Sequences and polymorphisms of the canine monoamine transporter genes SLC6A2, SLC6A3, and SLC6A4 among five dog breeds

Journal of Veterinary Medical Science

Volumn 70, Issue 9, 2008, Pages 971-975

  Arata, Sayaka ^a   Ogata, Niwako ^a   Shimozuru, Michito ^a   Takeuchi, Yukari ^a   Mori, Yuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Breed difference; Canine; Monoamine transporter; Polymorphism

Indexed keywords

PRIMER DNA; VESICULAR MONOAMINE TRANSPORTER;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DNA SEQUENCE; DOG; GENE FREQUENCY; GENETICS; GENOTYPE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES DIFFERENCE;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DOGS; GENE FREQUENCY; GENOTYPE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; SPECIES SPECIFICITY; VESICULAR MONOAMINE TRANSPORT PROTEINS;

CANIS FAMILIARIS;

EID: 54349114960     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.70.971     Document Type: Article

References (29)

1. Barrett, J. C., Fry, B., Maller, J. and Daly, M. J. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
2. Chen, N. H., Reith, M. E. and Quick, M. W. 2004. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers. Arch. 447: 519-531.
3. Diederich, C. and Giffroy, J. M. 2006. Behavioural testing in dogs: A review of methodology in search for standardisation. Appl. Anim. Behav. Sci. 97: 51-72.
4. Giros, B. and Caron, M. G. 1993. Molecular characterization of the dopamine transporter. Trends. Pharmacol. Sci. 14: 43-49.
5. Hahn, M. K. and Blakely, R. D. 2007. The functional impact of SLC6 transporter genetic variation. Annu. Rev. Pharmacol. Toxicol. 47: 401-441.
6. Hashizume, C., Masuda, K., Momozawa, Y., Kikusui, T., Takeuchi, Y. and Mori, Y. 2005. Identification of an cysteine-to-arginine substitution caused by a single nucleotide polymorphism in the canine monoamine oxidase B gene. J. Vet. Med. Sci. 67: 199-201.
7. Hejjas, K., Vas, J., Kubinyi, E., Sasvari-Szekely, M., Miklosi, A. and Ronai, Z. 2007. Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves. Mamm. Genome. 18: 871-879.
8. Hejjas, K., Vas, J., Topal, J., Szantai, E., Ronai, Z., Szekely, A., Kubinyi, E., Horvath, Z., Sasvari-Szekely, M. and Miklosi, A. 2007. Association of polymorphisms in the dopamine D4 receptor gene and the activity-impulsivity endophenotype in dogs. Anim. Genet. 38: 629-633.
9. Hong, K.-W., Maejima, M., Inoue-Murayama, M., Morita, M., Mutayama, Y. and Ito, S. 2006. Dog serotonin transporter polymorphism and the association with behavioral traits. DNA Polymorphism 14: 181-187.
10. Houpt, K. A. 2007. Review article genetics of canine Behavior. Acta. Vet. Brno. 76: 431-444.
11. Ito, H., Nara, H., Inoue-Murayama, M., Shimada, M. K., Koshimura, A., Ueda, Y., Kitagawa, H., Takeuchi, Y., Mori, Y., Murayama, Y., Morita, M., Iwasaki, T., Ota, K., Tanabe, Y. and Ito, S. 2004. Allele frequency distribution of the canine dopamine receptor D4 gene exon III and I in 23 breeds. J. Vet. Med. Sci. 66: 815-820.
12. Jayanthi, L. D. and Ramamoorthy, S. 2005. Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. Aaps. J. 7: E728-738.
13. Jones, A. C. and Gosling, S. D. 2005. Temperament and personality in dogs (Canis familiaris): A review and evaluation of past research. Appl. Anim. Behav. Sci. 95: 1-53.
14. Masuda, K., Hashizume, C., Kikusui, T., Takeuchi, Y. and Mori, Y. 2004. Breed differences in genotype and allele frequency of catechol O-methyltransferase gene polymorphic regions in dogs. J. Vet. Med. Sci. 66: 183-187.
15. Masuda, K., Hashizume, C., Ogata, N., Kikusui, T., Takeuchi, Y. and Mori, Y. 2004. Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C genes and identification of polymorphisms in the 5-HTR1B gene. J. Vet. Med. Sci. 66: 965-972.
16. Ogata, N., Hashizume, C., Momozawa, Y., Masuda, K., Kikusui, T., Takeuchi, Y. and Mori, Y. 2006. Polymorphisms in the canine glutamate transporter-1 gene: identification and variation among five dog breeds. Erratum appeared in vol. 68 (7) J. Vet. Med. Sci. 68: 157-159.
17. Ostrander, E. A., Giger, U. and Lindblad-Toh, K. 2006. From wild wolf to domestic dog. pp. 95-117. In: The Dog and its Genome, Cold Spring Harbor Laboratory Press, New York.
18. Rebbeck, T. R., Spitz, M. and Wu, X. 2004. Assessing the function of genetic variants in candidate gene association studies. Nat. Rev. Genet. 5: 589-597.
19. Serretti, A., Calati, R., Mandelli, L. and De Ronchi, D. 2006. Serotonin transporter gene variants and behavior: a comprehensive review. Curr. Drug. Targets 7: 1659-1669.
20. Sher, L. 2000. Psychiatric diagnoses and inconsistent results of association studies in behavioral genetics. Med. Hypotheses. 54: 207-209.
21. Spady, T. C. and Ostrander, E. A. 2008. Canine behavioral genetics: pointing out the phenotypes and herding up the genes. Am. J. Hum. Genet. 82: 10-18.
22. Takeuchi, Y., Hashizume, C., Chon, E. M., Momozawa, Y., Masuda, K., Kikusui, T. and Mori, Y. 2005. Canine tyrosine hydroxylase (TH) gene and dopamine beta -hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds. J. Vet. Med. Sci. 67: 861-867.
23. Takeuchi, Y. and Houpt, K. A. 2003. Behavior genetics. Vet. Clin. N. Am. Small. 33: 345-363.
24. Takeuchi, Y. and Mori, Y. 2006. A comparison of the behavioral profiles of purebred dogs in Japan to profiles of those in the United States and United Kingdom. J. Vet. Med. Sci. 68: 789-796.
25. Vaage, J. and Lingaas, F. 2008. Single nucleotide polymorphisms (SNPs) in coding regions of canine dopamine- and serotonin-related genes. BMC Genet. 9: 10.
26. Van den Berg, L., Kwant, L., Hestand, M. S., van Oost, B. A. and Leegwater, P. A. 2005. Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). J. Hered. 96: 786-796.
27. Van den Berg, L., Vos-Loohuis, M., Schilder, M. B., van Oost, B. A., Hazewinkel, H. A., Wade, C. M., Karlsson, E. K., Lindblad-Toh, K., Liinamo, A. E. and Leegwater, P. A. 2008. Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs. Behav. Genet. 38: 55-66.
28. Waldman, I. D. and Gizer, I. R. 2006. The genetics of attention deficit hyperactivity disorder. Clin. Psychol. Rev. 26: 396-432.
29. Xu, F., Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Bohn, L. M., Miller, G. W., Wang, Y. M. and Caron, M. G. 2000. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat. Neurosci. 3: 465-471.