Basophils initiate IL-4 production during a memory T-dependent response

Journal of Experimental Medicine

Volumn 200, Issue 7, 2004, Pages 857-870

  Khodoun, Marat V ^d   Orekhova, Tatyana ^a   Potter, Crystal ^a   Morris, Suzanne ^a,b   Finkelman, Fred D ^a,b,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d NONE

Author keywords

Allergy; Cytokine; Eosinophil; Mast cell; NKT cell

Indexed keywords

FC RECEPTOR; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; BASOPHIL; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EOSINOPHIL; GENE EXPRESSION; GOAT; IMMUNE RESPONSE; IMMUNIZATION; MAST CELL; MEMORY CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE ACTIVATION;

ANIMALS; BASOPHILS; CHYMASES; CYTOKINES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; IMMUNIZATION; IMMUNOLOGIC MEMORY; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; SERINE ENDOPEPTIDASES; SPLEEN; T-LYMPHOCYTES; TIME FACTORS;

EID: 5444254615     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20040598     Document Type: Article

References (56)

1. Finkelman, F.D., T. Shea-Donohue, J. Goldhill, C.A. Sullivan, S.C. Morris, K.B. Madden, W.C. Gause, and J.F. Urban Jr. 1997. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu. Rev. Immunol. 15:505-533.
2. Wills-Karp, M., S.H. Gavett, B. Schofield, and F. Finkelman. 1996. Role of interleukin-4 in the development of allergic airway inflammation and airway hyperresponsiveness. Adv. Exp. Med. Biol. 409:343-347.
3. + T cell clones. J. Immunol. 141:849-855.
4. + T cells can be primed in vitro to produce IL-4. J. Immunol. 148:1652-1656.
5. + T cells in a TH2 response and in immunoglobulin E production. Science. 270:1845-1847.
6. Seder, R.A., W.E. Paul, A.M. Dvorak, S.J. Sharkis, A. Kagey-Sobotka, Y. Niv, F.D. Finkelman, S.A. Barbieri, S.J. Galli, and M. Plaut. 1991. Mouse splenic and bone marrow cell populations that express high-affinity Fcε receptors and produce interleukin 4 are highly enriched in basophils. Proc. Natl. Acad. Sci. USA. 88:2835-2839.
7. Bradding, P., I.H. Feather, P.H. Howarth, R. Mueller, J.A. Roberts, K. Britten, J.P. Bews, T.C. Hunt, Y. Okayama, C.H. Heusser, et al. 1992. Interleukin 4 is localized to and released by human mast cells. J. Exp. Med. 176:1381-1386.
8. Moqbel, R., S. Ying, J. Barkans, T.M. Newman, P. Kimmitt, M. Wakelin, L. Taborda-Barata, Q. Meng, C.J. Corrigan, S.R. Durham, et al. 1995. Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J. Immunol. 155: 4939-4947.
9. Finkelman, F.D., J. Holmes, J.F. Urban Jr., W.E. Paul, and I.M. Katona. 1989. T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production. J. Immunol. 142:403-408.
10. + T cells regulate the IgE response and protective immunity in mice. Exp. Parasitol. 73:500-511.
11. Kay, A.B., S. Ying, and S.R. Durham. 1995. Phenotype of cells positive for interleukin-4 and interleukin-5 mRNA in allergic tissue reactions. Int. Arch. Allergy Immunol. 107:208-210.
12. Hu-Li, J., C. Pannetier, L. Guo, M. Lohning, H. Gu, C. Watson, M. Assenmacher, A. Radbruch, and W.E. Paul. 2001. Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity. 14:1-11.
13. Mohrs, M., K. Shinkai, K. Mohrs, and R.M. Locksley. 2001. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 15:303-311.
14. Min, B., M. Prout, J. Hu-Li, J. Zhu, D. Jankovic, E.S. Morgan, J.F. Urban Jr., A.M. Dvorak, F.D. Finkelman, G. LeGros, and W.E. Paul. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200:507-517.
15. Shinkai, K., M. Mohrs, and R.M. Locksley. 2002. Helper T cells regulate type-2 innate immunity in vivo. Nature. 420: 825-829.
16. Han, B., and J.T. Zhang. 2002. Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Mol. Cell. Biol. 22:7372-7384.
17. Pozner, A., D. Goldenberg, V. Negreanu, S.Y. Le, O. Elroy-Stein, D. Levanon, and Y. Groner. 2000. Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms. Mol. Cell. Biol. 20:2297-2307.
18. Svetic, A., F.D. Finkelman, Y.C. Jian, C.W. Dieffenbach, D.E. Scott, K.F. McCarthy, A.D. Steinberg, and W.C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391-2397.
19. Finkelman, F.D., and S.C. Morris. 1999. Development of an assay to measure in vivo cytokine production in the mouse. Int. Immunol. 11:1811-1818.
20. + T cefl development and early IL-4 production in CD1-deficient mice. Immunity. 6:459-467.
21. 1 intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules. J. Exp. Med. 190:885-890.
22. Dombrowicz, D., V. Flamand, K.K. Brigman, B.H. Koller, and J.P. Kinet. 1993. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene. Cell. 75:969-976.
23. Oettgen, H.C., T.R. Martin, A. Wynshaw-Boris, C. Deng, J.M. Drazen, and P. Leder. 1994. Active anaphylaxis in IgE-deficient mice. Nature. 370:367-370.
24. Finkelman, F.D., S.W. Kessler, J.F. Mushinski, and M. Potter. 1981. IgD-secreting murine plasmacytomas: identification and partial characterization of two IgD myeloma proteins. J. Immunol. 126:680-687.
25. Zitron, I.M., and B.L. Clevinger. 1980. Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-δ antibody that induces allotype-specific proliferation. J. Exp. Med. 152:1135-1146.
26. Goroff, D.K., A. Stall, J.J. Mond, and F.D. Finkelman. 1986. In vitro and in vivo B lymphocyte-activating properties of monoclonal anti-δ antibodies. I. Determinants of B lymphocyte-activating properties. J. Immunol. 136:2382-2392.
27. Wilde, D.B., P. Marrack, J. Kappler, D.P. Dialynas, and F.W. Fitch. 1983. Evidence implicating L3T4 in class II MHC antigen reactivity: monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J. Immunol. 131:2178-2183.
28. Sarmiento, M.A., A.L. Glasebrook, and F.W. Fitch. 1980. IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Ly2 antigen block T cell-mediated cytolysis in the absence of complement. J. Immunol. 125:2665-2672.
29. Baniyash, M., and Z. Eshhar. 1984. Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE. Eur. J. Immunol. 14:799-807.
30. Unkeless, J.C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580-596.
31. Kofler, H., I. Schnegg, S. Geley, A. Helmberg, J.M. Varga, and R. Kofler. 1992. Mechanism of allergic cross-reactions-III. cDNA cloning and variable-region sequence analysis of two IgE antibodies specific for trinitrophenyl. Mol. Immunol. 29:161-166.
32. Fleming, T.J., M.L. Fleming, and T.R. Malek. 1993. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151:2399-2408.
33. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84: 1374-1378.
34. Ohara, J., and W.E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature. 315:333-336.
35. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191:1895-1903.
36. Finkelman, F.D., K.B. Madden, S.C. Morris, J.M. Holmes, N. Boiani, I.M. Katona, and C.R. Maliszewski. 1993. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 151:1235-1244.
37. Knight, P.A., S.H. Wright, C.E. Lawrence, Y.Y. Paterson, and H.R. Miller. 2000. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J. Exp. Med. 192:1849-1856.
38. Finkelman, F.D., S.C. Morris, T. Orekhova, and D. Sehy. 2003. The in vivo cytokine capture assay (IVCCA) for measurement of in vivo cytokine production in the mouse. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons Inc., New York. 6.28.1-6.28.10.
39. Stetson, D.B., M. Mohrs, R.L. Reinhardt, J.L. Baron, Z.E. Wang, L. Gapin, M. Kronenberg, and R.M. Locksley. 2003. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J. Exp. Med. 198:1069-1076.
40. Oliveira, S.H., D.D. Taub, J. Nagel, R. Smith, C.M. Hogaboam, A. Berlin, and N.W. Lukacs. 2002. Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. Blood. 100:4291-4297.
41. Finkelman, F. 2001. Cytokine regulation of type 2 immunity. In Samter's Immunologic Diseases. K.F. Austen, M.M. Frank, J.P. Atkinson, and H. Cantor, editors. Lippincott Williams & Wilkins, Philadelphia. 111-126.
42. Tite, J.P., A. Sloan, and C.A. Janeway Jr. 1986. The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal. J. Mol. Cell. Immunol. 2:179-190.
43. Smiley, S.T., M.H. Kaplan, and M.J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 275:977-979.
44. Seder, R.A., W.E. Paul, S.Z. Ben-Sasson, G.S. LeGros, A. Kagey-Sobotka, F.D. Finkelman, J.H. Pierce, and M. Plaut. 1991. Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils. Int. Arch. Allergy Appl. Immunol. 94:137-140.
45. Dvorak, A.M., R.A. Seder, W.E. Paul, E.S. Morgan, and S.J. Galli. 1994. Effects of interleukin-3 with or without the c-kit ligand, stem cell factor, on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro. Am. J. Pathol. 144:160-170.
46. Singer, M., J. Lefort, and B.B. Vargaftig. 2002. Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation, and secretion induced by rmIL-13 or antigen. Am. J. Respir. Cell Mol. Biol. 26:74-84.
47. Jones, R.E., F.D. Finkelman, R.B. Hester, and S.G. Kayes. 1994. Toxocara canis: failure to find IgE receptors (FcεR) on eosinophils from infected mice suggests that murine eosinophils do not kill helminth larvae by an IgE-dependent mechanism. Exp. Parasitol. 78:64-75.
48. de Andres, B., B. Cardaba, V. del Pozo, E. Martin-Orozco, S. Gallardo, P. Tramon, P. Palomino, and C. Lahoz. 1994. Modulation of the FcγRII and FcγRIII induced by GM-CSF, IFN-γ and IL-4 on murine eosinophils. Immunology. 83:155-160.
49. Finkelman, F.D., N. Villacreses, and J.M. Holmes. 1992. Role of antigen-specific T cell help in the generation of in vivo antibody responses. II. Sustained antigen-specific T cell help is required to induce a specific antibody response. J. Immunol. 149:3845-3850.
50. Finkelman, F.D., S.C. Morris, T. Orekhova, M. Mori, D. Donaldson, S.L. Reiner, N.L. Reilly, L. Schopf, and J.F. Urban Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J. Immunol. 164:2303-2310.
51. Madden, K.B., L. Whitman, C. Sullivan, W.C. Gause, J.F. Urban Jr., I.M. Katona, F.D. Finkelman, and T. Shea-Donohue. 2002. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J. Immunol. 169:4417-4422.
52. Strait, R.T., S.C. Morris, K. Smiley, J.F. Urban Jr., and F.D. Finkelman. 2003. IL-4 exacerbates anaphylaxis. J. Immunol. 170:3835-3842.
53. Urban, J.F., Jr., N. Noben-Trauth, L. Schopf, K.B. Madden, and F.D. Finkelman. 2001. Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites. J. Immunol. 167:6078-6081.
54. + T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285-1295.
55. Dent, L.A., M. Strath, A.L. Mellor, and C.J. Sanderson. 1990. Eosinophilia in transgenic mice expressing interleukin 5. J. Exp. Med. 172:1425-1431.
56. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 4:15-24.