Anti-inflammatory effects of m-chlorophenylpiperazine in brain glia cells

International Immunopharmacology

Volumn 8, Issue 12, 2008, Pages 1686-1694

  Hwang, Jaegyu ^a   Zheng, Long Tai ^a   Ock, Jiyeon ^a   Lee, Maan Gee ^a   Suk, Kyoungho ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Astrocyte; Inflammation; m CPP; Microglia; Neuroprotection; Serotonin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; SEROTONIN 1 AGONIST; SEROTONIN 1 RECEPTOR; SEROTONIN 2 AGONIST; SEROTONIN 2 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; ENCEPHALITIS; ENZYME PHOSPHORYLATION; GLIA CELL; MICROGLIA; MOLECULAR MECHANICS; MOUSE; NEUROBLASTOMA; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SYNAPTIC TRANSMISSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; CELLS, CULTURED; CYTOPROTECTION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED ICR; NEUROGLIA; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PIPERAZINES; RATS; SEROTONIN AGONISTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 54549086524     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.08.004     Document Type: Article

References (55)

1. Liu B., and Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304 (2003) 1-7
2. Minghetti L., and Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54 (1998) 99-125
3. Gonzalez-Scarano F., and Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22 (1999) 219-240
4. McGeer E.G., and McGeer P.L. Inflammatory processes in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 27 (2003) 741-749
5. Farina C., Aloisi F., and Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 28 (2007) 138-145
6. Suk K. Regulation of neuroinflammation by herbal medicine and its implications for neurodegenerative diseases. A focus on traditional medicines and flavonoids. Neurosignals 14 (2005) 23-33
7. Kahn R.S., and Wetzler S. m-Chlorophenylpiperazine as a probe of serotonin function. Biol. Psychiatry 30 (1991) 1139-1166
8. Gijsman H.J., Cohen A.F., and Van Gerven J.M. The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system. J Psychopharmacol 18 (2004) 7-13
9. 2 receptor subtypes: a family re-united?. Trends Pharmacol Sci 16 (1995) 105-110
10. 2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology (Berl) 122 (1995) 237-243
11. 1C receptors. Br J Pharmacol 94 (1988) 137-147
12. Antonatos S., and Galanopoulou P. Effects of m-CPP and mesulergine on dietary choices in deprived rats: possible mechanisms of their action. Prog Neuropsychopharmacol Biol Psychiatry 30 (2006) 112-119
13. 2C receptor antagonist. Neuropharmacology 36 (1997) 609-620
14. 2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behav Brain Res 73 (1996) 277-280
15. 2 receptor subtypes. Pharmacol Biochem Behav 88 (2008) 367-373
16. 2C receptors. Behav Brain Res 16 (2003) 175-179
17. Feuchtl A., Bagli M., Stephan R., Frahnert C., Kölsch H., Kühn K.U., et al. Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile. Pharmacopsychiatry 37 (2004) 180-188
18. Rotzinger S., Fang J., and Baker G.B. Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Drug Metab Dispos 26 (1998) 572-575
19. Bocchini V., Mazzolla R., Barluzzi R., Blasi E., Sick P., and Kettenmann H. An immortalized cell line expresses properties of activated microglial cells. J Neurosci Res 31 (1992) 616-621
20. Cheepsunthorn P., Radov L., Menzies S., Reid J., and Connor J.R. Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia 35 (2001) 53-62
21. Saura J., Tusell J.M., and Serratosa J. High-yield isolation of murine microglia by mild trypsinization. Glia 44 (2003) 183-189
22. Lee S., and Suk K. Heme oxygenase-1 mediates cytoprotective effects of immunostimulation in microglia. Biochem Pharmacol 74 (2007) 723-729
23. Sung B., Pandey M.K., and Aggarwal B.B. Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated Ikappa Balpha kinase activation. Mol Pharmacol 71 (2007) 1703-1714
24. Woo M.S., Jang P.G., Park J.S., Kim W.K., Joh T.H., and Kim H.S. Selective modulation of lipopolysaccharide-stimulated cytokine expression and mitogen-activated protein kinase pathways by dibutyryl-cAMP in BV2 microglial cells. Brain Res Mol Brain Res 113 (2003) 86-96
25. Park S.Y., Lee H., Hur J., Kim S.Y., Kim H., Park J.H., et al. Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. Brain Res Mol Brain Res 107 (2002) 9-16
26. Da Silva J., Pierrat B., Mary J.L., and Lesslauer W. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J Biol Chem 272 (1997) 28373-28380
27. Jongeneel C.V. Transcriptional regulation of the tumor necrosis factor alpha gene. Immunobiology 193 (1995) 210-216
28. Stoll G., and Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58 (1999) 233-247
29. Streit W.J., Walter S.A., and Pennell N.A. Reactive microgliosis. Prog Neurobiol 57 (1999) 563-581
30. Kim S., Ock J., Kim A.K., Lee H.W., Cho J.Y., Kim D.R., et al. Neurotoxicity of microglial cathepsin D revealed by secretome analysis. J Neurochem 103 (2007) 2640-2650
31. Lee Y., Nagai A., and Kim S.U. Cytokines, chemokines and cytokine receptors in human microglia. J Neurosci Res 69 (2002) 94-103
32. McGeer P.L., Kawamata T., Walker D.G., Akiyama H., Tooyama I., and McGeer E.G. Microglia in degenerative neurological disease. Glia 7 (1993) 84-92
33. Schmidt H.H., and Walter U. NO at work. Cell 78 (1994) 919-925
34. 3H]5-HT binding sites and 5-HT-sensitive adenylate cyclase in glial cell membrane fraction. Brain Res 198 (1980) 361-374
35. Tardy M., Costa M.F., Fages C., Bardakdjian J., and Gonnard P. Uptake and binding of serotonin by primary cultures of mouse astrocytes. Dev Neurosci 5 (1982) 19-26
36. 1A receptors to astroglial cells in adult rats: implications for neuronal-glial interactions and psychoactive drug mechanisms of action. Synapse 14 (1993) 201-205
37. Ding D., Toth M., Zhou Y., Parks C., Hoffman B.J., and Shenk T. Glial cell-specific expression of the serotonin 2 receptor gene: selective reactivation of a repressed promoter. Brain Res Mol Brain Res 20 (1993) 181-191
38. Hirst W.D., Price G.W., Rattray M., and Wilkin G.P. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. Br J Pharmacol 120 (1997) 509-515
39. 2C receptor in glial cells. Brain Res Bull 38 (1995) 153-159
40. Cohen Z., Bouchelet I., Olivier A., Villemure J.G., Ball R., Stanimirovic D.B., et al. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. J Cereb Blood Flow Metab 19 (1999) 908-917
41. 7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. Neuropharmacology 49 (2005) 40-47
42. Bianchi M., Sacerdote P., and Panerai A.E. Fluoxetine reduces inflammatory edema in the rat: involvement of the pituitary-adrenal axis. Eur J Pharmacol 263 (1994) 81-84
43. Sawynok J., Esser M.J., and Reid A.R. Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain 82 (1999) 149-158
44. Abdel-Salam O.M., Baiuomy A.R., and Arbid M.S. Studies on the anti-inflammatory effect of fluoxetine in the rat. Pharmacol Res 49 (2004) 119-131
45. Abdel-Salam O.M., Nofal S.M., and El-Shenawy S.M. Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol Res 48 (2003) 157-165
46. Shen K.P., Liou S.F., Hsieh S.L., Chen I.J., and Wu B.N. Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2. J Pharm Pharmacol 59 (2007) 879-889
47. Shen K.P., Lo Y.C., Yang R.C., Liu H.W., Chen I.J., and Wu B.N. Antioxidant eugenosedin-A protects against lipopolysaccharide-induced hypotension, hyperglycaemia and cytokine immunoreactivity in rats and mice. J Pharm Pharmacol 57 (2005) 117-125
48. Kubera M., Maes M., Kenis G., Kim Y.K., and Lasoń W. Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor-alpha and interleukin-6. Psychiatry Res 134 (2005) 25-28
49. Schmedtje Jr. J.F., Ji Y.S., Liu W.L., DuBois R.N., and Runge M.S. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272 (1997) 601-608
50. Yamamoto Y., and Gaynor R.B. Therapeutic potential of inhibition of the NF-kB pathway in the treatment of inflammation and cancer. J Clin Invest 107 (2001) 135-142
51. Lee P., Hur J., Lee J., Kim J., Jeong J., Kang I., et al. 15,16-dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide. Neurochem Int 48 (2006) 60-66
52. Ye S.M., and Johnson R.W. Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kB. J Neuroimmunol 117 (2001) 87-96
53. Le W., Rowe D., Xie W., Ortiz I., He Y., and Appel S.H. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci 21 (2001) 8447-8455
54. Esposito E., Di Matteo V., Benigno A., Pierucci M., Crescimanno G., and Di Giovanni G. Non-steroidal anti-inflammatory drugs in Parkinson's disease. Exp Neurol 205 (2007) 295-312
55. Combs C.K., Karlo J.C., Kao S.C., and Landreth G.E. Beta-amyloid stimulation of microglia and monocytes results in TNF-alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 21 (2001) 1179-1188