메뉴 건너뛰기




Volumn 6, Issue 10, 2008, Pages 1575-1581

Association of HDM2 transcript levels with age of onset and prognosis in soft tissue sarcomas

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 54249091118     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-07-2150     Document Type: Article
Times cited : (8)

References (35)
  • 1
    • 38049054248 scopus 로고    scopus 로고
    • Updates on p53: Modulation of p53 degradation as a therapeutic approach
    • Dey A, Verma CS, Lane DP. Updates on p53: modulation of p53 degradation as a therapeutic approach. Br J Cancer 2008;98:4-8.
    • (2008) Br J Cancer , vol.98 , pp. 4-8
    • Dey, A.1    Verma, C.S.2    Lane, D.P.3
  • 2
    • 34548256424 scopus 로고    scopus 로고
    • The role of ubiquitination in the direct mitochondrial death program of p53
    • Marchenko ND, Moll UM. The role of ubiquitination in the direct mitochondrial death program of p53. Cell Cycle 2007;6:1718-23.
    • (2007) Cell Cycle , vol.6 , pp. 1718-1723
    • Marchenko, N.D.1    Moll, U.M.2
  • 3
    • 0029131447 scopus 로고
    • A functional p53-responsive intronic promoter is contained within the human mdm2 gene
    • Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res 1995;23:2584-92.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2584-2592
    • Zauberman, A.1    Flusberg, D.2    Haupt, Y.3    Barak, Y.4    Oren, M.5
  • 4
    • 27144540980 scopus 로고    scopus 로고
    • Characterisation of a novel p53 down-regulated promoter in intron 3 of the human MDM2 oncogene
    • Liang H, Lunec J. Characterisation of a novel p53 down-regulated promoter in intron 3 of the human MDM2 oncogene. Gene 2005;361: 112-8.
    • (2005) Gene , vol.361 , pp. 112-118
    • Liang, H.1    Lunec, J.2
  • 5
    • 0033533737 scopus 로고    scopus 로고
    • Role of two upstream open reading frames in the translational control of oncogene mdm2
    • Brown CY, Mize GJ, Pineda M, George DL, Morris DR. Role of two upstream open reading frames in the translational control of oncogene mdm2. Oncogene 1999;18:5631-7.
    • (1999) Oncogene , vol.18 , pp. 5631-5637
    • Brown, C.Y.1    Mize, G.J.2    Pineda, M.3    George, D.L.4    Morris, D.R.5
  • 6
    • 0028049474 scopus 로고
    • Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
    • Barak Y, Gottlieb E, Juven-Gershon T, Oren M. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev 1994;8:1739-49.
    • (1994) Genes Dev , vol.8 , pp. 1739-1749
    • Barak, Y.1    Gottlieb, E.2    Juven-Gershon, T.3    Oren, M.4
  • 7
    • 0037815066 scopus 로고    scopus 로고
    • The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties
    • Jin X, Turcott E, Englehardt S, Mize GJ, Morris DR. The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties. J Biol Chem 2003;278:25716-21.
    • (2003) J Biol Chem , vol.278 , pp. 25716-25721
    • Jin, X.1    Turcott, E.2    Englehardt, S.3    Mize, G.J.4    Morris, D.R.5
  • 8
    • 8844278362 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the Mdm2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    • Bond GL, Hu W, Bond EE, et al. A single nucleotide polymorphism in the Mdm2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 2004;119:591-602.
    • (2004) Cell , vol.119 , pp. 591-602
    • Bond, G.L.1    Hu, W.2    Bond, E.E.3
  • 9
    • 33744899069 scopus 로고    scopus 로고
    • MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner
    • Bond GL, Hirshfield KM, Kirchhoff T, et al. MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res 2006;66:5104-10.
    • (2006) Cancer Res , vol.66 , pp. 5104-5110
    • Bond, G.L.1    Hirshfield, K.M.2    Kirchhoff, T.3
  • 10
    • 1042274013 scopus 로고    scopus 로고
    • Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma
    • Bartel F, Meye A, Würl P, et al. Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. Int J Cancer 2001;95:168-75.
    • (2001) Int J Cancer , vol.95 , pp. 168-175
    • Bartel, F.1    Meye, A.2    Würl, P.3
  • 11
    • 0034633702 scopus 로고    scopus 로고
    • Generation of oscillations by the p53-2 feedback loop: A theoretical and experimental study
    • Lev Bar-Or R, Maya R, Segel LA, et al. Generation of oscillations by the p53-2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A 2000;97:11250-5.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11250-11255
    • Lev Bar-Or, R.1    Maya, R.2    Segel, L.A.3
  • 12
    • 34047247060 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells
    • Hu W, Feng Z, Ma L, et al. A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res 2007; 67:2757-65.
    • (2007) Cancer Res , vol.67 , pp. 2757-2765
    • Hu, W.1    Feng, Z.2    Ma, L.3
  • 13
    • 34250888210 scopus 로고    scopus 로고
    • Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs
    • Nayak MS, Yang JM, Hait WN. Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs. Cancer Res 2007;67:5831-9.
    • (2007) Cancer Res , vol.67 , pp. 5831-5839
    • Nayak, M.S.1    Yang, J.M.2    Hait, W.N.3
  • 14
    • 33144460815 scopus 로고    scopus 로고
    • Association between MDM2-309 and age at colorectal cancer diagnosis according to p53 mutation status
    • Menin C, Scaini MC, De Salvo GL, et al. Association between MDM2-309 and age at colorectal cancer diagnosis according to p53 mutation status. J Natl Cancer Inst 2006;98:285-8.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 285-288
    • Menin, C.1    Scaini, M.C.2    De Salvo, G.L.3
  • 15
    • 33745783716 scopus 로고    scopus 로고
    • Association of breast cancer outcome with status of p53 and MDM2 SNP309
    • Boersma BJ, Howe TM, Goodman JE, et al. Association of breast cancer outcome with status of p53 and MDM2 SNP309. J Natl Cancer Inst 2006;98: 911-9.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 911-919
    • Boersma, B.J.1    Howe, T.M.2    Goodman, J.E.3
  • 16
    • 42949134397 scopus 로고    scopus 로고
    • Both somatic and germline genetics of the TP53-pathway influence ovarian cancer incidence and survival
    • Böhnke A, Jung J, Taubert H, Hauptmann S, Bartel F. Both somatic and germline genetics of the TP53-pathway influence ovarian cancer incidence and survival. Verh Dtsch Ges Pathol 2007;91:233-42.
    • (2007) Verh Dtsch Ges Pathol , vol.91 , pp. 233-242
    • Böhnke, A.1    Jung, J.2    Taubert, H.3    Hauptmann, S.4    Bartel, F.5
  • 17
    • 34250648071 scopus 로고    scopus 로고
    • A polymorphism in HDM2 (SNP309) associates with early onset in superficial tumors, TP53 mutations, and poor outcome in invasive bladder cancer
    • Sanchez-Carbayo M, Socci ND, Kirchoff T, et al. A polymorphism in HDM2 (SNP309) associates with early onset in superficial tumors, TP53 mutations, and poor outcome in invasive bladder cancer. Clin Cancer Res 2007; 13:3215-20.
    • (2007) Clin Cancer Res , vol.13 , pp. 3215-3220
    • Sanchez-Carbayo, M.1    Socci, N.D.2    Kirchoff, T.3
  • 18
    • 9844229070 scopus 로고    scopus 로고
    • Prognostic value of immunohistochemistry for p53 in primary soft-tissue sarcomas: A multivariate analysis of five antibodies
    • Würl P, Taubert H, Meye A, et al. Prognostic value of immunohistochemistry for p53 in primary soft-tissue sarcomas: a multivariate analysis of five antibodies. J Cancer Res Clin Oncol 1997;123:502-8.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 502-508
    • Würl, P.1    Taubert, H.2    Meye, A.3
  • 19
    • 33845803180 scopus 로고    scopus 로고
    • Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops
    • Cheng TH, Cohen SN. Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops. Mol Cell Biol 2007;27: 111-9.
    • (2007) Mol Cell Biol , vol.27 , pp. 111-119
    • Cheng, T.H.1    Cohen, S.N.2
  • 20
  • 21
    • 0030895921 scopus 로고    scopus 로고
    • A comparison of selected mRNA and protein abundances in human liver
    • Anderson L, Seilhamer J. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis 1997;18:533-7.
    • (1997) Electrophoresis , vol.18 , pp. 533-537
    • Anderson, L.1    Seilhamer, J.2
  • 22
    • 0036549767 scopus 로고    scopus 로고
    • Discordant protein and mRNA expression in lung adenocarcinomas
    • Chen G, Gharib TG, Huang CC, et al. Discordant protein and mRNA expression in lung adenocarcinomas. Mol Cell Proteomics 2002;1: 304-13.
    • (2002) Mol Cell Proteomics , vol.1 , pp. 304-313
    • Chen, G.1    Gharib, T.G.2    Huang, C.C.3
  • 23
    • 0033655386 scopus 로고    scopus 로고
    • mdm2 mRNA level is a prognostic factor in soft tissue sarcoma
    • Taubert H, Koehler T, Meye A, et al. mdm2 mRNA level is a prognostic factor in soft tissue sarcoma. Mol Med 2000;6:50-9.
    • (2000) Mol Med , vol.6 , pp. 50-59
    • Taubert, H.1    Koehler, T.2    Meye, A.3
  • 24
    • 0030828285 scopus 로고    scopus 로고
    • mdm 2 mRNA expression is associated with survival in ovarian cancer
    • Tanner B, Hengstler JG, Laubscher S, et al. mdm 2 mRNA expression is associated with survival in ovarian cancer. Int J Cancer 1997;74: 438-42.
    • (1997) Int J Cancer , vol.74 , pp. 438-442
    • Tanner, B.1    Hengstler, J.G.2    Laubscher, S.3
  • 25
    • 29944447632 scopus 로고    scopus 로고
    • Tumor suppression and normal aging in mice with constitutively high p53 activity
    • Mendrysa SM, O'Leary KA, McElwee MK, et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev 2006;20: 16-21.
    • (2006) Genes Dev , vol.20 , pp. 16-21
    • Mendrysa, S.M.1    O'Leary, K.A.2    McElwee, M.K.3
  • 26
    • 20244376287 scopus 로고    scopus 로고
    • Increased survivin transcript levels: An independent negative predictor of survival in soft tissue sarcoma patients
    • Kappler M, Köhler T, Kampf C, et al. Increased survivin transcript levels: an independent negative predictor of survival in soft tissue sarcoma patients. Int J Cancer 2001;95:360-3.
    • (2001) Int J Cancer , vol.95 , pp. 360-363
    • Kappler, M.1    Köhler, T.2    Kampf, C.3
  • 27
    • 0037117121 scopus 로고    scopus 로고
    • Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma
    • Würl P, Kappler M, Meye A, et al. Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma. Lancet 2002; 359:943-5.
    • (2002) Lancet , vol.359 , pp. 943-945
    • Würl, P.1    Kappler, M.2    Meye, A.3
  • 28
    • 0027431795 scopus 로고
    • Grading of soft tissue sarcomas: Experience of the EORTC Soft and Bone Sarcoma Group
    • van Unnik JAM, Coindre JM, Contesso C, et al. Grading of soft tissue sarcomas: experience of the EORTC Soft and Bone Sarcoma Group. Eur J Cancer 1993;29A:2089-93.
    • (1993) Eur J Cancer , vol.29 A , pp. 2089-2093
    • van Unnik, J.A.M.1    Coindre, J.M.2    Contesso, C.3
  • 29
  • 30
    • 20444482051 scopus 로고    scopus 로고
    • MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm
    • Phelps M, Phillips A, Darley M, Blaydes JP. MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. J Biol Chem 2005;280:16651-8.
    • (2005) J Biol Chem , vol.280 , pp. 16651-16658
    • Phelps, M.1    Phillips, A.2    Darley, M.3    Blaydes, J.P.4
  • 31
    • 26444599546 scopus 로고    scopus 로고
    • Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    • Bartel F, Schulz J, Böhnke A, et al. Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis. Int J Cancer 2005;117: 469-75.
    • (2005) Int J Cancer , vol.117 , pp. 469-475
    • Bartel, F.1    Schulz, J.2    Böhnke, A.3
  • 32
    • 0031841402 scopus 로고    scopus 로고
    • Soft tissue sarcomas and p53 mutations
    • Taubert H, Meye A, Würl P. Soft tissue sarcomas and p53 mutations. Mol Med 1998;4:365-72.
    • (1998) Mol Med , vol.4 , pp. 365-372
    • Taubert, H.1    Meye, A.2    Würl, P.3
  • 33
    • 0344906097 scopus 로고    scopus 로고
    • Prognostic relevance of C-terminal MDM2 detection is enhanced by positivity in soft tissue sarcomas
    • Würl P, Meye A, Berger D, et al. Prognostic relevance of C-terminal MDM2 detection is enhanced by positivity in soft tissue sarcomas. Diagn Mol Pathol 1997;6:249-54.
    • (1997) Diagn Mol Pathol , vol.6 , pp. 249-254
    • Würl, P.1    Meye, A.2    Berger, D.3
  • 34
    • 0037403684 scopus 로고    scopus 로고
    • Reduced expression of hMSH2 protein is correlated to poor survival for soft tissue sarcoma patients
    • Taubert H, Bartel F, Kappler M, et al. Reduced expression of hMSH2 protein is correlated to poor survival for soft tissue sarcoma patients. Cancer 2003;97: 2273-8.
    • (2003) Cancer , vol.97 , pp. 2273-2278
    • Taubert, H.1    Bartel, F.2    Kappler, M.3
  • 35
    • 33847308066 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans
    • Bond GL, Levine AJ. A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans. Oncogene 2007;26:1317-23.
    • (2007) Oncogene , vol.26 , pp. 1317-1323
    • Bond, G.L.1    Levine, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.