Extracellular signal-regulated kinases mediate melittin-induced hypersensitivity of spinal neurons to chemical and thermal but not mechanical stimuli

Brain Research Bulletin

Volumn 77, Issue 5, 2008, Pages 227-232

  Li, Meng Meng ^a,c   Yu, Yao Qing ^a   Fu, Han ^a   Xie, Fang ^a   Xu, Li Xian ^d   Chen, Jun ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bee venom; Central sensitization; Extracellular signal regulated kinases; Melittin; Pain hypersensitivity; Persistent spontaneous nociception; Spinal dorsal horn

Indexed keywords

CAPSAZEPINE; MELITTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UO 126; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; MALE; MECHANICAL STIMULATION; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPRAGUE DAWLEY RAT; STIMULUS RESPONSE; THERMAL STIMULATION;

ANIMALS; BUTADIENES; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYPERESTHESIA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MELITTEN; NEURONS; NITRILES; NOCICEPTORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TEMPERATURE; TOUCH;

EID: 54549096940     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.07.009     Document Type: Article

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