Cancer Res , vol.57 , Issue.9 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 14
    • 55249083684 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic trial of e farnesyltransferase inhibitor R115777 on a 21-day dosing schedule (meeting abstract)
    • Presented at:, GA, USA, 15-18 May
    • Hudes G, Schol J, Baab J et al. Phase I clinical and pharmacokinetic trial of e farnesyltransferase inhibitor R115777 on a 21-day dosing schedule (meeting abstract). Presented at: 35th ASCO Annual Meeting. GA, USA, 15-18 May 1999.
    • (1999) 35th ASCO Annual Meeting
    • Hudes, G.1    Schol, J.2    Baab, J.3
  • 15
    • 0038413837 scopus 로고    scopus 로고
    • Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma
    • Cohen SJ, Ho L, Ranganathan S et al. Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. J. Clin. Oncol. 21(7), 1301-1306 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.7 , pp. 1301-1306
    • Cohen, S.J.1    Ho, L.2    Ranganathan, S.3
  • 16
    • 2342645506 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer
    • Van Cutsem E, van de Velde H, Karasek P et al. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J. Clin. Oncol. 22(8), 1430-1438 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.8 , pp. 1430-1438
    • Van Cutsem, E.1    van de Velde, H.2    Karasek, P.3
  • 17
    • 0035132538 scopus 로고    scopus 로고
    • Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • End DW, Smets G, Todd AV et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61(1), 131-137 (2001).
    • (2001) Cancer Res , vol.61 , Issue.1 , pp. 131-137
    • End, D.W.1    Smets, G.2    Todd, A.V.3
  • 18
    • 0038352147 scopus 로고    scopus 로고
    • Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer
    • Johnston SR, Hickish T, Ellis P et al. Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer. J. Clin. Oncol. 21(13), 2492-2499 (2003).
    • (2003) J. Clin. Oncol , vol.21 , Issue.13 , pp. 2492-2499
    • Johnston, S.R.1    Hickish, T.2    Ellis, P.3
  • 19
    • 0037372488 scopus 로고    scopus 로고
    • Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
    • Cortes J, Albitar M, Thomas D et al. Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood 101(5), 1692-1697 (2003).
    • (2003) Blood , vol.101 , Issue.5 , pp. 1692-1697
    • Cortes, J.1    Albitar, M.2    Thomas, D.3
  • 20
    • 0026020115 scopus 로고
    • Transforming growth factor α and epidermal growth factor in human pancreatic cancer
    • Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR. Transforming growth factor α and epidermal growth factor in human pancreatic cancer. J. Pathol. 163(2), 111-116 (1991).
    • (1991) J. Pathol , vol.163 , Issue.2 , pp. 111-116
    • Barton, C.M.1    Hall, P.A.2    Hughes, C.M.3    Gullick, W.J.4    Lemoine, N.R.5
  • 21
    • 0026462778 scopus 로고
    • Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth fictor α
    • Korc M, Chandrasekar B, Yamanaka Y, Friess H, Buchier M, Beger HG. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth fictor α. J. Clin. Invest. 90(4), 1352-1360 (1992).
    • (1992) J. Clin. Invest , vol.90 , Issue.4 , pp. 1352-1360
    • Korc, M.1    Chandrasekar, B.2    Yamanaka, Y.3    Friess, H.4    Buchier, M.5    Beger, H.G.6
  • 22
    • 21644469223 scopus 로고    scopus 로고
    • Gefitinib ('Iressi', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation
    • Li J, Kleeff J, Giese N, Büchler MW, Korc M, Friess H. Gefitinib ('Iressi', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. Int. J. Oncol. 25(1), 203-210 (2004).
    • (2004) Int. J. Oncol , vol.25 , Issue.1 , pp. 203-210
    • Li, J.1    Kleeff, J.2    Giese, N.3    Büchler, M.W.4    Korc, M.5    Friess, H.6
  • 23
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A Phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a Phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin. Oncol. 25(15), 1960-1966 (2007).
    • (2007) J Clin. Oncol , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 24
    • 55249083241 scopus 로고    scopus 로고
    • Philip PA, Benedetti J, Fenoglio-Preiser C et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. J. Clin. Oncol. 25(Suppl. Pt 1), 18S LBA4509 (2007).
    • Philip PA, Benedetti J, Fenoglio-Preiser C et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. J. Clin. Oncol. 25(Suppl. Pt 1), 18S LBA4509 (2007).
  • 25
    • 34548071941 scopus 로고    scopus 로고
    • A multicenter Phase II study of docetaxel in combination with gefitinib in gemcitabine-pretreated patients with advanced/metastatic pancreatic cancer
    • Ignatiadis M, Polyzos A, Stathopoulos GP et al. A multicenter Phase II study of docetaxel in combination with gefitinib in gemcitabine-pretreated patients with advanced/metastatic pancreatic cancer. Oncology 71(3-4), 159-163 (2006).
    • (2006) Oncology , vol.71 , Issue.3-4 , pp. 159-163
    • Ignatiadis, M.1    Polyzos, A.2    Stathopoulos, G.P.3
  • 26
    • 34548071941 scopus 로고    scopus 로고
    • A multicenter Phase II study of docetaxel in combination with gefitinib in gemcitabine-pretreated patients with advanced/metastatic pancreatic cancer
    • Ignatiadis M, Polyzos A, Stathopoulos GP et al. A multicenter Phase II study of docetaxel in combination with gefitinib in gemcitabine-pretreated patients with advanced/metastatic pancreatic cancer. Oncology 71(3-4), 159-163 (2006).
    • (2006) Oncology , vol.71 , Issue.3-4 , pp. 159-163
    • Ignatiadis, M.1    Polyzos, A.2    Stathopoulos, G.P.3
  • 27
    • 17144415942 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents
    • Jimeno A, Rubio-Viqueira B, Amador ML et al. Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents. Cancer Res. 65(8), 3003-3010 (2005).
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3003-3010
    • Jimeno, A.1    Rubio-Viqueira, B.2    Amador, M.L.3
  • 28
    • 4944249117 scopus 로고    scopus 로고
    • RAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Withelm. SM, Carter C, Tang L et al. RAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64(19), 7099-7109 (2004).
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Withelm, S.M.1    Carter, C.2    Tang, L.3
  • 29
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350(21), 2129-2139 (2004).
    • (2004) N. Engl. J. Med , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 30
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Jänne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304(5676), 1497-1500 (2004).
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 31
    • 34247149803 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • Lee J, Jang KT, Ki CS et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 109(8), 1561-1569 (2007).
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1561-1569
    • Lee, J.1    Jang, K.T.2    Ki, C.S.3
  • 32
    • 33947322389 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer
    • Tzeng CW, Frolov A, Frolova N et al. Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer. Surgery 141(4), 464-469 (2007).
    • (2007) Surgery , vol.141 , Issue.4 , pp. 464-469
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3
  • 33
    • 33744725273 scopus 로고    scopus 로고
    • Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
    • Immervoll H, Hoem D, Kugarajh K, Steine SJ, Molven A. Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes. Virchows Arch. 448(6), 788-796 (2006).
    • (2006) Virchows Arch , vol.448 , Issue.6 , pp. 788-796
    • Immervoll, H.1    Hoem, D.2    Kugarajh, K.3    Steine, S.J.4    Molven, A.5
  • 34
    • 34548039272 scopus 로고    scopus 로고
    • Coexpression of EGFR and HER-2 in pancreatic ductal adenocarcinoma: A comparative study using immunohistochemistry correlated with gene amplification by fluorescencent in situ hybridization
    • Dancer J, Takei H, Ro JY, Lowery-Nordberg M. Coexpression of EGFR and HER-2 in pancreatic ductal adenocarcinoma: a comparative study using immunohistochemistry correlated with gene amplification by fluorescencent in situ hybridization. Oncol. Rep. 18(1), 151-155 (2007).
    • (2007) Oncol. Rep , vol.18 , Issue.1 , pp. 151-155
    • Dancer, J.1    Takei, H.2    Ro, J.Y.3    Lowery-Nordberg, M.4
  • 35
    • 0027435936 scopus 로고
    • Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage
    • Yamanaka Y, Friess H, Buchler M et al. Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage. Cancer Res. 53(21), 5289-5296 (1993).
    • (1993) Cancer Res , vol.53 , Issue.21 , pp. 5289-5296
    • Yamanaka, Y.1    Friess, H.2    Buchler, M.3
  • 36
    • 0034793404 scopus 로고    scopus 로고
    • Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma
    • Safran H, Steinhoff M, Mangray S et al. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am. J. Clin. Oncol. 24(5), 496-499 (2001).
    • (2001) Am. J. Clin. Oncol , vol.24 , Issue.5 , pp. 496-499
    • Safran, H.1    Steinhoff, M.2    Mangray, S.3
  • 37
    • 55249102852 scopus 로고    scopus 로고
    • Safran H, Iannitti D, Miner T et al. GW572016, gemcitabine and GW572016, gemcitabine, oxaliplatin, a two-stage, Phase I study for advanced pancreaticobiliary cancer. J. Clin. Oncol. 24(Suppl. Pt 1), 18S 4002 (2006).
    • Safran H, Iannitti D, Miner T et al. GW572016, gemcitabine and GW572016, gemcitabine, oxaliplatin, a two-stage, Phase I study for advanced pancreaticobiliary cancer. J. Clin. Oncol. 24(Suppl. Pt 1), 18S 4002 (2006).
  • 38
    • 34548251394 scopus 로고    scopus 로고
    • ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib
    • Frolov A, Schuller K, Tzeng CW et al. ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib. Cancer Biol. Ther. 6(4), 548-554 (2007).
    • (2007) Cancer Biol. Ther , vol.6 , Issue.4 , pp. 548-554
    • Frolov, A.1    Schuller, K.2    Tzeng, C.W.3
  • 39
    • 0024292722 scopus 로고    scopus 로고
    • Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53(4), 549-554 (1988).
    • Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53(4), 549-554 (1988).
  • 40
    • 55249109458 scopus 로고    scopus 로고
    • Genetic predictors of cetuximab response in metastatic colorectal cancer
    • Presented at:, FL, USA, 25-27 January
    • Viret F, Smedra BT, Esteyries S et al. Genetic predictors of cetuximab response in metastatic colorectal cancer. Presented at: 2008 Gastrointestinal Cancers Symposium. FL, USA, 25-27 January 2008.
    • (2008) 2008 Gastrointestinal Cancers Symposium
    • Viret, F.1    Smedra, B.T.2    Esteyries, S.3
  • 41
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal. cancer treated with cetuximab
    • Lièvre A, Bachet JB, Boige V et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal. cancer treated with cetuximab. J. Clin. Oncol, 26(3), 374-379 (2008).
    • (2008) J. Clin. Oncol , vol.26 , Issue.3 , pp. 374-379
    • Lièvre, A.1    Bachet, J.B.2    Boige, V.3
  • 42
    • 15544391142 scopus 로고    scopus 로고
    • Angiogenesis of breast cancer
    • Schneider BP, Miller KD. Angiogenesis of breast cancer. J. Clin. Oncol. 23(8), 1782-1790 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.8 , pp. 1782-1790
    • Schneider, B.P.1    Miller, K.D.2
  • 43
    • 0034901122 scopus 로고    scopus 로고
    • Phase I trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer
    • Rudin CM, Holmlund J, Fleming GF et al. Phase I trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer. Clin. Cancer Res. 7(5), 1214-1220 (2001).
    • (2001) Clin. Cancer Res , vol.7 , Issue.5 , pp. 1214-1220
    • Rudin, C.M.1    Holmlund, J.2    Fleming, G.F.3
  • 44
    • 31544460436 scopus 로고    scopus 로고
    • Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu LL, Awada A, Takimoto CH et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin. Cancer Res. 12(1), 144-151 (2006).
    • (2006) Clin. Cancer Res , vol.12 , Issue.1 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3
  • 45
    • 0033590636 scopus 로고    scopus 로고
    • Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
    • Hoshino It, Chatani Y, Yamori T et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogenen 18(3), 813-822 (1999).
    • (1999) Oncogenen , vol.18 , Issue.3 , pp. 813-822
    • Hoshino, I.1    Chatani, Y.2    Yamori, T.3
  • 46
    • 23944439944 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
    • Lorusso PM, Adjei AA, Varterasian M et al. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J. Clin. Oncol. 23(23), 5281-5293 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.23 , pp. 5281-5293
    • Lorusso, P.M.1    Adjei, A.A.2    Varterasian, M.3
  • 47
    • 14844285975 scopus 로고    scopus 로고
    • Multicenter Phase II study of the oral MEK inhibitor, CI-1040, patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
    • Rinehart J, Adjei AA, Lorusso PM et al. Multicenter Phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J. Clin. Oncol. 22(22), 4456-4462 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.22 , pp. 4456-4462
    • Rinehart, J.1    Adjei, A.A.2    Lorusso, P.M.3
  • 49
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
    • Viloria-Petit A, Crombet T, Jothy S et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res. 61(13), 5090-5101 (2001).
    • (2001) Cancer Res , vol.61 , Issue.13 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3
  • 50
    • 35548941394 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized Phase III trial of gemcitabine (G) plus bevacizurnab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of Cancer and Leukemia Group B (CALGB). J Clin. Oncol. 25(Suppl
    • Kindler HI, Niedzwiecki D, Hollis D et al. A double-blind, placebo-controlled, randomized Phase III trial of gemcitabine (G) plus bevacizurnab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of Cancer and Leukemia Group B (CALGB). J Clin. Oncol. 25(Suppl. Pt I), 18S 4508 (2007).
    • (2007) Pt I) , vol.18 S , pp. 4508
    • Kindler, H.I.1    Niedzwiecki, D.2    Hollis, D.3
  • 51
    • 55249105862 scopus 로고    scopus 로고
    • Wallace JA, Locker G, Nattam S et al. Sorafenib (S) plus genicitabine (G) for advanced pancreatic cancer (PC): a Phase II trial of the University of Chicago Phase II Consortium. J. Clin. Oncol. 25(Suppl. Pt 1), 18S 4608 (2007).
    • Wallace JA, Locker G, Nattam S et al. Sorafenib (S) plus genicitabine (G) for advanced pancreatic cancer (PC): a Phase II trial of the University of Chicago Phase II Consortium. J. Clin. Oncol. 25(Suppl. Pt 1), 18S 4608 (2007).
  • 52
    • 55249083240 scopus 로고    scopus 로고
    • Spano J, Chodkiewicz C, Maurel J et al. A randomized Phase II study of axitinib (AG-013736) and gemicitabine versus gemicitabine in advanced pancreatic cancer, preceded by a Phase I component. J. Clin. Oncol. 25(Suppl. Pt 1), 18S 4551 (2007).
    • Spano J, Chodkiewicz C, Maurel J et al. A randomized Phase II study of axitinib (AG-013736) and gemicitabine versus gemicitabine in advanced pancreatic cancer, preceded by a Phase I component. J. Clin. Oncol. 25(Suppl. Pt 1), 18S 4551 (2007).
  • 53
    • 55249085334 scopus 로고    scopus 로고
    • Kuo T, Fitzgerald A, Kaiser H, Sikic BI, Fisher GA. A Phase I study of the VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK 222584) and gemcitabine in patients with advanced pancreatic cancer. J. Clin. Oncol. 24(Suppl. Pt 1), 18S 4122 (2006).
    • Kuo T, Fitzgerald A, Kaiser H, Sikic BI, Fisher GA. A Phase I study of the VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK 222584) and gemcitabine in patients with advanced pancreatic cancer. J. Clin. Oncol. 24(Suppl. Pt 1), 18S 4122 (2006).
  • 54
    • 55249100695 scopus 로고    scopus 로고
    • Gharibo MM, Juvidian P, Patrick-Miller L et al. Phase II trial of Gleevec (imatinib mesylate) in patients with metastatic unresectable pancreatic cancer. J. Clin. Oncol. 23(Suppl. Pt 1), 16S 4183 (2005).
    • Gharibo MM, Juvidian P, Patrick-Miller L et al. Phase II trial of Gleevec (imatinib mesylate) in patients with metastatic unresectable pancreatic cancer. J. Clin. Oncol. 23(Suppl. Pt 1), 16S 4183 (2005).
  • 55
    • 77249173477 scopus 로고    scopus 로고
    • A small molecule inhibitor of insurin-like growth factor 1 receptor (PQIP) inhibits human pancreatic cancer cell proliferation in vitro and synergizes with erlotinib
    • Presented at:, FL, USA, 25-27 January
    • Yendluri V, Wright JR, Coppola D et al. A small molecule inhibitor of insurin-like growth factor 1 receptor (PQIP) inhibits human pancreatic cancer cell proliferation in vitro and synergizes with erlotinib, Presented at: 2008 Gastrointestinal Cancers Symposium. FL, USA, 25-27 January 2008.
    • (2008) 2008 Gastrointestinal Cancers Symposium
    • Yendluri, V.1    Wright, J.R.2    Coppola, D.3
  • 56
    • 38949101910 scopus 로고    scopus 로고
    • Understanding tumor endothehal cell abnormalities to develop ideal antiangiogenic therapies
    • Hida K. Hida Y, Shindoh M. Understanding tumor endothehal cell abnormalities to develop ideal antiangiogenic therapies. Cancer Sci. 99(3), 459-466 (2008).
    • (2008) Cancer Sci , vol.99 , Issue.3 , pp. 459-466
    • Hida, K.1    Hida, Y.2    Shindoh, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.