Cytokine profile and correlation to the apache iii and mpm ii scores m patients with sepsis

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 3 I, 1997, Pages 825-832

  Presterl, Elisabeth ^a   Staudinger, Thomas ^a   Pettermann, Maria ^a   Lassnigg, Andrea ^a   Burgmann, Heinz ^a   Winkler, Stefan ^a   Frass, Michael ^a   Graninger, Wolfgang ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; MALE; MORTALITY; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; SEPSIS;

EID: 0030853795     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.3.9607131     Document Type: Article

References (35)

1. Balk, R. A., and R. C. Bone. 1989. The septic syndrome: definition and clinical implications. Crit. Care Clinics 5:1.
2. Parrillo, J. E., M. M. Parker, and C. Natanson. 1990. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction and therapy. Ann. Intern. Med. 113:227.
3. Kreger, B. E., D. E. Craven, and W. R. McCabe. 1980. Gram-negative bacteremia, IV: re-evaluation of clinical features and treatment in 612 patients. Am. J. Med. 68:344-349.
4. Lemeshow, S., D. Teres, J. Klar, J. S. Avrunin, S. H. Gehlbach, and J. Rapopert. 1993. Mortality Probability Models (MPM II) based on an international cohort of intensive care unit patients. J.A.M.A. 270:2478-2486.
5. Knaus, W. A., E. A. Draper, D. P. Wagner, and J. E. Zimmermann. 1985. APACHE II: a severity of disease classification system. Crit. Care Med. 13:818-828.
6. Knaus, W. A., D. P. Wagner, E. A. Draper, J. E. Zimmermann, M. Bergner, P. G. Bastos, C. A. Sirio, D. J. Murphy, T. Lotring, A. Damiano, and F. E. Harreil. 1981. The APACHE III prognostic system: risk prediction of hospital mortality for critically ill hospitalized adults. Chest 100:1619-1636.
7. LeGall, J. R., S. Lemeshow, and F. Saulnier. 1993. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J.A.M.A. 270:2957-2963.
8. Stroud, M., B. Swindell, and G. R. Bernard. 1990. Cellular and humoral mediators of sepsis. Crit. Care Clinics 2:151.
9. Leeper-Woodard, K., P. D. Carey, and K. Byrne. 1991. Tumor necrosis factor. Am. Rev. Respir. Dis. 143:1076.
10. Mohler, K. M., D. S. Torrance, and C. A. Smith. 1993. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxinemia and function simultaneously as both TNF carriers and TNF antagonists. J. Immunol. 151:1548-1561.
11. Flier, J. S., and L. H. Underhill. 1996. The tumor necrosis factor ligand and families. N. Engl. J. Med. 334:1717-1725.
12. Wand, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1994. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J. Immunol. 153:822-826.
13. Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee. 1992. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organs failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20:864-874.
14. LeGall, J. R., S. Lemeshow, G. Leleu, J. Huillard, M. Rue, D. Teres, and A. Artigas for the Intensive Care Unit Scoring Group. 1995. Customized probability models for early severe sepsis in adult intensive care patients. J.A.M.A. 273:644-650.
15. Pinsky, M. R., and G. M. Matuchak. 1990. Multiple systems organ failure: failure of the host defense homoiostasis. Crit. Care Clinics 2:151.
16. Damas, P., A. Reuter, P. Gysen, J. Demonty, M. Lemay, and P. Franchimont. 1989. Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit. Care Med. 17:975-978.
17. Debets, J. M. H., R. Kampmeijer, M. P. M. H. van der Linden, W. A. Binirman, and C. V. van der Linden. 1989. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit. Care Med. 17:975-978.
18. Waage, A., A. Halstensen, and T. Espevik. 1987. Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1:355-357.
19. Calandra, T., J. D. Baumgartner, G. E. Grau, M. M. Wu, P. H. Lambert, and J. Schellekens. 1990. Prognostic values of tumor necrosis factor/ cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock. J. Infect. Dis. 161:928-987.
20. Waage, A., P. Brandtzaeg, A. Halstensen, P. Kierulf, and T. Espevik. 1989. The complex pattern of cytokines in serum of patients with meningococcal septic shock. J. Exp. Med. 169:333-338.
21. Casey, L. C., R. A. Balk, and R. C. Bone. 1993. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann. Intern. Med. 119:771-778.
22. Marchant, A., J. Deviere, B. Byl, D. De Groote, J. Vincent, and M. Goldman. 1994. Interleukin-10 production during septicemia. Lancet 343:707-708.
23. Calandra, T., J. Gerain, D. Heumann, J. D. Baumgartner, and M. P. Glauser. 1991. High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am. J. Med. 91:23-29.
24. Helfgott, D. C., S. B. Tatter, U. Santhanam, R. H. Clarick, N. Bhardwaj, and L. T. May. 1989. Multiple forms of IFN-β/IL-6 in serum and body fluids during acute bacterial infection. J. Immunol. 142:948-953.
25. Gardlund, B., J. Sjölin, A. Nilsson, M. Roll, C. J. Wickerts, and B. Wretlind. 1995. Plasma levels of cytokines in primary septic shock in humans: correlation with disease severity. J. Infect Dis. 172:296-301.
26. Andrejko, K. M., and C. S. Deutschmann. 1996. Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-α abundance but not with plasma tumor necrosis factor concentrations during sepsis/systemic inflammatory response syndrome in the rat. Crit. Care Med. 24:1947-1952.
27. Girardin, E., P. Roux-Lombard, G. E. Grau, P. Suter, H. Gallati, the J5 Study Group, and J. M. Dayer. 1991. Imbalance between tumor necrosis factor alpha and soluble TNF receptor concentrations in severe meningococcaemia. Immunology 76:20-23.
28. Kern, W. V., A. Engel, and P. Kern. 1995. Soluble tumor necrosis factor receptors in febrile neutropenic cancer patients. Infection 23:64-65.
29. Rogy, M. A., S. M. Coyle, H. S. A. Oldenburg, C. S. Rock, P. S. Barie, J. Van Zee, C. G. Smith, L. L. Moldawer, and S. F. Lowry. 1994. Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients. J. Am. Coll. Surg. 178:132-138.
30. Humbert, M., P. Roux-Lombard, J. Cerrina, A. Magnan, G. Simonneau, P. Darteville, P. Galanaud, J. M. Dayer, and D. Emilie. 1994. Soluble TNF receptor (TNF-sR55 and TNF-sR75) in lung allograft recipients displaying cytomegalovirus pneumonitis. Am. J. Respir. Crit. Care Metl. 149:1681-1685.
31. Zabel, P., M. M. Schönharting, D. T. Welter, and U. F. Schade. 1989. Oxpentifylline in endotoxinaemia. Lancet II:1474-1477.
32. Moldawer, L. L. 1994. Biology of proinflammatory cytokines and their antagonists. Crit. Care. Med. 22:S3-S7.
33. Doherty, G. M., J. R. Lange, H. N. Langstein, R. Alexander, C. M. Buresh, and J. A. Norton. 1992. Evidence of IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor. J. Immunol. 149: 1666-1670.
34. Heinzel, F. P., R. M. Rerko, P. Ling, J. Hakimi, and D. S. Schoenhaut. 1994. Interleukin 12 is produced in vivo during endotoxinemia and stimulates synthesis of gamma interferon. Infect. Immunity 61:4144-4249.
35. Friedland, J. S., J. C. Porter, S. Daryanani, J. M. Bland, N. J. Screaton, M. J. J. Vesely, G. E. Griffin, E. D. Bennett, and D. G. Remick. 1996. Plasma proinflammatory cytokine concentrations. Acute Physiology and Chronic Health Evaluation (APACHE) III score and survival in patients in an intensive care unit. Crit Care Med. 24:1775-1781.