Overexpression of telomerase-associated chaperone proteins in prostatic intraepithelial neoplasia and carcinomas

Oncology Reports

Volumn 20, Issue 3, 2008, Pages 613-617

  Elmore, Lynne W ^a   Forsythe, Robert ^a   Forsythe, Heidi ^a   Bright, A Taylor ^a   Nasim, Suhail ^a   Endo, Kanendori ^a   Holt, Shawn E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chaperones; hsp90; hTERT; p23; Prostate cancer; Prostatic intraepithelial neoplasia; Telomerase

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 90; PROTEIN P23; TELOMERASE REVERSE TRANSCRIPTASE; ISOMERASE; PROSTAGLANDIN E SYNTHASE; TELOMERASE; TERT PROTEIN, HUMAN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER STAGING; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLEASON SCORE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; ADENOCARCINOMA; CELL NUCLEUS; ENZYME IMMUNOASSAY; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; PROGNOSIS; PROSTATE; PROSTATE TUMOR;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CELL NUCLEUS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; TELOMERASE;

EID: 54549110143     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or_00000049     Document Type: Article

References (19)

1. Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer S: 787-791, 1997.
2. Feng J, Funk WD, Wang S-S, et al: The RNA component of human telomerase. Science 269: 1236-1241, 1995.
3. Meyerson M, Counter CM, Eaton EN, et al: hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immobilization. Cell 90: 785-795, 1997.
4. Nakamura TM, Morin GB, Chapman KB, et al: Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959, 1997.
5. Holt SE, Aisner DL, Baur J, et al: Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev 13: 817-826, 1999.
6. Forsythe HL, Jarvis JL, Turner JW, et al: Stable association of hsp90 and p23, but not hsp70, with active human telomerase. J Biol Chem 276: 15571-15574, 2001.
7. Neckers L and Ivy SP: Heat shock protein 90. Curr Opin Oncol 15: 419-426, 2003.
8. Goetz MP, Toft DO, Ames MM and Erlichman C: The Hsp90 chaperone complex as a novel target for cancer therapy. Ann Oncol 14: 1169-1176, 2003.
9. Neckers L: Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8: S55-S61, 2002.
10. Akalin A, Elmore LW, Forsythe HL, et al: A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression. Cancer Res 61: 4791-4796, 2001.
11. Zhang W, Kapusta LR, Slingerland JM, et al: Telomerase activity in prostate cancer, prostatic intraepithelial neoplasia, and benign prostatic epithelium. Cancer Res 58: 619-621, 1998.
12. Kurahashi T, Miyake H, Hara I and Fujisawa M: Expression of major heat shock proteins in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy. J Urol 177: 757-761, 2007.
13. Zellweger T, Ninck C, Bloch M, et al: Expression patterns of potential therapeutics targets in prostate cancer. Int J Cancer 113: 619-628, 2005.
14. Felt SJ and Toft DO: p23, a simple protein with complex activities. Cell Stress Chaperones 8: 108-113, 2003.
15. 2+-binding modulator protein involved in cell proliferation and in cell death. Biochim Biophysica Acta 1600: 68-73, 2002.
16. Iczkowski KA, Pantazis G, McGregor DH, et al: Telomerase reverse transcriptase subunit immunoreactivity. Cancer 95: 2487-2493, 2002.
17. Ma Y and Hendershot LM: ER chaperone functions during normal and stress conditions. J Chem Neuroanat 28: 51-65, 2004.
18. Wymenga LFA, Wisman GBA, Veenstra R, et al: Telomerase activity in needle biopsies from prostate cancer and benign prostates. Eur J Clin Invest 30: 330-335, 2000.
19. Lam JS and Reiter RE: Stem cells in prostate and prostate cancer development. Urol Oncol 24: 131-140, 2006.