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Volumn 6, Issue 5, 1997, Pages 249-254

Prognostic relevance of C-terminal Mdm2 detection is enhanced by p53 positivity in soft tissue sarcomas

Author keywords

Immunohistochemistry; Mdm2; p53; Prognosis; Soft tissue sarcoma

Indexed keywords

PROTEIN P53;

EID: 0344906097     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199710000-00001     Document Type: Article
Times cited : (26)

References (47)
  • 1
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J 1993;12:461-8.
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 2
    • 0026523614 scopus 로고
    • Enhanced binding of a 95 kD protein to p53 in cells undergoing p53 mediated growth arrest
    • Barak Y, Oren M. Enhanced binding of a 95 kD protein to p53 in cells undergoing p53 mediated growth arrest. EMBO J 1992;11: 2115-21.
    • (1992) EMBO J , vol.11 , pp. 2115-2121
    • Barak, Y.1    Oren, M.2
  • 3
    • 0029818380 scopus 로고    scopus 로고
    • Identification of novel mdm2 binding peptides by phage display
    • Böttger V, Böttger A, Howard SF, et al. Identification of novel mdm2 binding peptides by phage display. Oncogene 1996;13: 2141-7.
    • (1996) Oncogene , vol.13 , pp. 2141-2147
    • Böttger, V.1    Böttger, A.2    Howard, S.F.3
  • 4
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen J, Marechal V, Levine AJ. Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol 1993;13:4107-14.
    • (1993) Mol Cell Biol , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 5
    • 0029913730 scopus 로고    scopus 로고
    • mdm2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • Chen J, Wu X, Lin J, Levine AJ. mdm2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996;16:2445-52.
    • (1996) Mol Cell Biol , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 6
    • 0028098165 scopus 로고
    • Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
    • Cordon-Cardo C, Latres E, Drobnjak M, et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994;54:794-9.
    • (1994) Cancer Res , vol.54 , pp. 794-799
    • Cordon-Cardo, C.1    Latres, E.2    Drobnjak, M.3
  • 7
    • 0031038770 scopus 로고    scopus 로고
    • Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma
    • Dei Tos AP, Doglioni C, Piccinin S, et al. Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. J Pathol 1997; 181:8-13.
    • (1997) J Pathol , vol.181 , pp. 8-13
    • Dei Tos, A.P.1    Doglioni, C.2    Piccinin, S.3
  • 8
    • 0029981711 scopus 로고    scopus 로고
    • Tumor suppressor genes and related molecules in leiomyosarcoma
    • Dei Tos AP, Maestro R, Doglioni C, et al. Tumor suppressor genes and related molecules in leiomyosarcoma. Am J Pathol 1996;148: 1037-45.
    • (1996) Am J Pathol , vol.148 , pp. 1037-1045
    • Dei Tos, A.P.1    Maestro, R.2    Doglioni, C.3
  • 9
    • 0025853776 scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh SS, Trusko SP, George DL. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 1991;10:1565-9.
    • (1991) EMBO J , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 10
    • 0027498314 scopus 로고
    • The mdm2 oncogene can overcome wild type p53 suppression of transformed cell growth
    • Finlay CA. The mdm2 oncogene can overcome wild type p53 suppression of transformed cell growth. Mol Cell Biol 1993;13: 301-6.
    • (1993) Mol Cell Biol , vol.13 , pp. 301-306
    • Finlay, C.A.1
  • 12
    • 0029829291 scopus 로고    scopus 로고
    • A molecular and immunohistochemical study of the mdm2 isoforms and p53 gene product in bronchiogenic carcinoma
    • Gorgoulis VG, Zoumpourlis V, Rassidakis GZ, et al. A molecular and immunohistochemical study of the mdm2 isoforms and p53 gene product in bronchiogenic carcinoma. J Pathol 1996;180:129-37.
    • (1996) J Pathol , vol.180 , pp. 129-137
    • Gorgoulis, V.G.1    Zoumpourlis, V.2    Rassidakis, G.Z.3
  • 13
    • 0028299342 scopus 로고
    • P53 in tumor pathology: Can we trust immunohistochemistry? - Revisited!
    • Hall P, Lane DP. P53 in tumor pathology: can we trust immunohistochemistry? - Revisited! J Pathol 1994;172:1-4.
    • (1994) J Pathol , vol.172 , pp. 1-4
    • Hall, P.1    Lane, D.P.2
  • 14
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the mdm2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie PH, Gorina S, Marechal V, et al. Structure of the mdm2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 1996;274:948-53.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3
  • 17
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
    • Landers JE, Haines DS, Straus JF, George DL. Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 1994;9:2745-50.
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Straus, J.F.3    George, D.L.4
  • 18
    • 0027232042 scopus 로고
    • p53 mutation and mdm2 amplification in human soft tissue sarcomas
    • Leach FS, Tokino T, Meltzer P, et al. p53 mutation and mdm2 amplification in human soft tissue sarcomas. Cancer Res 1993;53: 2231-4.
    • (1993) Cancer Res , vol.53 , pp. 2231-2234
    • Leach, F.S.1    Tokino, T.2    Meltzer, P.3
  • 19
    • 0028023524 scopus 로고
    • Altered patterns of MDM2 and TP53 expression in human bladder cancer
    • Lianes P, Orlow I, Zhang ZF, et al. Altered patterns of MDM2 and TP53 expression in human bladder cancer. J Natl Cancer Inst 1994;86:1325-30.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1325-1330
    • Lianes, P.1    Orlow, I.2    Zhang, Z.F.3
  • 20
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin J, Chen J, Elenbaas B, Levine AJ. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein Genes Dev 1994;8:1235-46.
    • (1994) Genes Dev , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 22
    • 0029796241 scopus 로고    scopus 로고
    • MDM2 amplification in a primary alveolar rhabdomyosarcoma displaying a t(2;13)(q35;q14)
    • Meddeb M, Valent A, Danglot G, et al. MDM2 amplification in a primary alveolar rhabdomyosarcoma displaying a t(2;13)(q35;q14). Cytogenet Cell Genet 1996;73:325-30.
    • (1996) Cytogenet Cell Genet , vol.73 , pp. 325-330
    • Meddeb, M.1    Valent, A.2    Danglot, G.3
  • 23
    • 0026235072 scopus 로고
    • Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors
    • Meltzer PS, Jankowski SA, Dal Cin P, Sandberg AA, Paz IB, Coccia MA. Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. Cell Growth Differ 1991;2:495-501.
    • (1991) Cell Growth Differ , vol.2 , pp. 495-501
    • Meltzer, P.S.1    Jankowski, S.A.2    Dal Cin, P.3    Sandberg, A.A.4    Paz, I.B.5    Coccia, M.A.6
  • 24
    • 0029984820 scopus 로고    scopus 로고
    • Analysis of the proportion of p53 bound to mdm2 in cells with defined growth characteristics
    • Momand J, Zambetti GP. Analysis of the proportion of p53 bound to mdm2 in cells with defined growth characteristics. Oncogene 1996;12:2279-89.
    • (1996) Oncogene , vol.12 , pp. 2279-2289
    • Momand, J.1    Zambetti, G.P.2
  • 25
    • 0026649648 scopus 로고
    • The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation. Cell 1992;69:1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 26
  • 28
    • 0027179604 scopus 로고
    • Identification and characterisation of multiple mdm2 proteins and mdm2-p53 protein complexes
    • Olson DC, Marechal V, Momand J, Chen J, Romocki C, Levine AJ. Identification and characterisation of multiple mdm2 proteins and mdm2-p53 protein complexes. Oncogene 1993;8:2353-60.
    • (1993) Oncogene , vol.8 , pp. 2353-2360
    • Olson, D.C.1    Marechal, V.2    Momand, J.3    Chen, J.4    Romocki, C.5    Levine, A.J.6
  • 29
    • 0027291285 scopus 로고
    • Upregulation of mdm2 expression in meth a tumor cells tolerating wild type p53
    • Otto A, Deppert W. Upregulation of mdm2 expression in meth a tumor cells tolerating wild type p53. Oncogene 1993;8:2591-603.
    • (1993) Oncogene , vol.8 , pp. 2591-2603
    • Otto, A.1    Deppert, W.2
  • 30
    • 0029992335 scopus 로고    scopus 로고
    • p53 and MDM2 immunostaining in pulmonary blastomas and bronchiogenic carcinomas
    • Pacinda SJ, Ledet SC, Gondo MM, et al. p53 and MDM2 immunostaining in pulmonary blastomas and bronchiogenic carcinomas. Hum Pathol 1996;27:542-6.
    • (1996) Hum Pathol , vol.27 , pp. 542-546
    • Pacinda, S.J.1    Ledet, S.C.2    Gondo, M.M.3
  • 31
    • 0007267495 scopus 로고    scopus 로고
    • Amplification and over-expression of the mdm2 gene in human soft tissue tumours
    • Patterson H, Bares D, Gill S, et al. Amplification and over-expression of the mdm2 gene in human soft tissue tumours. Sarcoma 1997;1:17-22.
    • (1997) Sarcoma , vol.1 , pp. 17-22
    • Patterson, H.1    Bares, D.2    Gill, S.3
  • 32
    • 0027964904 scopus 로고
    • Immunochemical analysis of the interaction of p53 with MDM2: Fine mapping of the MDM2 binding site on p53 using synthetic peptides
    • Picksley SM, Vojtesk B, Sparks A, Lane DP. Immunochemical analysis of the interaction of p53 with MDM2: fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 1994;9:2523-9.
    • (1994) Oncogene , vol.9 , pp. 2523-2529
    • Picksley, S.M.1    Vojtesk, B.2    Sparks, A.3    Lane, D.P.4
  • 33
    • 0031046598 scopus 로고    scopus 로고
    • Distinct mdm2/p53 expression patterns in liposarcoma subgroups: Implications for different pathogenic mechanisms
    • Pilotti S, Della Torre G, Lavarino C, et al. Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenic mechanisms. J Pathol 1997;181:14-24.
    • (1997) J Pathol , vol.181 , pp. 14-24
    • Pilotti, S.1    Della Torre, G.2    Lavarino, C.3
  • 34
    • 0001812125 scopus 로고    scopus 로고
    • Enhanced mdm2 oncoprotein expression in soft tissue sarcoma: Several possible mechanisms
    • Pollock RE, Lang A, El-Naggar AK, Radinsky R, Hung MC. Enhanced mdm2 oncoprotein expression in soft tissue sarcoma: several possible mechanisms. Sarcoma 1997;1:23-9.
    • (1997) Sarcoma , vol.1 , pp. 23-29
    • Pollock, R.E.1    Lang, A.2    El-Naggar, A.K.3    Radinsky, R.4    Hung, M.C.5
  • 35
    • 0030028076 scopus 로고    scopus 로고
    • MDM2 amplification, p53 mutation, and accumulation of the p53 gene product in malignant fibrous histiocytoma
    • Reid AH, Tsai MM, Venzon DJ, Wright CE, Lack EE, O'Leary TJ. MDM2 amplification, p53 mutation, and accumulation of the p53 gene product in malignant fibrous histiocytoma. Diagn Mol Pathol 1996;5:65-73.
    • (1996) Diagn Mol Pathol , vol.5 , pp. 65-73
    • Reid, A.H.1    Tsai, M.M.2    Venzon, D.J.3    Wright, C.E.4    Lack, E.E.5    O'Leary, T.J.6
  • 36
    • 0029824669 scopus 로고    scopus 로고
    • Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: Transforming ability and frequent detection in human cancer
    • Sigalas I, Calvert AH, Anderson JJ, Neal DE, Lunec J. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nature Med 1996;2:912-7.
    • (1996) Nature Med , vol.2 , pp. 912-917
    • Sigalas, I.1    Calvert, A.H.2    Anderson, J.J.3    Neal, D.E.4    Lunec, J.5
  • 37
    • 0028915250 scopus 로고
    • Characterisation of epitopes on human p53 using phage-displayed peptide libraries: Insight into antibody-peptide interactions
    • Stephen CW, Helminen P, Lane DP. Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insight into antibody-peptide interactions. J Mol Biol 1995;248:58-78.
    • (1995) J Mol Biol , vol.248 , pp. 58-78
    • Stephen, C.W.1    Helminen, P.2    Lane, D.P.3
  • 38
    • 0029810442 scopus 로고    scopus 로고
    • Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients
    • Taubert H, Meye A, Würl P. Prognosis is correlated with p53 mutation type for soft tissue sarcoma patients. Cancer Res 1996; 56:4134-6.
    • (1996) Cancer Res , vol.56 , pp. 4134-4136
    • Taubert, H.1    Meye, A.2    Würl, P.3
  • 39
    • 0029145778 scopus 로고
    • Molecular and immunohistochemical p53 status in liposarcoma and malignant fibrous histiocytoma
    • Taubert H, Würl P, Meye A, et al. Molecular and immunohistochemical p53 status in liposarcoma and malignant fibrous histiocytoma. Cancer 1995;76:1187-96.
    • (1995) Cancer , vol.76 , pp. 1187-1196
    • Taubert, H.1    Würl, P.2    Meye, A.3
  • 40
    • 0029952064 scopus 로고    scopus 로고
    • High levels of mdm2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines
    • Ungar S, Van de Meeren A, Tammilehto L, Linnainmaa K, Mattson K, Gerwin BI. High levels of mdm2 are not correlated with the presence of wild-type p53 in human malignant mesothelioma cell lines. Br J Cancer 1996;74:1534-40.
    • (1996) Br J Cancer , vol.74 , pp. 1534-1540
    • Ungar, S.1    Van De Meeren, A.2    Tammilehto, L.3    Linnainmaa, K.4    Mattson, K.5    Gerwin, B.I.6
  • 41
    • 0008702656 scopus 로고
    • Grading of soft tissue sarcomas: Experience of the EORTC soft tissue sarcoma group
    • Ryan JR, Baker LO, eds. Dordrecht, The Netherlands: Kluwer Academic
    • Van Unnik JAM, Coindre JM, Contesso G, et al. Grading of soft tissue sarcomas: experience of the EORTC soft tissue sarcoma group. In: Ryan JR, Baker LO, eds. Recent concepts in sarcoma treatment. Dordrecht, The Netherlands: Kluwer Academic, 1988: 7-13.
    • (1988) Recent Concepts in Sarcoma Treatment , pp. 7-13
    • Van Unnik, J.A.M.1    Coindre, J.M.2    Contesso, G.3
  • 42
    • 0030615220 scopus 로고    scopus 로고
    • p21WAF1/CIP1 and mdm2 expression in non-Hodgkin's lymphoma and their relationship to p53 status: A p53+, mdm2-, p21- Immunophenotype associated with missense p53 mutations
    • Villuendas R, Pezzella F, Gatter K, et al. p21WAF1/CIP1 and mdm2 expression in non-Hodgkin's lymphoma and their relationship to p53 status: a p53+, mdm2-, p21-immunophenotype associated with missense p53 mutations. J Pathol 1997;181:51-61.
    • (1997) J Pathol , vol.181 , pp. 51-61
    • Villuendas, R.1    Pezzella, F.2    Gatter, K.3
  • 43
    • 0027136159 scopus 로고
    • Infrequency of mdm2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas
    • Waber PG, Chen J, Nisen PD. Infrequency of mdm2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas. Cancer Res 1993; 53:6028-30.
    • (1993) Cancer Res , vol.53 , pp. 6028-6030
    • Waber, P.G.1    Chen, J.2    Nisen, P.D.3
  • 44
    • 0027244853 scopus 로고
    • The p53-mdm2 autoregulatory feedback loop
    • Wu X, Bayle H, Olson D, Levine AJ. The p53-mdm2 autoregulatory feedback loop. Genes Dev 1993;7:1126-32.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, H.2    Olson, D.3    Levine, A.J.4
  • 45
    • 0345556004 scopus 로고    scopus 로고
    • Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors
    • Würl P, Taubert H, Bache M, et al. Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors. Int J Cancer 1996;69: 317-23.
    • (1996) Int J Cancer , vol.69 , pp. 317-323
    • Würl, P.1    Taubert, H.2    Bache, M.3
  • 46
    • 9844229070 scopus 로고    scopus 로고
    • Prognostic value of immunohistochemistry for p53 in primary soft tissue sarcomas: A multivariate analysis of five antibodies
    • Würl P, Taubert H, Meye A, et al. Prognostic value of immunohistochemistry for p53 in primary soft tissue sarcomas: a multivariate analysis of five antibodies. J Cancer Res Clin Oncol 1997; 123:502-8.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 502-508
    • Würl, P.1    Taubert, H.2    Meye, A.3
  • 47
    • 0029028354 scopus 로고
    • Interaction between the retinoblastoma protein and the oncoprotein mdm2
    • Xiao ZX, Chen J, Levine AJ, et al. Interaction between the retinoblastoma protein and the oncoprotein mdm2. Nature 1995;375: 694-8.
    • (1995) Nature , vol.375 , pp. 694-698
    • Xiao, Z.X.1    Chen, J.2    Levine, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.