Inhibitory monoclonal antibodies to human cytochrome P450 2D6

Biochemical Pharmacology

Volumn 54, Issue 1, 1997, Pages 15-17

  Krausz, Kristopher W ^a   Yang, Tian Jian ^a   Gonzalez, Frank J ^a   Shou, Magang ^a   Gelboin, Harry V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Baculo expressed P450; Bufuralol; Cytochrome P450 2D6; Human 2D6 P450; Inhibitory mononuclear antibodies

Indexed keywords

BUFURALOL; CYTOCHROME P450; ENZYME ANTIBODY; ISOENZYME; MONOCLONAL ANTIBODY;

ARTICLE; DRUG METABOLISM; ENZYME BINDING; ENZYME INHIBITION; HISTOCHEMISTRY; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; CROSS REACTIONS; CYTOCHROME P-450 CYP2D6; ETHANOLAMINES; HUMANS; HYDROXYLATION; PHENANTHRENES;

EID: 0030843861     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00261-X     Document Type: Article

References (10)

1. Gonzalez FJ, The CYP2D subfamily. In: Cytochromes P450: Metabolic and Toxicological Aspects (Ed. Ioannides C), pp. 183-210. CRC Press, Boca Raton, FL, 1996.
2. Guengerich FP, Catalytic selectivity of human cytochrome P450 enzymes: Relevance to drug metabolism and toxicity. Toxicol Lett 70: 133-138, 1994.
3. Gelboin HV, Cytochrome P450 and monoclonal antibodies. Pharmacol Rev 45: 413-453, 1993.
4. Gelboin HV, Goldfarb I, Krausz KW, Grogan J, Korzekwa KR, Gonzalez FJ and Shou M, Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1. Chem Res Toxicol 9: 1023-1030, 1996.
5. Gelboin HV, Krausz KW, Goldfarb I, Buters JTM, Yang SK, Gonzalez FJ, Korzekwa KR and Shou M, Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4. Biochem Pharmacol 50: 1841-1850, 1995.
6. Gonzalez FJ, Kimura S, Tamura S and Gelboin HV, Expression of mammalian cytochrome P450 using baculovirus. Methods Enzymol 206: 93-99, 1991.
7. Kronbach T, Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450 2D6. Methods Enzymol 206: 509-517, 1991.
8. Shou M, Korzekwa KR, Krausz KW, Crespi CL, Gonzalez FJ and Gelboin HV, Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA expressed human and rodent cytochromes P450. Cancer Lett 83: 305-313, 1994.
9. Dahl ML and Bertilsson L, Genetically variable metabolism of antidepressants and neuroleptic drugs in man. Pharmocogenetics 3: 61-70, 1993.
10. Buchert E and Woosley RL, Clinical implications of variable anti-arrhythmic drug metabolism. Pharmacogenetics 2: 2-11, 1992.