Insect Excretory Mechanisms

Advances in Insect Physiology

Volumn 35, Issue , 2008, Pages 1-122

  O'Donnell, Michael ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 54349118635     PISSN: 00652806     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2806(08)00001-5     Document Type: Review

References (334)

1. Abu-Qare A.W., Elmasry E., and Abou-Donia M.B. A role for P-glycoprotein in environmental toxicology. J. Toxicol. Environ. Health B. Crit. Rev. 6 (2003) 279-288
2. Ainsworth C., Wan S., and Skaer H. Coordinating cell fate and morphogenesis in Drosophila renal tubules. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (2000) 931-937
3. Al-Fifi Z.I.A., Anstee J.H., and Bowler K. The action of inhibitors of protein kinases on fluid and ion secretion by Malpighian tubules of Locusta migratoria, L. J. Insect Physiol. 44 (1998) 973-980
4. Allan A.K., Du J., Davies S.A., and Dow J.A. Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiol. Genomics 22 (2005) 128-138
5. Aneshansley D.J., Marler C.E., and Beyenbach K.W. Transepithelial voltage measurements in isolated Malpighian tubules of Aedes aegypti. J. Insect Physiol. 35 (1988) 41-52
6. Anstee J.H., Bell D.M., and Fathpour H. Fluid and cation secretion by the Malpighian tubules of Locusta. J. Insect Physiol. 25 (1979) 373-380
7. Audsley N., Coast G.M., and Schooley D.A. The effect of Manduca sexta diuretic hormone on fluid transport by the Malpighian tubules and cryptonephric complex of Manduca sexta. J. Exp. Biol. 178 (1993) 231-243
8. Bain L.J., and LeBlanc G.A. Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol. Appl. Pharmacol. 141 (1996) 288-298
9. Balshin M., and Phillips J.E. Active absorption of amino acids in the rectum of the desert locust (Schistocerca gregaria). Nature 233 (1971) 53-55
10. Bard S.M. Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms. Aquat. Toxicol. 48 (2000) 357-389
11. Barthomeuf C., Demeule M., Grassi J., Saidkhodjaev A., and Beliveau R. Conferone from Ferula schtschurowskiana enhances vinblastine cytotoxicity in MDCK-MDR1 cells by competitively inhibiting P-glycoprotein transport. Planta Med. 72 (2006) 634-639
12. Bednarczyk D., Mash E.A., Aavula B.R., and Wright S.H. NBD-TMA: a novel fluorescent substrate of the peritubular organic cation transporter of renal proximal tubules. Pflug. Archiv. 440 (2000) 184-192
13. Begun D.J., and Whitley P. Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster. Heredity 85 (2000) 184-190
14. Ben-Aziz A., Meisner J., Aharonson N., and Ascher K.R.S. Excretion of unchanged organophosphorus compounds after their consumption by larvae of the Egyptian cotton leafworm, Spodoptera littoralis (Boisd.). Pestic. Biochem. Physiol. 6 (1976) 58-64
15. Beyenbach K.W. Transport of magnesium across biological membranes. Magnes. Trace Elem. 9 (1990) 233-254
16. Beyenbach K.W. Transport mechanisms of diuresis in Malpighian tubules of insects. J. Exp. Biol. 206 (2003) 3845-3856
17. Beyenbach K.W., and Masia R. Membrane conductances of principal cells in Malpighian tubules of Aedes aegypti. J. Insect Physiol. 48 (2002) 375-386
18. +-ATPase: molecular structure and function, physiological roles and regulation. J. Exp. Biol. 209 (2006) 577-589
19. Bijelic G., and O'Donnell M.J. Diuretic factors and second messengers stimulate secretion of the organic cation TEA by the Malpighian tubules of Drosophila melanogaster. J Insect Physiol. 51 (2005) 267-275
20. Bijelic G., Kim N., and O'Donnell M.J. Effects of dietary or injected organic cations on larval Drosophila melanogaster: mortality and elimination of tetraethylammonium from the haemolymph. Archiv. Insect. Biochem. Physiol. 60 (2005) 93-103
21. Bradley T.J. Comprehensive insect physiology, biochemistry and pharmacology. In: Kerkut G.A., and Gilbert L.I. (Eds). The Excretory System: Structure and Function vol. 4 (1985), Pergamon, London and New York 421-465
22. Bradley T.J. Physiology of osmoregulation in mosquitoes. Ann. Rev. Entomol. 32 (1987) 439-462
23. Bradley T.J., and Phillips J.E. The location and mechanism of hyperosmotic fluid secretion in the rectum of the saline-water mosquito larvae Aedes taeniorhynchus. J. Exp. Biol. 66 (1977) 111-126
24. Bradley T.J., and Satir P. Insect axopods. J. Cell Sci. 35 (1979) 165-175
25. Braeckman B., Smagghe G., Brutsaert N., Cornelis R., and Raes H. Cadmium uptake and defense mechanism in insect cells. Environ. Res. 80 (1999) 231-243
26. Bresler V.M., Belyaeva E.A., and Mozhayeva M.G. A comparative study on the system of active transport of organic acids in Malpighian tubules of insects. J. Insect Physiol. 36 (1990) 259-270
27. Buchanan B.B., Gruissem W., and Jones R.L. Biochemistry and Molecular Biology of Plants (2000), American Society of Plant Physiologists, Rockville, MD
28. Buchwalter D.B., and Luoma S.N. Differences in dissolved cadmium and zinc uptake among stream insects: mechanistic explanations. Environ. Sci. Technol. 39 (2005) 498-504
29. Buckner J.S. Hormonal control of uric acid storage in the fat body during last-larval instar of Manduca sexta. J. Insect Physiol. 28 (1982) 987-993
30. Buckner J.S., and Newman S.M. Uric acid storage in the epidermal cells of Manduca sexta: localization and movement during the larval-pupal transformation. J. Insect Physiol. 36 (1990) 219-229
31. Buckner J.S., Caldwell J.M., and Knoper J.A. Subcellular localization of uric acid storage in the fat body of Manduca sexta during the larval-pupal transformation. J. Insect Physiol. 31 (1985) 741-753
32. Buckner J.S., Henderson T.A., Ehresmann D.D., and Graf G. Structure and composition of urate storage granules from the fat body of Manduca sexta. Insect Biochem. 20 (1990) 203-214
33. Bursell E. Nitrogenous waste products of the tsetse fly, Glossina morsitans. J. Insect Physiol. 11 (1965) 993-1001
34. Buss D.S., McCaffery A.R., and Callaghan A. Evidence for P-glycoprotein modification of insecticide toxicity in mosquitoes of the Culex pipiens complex. Med. Vet. Entomol. 16 (2002) 218-222
35. Byrne D.N., and Miller W.B. Carbohydrate and amino acid composition of phloem sap and honeydew produced by Bemisia tabaci. J. Insect Physiol. 36 (1990) 433-439
36. Cannings S.C. The influence of salinity on the cuticular permeability of Cenocorixa bifida hungerfordi Lansbury (Hemiptera: Corixidae). Can. J. Zool. 59 (1981) 1505-1509
37. Chamberlin M.E., and Phillips J.E. Regulation of haemolymph amino acid levels and active secretion of proline by Malpighian tubules of locusts. Can. J. Zool. 60 (1982) 2745-2752
38. Chintapalli V.R., Wang J., and Dow J.A. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat. Genet. 39 (2007) 715-720
39. Coast G. The endocrine control of salt balance in insects. Gen. Comp. Endocrinol. 152 (2007) 332-338
40. Coast G.M., Orchard I., Phillips J.E., and Schooley D.A. Insect diuretic and antidiuretic hormones. Adv. Insect Physiol. 29 (2002) 279-409
41. Cochran D.G. Comprehensive insect physiology, biochemistry and pharmacology. In: Kerkut G.A., and Gilbert L.I. (Eds). Nitrogenous Excretion (1985), Pergamon, London 467-506
42. - and pH gradients in extracellular unstirred layers: ion secretion and reabsorption by Malpighian tubules of an insect, Rhodnius prolixus. J. Exp. Biol. 200 (1997) 1627-1638
43. 2 regulation in the freshwater water boatman, Cenocorixa blaisdelli (Hung.) (Hemiptera, Corixidae). Physiol. Zool. 60 (1987) 465-471
44. Cooper P.D., Scudder G.G.E., and Quamme G.A. Segmental differences in secretion by the Malpighian tubules of the fresh water dwelling corixid, Cenocorixa blaisdelli (Hung.) (Corixidae, Hemiptera). J. Insect Physiol. 35 (1989) 531-536
45. Crafts-Brandner S.J. Plant nitrogen status rapidly alters amino acid metabolism and excretion in Bemisia tabaci. J. Insect Physiol. 48 (2002) 33-41
46. Craig A., Hare L., Charest P.M., and Tessier A. Effect of exposure regime on the internal distribution of cadmium in Chironomus staegeri larvae (Insecta, Diptera). Aquat. Toxicol. 41 (1998) 265-275
47. Craig A., Hare L., and Tessier A. Experimental evidence for cadmium uptake via calcium channels in the aquatic insect Chironomus staegeri. Aquat. Toxicol. 44 (1999) 255-262
48. Dalton T., and Windmill D.M. The permeability characteristics of the isolated Malphigian tubules of the housefly Musca domestica. Comp. Biochem. Physiol. 69A (1981) 211-217
49. David W.A.L., and Gardiner B.O.C. Systemic insecticidal action of nicotine and certain other organic bases. Ann. Appl. Biol. 40 (1953) 91-105
50. Davies S.A., and Day J.P. cGMP signalling in a transporting epithelium. Biochem. Soc. Trans. 34 (2006) 512-514
51. Davies S.A., Goodwin S.F., Kelly D.C., Wang Z., Sozen M.A., Kaiser K., and Dow J.A. Analysis and inactivation of vha55, the gene encoding the vacuolar ATPase B-subunit in Drosophila melanogaster reveals a larval lethal phenotype. J. Biol. Chem. 271 (1996) 30677-30684
52. Day J.P., Houslay M.D., and Davies S.A. A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochem. J. 393 (2006) 481-488
53. Deeley R.G., Westlake C., and Cole S.P. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol. Rev. 86 (2006) 849-899
54. Delaunay H. L'excretion azotée des invertébrés. Biol. Rev. 6 (1931) 265-301
55. Dijkstra S., Lohrmann E., Van Kerkhove E., and Greger R. Characteristics of the luminal proton pump in Malpighian tubules of the ant. Ren. Physiol. Biochem. 17 (1994) 27-39
56. 14C malathion in susceptible and resistant strains of Plutella xylostella. Comp. Biochem. Physiol., C 101 (1992) 583-588
57. + concentration gradients adjacent to the surface of anal papillae of the mosquito Aedes aegypti: application of self-referencing ion-selective microelectrodes. J. Exp. Biol. 208 (2005) 603-610
58. Donini A., Patrick M.L., Bijelic G., Christensen R.J., Ianowski J.P., Rheault M.R., and O'Donnell M.J. Secretion of water and ions by Malpighian tubules of larval mosquitoes: effects of diuretic factors, 2nd messengers and salinity. Physiol. Biochem. Zool. 79 (2006) 645-655
59. Douglas A.E. The nutritional quality of phloem sap utilized by natural aphid populations. Ecol. Entomol. 18 (1993) 31-38
60. Douglas A.E. Nutritional interactions in insect-microbial symbiosis: aphids and their symbiotic bacteria Buchnera. Ann. Rev. Entomol. 43 (1998) 17-37
61. Dow J.A. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J. Bioenerg. Biomembr. 31 (1999) 75-83
62. Dow J.A., and Davies S.A. Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiol. Rev. 83 (2003) 687-729
63. Dow J.A., and Davies S.A. The Malpighian tubule: rapid insights from post-genomic biology. J. Insect Physiol. 52 (2006) 365-378
64. Dow J.A., Davies S.A., Guo Y., Graham S., Finbow M.E., and Kaiser K. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. J. Exp. Biol. 200 (1997) 237-245
65. Drose S., and Altendorf K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J. Exp. Biol. 200 (1997) 1-8
66. Dube K.A., McDonald D.G., and O'Donnell M.J. Calcium homeostasis in larval and adult Drosophila melanogaster. Archiv. Insect Biochem. Physiol. 44 (2000) 27-39
67. Dube K.A., McDonald D.G., and O'Donnell M.J. Calcium transport by isolated anterior and posterior Malpighian tubules of Drosophila melanogaster: roles of sequestration and secretion. J. Insect Physiol. 46 (2000) 1449-1460
68. Dubreuil R.R. Copper cells and stomach acid secretion in the Drosophila midgut. Int. J. Biochem. Cell Biol. 36 (2004) 745-752
69. Duffey S.S., and Scudder G.G.E. Cardiac glycosides in Oncopeltus fasciatus (Dallas) (Hemiptera: Lygaeidae). I. The uptake and distribution of natural cardenolides in the body. Can. J. Zool. 52 (1974) 283-290
70. Duffey S.S., Blum M.S., Isman M.B., and Scudder G.G.E. Cardiac glycosides: a physical system for their sequestration by the milkweed bug. J. Insect Physiol. 24 (1978) 639-645
71. Echevarria M., Ramirez-Lorca R., Hernandez C.S., Gutierrez A., Mendez-Ferrer S., Gonzalez E., Toledo-Aral J.J., Ilundain A.A., and Whittembury G. Identification of a new water channel (Rp-MIP) in the Malpighian tubules of the insect Rhodnius prolixus. Pflug. Archiv. 442 (2001) 27-34
72. Ehresmann D.D., Buckner J.S., and Graf G. Uric acid translocation from the fat body of Manduca sexta during the pupal-adult transformation: effects of 20-hydroxyecdysone. J. Insect Physiol. 36 (1990) 173-180
73. + channels in Drosophila melanogaster renal function. J. Exp. Biol. 208 (2005) 3771-3783
74. Fabrick J.A., Kanost M.R., and Baker J.E. RNAi-induced silencing of embryonic tryptophan oxygenase in the pyralid moth, Plodia interpunctella. J. Insect Sci. 4 (2004) 15
75. Farquharson P.A. A study of the Malpighian tubules of the pill millipede, Glomeris marginata (Viller3). III. The permeability characteristics of the tubule. J. Exp. Biol. 60 (1974) 41-51
76. Feyereisen R. Insect P450 enzymes. Annu. Rev. Entomol. 44 (1999) 507-533
77. Frankfater C., Schuhly W., Fronczek F.R., and Slattery M. Processing of a sesquiterpene lactone by Papilio glaucus caterpillars. J. Chem. Ecol. 31 (2005) 2541-2550
78. Friedman T.B., and Johnson D.H. Temporal control of urate oxidase activity in Drosophila: evidence of an autonomous timer in Malpighian tubules. Science 197 (1977) 477-479
79. Gäde G. The hormonal integration of insect flight metabolism. Zool. Jahrb. 96 (1992) 211-225
80. Gade G., Hoffmann K.H., and Spring J.H. Hormonal regulation in insects: facts, gaps, and future directions. Physiol. Rev. 77 (1997) 963-1032
81. Gaertner L.S., and Morris C.E. Accumulation of daunomycin and fluorescent dyes by drug-transporting Malpighian tubule cells of the tobacco hornworm, Manduca sexta. Tissue Cell 31 (1999) 185-194
82. Gaertner L.S., Murray C.L., and Morris C.E. Transepithelial transport of nicotine and vinblastine in isolated malpighian tubules of the tobacco hornworm (Manduca sexta) suggests a P-glycoprotein-like mechanism. J. Exp. Biol. 201 (1998) 2637-2645
83. Garayoa M., Villaro A.C., Klein U., Zimmermann B., Montuenga L.M., and Sesma P. Immunocytochemical localization of a vacuolar-type-ATPase in Malpighian tubules of the ant Formica polyctena. Cell Tissue Res. 282 (1995) 343-350
84. 2)-dihydroazadirachtin A in the blood-feeding bug, Rhodnius prolixus. J. Insect Physiol. 35 (1989) 743-749
85. Geiser D.L., Chavez C.A., Flores-Munguia R., Winzerling J.J., and Pham D.Q. Aedes aegypti ferritin. Eur. J. Biochem. 270 (2003) 3667-3674
86. Geiser D.L., Zhang D., and Winzerling J.J. Secreted ferritin: mosquito defense against iron overload?. Insect Biochem. Mol. Biol. 36 (2006) 177-187
87. Giannakou M.E., and Dow J.A.T. Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family. J. Exp. Biol. 204 (2001) 3703-3716
88. Goldstrohm D.A., Pennington J.E., and Wells M.A. The role of haemolymph proline as a nitrogen sink during blood meal digestion by the mosquito Aedes aegypti. J. Insect Physiol. 49 (2003) 115-121
89. Graca-Souza A.V., Maya-Monteiro C., Paiva-Silva G.O., Braz G.R., Paes M.C., Sorgine M.H., Oliveira M.F., and Oliveira P.L. Adaptations against heme toxicity in blood-feeding arthropods. Insect Biochem. Mol. Biol. 36 (2006) 322-335
90. Grodowitz M.J., Broce A.B., and Kramer K.J. Morphology and biochemical composition of mineralized granules from the Malpighian tubules of Musca autumnalis de Geer larvae (Diptera: Muscidae). Insect Biochem. 17 (1987) 335-345
91. Groenendijk D., Lucker S.M., Plans M., Kraak M.H., and Admiraal W. Dynamics of metal adaptation in riverine chironomids. Environ. Pollut. 117 (2002) 101-109
92. Gutierrez A.M., Hernandez C.S., and Whittembury G. A model for fluid secretion in Rhodnius upper Malpighian tubules (UMT). J. Membr. Biol. 202 (2004) 105-114
93. +-ATPases. J. Exp. Biol. 200 (1997) 139-147
94. - channel blockers and acetazolamide. J. Insect Physiol. 43 (1997) 657-665
95. Hanna M.A., and Atallah Y.H. Penetration and biodegradation of carbaryl in susceptible and resistant strains of the Egyptian cotton leafworm. J. Econ. Entomol. 64 (1971) 1391-1395
96. Harrison J.F., and Phillips J.E. Recovery from acute haemolymph acidosis in unfed locusts: II. Role of ammonium and titratable acid excretion. J. Exp. Biol. 165 (1992) 97-110
97. + V-ATPases. J. Exp. Biol. 200 (1997) 203-216
98. Haunerland N.H., and Bowers W.S. Comparative studies on pharmacokinetics and metabolism of anti-juvenile hormone precocene II. Archiv. Insect Biochem. Physiol. 2 (1985) 55-63
99. Hayashi Y. Xanthine dehydrogenase in the silkworm, Bombyx mori L. Nature 186 (1960) 1053-1054
100. Hazelton S.R., Felgenhauer B.E., and Spring J.H. Ultrastructural changes in the Malpighian tubules of the house cricket, Acheta domesticus, at the onset of diuresis: a time study. J. Morphol. 247 (2001) 80-92
101. Hegarty J.L., Zhang B., Pannabecker T.L., Petzel D.H., Baustian M.D., and Beyenbach K.W. Dibutyryl cyclic AMP activates bumetanide-sensitive electrolyte transport in Malpighian tubules. Am. J. Physiol. 216 (1991) C521-C529
102. Hemingway J., and Ranson H. Insecticide resistance in insect vectors of human disease. Annu. Rev. Entomol. 45 (2000) 371-391
103. Herbst D.B., and Bradley T.J. A Malpighian tubule lime gland in an insect inhabiting alkaline salt lakes. J. Exp. Biol. 145 (1989) 63-78
104. Herbst D.B., Conte F.P., and Brookes V.J. Osmoregulation in an alkaline salt lake insect, Ephydra (hydropyrus) hians Say (Diptera: Ephydridae) in relation to water chemistry. J. Insect Physiol. 34 (1988) 903-909
105. Hernandez C.S., Gutierrez A.M., Vargas-Janzen A., Noria F., Gonzalez E., Ruiz V., and Whittembury G. Fluid secretion in Rhodnius upper malpighian tubules (UMT): water osmotic permeabilities and morphometric studies. J. Membr. Biol. 184 (2001) 283-290
106. Higgins C.F., and Gottesman M.M. Is the multidrug transporter a flippase?. Trends Biochem. Sci. 17 (1992) 18-21
107. Hopkins T.L., and Lofgren P.A. Adenine metabolism and urate storage in the cockroach Leucophaea maderae. J. Insect Physiol. 14 (1968) 1803-1814
108. Ianowski J.P., and O'Donnell M.J. Transepithelial potential in Malpighian tubules of Rhodnius prolixus: lumen-negative voltages and the triphasic response to serotonin. J. Insect Physiol. 46 (2001) 107-117
109. - conductance. J. Exp. Biol. 207 (2004) 2599-2609
110. + across the apical membrane in Malpighian (renal) tubule cells of Rhodnius prolixus. J. Exp. Biol. 209 (2006) 1964-1975
111. - cotransport across the basolateral membrane. J. Exp. Biol. 205 (2002) 1645-1655
112. + in bumetanide-sensitive transport by Malpighian tubules of Rhodnius prolixus. J. Exp. Biol. 207 (2004) 3707-3716
113. Isaacson L., and Nicolson S. A reappraisal of the oil-gap technique for the measurement of transtubular potentials in insect epithelia. J. Exp. Biol. 141 (1989) 429-440
114. Isman M.B., Proksch P., and Witte L. Metabolism and excretion of acetylchromenes by the migratory grasshopper. Archiv. Insect Biochem. Physiol. 6 (1987) 109-120
115. Iyengar S., Arnason J.T., Philogene B.J.R., Werstiuk N.H., and Morand P. Comparative metabolism of the phototoxic allelochemical α-terthienyl in three species of lepidopterans. Pest. Biochem. Physiol. 37 (1990) 154-164
116. Jarial M.S., Scudder G.G.E., and Teraguchi S. Observations on the labium of Corixidae (Hemiptera). Can. J. Zool. 47 (1969) 713-715
117. Johnson D.L., Majak W., and Benn M.H. Excretion of miserotoxin and detoxification of the aglycone by grasshoppers (Orthoptera: Acrididae). Phytochemistry 58 (2001) 739-742
118. Kamm C.D., Tawara J.N., and Stermitz F.R. Spruce budworm larval processing of piperidine alkaloids from spruce needles. J. Chem. Ecol. 24 (1998) 1153-1160
119. + transport in reconstituted proteoliposomes. Am. J. Physiol. 292 (2007) F1501-F1512
120. Karnaky Jr. K.J., Petzel D., Sedmerova M., Gross A., and Miller D.S. Mrp2-like transport of Texas Red by Malpighian tubules of the common American cockroach, Periplaneta americana. Bull. Mt. Des. Isl. Biol. Lab. 39 (2000) 52-53
121. Karnaky Jr. K.J., Sedmerova M., Petzel D., Bridges J., Boatwright S.W., and Miller D.S. Mrp2-like transport in the Malpighian tubule of the cricket, Acheta domesticus. Bull. Mt. Des. Isl. Biol. Lab. 40 (2001) 53-55
122. Karnaky Jr. K.J., Hazen-Martin D., and Miller D.S. The xenobiotic transporter, MRP2, in epithelia from insects, sharks, and the human breast: implications for health and disease. J. Exp. Zool. 300 (2003) 91-97
123. Kaufmann N., Mathai J.C., Hill W.G., Dow J.A., Zeidel M.L., and Brodsky J.L. Developmental expression and biophysical characterization of a Drosophila melanogaster aquaporin. Am. J. Physiol. 289 (2005) C397-C407
124. 4 content. J. Exp. Biol. 61 (1974) 749-760
125. Kim Y.K., and Dantzler W.H. Relation of membrane potential to basolateral TEA transport in isolated snake proximal renal tubules. Am. J. Physiol. 268 (1995) R1539-R1545
126. Klein U. The insect V-ATPase, a plasma membrane proton pump energizing secondary active transport: immunological evidence for the occurrence of a V-ATPase in insect ion-transporting epithelia. J. Exp. Biol. 172 (1992) 345-354
127. Knepper M.A., Good D.W., and Burg M.B. Mechanism of ammonia secretion by cortical collecting ducts of rabbits. Am. J. Physiol. 247 (1984) F729-F738
128. Knowles G. The reduced glucose permeability of the isolated Malpighian tubules of the blowfly Calliphora vomitoria. J. Exp. Biol. 62 (1975) 327-334
129. Knowles G. The removal of sulphate by the excretory apparatus of the blowfly Calliphora vomitoria. J. Exp. Biol. 63 (1975) 237-248
130. Komnick H., and Schmitz M. Cutane chloridaufnahme aus hypo-osmotischer Konsentration durch di chlorizellen von Corixa punctata. J. Insect Physiol. 23 (1977) 165-173
131. Komoto N., Yukuhiro K., and Tamura T. Structure and expression of tandemly duplicated xanthine dehydrogenase genes of the silkworm (Bombyx mori). Insect Mol. Biol. 8 (1999) 73-83
132. Koren G., Woodland C., and Ito S. Toxic digoxin-drug interactions: the major role of renal P-glycoprotein. Vet. Hum. Toxicol. 40 (1998) 45-46
133. Krueger R.A., Broce A.B., and Hopkins T.L. Dissolution of granules in the Malpighian tubules of Musca autumnalis de greer, during mineralization of the puparium. J. Insect Physiol. 33 (1987) 255-263
134. Krueger R.A., Broce A.B., Hopkins T.L., and Kramer K.J. Calcium transport from Malpighian tubules to puparial cuticle of Musca autumnalis. J. Comp. Physiol. B 158 (1988) 413-419
135. Kuppers J., Plagemann A., and Thurm U. Uphill transport of water by electro-osmosis. J. Memb. Biol. 91 (1986) 107-119
136. Kuterbach D.A., and Walcott B. Iron-containing cells in the honey-bee (Apis mellifera). I. Adult morphology and physiology. J. Exp. Biol. 126 (1986) 375-387
137. Kuterbach D.A., and Walcott B. Iron-containing cells in the honey-bee (Apis mellifera). II. Accumulation during development. J. Exp. Biol. 126 (1986) 389-401
138. Kuterbach D.A., Walcott B., Reeder R.J., and Frankel R.B. Iron containing cells in the honey bee (Apis mellifera). Science 218 (1982) 695-697
139. Kuzhivelil B.T., and Mohamed U.V.K. The concentration of ammonia in the excreta of sixth instar larvae of Lamida moncusalis Walker (Pyralidae: Lepidoptera) during development. Experientia 43 (1987) 879-880
140. Lane N.J., and Skaer H.B. Intercellular junctions in insects. Adv. Insect Pkysiol. 15 (1980) 35-213
141. Lazar K.V., and Mohamed U.V.K. The excretion of urea by the larvae of Spodoptera mauritia Boisd. (Noctuidae: Lepidoptera) during development. Experientia 35 (1979) 1468
142. Leader J.P., and O'Donnell M.J. Transepithelial transport of fluorescent P-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets. J. Exp. Biol. 208 (2005) 4363-4376
143. Lembke H.F., and Cochran D.G. Uric acid in the Malpighian tubules of some blattellid cockroaches. Comp. Biochem. Physiol. 91A (1988) 587-597
144. Leslie E.M., Deeley R.G., and Cole S.P. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204 (2005) 216-237
145. Levinson G., and Bradley T.J. Removal of insect basal laminae using elastase. Tissue Cell 16 (1984) 367-375
146. + uptake across the basal membrane of Malpighian tubules of Formica polyctena: the effects of ions and inhibitors. J. Exp. Biol. 195 (1994) 123-145
147. Li X., Schuler M.A., and Berembaum M.R. Jasmonate and salicylate induce expression of herbivore cytochrome P450 genes. Nature 419 (2002) 712-715
148. Lindqvist L., Block M., and Tjalve H. Distribution and excretion of Cd, Hg, Methyl-Hg and Zn in the predatory beetle Pterostichus niger (Coleoptera: Carabidae). Environ. Toxicol. Chem. 14 (1995) 1195-1201
149. +-ATPase to basolateral ion transport in Malpighian tubules of Drosophila melanogaster. J. Exp. Biol. 202 (1999) 1561-1570
150. Linton S.M., and O'Donnell M.J. Novel aspects of the transport of organic anions by the Malpighian tubules of Drosophila melanogaster. J. Exp. Biol. 203 (2000) 3575-3584
151. Lison L. Études histophysiologiques sur les tubes de Malpighi des insectes. I. Elimination des colorants acides chez les Orthoptères. Archs. Biol. Paris 48 (1937) 321-360
152. Locke M., and Nichol H. Iron economy in insects: Transport, metabolism, and storage. Annu. Rev. Entomol. 37 (1992) 195-215
153. Loveridge J.P. Studies on the water balance of adult locusts. III. The water balance of non-flying locusts. Zool. Afr. 10 (1975) l-28
154. Machin J. Water vapor absorption in insects. Am. J. Physiol. 244 (1983) R187-R192
155. Maddrell S.H., Gardiner B.O., Pilcher D.E., and Reynolds S.E. Active transport by insect Malpighian tubules of acidic dyes and of acylamides. J. Exp. Biol. 61 (1974) 357-377
156. Maddrell S.H., Whittembury G., Mooney R.L., Harrison J.B., Overton J.A., and Rodriguez B. The fate of calcium in the diet of Rhodnius prolixus: storage in concretion bodies in the Malpighian tubules. J. Exp. Biol. 157 (1991) 483-502
157. Maddrell S.H.P. Secretion by the Malpighian tubules of Rhodnius. The movements of ions and water. J. Exp. Biol. 51 (1969) 71-97
158. Maddrell S.H.P. The mechanisms of insect excretory systems. Adv. Insect Physiol. 8 (1971) 199-331
159. Maddrell S.H.P. Transport of ions and water in animal tissues. In: Gupta B.L., Moreton R.B., Oschman J.L., and Wall B.J. (Eds). Insect Malpighian tubules (1977), Academic Press, London 541-569
160. Maddrell S.H.P. The functional design of the insect excretory system. J. Exp. Biol. 90 (1981) 1-15
161. Maddrell S.H.P. The fastest fluid-secreting cell known: the upper Malpighian tubule cell of Rhodnius. BioEssays 13 (1991) 357-362
162. Maddrell S.H.P., and Gardiner B.O.C. The passive permeability of insect Malpighian tubules to organic solutes. J. Exp. Biol. 60 (1974) 641-652
163. Maddrell S.H.P., and Gardiner B.O.C. Induction of transport of organic anions in Malpighian tubules of Rhodnius. J. Exp. Biol. 63 (1975) 755-761
164. Maddrell S.H., and Gardiner B.O.C. Excretion of alkaloids by Malpighian tubules of insects. J. Exp. Biol. 64 (1976) 267-281
165. Maddrell S.H.P., and O'Donnell M.J. Insect Malpighian tubules: V-ATPase action in ion and fluid transport. J. Exp. Biol. 172 (1992) 417-429
166. Maddrell S.H.P., and O'Donnell M.J. Gramicidin switches transport in insect epithelia from potassium to sodium. J. Exp. Biol. 177 (1993) 287-292
167. Maddrell S.H.P., and Overton J.A. Stimulation of sodium transport and fluid secretion by ouabain in an insect Malpighian tubule. J. Exp. Biol. 137 (1988) 265-276
168. Maddrell S.H.P., and Phillips J.E. Active transport of sulphate ions by the Malpighian tubules of the larvae of the mosquito Aedes campestris. J. Exp. Biol. 62 (1975) 367-378
169. Maddrell S.H.P., and Phillips J.E. Secretion of hypoosmotic fluid by the lower Malpighian tubules of Rhodnius prolixus. J. Exp. Biol. 62 (1975) 671-683
170. Maddrell S.H.P., and Phillips J.E. Induction of sulphate sransport and hormonal control of fluid secretion by Malpighian tubules of larvae of the mosquito, Aedes taeniorhynchus. J. Exp. Biol. 72 (1978) 181-202
171. Maddrell S.H.P., O'Donnell M.J., and Caffrey R. The regulation of haemolymph potassium activity during initiation and maintenance of diuresis in fed Rhodnius prolixus. J. Exp. Biol. 177 (1993) 273-285
172. Majak W., Johnson D.L., and Benn M.H. Detoxification of 3-nitropropionic acid and karakin by melanopline grasshoppers. Phytochem. 49 (1998) 419-422
173. Maroni G., and Watson D. Uptake and binding of cadmium, copper and zinc in Drosophila melanogaster larvae. Insect Biochem. 15 (1985) 55-63
174. Marshall A.T., and Wood R.W. Ionic and osmotic regulation by larvae of the sheep blowfly Lucilia cuprina. J. Insect Physiol. 36 (1990) 635-639
175. Marshall A.T., and Wright A. Ultrastructure changes associated with osmoregulation in the hindgut cells of a saltwater insect, Ephydrell sp. (ephydridae, diptera). Tissue Cell 6 (1974) 301-308
176. Marshall A.T., Cooper P., Rippon G.D., and Patak A.E. Ion and fluid secretion by different segments of the Malpighian tubules of the black field cricket Teleogryllus oceanicus. J. Exp. Biol. 177 (1993) 1-22
177. Martinez-Barnetche J., Garcia Solache M., Neri Lecona A., Tello Lopez A.T., del Carmen Rodriguez M., Gamba G., Vazquez N., Rodriguez M.H., and Lanz-Mendoza H. Cloning and functional characterization of the Anopheles albimanus DMT1/NRAMP homolog: implications in iron metabolism in mosquitoes. Insect Biochem. Mol. Biol. 37 (2007) 532-539
178. Martini S.V., Goldenberg R.C., Fortes F.S., Campos-de-Carvalho A.C., Falkenstein D., and Morales M.M. Rhodnius prolixus Malpighian tubule's aquaporin expression is modulated by 5-hydroxytryptamine. Archiv. Insect Biochem. Physiol. 57 (2004) 133-141
179. Masia R., Aneshansley D., Nagel W., Nachman R.J., and Beyenbach K.W. Voltage clamping single cells in intact Malpighian tubules of mosquitoes. Am. J. Physiol. Renal Physiol. 279 (2000) F744-F754
180. Meredith J., and Phillips J.E. Rectal ultrastructure in salt- and freshwater mosquito larvae in relation to physiological state. Cell Tissue Res. 138 (1973) 1-22
181. Meredith J., Moore L., and Scudder G.G.E. Excretion of ouabain by Malpighian tubules of Oncopeltus fasciatus. Am. J. Physiol. 246 (1984) R705-R715
182. Meredith J., Ring M., Macins A., Marschall J., Cheng N.N., Theilmann D., Brock H.W., and Phillips J.E. Locust ion transport peptide (ITP): primary structure, cDNA and expression in a baculovirus system. J. Exp. Biol. 199 (1996) 1053-1061
183. Merzendorfer H., Graf R., Huss M., Harvey W.R., and Wieczorek H. Regulation of proton-translocating V-ATPases. J. Exp. Biol. 200 (1997) 225-235
184. Meulemans W., and De Loof A. Transport of the cationic fluorochrome rhodamine 123 in an insect's Malpighian tubule: indications of a reabsorptive function of the secondary cell type. J. Cell Sci. 101 (1992) 349-361
185. Miles P.W. A modification of Wigglesworth's model for the excretion of uric acid in insects, in the light of modern hypotheses of ion transport. J. Theor. Biol. 12 (1966) 130-132
186. Montoreano R., Triana F., Abate T., and Rangel-Aldao R. Cyclic AMP in the Malpighian tubule fluid and in the urine of Rhodnius prolixus. Gen. Comp. Endocrinol. 77 (1990) 136-142
187. Mordue A.J., and Blackwell A. Azadirachtin: an update. J. Insect Physiol. 39 (1993) 903-924
188. Mullins D.E. Nitrogen metabolism in the American cockroach: an examination of whole body ammonium and other cations excreted in relation to water requirements. J. Exp. Biol. 61 (1974) 541-556
189. Mullins D.E., and Cochran D.G. Nitrogen excretion in cockroaches: uric acid is not a major product. Science 177 (1972) 699-701
190. Mullins D.E., and Cochran D.G. Nitrogenous excretory materials from the American cockroach. J. Insect Physiol. 19 (1973) 1007-1018
191. Mullins D.E., and Cochran D.G. Tryptophan metabolite excretion by the American cockroach. Comp. Biochem. Physiol., B 44 (1973) 549-555
192. Mullins D.E., and Cochran D.G. Nitrogen metabolism in the American cockroach. II. An examination of negative nitrogen balance with respect to mobilization of uric acid and stores. Comp. Biochem. Physiol. 50A (1975) 501-510
193. Murray C.L., Quaglia M., Arnason J.T., and Morris C.E. A putative nicotine pump at the metabolic blood-brain barrier of the tobacco hornworm. J. Neurobiol. 25 (1994) 23-34
194. Nachman R.J., Strey A., Isaac E., Pryor N., Lopez J.D., Deng J.G., and Coast G.M. Enhanced in vivo activity of peptidase-resistant analogs of the insect kinin neuropeptide family. Peptides 23 (2002) 735-745
195. Neufeld D.S.G., Kauffman R., and Kurtz Z. Specificity of the fluorescein transport process in Malpighian tubules of the cricket Acheta domesticus. J. Exp. Biol. 208 (2005) 2227-2236
196. Nicolson S., and Isaacson L. Patch clamp of the basal membrane of beetle Malpighian tubules: direct demonstration of potassium channels. J. Insect Physiol. 36 (1990) 877-884
197. Nicolson S., Isaacson L., and Gerneke D. A new method of preparing the basal membrane of renal tubules for patch clamp, using beetle malpihian tubules. Pflug. Archiv. 417 (1991) 654-656
198. Nijhout H.F. Excretory role of the midgut in larvae of the tobacco hornworm, Manduca sexta (L.). J. Exp. Biol. 62 (1975) 221-230
199. Nitao J.K. Metabolism and excretion of the furanocoumarin xanthotoxin by parsnip webworm, Depressaria pastinacella. J. Chem. Ecol. 16 (1990) 417-428
200. Noble-Nesbitt J. Water balance in the Firebrat, Thermobia domestica (Packard). The site of uptake of water from the atmosphere. J. Exp. Biol. 52 (1970) 193-200
201. O'Connor K.R., and Beyenbach K.W. Chloride channels in apical membrane patches of stellate cells of Malpighian tubules of Aedes aegypti. J. Exp. Biol. 204 (2001) 367-378
202. O'Donnell M.J., and Leader J.P. Changes in fluid secretion rate alter net transepithelial transport of MRP2 and P-glycoprotein substrates in Malpighian tubules of Drosophila melanogaster. Archiv. Insect Biochem. Physiol. 63 (2006) 123-134
203. O'Donnell M.J., and Machin J. Water vapor absorption by terrestrial organisms. Adv. Comp. Environ. Physiol. 2 (1988) 47-90
204. O'Donnell M.J., and Machin J. Ion activities and electrochemical gradients in the mealworm rectal complex. J. Exp. Biol. 155 (1991) 375-402
205. O'Donnell M.J., and Maddrell S.H.P. Secretion by the Malpighian tubules of Rhodnius prolixus Stal: electrical events. J. Exp. Biol. 110 (1984) 275-290
206. O'Donnell M.J., and Maddrell S.H.P. Fluid reabsorption and ion transport by the lower Malpighian tubules of adult female Drosophila. J. Exp. Biol. 198 (1995) 1643-1647
207. O'Donnell M.J., and Rheault M.R. Ion-selective microelectrode analysis of salicylate transport by the Malpighian tubules and gut of Drosophila melanogaster. J Exp. Biol. 208 (2005) 93-104
208. O'Donnell M.J., Aldis G.K., and Maddrell S.H.P. Measurements of osmotic permeability in the Malpighian tubules of an insect, Rhodnius prolixus Stal. Proc. Roy. Soc. Lond. B 216 (1982) 267-277
209. O'Donnell M.J., Maddrell S.H.P., and Gardiner B.O.C. Transport of uric acid by the Malpighian tubules of Rhodnius prolixus and other insects. J. Exp. Biol. 103 (1983) 169-184
210. O'Donnell M.J., Maddrell S.H.P., and Gardiner B.O.C. Passage of solutes through the walls of the Malpighian tubules of Rhodnius by paracellular and transcellular routes. Am. J. Physiol. 246 (1984) R759-R769
211. O'Donnell M.J., Dow J.A.T., Huesmann G.R., Tublitz N.J., and Maddrell S.H.P. Separate control of anion and cation transport in Malpighian tubules of Drosophila melanogaster. J. Exp. Biol. 199 (1996) 1163-1175
212. O'Donnell M.J., Rheault M.R., Davies S.A., Rosay P., Harvey B.J., Maddrell S.H.P., Kaiser K., and Dow J.A.T. Hormonally-controlled chloride movement across Drosophila tubules is via ion channels in stellate cells. Am. J. Physiol. 43 (1998) R1039-R1049
213. O'Donnell M.J., Ianowski J.P., Linton S.M., and Rheault M.R. Inorganic and organic anion transport by insect renal epithelia. Biochim. Biophys. Acta 1618 (2003) 194-206
214. Orchard I. Serotonin: a coordinator of feeding-related physiological events in the blood-gorging bug, Rhodnius prolixus. Comp. Biochem. Physiol. A 144 (2006) 316-324
215. Paiva-Silva G.O., Cruz-Oliveira C., Nakayasu E.S., Maya-Monteiro C.M., Dunkov B.C., Masuda H., Almeida I.C., and Oliveira P.L. A haeme-degradation pathway in a blood-sucking insect. Proc. Natl. Acad. Sci. USA 103 (2006) 8030-8035
216. Pasteur N., Nance E., and Bons N. Tissue localization of overproduced esterases in the mosquito Culex pipiens (Diptera: Culicidae). J. Med. Entomol. 38 (2001) 791-801
217. Patrick M.L., and Bradley T.J. The physiology of salinity tolerance in larvae of two species of Culex mosquitoes: the role of compatible solutes. J. Exp. Biol. 203 (2000) 821-830
218. Patrick M.L., and Bradley T.J. Regulation of compatible solute accumulation in larvae of the mosquito Culex tarsalis: osmolarity versus salinity. J. Exp. Biol. 203 (2000) 831-839
219. +-ATPase expression patterns in the osmoregulatory organs of larval and adult mosquito Aedes aegypti. J. Exp. Biol. 209 (2006) 4638-4651
220. Peach J.L., and Phillips J.E. Metabolic support of chloride-dependent short-circuit current across the locust (Schistocerca gregaria) ileum. J. Insect Physiol. 37 (1991) 255-260
221. + exchange in mosquito Malpighian tubules. Am. J. Physiol. 279 (2000) R1996-R2003
222. Phillips J.E. Rectal absorption in the desert locust, Schistocerca gregaria Forskål. I. Water. J. Exp. Biol. 41 (1964) 15-38
223. Phillips J.E. Rectal absorption in the desert locust, Schistocerca gregaria Forskål. II. Sodium, potassium and chloride. J. Exp.Biol. 41 (1964) 39-67
224. Phillips J.E. Excretion in insects: function of gut and rectum in concentrating and diluting the urine. Fed. Proc. 36 (1977) 2480-2486
225. Phillips J.E. Comparative physiology of insect renal function. Am. J. Physiol. 241 (1981) R241-R257
226. Phillips J.E., and Dockrill A.A. Molecular sieving of hydrophilic molecules by the rectal intima of the desert locust (Schistocerca gregaria). J. Exp. Biol. 48 (1968) 521-532
227. Phillips J.E., and Maddrell S.H.P. Active transport of magnesium by the Malpighian tubules of the larvae of the mosquito, Aedes campestris. J. Exp. Biol. 61 (1974) 761-771
228. Phillips J.E., Hanrahan J., Chamberlin M., and Thomson B. Mechanisms and control of reabsorption in insect hindgut. Adv. Insect Physiol. 19 (1986) 329-422
229. Phillips J.E., Wiens C., Audsley N., Jeffs L., Bilgen T., and Meredith J. Nature and control of chloride transport in insect absorptive epithelia. J. Exp. Zool. 275 (1996) 292-299
230. Plapp F.W., Bigley W.S., Darrow D.I., and Eddy G.W. Studies on parathion metabolism in normal and parathion resistant houseflies. J. Econ. Entomol. 54 (1961) 389-392
231. Podsiadlowski L., Matha V., and Vilcinskas A. Detection of a P-glycoprotein related pump in Chironomus larvae and its inhibition by verapamil and cyclosporin A. Comp. Biochem. Physiol., B 121 (1998) 443-450
232. Polles S.G., and Vinson S.B. Penetration, distribution and metabolism of 14C endrin in resistant and susceptible tobacco budworm larvae. J. Agr. Food Chem. 20 (1972) 38-41
233. Pond B.B., Galeffi F., Ahrens R., and Schwartz-Bloom R.D. Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus. Neuropharmacology 47 (2004) 253-262
234. Postma J.F., van Nugteren P., and Buckert-de Jong M.B. Increased cadmium excretion in metal-adapted populations of the midge Chironomus riparius (Diptera). Environ. Toxicol. Chem. 15 (1996) 332-339
235. Pritchard J.B., and Miller D.S. Comparative insights into the mechanisms of renal organic anion and cation secretion. Am. J. Physiol. 261 (1991) R1329-R1340
236. Pritchard J.B., and Miller D.S. Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. 73 (1993) 765-796
237. 4Cl by the hindgut of Sarcophaga bullata larvae. Comp. Biochem. Physiol. 41A (1972) 215-223
238. Prusch R.D. Unidirectional ion movements in the hindgut of larval Sarcophaga bullata. J. Exp. Biol. 64 (1976) 89-100
239. Pullikuth A.K., Filippov V., and Gill S.S. Phylogeny and cloning of ion transporters in mosquitoes. J. Exp. Biol. 206 (2003) 3857-3868
240. Pullikuth A.K., Aimanova K., Kang'ethe W., Sanders H.R., and Gill S.S. Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti. J. Exp. Biol. 209 (2006) 3529-3544
241. Rabitsch W.B. Tissue-specific accumulation patterns of Pb, Cd, Cu, Zn, Fe, and Mn in workers of three ant species (Formicidae, Hymenoptera) from a metal-polluted site. Archiv. Environ. Contam. Toxicol. 32 (1997) 172-177
242. Rafaeli-Bernstein A., and Mordue W. The transport of the cardiac glycoside ouabain by the Malpighian tubules of Zonocerus variegatus. Physiol. Entomol. 3 (1978) 59-63
243. Ramsay J.A. The excretory system of the stick insect, Dixippus morosus (Orthoptera, Phasmidae). J. Exp. Biol. 32 (1955) 183-199
244. Ramsay J.A. The excretion of sodium, potassium and water by the Malpighian tubules of the stick insect, Dixippus morosus (Orthoptera, Phasmidae). J. Exp. Biol. 32 (1955) 200-216
245. Ramsay J.A. Excretion by the Malpighian tubules of the stick insect, Dixippus morosus (Orthoptera, Phasmidae): amino acids, sugars and urea. J. Exp. Biol. 35 (1958) 871-891
246. Ramsay J.A. Insect rectum. Phil. Trans. R. Soc. Lond. B 262 (1971) 251-260
247. Ranson H., and Hemingway J. Mosquito glutathione transferases. Methods Enzymol. 401 (2005) 226-241
248. - cotransporter from the Malpighian tubules of the tobacco hornworm, Manduca sexta. Insect Biochem. Mol. Biol. 25 (1995) 875-880
249. Reaume A.G., Knecht D.A., and Chovnick A. The rosy locus in Drosophila melanogaster: xanthine dehydrogenase and eye pigments. Genetics 129 (1991) 1099-1109
250. Rheault M.R., and O'Donnell M.J. Organic cation transport by Malpighian tubules of Drosophila melanogaster: application of two novel electrophysiological methods. J. Exp. Biol. 207 (2004) 2173-2184
251. Rheault M.R., Debicki D.M., and O'Donnell M.J. Characterization of tetraethylammonium uptake across the basolateral membrane of the Drosophila Malpighian (renal) tubule. Am. J. Physiol. 289 (2005) R495-R504
252. Rheault M.R., Plaumann J.S., and O'Donnell M.J. TEA and nicotine transport by the Malpighian tubules of insects. J. Insect Physiol. 52 (2006) 487-498
253. + antiporter (NHA) from a metazoan, Anopheles gambiae. J Exp. Biol. 210 (2007) 3848-3861
254. Riegel J.A., Maddrell S.H., Farndale R.W., and Caldwell F.M. Stimulation of fluid secretion of malpighian tubules of Drosophila melanogaster Meig. by cyclic nucleotides of inosine, cytidine, thymidine and uridine. J. Exp. Biol. 201 (1998) 3411-3418
255. Riegel J.A., Farndale R.W., and Maddrell S.H. Fluid secretion by isolated Malpighian tubules of Drosophila melanogaster Meig.: effects of organic anions, quinacrine and a diuretic factor found in the secreted fluid. J. Exp. Biol. 202 (1999) 2339-2348
256. Riskallah M.R., and Esaac E.G. Metabolism and excretion of leptophos and its phenol in S and R larvae of the Egyptian cotton leafworm. Archiv. Environ. Contam. Toxicol. 11 (1982) 253-257
257. Ruiz-Sanchez E., and O'Donnell M.J. Characterization of salicylate uptake across the basolateral membrane of the Malpighian tubules of Drosophila melanogaster. J. Insect Physiol. 52 (2006) 920-928
258. Ruiz-Sanchez E., and O'Donnell M.J. Characterization of transepithelial transport of salicylate by the Malpighian tubules of Drosophila melanogaster and the effects of changes in fluid secretion rate. Physiol. Entomol. 32 (2007) 157-166
259. Ruiz-Sanchez E., and O'Donnell M.J. Effects of chronic exposure to dietary salicylate on elimination and renal excretion of salicylate by Drosophila melanogaster larvae. J. Exp. Biol. 210 (2007) 2464-2471
260. Ruiz-Sanchez E., Livingston A., Van Walderveen M.C., and O'Donnell M.J. Transepithelial transport of salicylate by the Malpighian tubules of insects from different orders. J. Insect Physiol. 53 (2007) 1034-1045
261. Russell J.M. Sodium-potassium-chloride cotransporter. Phys. Rev. 80 (2000) 211-276
262. Sasaki T., and Ishikawa H. Production of essential amino acids from glutamate by Mycetocyte symbionts of the pea aphid, Acyrthosiphon pisum. J. Insect Physiol. 41 (1995) 41-46
263. Sawyer D.B., and Beyenbach K.W. Dibutyryl-cAMP increases basolateral sodium conductance of mosquito Malpighian tubules. Am. J. Physiol. 248 (1985) R339-R345
264. Scaraffia P.Y., Isoe J., Murillo A., and Wells M.A. Ammonia metabolism in Aedes aegypti. Insect Biochem. Mol. Biol. 35 (2005) 491-503
265. Schofield R.M., Postlethwait J.H., and Lefevre H.W. MeV-ion microprobe analyses of whole Drosophila suggest that zinc and copper accumulation is regulated storage not deposit excretion. J. Exp. Biol. 200 (1997) 3235-3243
266. Schwantes U. Uric acid during pupal and adult development of Musca domestica L. (Diptera). Zool. Jb. Physiol. 94 (1990) 1-18
267. +-driven anion exchanger protein NDAE1 from Drosophila melanogaster. Am. J. Physiol. 281 (2001) C449-C463
268. Scudder G.G.E. The fauna of saline lakes of the Fraser plateau in British Columbia. Vekr. Intemat. Verein. Lirnnol. 17 (1969) 430-439
269. Seidman L.A., Bergtom G., and Remsen C.C. Structure of the larval midgut of the fly Chironomus thummi and its relationship to sites of cadmium sequestration. Tissue Cell 18 (1986) 407-418
270. Seidman L.A., Bergtrom G., Gingrich D.J., and Remsen C.C. Accumulation of cadmium by the fourth instar larva of the fly Chironomus thummi. Tissue Cell 18 (1986) 395-405
271. Self L.S., Guthrie F.E., and Hodgson E. Adaptation of tobacco hornworms to the ingestion of nicotine. J. Insect Physiol. 10 (1964) 907-914
272. Skaer H.B., Maddrell S.H., and Harrison J.B. The permeability properties of septate junctions in Malpighian tubules of Rhodnius. J. Cell Sci. 88 (1987) 251-265
273. 2+ influx and efflux. Methods Cell Biol. 40 (1994) 115-134
274. Smitherman P.K., Townsend A.J., Kute T.E., and Morrow C.S. Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J. Pharmacol. Exp. Ther. 308 (2004) 260-267
275. Snyder M.J., Walding J.K., and Feyereisen R. Metabolic fate of the allelochemical nicotine in the tobacco hornworm Manduca sexta. Insect Biochem. Mol. Biol. 24 (1994) 837-846
276. Sohal R.S., Peters P.D., and Hall T.A. Origin, structure, composition and age dependence of mineralised dense bodies (concretions) in the midgut epithelium of the adult housefly Musca domestica. Tissue Cell 9 (1977) 87-102
277. Souza A.V., Petretski J.H., Demasi M., Bechara E.J., and Oliveira P.L. Urate protects a blood-sucking insect against hemin-induced oxidative stress. Free Radic. Biol. Med. 22 (1997) 209-214
278. Spring J.H., and Felgenhauer B.E. Excretion in the house cricket, Acheta domesticus: effects of diuretics on the structure of the mid-tubule. J. Morphol. 230 (1996) 43-53
279. Spring J.H., and Hazelton S.R. Excretion in the house cricket (Acheta domesticus): stimulation of diuresis by tissue homogenates. J. Exp. Biol. 129 (1987) 63-81
280. Spring J.H., Robichaux S.R., Kaufmann N., and Brodsky J.L. Localization of a Drosophila DRIP-like aquaporin in the Malpighian tubules of the house cricket, Acheta domesticus. Comp. Biochem. Physiol. 148 (2007) 92-100
281. Staddon B.W. The excretion and storage of ammonia by aquatic larvae of Sialis lutaria (Neuroptera). J. Exp. Biol. 32 (1955) 84-94
282. Staddon B.W. Nitrogen excretion in nymphs of Aeshna cyanea (Müll.) (Odonata, Anisoptera). J. Exp. Biol. 36 (1959) 566-574
283. Stagg A.P., Harrison J.F., and Phillips J.E. Acid-base variables in Malpighian tubule secretion and response to acidosis. J. Exp. Biol. 159 (1991) 433-447
284. Stobbart R.H. The effect of some anions and cations upon the fluxes and net uptake of chloride in the larva of Aedes aegypti (L.), and the nature of the uptake mechanisms for sodium and chloride. J. Exp. Biol. 47 (1967) 35-57
285. Storelli C., Corcelli A., Cassano G., Hildmann B., Murer H., and Lippe C. Polar distribution of sodium-dependent and sodium-independent transport systems for L-lactate in the plasma membrane of rat enterocytes. Pflug. Archiv. 388 (1980) 11-16
286. 2 secretion. Am. J. Physiol. 246 (1984) R727-R734
287. - transport in insect salt gland. J. Membr. Biol. 83 (1985) 25-37
288. 3 lakes. J. Exp. Biol. 101 (1982) 171-186
289. - exchange. Am. J. Physiol. 246 (1984) R735-R740
290. Stratakis E. Ommochrome synthesis and kynurenic acid excretion in relation to metamorphosis and allatectomy in the stick insect, Carausius morosus. J. Insect Physiol. 25 (1979) 925-929
291. Suzuki K.T., Aoki Y., Nishikawa M., Masui H., and Matsubara F. Effect of cadmium-feeding on tissue concentrations of elements in germ-free silkworm (Bombyx mori) larvae and distribution of cadmium in the alimentary canal. Comp. Biochem. Physiol., C 79 (1984) 249-253
292. Szibbo C.M., and Scudder G.G.E. Secretory activity of the segmented Malpighian tubules of Cenocorixa bifida (Hung.). J. Insect Physiol. 25 (1979) 931-937
293. Tapadia M.G., and Lakhotia S.C. Expression of MDR49 and MDR65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions. Cell Stress Chap. 10 (2005) 7-11
294. Taylor C.W. Calcium regulation in blowflies: absence of a role for midgut. Am. J. Physiol. 249 (1985) R209-R213
295. Tearle R. Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster. Genet. Res. 57 (1991) 257-266
296. Terhzaz S., O'Connell F.C., Pollock V.P., Kean L., Davies S.A., Veenstra J.A., and Dow J.A. Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. J. Exp. Biol. 202 (1999) 3667-3676
297. Thomson R.B., Thomson J.M., and Phillips J.E. transport in acid-secreting insect epthelium. Am. J. Physiol. 254 (1988) R348-R356
298. Torrie L.S., Radford J.C., Southall T.D., Kean L., Dinsmore A.J., Davies S.A., and Dow J.A. Resolution of the insect ouabain paradox. Proc. Natl. Acad. Sci. USA 101 (2004) 13689-13693
299. Treherne J.E., Harrison J.B., Treherne J.M., and Lane N.J. Glial repair in an insect central nervous system: effects of surgical lesioning. J. Neurosci. 4 (1984) 2689-2697
300. + and urate balance in the fat body of the cockroach Periplaneta americana. J. Exp. Biol. 71 (1977) 67-79
301. Tucker L.E. Regulation of ions in the haemolymph of the cockroach Periplaneta americana during dehydration and rehydration. J. Exp. Biol. 71 (1977) 95-110
302. Van Kerkhove E., Weltens R., Roinel N., and De Decker N. Haemolymph composition in Formica (Hymenoptera) and urine formation by the short isolated Malpighian tubules: electrochemical gradients for ion transport. J. Insect Physiol. 35 (1989) 991-1003
303. Wall B.J. Local osmotic gradients in the rectal pads of an insect. Fed. Proc. 30 (1971) 42-48
304. Wang J., Kean L., Yang J., Allan A.K., Davies S.A., Herzyk P., and Dow J.A. Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biol. 5 (2004) R69
305. Wang Y.J., Zhao Y., Meredith J., Phillips J.E., Theilmann D.A., and Brock H.W. Mutational analysis of the C-terminus in ion transport peptide (ITP) expressed in Drosophila Kc1 cells. Archiv. Insect Biochem. Physiol. 45 (2000) 129-138
306. Weihrauch D. Active ammonia absorption in the midgut of the tobacco hornworm Manduca sexta L.: transport studies and mRNA expression analysis of a Rhesus-like ammonia transporter. Insect Biochem. Mol. Biol. 36 (2006) 808-821
307. Weis-Fogh T. Insects and physiology. In: Beament J.W.L., and Treherne J.E. (Eds). Metabolism and Weight Economy in Migrating Animals, Particularly Birds and Insects (1967), Oliver and Boyd, Edinburgh and London 143-159
308. Whittembury G., Biondi A.C., Paz-Aliaga A., Linares H., Parthe V., and Linares L. Transcellular and paracellular plow of water during secretion in the upper segment of the Malpighian tubule of Rhodnius prolixus: solvent drag of molecules of graded size. J. Exp. Biol. 123 (1986) 71-92
309. Wieczorek H. The insect V-ATPase, a plasma membrane proton pump energizing secondary active transport: molecular analysis of electrogenic potassium transport in the tobacco hornworm midgut. J. Exp. Biol. 172 (1992) 335-343
310. Wieczorek H., Weerth S., Schindlbeck M., and Klein U. A vacuolar-type proton pump in a vesicle fraction enriched with potassium transporting plasma membranes from tobacco hornworm midgut. J. Biol. Chem. 264 (1989) 11143-11148
311. + antiport in an animal plasma membrane. J. Biol. Chem. 266 (1991) 15340-15347
312. + V-ATPase. J. Exp. Biol. 203 (2000) 127-135
313. ATP channel involved?. J. Exp. Biol. 206 (2003) 959-965
314. Wigglesworth V.B. The physiology of excretion in a blood-sucking insect, Rhodnius prolixus (Hemiptera, Reduviidae). III. The mechanism of uric acid excretion. J. Exp. Biol. 8 (1931) 448-451
315. Wigglesworth V.B. The Principles of Insect Physiology. 7th edition (1972), Methuen, London
316. Wigglesworth V.B. Histochemical studies of uric acid in some insects. 1. Storage in the fat body of Periplaneta maericana and the action of the symbiotic bacteria. Tissue Cell 19 (1987) 83-91
317. Wigglesworth V.B. Histochemical studies of uric acid in some insects. 3. Excretion of uric acid by the Malpighian tubules in Calliphora vicina and Rhodnius prolixus. Tissue Cell 19 (1987) 275-286
318. Wilkinson T.L., and Douglas A.E. The impact of aposymbiosis on amino acid metabolism of pea aphids. Entomol. Exp. Appl. 80 (1996) 279-282
319. Williams L.A.D., and Mansingh A. The insecticidal and acaricidal actions of compounds from Azadirachta indica (A. Juss) and their use in tropical pest management. Int. Pest Manage. Rev. 1 (1996) 133-145
320. Wink M., and Theile V. Alkaloid tolerance in Manduca sexta and phylogenetically related sphingids (Lepidoptera : Sphingidae). Chemoecology 12 (2002) 29-46
321. Wright S.H., and Dantzler W.H. Molecular and cellular physiology of renal organic cation and anion transport. Physiol. Rev. 84 (2004) 987-1049
322. Wu D.S., and Beyenbach K.W. The dependence of electrical transport pathways in Malpighian tubules on ATP. J. Exp. Biol. 206 (2003) 233-243
323. Xu W., and Marshall A.T. Magnesium secretion by the distal segment of the Malpighian tubules of the black field cricket Teleogryllus oceanicus. J. Insect Physiol. 45 (1999) 777-784
324. Xu W., and Marshall A.T. X-ray microanalysis of the Malpighian tubules of the black field cricket Teleogryllus oceanicus: the roles of Na K-ATPase and the Na K 2Cl cotransporter. J. Insect Physiol. 45 (1999) 885-893
325. Yamamura M., Suzuki K.T., Hatakeyama S., and Kubota K. Tolerance to cadmium and cadmium-binding proteins induced in the midge larva, Chironomus yoshimatsui (Diptera, Chironomidae). Comp. Biochem. Physiol. C75 (1983) 21-24
326. Yang J., McCart C., Woods D.J., Terhzaz S., Greenwood K.G., ffrench-Constant R.H., and Dow J.A. A Drosophila systems approach to xenobiotic metabolism. Physiol. Genomics 30 (2007) 223-231
327. Yoshida N., Koizumi M., Adachi I., and Kawakami J. Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products. Food Chem. Toxicol. 44 (2006) 2033-2039
328. Yu M.-J., and Beyenbach K.W. Leucokinin and the modulation of the shunt pathway in Malpighian tubules. J. Insect Physiol. 47 (2001) 263-276
329. Yu M.-J., and Beyenbach K.W. Effects of leucokinin-VIII on Aedes Malpighian tubule segments lacking stellate cells. J. Exp. Biol. 207 (2004) 519-526
330. Zdobnov E.M., and Bork P. Quantification of insect genome divergence. Trends Genet. 23 (2007) 16-20
331. +-ATPase in Malpighian tubules of Formica polyctena: intracellular and luminal pH measurements. Pflug. Archiv. 426 (1994) 288-295
332. Zhao Y., Meredith J., Brock H.W., and Phillips J.E. Mutational analysis of the N-terminus in Schistocerca gregaria ion-transport peptide expressed in Drosophila Kc1 cells. Archiv. Insect Biochem. Physiol. 58 (2005) 27-38
333. Zhou G., Kohlhepp P., Geiser D., Frasquillo M.D., Vazquez-Moreno L., and Winzerling J.J. Fate of blood meal iron in mosquitoes. J. Insect Physiol. 53 (2007) 1169-1178
334. Zubrzak P., Williams H., Coast G.M., Isaac R.E., Reyes-Rangel G., Juaristi E., Zabrocki J., and Nachman R.J. Beta-amino acid analogs of an insect neuropeptide feature potent bioactivity and resistance to peptidase hydrolysis. Biopolymers 88 (2007) 76-82