New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants

Journal of Chromatography A

Volumn 1211, Issue 1-2, 2008, Pages 80-89

  Platis, D ^a   Drossard, J ^b   Fischer, R ^c   Ma, J K C ^d   Labrou, N E ^a  

^a AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

2G12; 4E10; Aqueous two phase system; Cation exchange chromatography; Immobilized metal affinity chromatography; Molecular farming; Monoclonal antibody

Indexed keywords

ACIDS; AFFINITY CHROMATOGRAPHY; AGRICULTURAL PRODUCTS; ALLERGIES; ANTIBODIES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; COLLOIDS; COLUMN CHROMATOGRAPHY; DIFFUSERS (OPTICAL); ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; GELATION; LEACHING; MERGERS AND ACQUISITIONS; METAL RECOVERY; METAL REFINING; MONOCLONAL ANTIBODIES; NETWORK PROTOCOLS; PHENOLS; PLANTS (BOTANY); POLYMERS; POSITIVE IONS; SODIUM CHLORIDE; SODIUM COMPOUNDS; SURFACE PLASMON RESONANCE; TOBACCO; ZINC;

2G12; 4E10; AQUEOUS TWO PHASE SYSTEM; CATION-EXCHANGE CHROMATOGRAPHY; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; MOLECULAR FARMING;

PURIFICATION;

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2G12; MONOCLONAL ANTIBODY 4E10; SEPHAROSE; SODIUM CHLORIDE; SODIUM DIHYDROGEN PHOSPHATE;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DRUG PURIFICATION; ELUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ION EXCHANGE CHROMATOGRAPHY; NONHUMAN; PH MEASUREMENT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PURIFICATION; TOBACCO; WESTERN BLOTTING;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, ION EXCHANGE; HIV ANTIBODIES; HUMANS; METALS; PLANTS, GENETICALLY MODIFIED; QUALITY CONTROL; TOBACCO;

HUMAN IMMUNODEFICIENCY VIRUS; NICOTIANA OBTUSIFOLIA;

EID: 54549100118     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.09.103     Document Type: Article

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