Double barrel shotgun scanning of the caveolin-1 scaffolding domain

ACS Chemical Biology

Volumn 2, Issue 7, 2007, Pages 493-500

  Levin, Aron M ^a   Murase, Katsuyuki ^a   Jackson, Pilgrim J ^a   Flinspach, Mack L ^c   Poulos, Thomas L ^a,b   Weiss, Gregory A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ARTICLE; BACTERIAL CELL; BINDING AFFINITY; BINDING KINETICS; COMBINATORIAL LIBRARY; CONTROLLED STUDY; ENZYME INHIBITION; ESCHERICHIA COLI; GENE MUTATION; MUTAGENESIS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; MOLECULAR GENETICS; THERMODYNAMICS;

AMINO ACID SEQUENCE; CAVEOLIN 1; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE SYNTHASE TYPE III; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

EID: 34548601774     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700055t     Document Type: Article

References (27)

1. Chaurasia, G., Iqbal, Y., Hanig, C., Herzel, H., Wanker, E. E., and Futschik, M. E. (2007) UniHI: an entry gate to the human protein interactome, Nucleic Acids Res. 35, D590-D594.
2. Vajdos, F. F., Adams, C. W., Breece, T. N., Presta, L. G., de Vos, A. M., and Sidhu, S. S. (2002) Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis, J. Mol. Biol. 320, 415-428.
3. Weiss, G. A., Watanabe, C. K., Zhong, A., Goddard, A., and Sidhu, S. S. (2000) Rapid mapping of protein functional epitopes by combinatorial alanine scanning, Proc. Natl. Acad. Sci. U.S.A. 97, 8950-8954.
4. Liu, P., Rudick, M., and Anderson, R. G. (2002) Multiple functions of caveolin-1, J. Biol. Chem. 277, 41295-41298.
5. Bender, F. C., Reymond, M. A., Bron, C., and Quest, A. F. (2000) Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity, Cancer Res. 60, 5870-5878.
6. Koleske, A. J., Baltimore, D., and Lisanti, M. P. (1995) Reduction of caveolin and caveolae in oncogenically transformed cells, Proc. Natl. Acad. Sci. U.S.A. 92, 1381-1385.
7. Razani, B., Woodman, S. E., and Lisanti, M. P. (2002) Caveolae: from cell biology to animal physiology. Pharmacol. Rev. 54, 431-467.
8. Garcia-Cardena, G., Fan, R., Stern, D. F., Liu, J., and Sessa, W. C. (1996) Endothelial nitric ocide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1, J. Biol. Chem. 271, 27237-27240.
9. Ju, H., Zou, R., Venema, V. J., and Venema, R. C. (1997) Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity, J. Biol. Chem. 272, 18522-18525.
10. Razani, B., Rubin, C. S., and Lisanti, M. P. (1999) Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A, J. Biol. Chem. 274, 26353-26360.
11. Andre, I., Kesvatera, T., Jonsson, B., and Linse, S. (2006) Salt enhances calmodulin-target interaction, Biophys. J. 90, 2903-2910.
12. Bayley, P. M., Findlay, W. A., and Martin, S. R. (1996) Target recognition by calmodulin: dissecting the kinetics and affinity of interaction using short peptide sequences, Protein Sci. 5, 1215-1228.
13. Houdusse, A., Gaucher, J. F., Krementsova, E., Mui, S., Trybus, K. M., and Cohen, C. (2006) Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features, Proc. Natl. Acad. Sci. U.S.A. 103, 19326-19331.
14. Ye, Q., Li, X., Wong, A., Mel, Q., and Jia, Z. (2006) Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode, Biochemistry 45, 738-745.
15. Levin, A. M., Coroneus, J. G., Cocco, M. J., and Weiss, G. A. (2006) Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and docking, Protein Sci. 15, 478-486.
16. Murase, K., Morrison, K. L., Tam, P. Y., Stafford, R. L., Jurnak, F., and Weiss, G. A. (2003) EF-Tu binding peptides identified, dissected, and affinity optimized by phage display, Chem. Biol. 10, 161-168.
17. Avrantinis, S. K., Stafford, R. L., Tian, X., and Weiss, G. A. (2002) Dissecting the streptavidin-biotin interaction by phage-displayed shotgun scanning, ChemBioChem 3, 1229-1234.
18. Sato, K., Simon, M. D., Levin, A. M., Shokat, K. M., and Weiss, G. A. (2004) Dissecting the engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning, Chem. Biol. 11, 1017-1023.
19. Cochran, J. R., Kim, Y. S., Lippow, S. M., Rao, B., and Wittrup, K. D. (2006) Improved mutants from directed evolution are biased to orthologous substitutions, Protein Eng. Des. Sel. 19, 245-253.
20. Levin, A. M., and Weiss, G. A. (2006) Optimizing the affinity and specificity of proteins with molecular display, Mol. Biosyst. 2, 49-57.
21. Fernandez, I., Ying, Y., Albanesi, J., and Anderson, R. G. (2002) Mechanism of caveolin filament assembly, Proc. Natl. Acad. Sci. U.S.A. 99, 11193-11198.
22. Bernatchez, P. N., Bauer, P. M., Yu, J., Prendergast, J. S., He, P., and Sessa, W. C. (2005) Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides, Proc. Natl. Acad. Sci. U.S.A. 102, 761-766.
23. Gratton, J. P., Fontana, J., O'Connor, D. S., Garcia-Cardena, G., McCabe, T. J., and Sessa, W. C. (2000) Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1, J. Biol. Chem. 275, 22268-22272.
24. Sato, Y., Sagami, I., and Shimizu, T. (2004) Identification of caveolin-1-interacting sites in neuronal nitric-oxide synthase. Molecular mechanism for inhibition of NO formation, J. Biol. Chem. 279, 8827-8836.
25. Sidhu, S. S., and Weiss, G. A. (2004) in Oligonucleotide-directed construction of phage display libraries (Lowman, H. L., and Clackson, T., Eds.), Oxford University Press, pp 27-41.
26. Sidhu, S. S., Lowman, H. B., Cunningham, B. C., and Wells, J. A. (2000) Phage display for selection of novel binding peptides, Methods Enzymol. 328, 333-363.
27. Kelm, M., Feelisch, M., Spahr, R., Piper, H. M., Noack, E. A., and Schrader, J. (1988) Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothehial cells, Biochem. Biophys. Res. Commun. 154, 236-244.