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Volumn 9, Issue 12, 2008, Pages 1968-1974

Influence of δ-functional groups on the enantiorecognition of secondary alcohols by Candida antarctica lipase B

Author keywords

Bioorganic chemistry; Candida antarctica lipase B; Molecular dynamics; Molecular modeling; Organic chemistry

Indexed keywords

ALANINE; ALCOHOL; FUNGAL ENZYME; LIPASE B; PEPTIDE; PEPTIDE NH; SECONDARY ALCOHOL; SERINE; UNCLASSIFIED DRUG;

EID: 54349122272     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800036     Document Type: Article
Times cited : (19)

References (49)
  • 8
    • 54349117864 scopus 로고    scopus 로고
    • P. I. Dalko, L. Moisan, Angew. Chem. 2004, 116, 5248-5286; Angew. Chem. Int. Ed. 2004, 43, 5138-5175.
    • g) P. I. Dalko, L. Moisan, Angew. Chem. 2004, 116, 5248-5286; Angew. Chem. Int. Ed. 2004, 43, 5138-5175.
  • 9
    • 54349094430 scopus 로고    scopus 로고
    • M. Breuer, K. Ditrich, T. Habicher, B. Hauer, M. Keßeler, R. Stürmer, T. Zelinski, Angew. Chem. 2004, 116, 806-843; Angew. Chem. Int. Ed. 2004, 43, 788-824.
    • M. Breuer, K. Ditrich, T. Habicher, B. Hauer, M. Keßeler, R. Stürmer, T. Zelinski, Angew. Chem. 2004, 116, 806-843; Angew. Chem. Int. Ed. 2004, 43, 788-824.
  • 11
    • 33751499686 scopus 로고
    • R and S selectivity are used for typical sec-alcohols in which the large group has the higher priority in the sequential rule for determining the configuration according to the Cahn-Ingold-Prelog system
    • R. J. Kazlauskas, A. N. E. Weissfloch, A. T. Rappaport, L. A. Cuccia, J. Org. Chem. 1991, 56, 2656-2665; R and S selectivity are used for typical sec-alcohols in which the large group has the higher priority in the sequential rule for determining the configuration according to the Cahn-Ingold-Prelog system.
    • (1991) J. Org. Chem , vol.56 , pp. 2656-2665
    • Kazlauskas, R.J.1    Weissfloch, A.N.E.2    Rappaport, A.T.3    Cuccia, L.A.4
  • 29
    • 54349116657 scopus 로고    scopus 로고
    • The E value (enantiomeric ratio) is applied only to enantiomers. In this case, the starting substrate is a mixture of rac/diastereomeric diols. It was found that the stereochemistry of the inner alcohol does not affect the enzyme-catalyzed acetylation of the less hindered alcohol. The measured kinetic parameter was called the pseudo E value.
    • The E value (enantiomeric ratio) is applied only to enantiomers. In this case, the starting substrate is a mixture of rac/diastereomeric diols. It was found that the stereochemistry of the inner alcohol does not affect the enzyme-catalyzed acetylation of the less hindered alcohol. The measured kinetic parameter was called the pseudo E value.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.