Structure and variation of three canine genes involved in serotonin binding and transport: The serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4)

Journal of Heredity

Volumn 96, Issue 7, 2005, Pages 786-796

  Van Den Berg, L ^a   Kwant, L ^a   Hestand, M S ^a   Van Oost, B A ^b   Leegwater, P A J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; OLIGONUCLEOTIDE; SERINE PROTEINASE; SERINE PROTEINASE OMI; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR 1A; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; DNA SPLICING; DOG; GENE SEQUENCE; GENE STRUCTURE; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; MICROSATELLITE MARKER; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CLONING, MOLECULAR; COMPUTER SIMULATION; DNA PRIMERS; DOGS; GENE ORDER; GENOTYPE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

BACTERIA (MICROORGANISMS); CANIS FAMILIARIS;

EID: 28644445619     PISSN: 00221503     EISSN: 14657333     Source Type: Journal    
DOI: 10.1093/jhered/esi108     Document Type: Article

References (55)

1. Abdolmaleky HM, Faraone SV, Glatt SJ, and Tsuang MT, 2004. Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia. Schizophr Res 67:53-62.
2. Anguelova M, Benkelfat C, and Turecki G, 2003. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 8:646-653.
3. Badino P, Odore R, Osella MC, Bergamasco L, Francone P, Girardi C, and Re G, 2004, Modifications of serotonergic and adrenergic receptor concentrations in the brain of aggressive Canis familiaris. Comp Biochem Physiol A Mol Integr Physiol 139:343-350.
4. Barker EL and Blakely RD, 1996. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Mol Pharmacol 50:957-965.
5. Barker EL, Perlman MA, Adkins EM, Houlihan WJ, Pristupa ZB, Niznik HB, and Blakely RD, 1998. High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J Biol Chem 273:19459-19468.
6. Beaver BV, 1994. Owner complaints about canine behavior. J Am Vet Med Assoc 204:1953-1955.
7. Bjork JM, Moeller FG, Dougherty DM, Swann AC, Machado MA, and Hanis CL, 2002. Serotonin 2a receptor T102C polymorphism and impaired impulse control. Am J Med Genet 114:336-339.
8. Chang AS, Chang SM, Starnes DM, Schroeter S, Bauman AL, and Blakely RD, 1996. Cloning and expression of the mouse serotonin transporter. Mol Brain Res 43:185-192.
9. Chen JG, Liu-Chen S, and Rudnick G, 1997. External cysteine residues in the serotonin transporter. Biochemistry 36:1479-1486.
10. Chen JG and Rudnick G, 2000. Permeation and gating residues in serotonin transporter. Proc Natl Acad Sci USA 97:1044-1049.
11. Chen K, Yang W, Grimsby J, and Shih JC, 1992. The human 5-HT2 receptor is encoded by a multiple intron-exon gene. Brain Res Mol Brain Res 14:20-26.
12. den Dunnen JT and Antonarakis SE, 2001. Nomenclature for the description of human sequence variations. Hum Genet 109:121-124.
13. Feldman RS, Meyer JS, and Quenzer LF, 1997. Serotonin. In: Principles of neuropsychopharmacology, 1st ed. (Feldman RS, Meyer JS, and Quenzer LF, eds). Sunderland, MA: Sinauer; 345-389.
14. Gelernter J, Pakstis AJ, and Kidd KK, 1995. Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17. Hum Genet 95:677-680.
15. Gingrich JA and Hen R, 2001. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology (Berl) 155:1-10.
16. Guest PC, Salim K, Skynner HA, George SE, Bresnick JN, and McAllister G, 2000. Identification and characterization of a truncated variant of the 5-hydroxytryptamine(2A) receptor produced by alternative splicing. Brain Res 876:238-244.
17. Guyon R, Lorentzen TD, Hitte C, Kim L, Cadieu E, Parker HG, Quignon P, Lowe JK, Renier C, Gelfenbeyn B, Vignaux F, DeFrance HB, Gloux S, Mahairas GG, Andre C, Galibert F, and Ostrander EA, 2003. A 1-Mb resolution radiation hybrid map of the canine genome. Proc Natl Acad Sci USA 100:5296-5301.
18. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, and Weinberger DR, 2002. Serotonin transporter genetic variation and the response of the human amygdala. Science 297:400-403.
19. Hart BL and Hart LA, 1988. The perfect puppy: how to choose your dog by its behaviour. New York: WH Freeman.
20. Hartig PR, 1997. Molecular biology and transductional characteristics of 5-HT receptors. In: Serotonergic neurons and 5-HT receptors in the CNS, 1st ed. (Baumgarten HG and Göthert M, eds). Berlin: Springer; 175-212.
21. Heisler LK, Chu HM, Brennan TJ, Danao JA, Bajwa P, Parsons LH, and Tecott LH, 1998. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci USA 95:15049-15054.
22. Holmes A, Murphy DL, and Crawley JN, 2003. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 54:953-959.
23. Hsieh CL, Bowcock AM, Farrer LA, Hebert JM, Huang KN, Cavalli-Sforza LL, Julius D, and Francke U, 1990. The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet 16:567-574.
24. Innan H and Kim Y, 2004. Pattern of polymorphism after strong artificial selection in a domestication event. Proc Natl Acad Sci USA 101:10667-10672.
25. Katsuragi S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S, and Akiyoshi J, 1999. Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol Psychiatry 45:368-370.
26. Khait VD, Huang YY, Zalsman G, Oquendo MA, Brent DA, Harkavy-Friedman JM, and Mann JJ, 2005. Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects. Neuropsychopharmacology 30:166-172.
27. Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W, Fraser CM, and Venter JC, 2003. The dog genome: survey sequencing and comparative analysis. Science 301:1898-1903.
28. Kobilka BK, Frielle T, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, and Caron MG, 1987. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329:75-79.
29. Kukekova AV, Trut LN, Oskina IN, Kharlamova AV, Shikhevich SG, Kirkness EF, Aguirre GD, and Acland GM, 2004. A marker set for construction of a genetic map of the silver fox (Vulpes vulpes). J Hered 95:185-194.
30. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, and Riederer P, 1994. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 95:157-162.
31. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, and Murphy DL, 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
32. Lesch KP, Jatzke S, Meyer J, Stober G, Okladnova O, Mossner R, and Riederer P, 1999. Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression. J Neural Transm 106:1223-1230.
33. Li R, Mignot E, Faraco J, Kadotani H, Cantanese J, Zhao B, Lin X, Hinton L, Ostrander EA, Patterson DF, and de Jong PJ, 1999. Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library. Genomics 58:9-17.
34. Lockwood R, 1995. The ethology and epidemiology of canine aggression. In: The domestic dog: its evolution, behaviour and interactions with people (Serpell J, ed). Cambridge: Cambridge University Press; 132-138.
35. Masuda K, Hashizume C, Ogata N, Kikusui T, Takeuchi Y, and Mori Y, 2004. Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C genes and identification of polymorphisms in the 5-HTR1B gene. J Vet Med Sci 66:965-972.
36. Mikkelsen J and Lund JD, 2000. Euthanasia of dogs due to behavioural problems: an epidemiological study of euthanasia of dogs in Denmark, with a special focus on problems of aggression. Eur J Comp Anim Pract 10:143-150.
37. Milanesi L and Rogozin IB, 1998. Prediction of human gene structure. In: Guide to human genome computing, 2nd ed. (Bishop MJ, ed). Cambridge: Academic Press; 215-259.
38. Miller SA, Dykes DD, and Polesky HF, 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
39. Nielen ALJ, van der Beek BS, Ubbink GJ, and Knol BW, 2001. Population parameters to compare dog breeds: differences between five Dutch purebred populations. Vet Q 23:43-49.
40. Pagani F and Baralle FE, 2004. Genomic variants in exons and introns: identifying the splicing spoilers. Nat Rev Genet 5:389-396.
41. Parks CL, Robinson PS, Sibille E, Shenk T, and Toth M, 1998. Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci USA 95:10734-10739.
42. Peremans K, Audenaert K, Coopman F, Blanckaert P, Jacobs F, Otte A, Verschooten F, van BH, van HK, Mertens J, Slegers G, and Dierckx R, 2003. Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150. Eur J Nucl Med Mol Imaging 30:1538-1546.
43. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, and Blakely RD, 1993. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542-2546.
44. Ramboz S, Oosting R, Amara DA, Kung HF, Blier P, Mendelsohn M, Mann JJ, Brunner D, and Hen R, 1998. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci USA 95:14476-14481.
45. Reisner IR, Mann JJ, Stanley M, Huang YY, and Houpt KA, 1996. Comparison of cerebrospinal fluid monoamine metabolite levels in dominant-aggressive and non-aggressive dogs. Brain Res 714:57-64.
46. Saltzman AG, Morse B, Whitman MM, Ivanshchenko Y, Jaye M, and Felder S, 1991. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. Biochem Biophys Res Commun 181:1469-1478.
47. Sparkes RS, Lan N, Klisak I, Mohandas T, Diep A, Kojis T, Heinzmann C, and Shih JC, 1991. Assignment of a serotonin 5HT-2 receptor gene (HTR2) to human chromosome 13q14-q21 and mouse chromosome 14. Genomics 9:461-465.
48. Stabej P, Imholz S, Versteeg SA, Zijlstra C, Stokhof AA, Domanjko-Petric A, Leegwater PA, and van Oost BA, 2004. Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann. Gene 340:241-249.
49. Stam NJ, Van Huizen F, Van Alebeek C, Brands J, Dijkema R, Tonnaer JA, and Olijve W, 1992. Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes. Eur J Pharmacol 227:153-162.
50. Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, and Ostrander EA, 2004. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Research 14:2388-2396.
51. Sutter NB and Ostrander EA, 2004. Dog star rising: the canine genetic system. Nat Rev Genet 5:900-910.
52. van den Berg L, Imholz S, Versteeg SA, Leegwater PAJ, Zijlstra C, Bosma AA, and van Oost BA, 2004. Isolation and characterization of the canine serotonin receptor 1B gene (htr1B). Gene 326:131-139.
53. van den Berg L, Schilder MBH, and Knol BW, 2003a. Behavior genetics of canine aggression: behavioral phenotyping of golden retrievers by means of an aggression test. Behav Genet 33:469-483.
54. van den Berg L, Versteeg SA, and van Oost BA, 2003b. Isolation and characterization of the canine serotonin receptor 1a gene (htr1A). J Hered 94:49-56.
55. Wright JC and Nesselrote MS, 1987. Classification of behavior problems in dogs: distributions of age, breed, sex and reproductive status. Appl Anim Behav Sci 19:169-178.