Progesterone regulates HLA-G gene expression through a novel progesterone response element

Human Reproduction

Volumn 21, Issue 10, 2006, Pages 2538-2544

  Yie, Shang Mian ^a   Xiao, Rong ^a   Librach, Clifford L ^a,b  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b NONE   (Canada)

Author keywords

Gene regulation; HLA G; Nnovel progesterone response element; Pregnancy; Progesterone

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; DNA FRAGMENT; HLA G ANTIGEN; MIFEPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR;

ARTICLE; BINDING SITE; CARCINOMA CELL; CHORIOCARCINOMA; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE MAMMARY TUMOR ONCOVIRUS; PREGNANCY; PROMOTER REGION; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION; UPREGULATION;

EID: 33749584353     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del126     Document Type: Article

References (34)

1. Barakonyi A, Polgar B, Par G, Faust Z, Palkovics T and Szereday (1999) The role of gamma/delta T cell in progesterone-mediated immunomodulation during pregnancy: A review. Am J Reprod Immunol 42,44-48.
2. Brierley J and Clark DA (1987) Characterization of hormone dependent suppressor cells in the uterus of mated and pseudopregnant mice. J Reprod Immunol 10,201-217.
3. Chaing MH and Main EK (1994) Nuclear regulation of HLA class I genes in human trophoblasts. Am J Reprod Immunol 32,167-172.
4. Choi BC, Polgar K, Xiao L and Hill JA (2000) Progesterone inhibits in-vitro embryotoxic TH1 cytokine production to trophoblast in women with recurrent pregnant loss. Hum Reprod 15 (Suppl. 1),46-59.
5. Chumble G, King A, Robertson K, Homes N and Loke YW (1994) Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol 155,312-322.
6. Clark DA (1997) HLA-G: Finally does something. Am J Reprod Immunol 38,75-78.
7. Clark JH, Schrader WT and O'Malley BW (1992) Mechanisms of action of steroid hormones. In Wilson JD and Foster DW (eds) Textbook of Endocrinology. WB Saunder Company, Philadelphia, PA, pp. 35-90.
8. Deniz G, Christmas SE, Brew R and Johnson PM (1994) Phenotypic and functional cellular differences between CD3-decidual and peripheral blood leukocytes. J Immunol 152,4255-4261.
9. Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM and Danielsen MD (1987) Lipofection: A highly efficient lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84,7413-7417.
10. Giangrande PH and McDonnell DP (1999) The A and B isoforms of the human progesterone receptors: Two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res 54,291-313.
11. Graham JD and Clarke CL (1997) Physiological action of progesterone in target tissues. Endocr Rev 18,502-519.
12. Hansen KA, Opsahl MS, Nieman LK, Baker JR Jr and Klaein TA (1992) Natural killer cell activity from pregnant subjects is modulated by RU486. Am J Obstet Gynecol 166,87-90.
13. Heyborne K, Cranfill RL, Cardin SR, Born WK and O'Brien R (1992) Characterization of γ/δ lymphocytes at the maternal-fetal interface. J Immunol 149,2872-2878.
14. Kapasi K, Albert S, Yie SM and Librach C (2000) HLA-G has a concentration dependent effect in allo-response: A novel mechanism for HLA-G medication immuno-modulation. Immunology 101,191-200.
15. Kim HS, Crone DE, Sprung CN, Tillman JB, Force WR, Crew MD, Mote PL and Spindler SR (1992) Positive and negative thyroid hormone response elements are composed of strong and weak half-sites 10 nucleotides in length. Mol Endocrinol 6,1489-1501.
16. Kirszenbaum M, Moreau P, Gluckman E, Dausset J and Carosella E (1994) An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes. Proc Natl Acad Sci USA 91,4209-4213.
17. Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ and DeMars R (1990) A class I antigen HLA-G, expressed in human trophoblasts. Science 248,220-223.
18. Kovats S, Librach C, Fisch P, Main EK, Sondel PM, Fisher SJ and DeMars R (1991) Expression and possible function of HLA-G alpha-chain in human cytotrophoblasts. Cell Mol Biol 212,21-29.
19. Lieberman BA, Bona BJ, Edwards DP and Nordeen SK (1993) The constitution of a progesterone response element. Mol Endocrinol 7,515-527.
20. Mannel DN, Falk W and Yron I (1990) Inhibition of urine cytotoxic T cell responses by progesterone. Immunol Lett 26,89-94.
21. Mansour I, Reznikoff-Etievant MF and Netter A (1994) No evidence for the expression of the progesterone receptor on peripheral blood lymphocytes during pregnancy. Hum Reprod 9,1546-1549.
22. McMaster MT, Librach CL, Zhou Y, Lim KH, Janatpour MJ, DeMars R, Kovats S, Damsky C and Fisher SJ (1995) Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol 154,3771-3378.
23. Onno M, Guillaudeux T, Amiot L, Renard I, Drenou B, Hirel B, Girr M, Semana G, Le Bouteiller P et al. (1994) The HLA-G gene is expressed at a low mRNA level in different human cells and tissues. Hum Immunol 41,79-86.
24. Parronchi P, Manetti R, Annunziato F, Livi C, Romagnani S and Maggi E (1995) Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 155, 128-133.
25. Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti R, Annunziato F, Livi C et al. (1995) Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 155,128-133.
26. Sander SK, Giblin PA and Kavathas P (1991) Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a non-classical major histocompatibility complex class I molecular on cytotrophoblasts. J Exp Med 174,737-740.
27. Schmidt CM, Ehlenfeldt RG, Athanasiou MC, Duvick LA, Heinrichs H, David CS and Orr HT (1993) Extraembryonic expression of the human MHC class I gene HLA-G in transgenic mice. Evidence for a positive regulatory region located 1 kilobase 5′ to the start site of transcription. J Immunol 151,2633-2645.
28. Schust DJ, Anderson DJ and Hill JA (1996) Progesterone-inducing immunosuppression is not mediated through the progesterone receptor. Hum Reprod 11,980-985.
29. Shanker YG and Rao AJ (1999) Progesterone receptor expression in the human placenta. Mol Hum Reprod 5,481-486.
30. Shibata H, Spencer TE, Onate SA, Jenster G, Tsai SY, Tsai MJ and O'Malley BW (1997) Role of co-activator and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res 52,141-164.
31. Stites DP and Siiteri PK (1983) Steroids as immunosuppressants in pregnancy. Immunol Rev 75,117-138.
32. Suzuki T, Hiromatsu K, Ando Y, Okamoto T, Tomoda Y and Yoshikai Y (1995) Regulatory role of γ/δ T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response. J Immunol 154,4476-4484.
33. Szekeres-Bartho J, Reznikoff-Etievant MF, Varga P, Pichon MF, Varga Z and Chaouat G (1989) Lymphocytic progesterone receptors in normal and pathological human pregnancy. J Reprod Immunol 16,239-247.
34. Yie SM, Li LH, Li GM, Xiao RL and Librach CL (2006) Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro. Hum Reprod 21,46-51.