The role of the innate immune response in hospital- versus community-acquired infection in febrile medical patients

International Journal of Infectious Diseases

Volumn 12, Issue 6, 2008, Pages 660-670

  Groeneveld, A B Johan ^a   Hack, C Erik ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CRUCELL HOLLAND BV   (Netherlands)

Author keywords

Community acquired infection; Healthcare related infection; Hospital infections; Host defense; Inflammatory mediators; Mortality

Indexed keywords

ALPHA 1 ANTITRYPSIN; COMPLEMENT COMPONENT C3A; CORTICOSTEROID; ELASTASE; INTERLEUKIN 6; PHOSPHOLIPASE A2; PROCALCITONIN; TRYPSIN INHIBITOR;

ADULT; AGED; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FEVER; HOSPITAL ADMISSION; HOSPITAL INFECTION; HUMAN; IMMUNOCOMPETENCE; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; SEPSIS; SEPTIC SHOCK;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTEREMIA; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; FEMALE; FEVER; HOSPITAL MORTALITY; HUMANS; IMMUNITY, INNATE; INFLAMMATION; MALE; MIDDLE AGED; SHOCK, SEPTIC; YOUNG ADULT;

EID: 54349092829     PISSN: 12019712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijid.2008.03.009     Document Type: Article

References (35)

1. Fassbender K., Dempfle C.E., Mielke O., Rossol S., Schneider S., Dollman M., et al. Proinflammatory cytokines: indicators of infection in high-risk patients. J Lab Clin Med 130 (1997) 535-539
2. Harbarth S., Ruef C.H., Francioli P., Widmer A., and Pittet D. Nosocomial infections in Swiss university hospitals: a multi-centre survey and review of the published literature. Schweiz Med Wochenschr 129 (1999) 1521-1528
3. Katja B., Hartmut K., Pawel M., Stefan B., Kox W.J., and Spies C.D. The value of immune modulating parameters in predicting the progression from peritonitis to septic shock. Shock 15 (2001) 95-100
4. Von Dossow V., Rotard K., Redlich U., Vargas Hein O., and Spies C.D. Circulating immune parameters predicting the progression form hospital-acquired pneumonia to septic shock in surgical patients. Crit Care 9 (2005) R662-R669
5. Mokart D., Merlin M., Sannini A., Brun J.P., Delpero J.R., Houvenaeghel G., et al. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anaesthesia 94 (2005) 767-773
6. Fabbro-Peray P., Sotto A., Defez C., Cazaban M., Molinari L., Pinède M., et al. Mortality attributable to nosocomial infection: a cohort of patients with and without nosocomial infection in a French university hospital. Infect Control Hosp Epidemiol 28 (2007) 265-272
7. Salemi C., Morgan J., Padilla S., and Morrissey R. Association between severity of illness and mortality from nosocomial infection. Am J Infect Control 23 (1995) 188-193
8. Dhainaut J.F., Claessens Y.E., Janes J., and Nelson D.R. Underlying disorders and their impact on the host response to infection. Clin Infect Dis 41 (2005) S481-S489
9. Groeneveld AB. Risk factors for increased mortality from hospital-acquired versus community-acquired infections in febrile medical patients. Am J Infect Control 2008; [in press].
10. Lark R.L., Saint S., Chenoweth C., Zemencuk J.K., Lipsky B.A., and Plorde J.J. Four-year prospective evaluation of community-acquired bacteremia: epidemiology, microbiology, and patient outcome. Diagn Microbiol Infect Dis 41 (2001) 15-22
11. Diekema D.J., Beekmann S.E., Chapin K.C., Morel K.A., Munson E., and Doern G.V. Epidemiology and outcome of nosocomial and community-onset bloodstream infection. J Clin Microbiol 41 (2003) 3655-3660
12. Calandra T., Gerain J., Heumann D., Baumgartner J.D., and Glauser M.P. High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 91 (1991) 23-29
13. Pinsky M.R., Vincent J.L., Deviere J., Alegre M., Kahn R.J., and Dupont E. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 103 (1993) 565-575
14. Damas P., Cavinet J.L., De Groote D., Vrindts Y., Albert A., Franchimont P., et al. Sepsis and serum cytokine concentrations. Crit Care Med 25 (1997) 405-412
15. Presterl E., Staudinger T., Pettermann M., Lassnigg A., Burgmann H., Winkler S., et al. Cytokine profile and correlation to the APACHE III and MPM II score in patients with sepsis. Am J Respir Crit Care Med 156 (1997) 825-832
16. Takala A., Jousela I., Jansson S.E., Olkkola K.T., Takkunen O.S., Orpana A., et al. Markers of systemic inflammation predicting organ failure in community-acquired septic shock. Clin Sci 97 (1999) 529-538
17. Gogos C.A., Drosou E., Bassaris H.P., and Skoutelis A. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 181 (2000) 176-180
18. van Langevelde P., Joop K., van Loon J., Frölich M., Groeneveld P.H., Westendorp R.G., et al. Endotoxin, cytokines, and procalcitonin in febrile patients admitted to the hospital: identification of subjects at high risk of mortality. Clin Infect Dis 31 (2000) 1343-1348
19. Selberg O., Hecker H., Martin M., Klos A., Bautsch W., and Köhl J. Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6. Crit Care Med 28 (2000) 2793-2798
20. Groeneveld A.B., Bossink A.W., van Mierlo G.J., and Hack C.E. Circulating inflammatory mediators in patients with fever: predicting bloodstream infection. Clin Diagn Lab Immunol 8 (2001) 1189-1195
21. Harbarth S., Holeckova K., Froidevaux C., Pittet D., Ricou B., Grau G.E., et al. the Geneva Sepsis Network. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 164 (2001) 396-402
22. Pettilä V., Hynninen M., Takkunen O., Kuusela P., and Valtonen M. Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med 28 (2002) 1220-1225
23. Fernández-Serrano S., Dorca J., Coromines M., Carratalà J., Gudiol F., and Manresa F. Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia. Clin Diagn Lab Immunol 10 (2003) 813-820
24. Groeneveld A.B., Tacx A.N., Bossink A.W., van Mierlo G.J., and Hack C.E. Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection. Clin Immunol 106 (2003) 106-115
25. Aalto H., Takala A., Kautinainen H., and Repo H. Laboratory markers of systemic inflammation as predictors of bloodstream infection in acutely ill patients admitted to hospital in emergency medicine. Eur J Clin Microbiol Infect Dis 23 (2004) 699-704
26. Lekkou A., Karakantza M., Mouzaki A., Kalfarentzos F., and Gogos C.A. Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol 11 (2004) 161-167
27. Oberholzer A., Souza S.M., Tschoeke S.K., Oberholzer C., Abouhamze A., Pribble J.P., et al. Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock 23 (2005) 488-493
28. Brown K.A., Brain S.D., Pearson J.D., Edgeworth J.D., Lewis S.M., and Treacher D.F. Neutrophils in development of multiple organ failure in sepsis. Lancet 368 (2006) 157-169
29. Heper Y., Akalm E.H., Mistik R., Akgöz S., Töre O., Göral G., et al. Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community-acquired sepsis, severe sepsis, and septic shock. Eur J Clin Microbiol Infect Dis 25 (2006) 481-491
30. Tang B.M., Eslick G.D., Craig J.C., and McLean A.S. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and metaanalysis. Lancet Infect Dis 7 (2007) 210-217
31. Kellum J.A., Kong L., Fink M.P., Weissfeld L.A., Yealy D.M., Pinsky M.R., et al. Understanding the inflammatory cytokine response in pneumonia and sepsis. Arch Intern Med 167 (2007) 1655-1663
32. Tejera A., Santolaria F., Diez M.L., Alemán M.R., González-Reimers E., Martínez-Riera A., et al. Prognosis of community-acquired pneumonia (CAP): value of triggering receptor expressed on myeloid cells (TREM-1) and other mediators of the inflammatory response. Cytokine 388 (2007) 117-123
33. Tsay R.W., Siu L.K., Fung C.P., and Chang F.Y. Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection. Arch Intern Med 162 (2002) 1021-1027
34. Moore L.J., Pridmore A.C., Lee M.E., and Read R.C. Induction of pro-inflammatory cytokine release by human macrophages during exposure of Streptococcus pneumoniae to penicillin is influenced by minimum inhibitory concentration ratio. Int J Antimicrob Agents 26 (2005) 188-196
35. Ziegeler S., Raddatz A., Hoff G., Buchinger H., Bauer I., Stockhausen A., et al. Antibiotics modulate the stimulated cytokine response to endotoxin in a human ex vivo, in vitro model. Acta Anaesthesiol Scand 50 (2006) 1103-1110