Association of a Lymphotoxin-α Gene Polymorphism and Atopic Asthma in Taiwanese Children

Pediatrics and Neonatology

Volumn 49, Issue 2, 2008, Pages 30-34

  Huang, Szu Chao ^a   Wu, Wen Jun ^b   Sun, Hai Lun ^a,b   Lue, Ko Huang ^a,b   Hsu, Chia Hsiu ^a   Liao, Pei Fen ^a   Ku, Min Sho ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

atopic asthma; gene polymorphism; lymphotoxin gene

Indexed keywords

CYTOKINE; LYMPHOTOXIN; TUMOR NECROSIS FACTOR;

ADOLESCENT; ALLELE; ALLERGIC ASTHMA; ARTICLE; ASTHMA; ATOPY; CASE CONTROL STUDY; CHROMOSOME 6P; CONFIDENCE INTERVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENE LOCATION; GENOTYPE; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; TAIWAN;

ADOLESCENT; ASTHMA; CHILD; FEMALE; GENOTYPE; HUMANS; LYMPHOTOXIN-ALPHA; MALE; POLYMORPHISM, GENETIC;

EID: 54149114897     PISSN: 18759572     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1875-9572(08)60008-X     Document Type: Article

References (38)

1. Robison D.S., Hamid Q., Ying S., et al. Predominant Th2-like bronchoalveolar T lymphocyte population in atopic asthma. N Engl J Med 326 (1992) 298-304
2. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease and asthma. Am Rev Respir Dis 136 (1988) 225-244
3. Holberg C.J., Elston R.C., Halonen M., et al. Segregation analysis of physician-diagnosed asthma in Hispanic and non-Hispanic white families. Am J Respir Crit Care Med 154 (1996) 140-150
4. European Community Respiratory Health Survey Group. Gene for asthma? An analysis of the European Community Respiratory Health Survey. Am J Respir Crit Care Med 156 (1997) 1773-1780
5. Wang T.N., Ko Y.C., Wang T.H., Li Cheng S.H., and Lin Y.C. Segregation analysis of asthma: a recessive major gene component for asthma in relation to history of atopic diseases. Am J Med Genet 93 (2000) 373-380
6. Sears M.R., Burrows B., Flannery E.M., Herbison G.P., Hewitt C.J., and Holdaway M.D. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 325 (1991) 1067-1071
7. Shibasaki M., Tajima K., Morikawa A., Mitsuhashi M., Sumazaki R., and Tokuyama K. Relation between frequency of asthma and IgE antibody levels against Dermatophagoides farinae and total serum IgE levels in school children. J Allergy Clin Immunol 82 (1988) 86-94
8. Denburg J.A. Bone marrow in atopy and asthma: hematopoietic mechanisms in allergic inflammation. Immunol Today 20 (1999) 111-113
9. Busse W.W., and Lemarke Jr. R.F. Asthma. N Engl J Med 344 (2001) 350-362
10. Ying S., Robinson D.S., Varney V., et al. TNF α mRNA expression in allergic inflammation. Clin Exp Allergy 21 (1991) 745-750
11. Carroll M.C., Katzman P., Alicot E.M., et al. Linkage map of the human major histocompatibility complex including the tumour necrosis factor genes. Proc Natl Acad Sci USA 84 (1987) 8535-8539
12. Albuquerque R.V., Hayden C.M., Palmer L.J., et al. Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma. Clin Exp Allergy 28 (1998) 578-584
13. Messer G., Spengler U., Jung M.C., et al. Polymorphic structure of the tumour necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med 173 (1991) 209-219
14. Stuber F., Udalova I.A., Book M., et al. -308 Tumor necrosis factor polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccaride inducibility of the human TNF promoter. J Inflamm 46 (1996) 42-50
15. Bidwell J., Keen L., Gallagher G., et al. Cytokine gene polymorphism in human disease. Genes Immun 2 (2001) 61-70
16. Hoffmann S.C., Stanley E.M., Cox E.D., et al. Association of cytokine polymorphism inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation 72 (2001) 1444-1450
17. Daniels S.E., Bhattacharrya S., James A., et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 383 (1996) 247-250
18. Wjst M., Fischer G., Immervoll T., et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 58 (1999) 1-8
19. Ruddle N.H., and Waksman B.H. Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. III. Analysis of mechanism. J Exp Med 128 (1968) 1267-1279
20. Gajewska B.U., Alvarez D., Vidric M., et al. Generation of experimental allergic airways inflammation in the absence of draining lymph nodes. J Clin Invest 108 (2001) 577-583
21. Worm M., Ebermayer K., and Henz B. Lymphotoxin-alpha is an important autocrine factor for CD40 interleukin-4-mediated B cell activation in normal and atopic donors. Immunology 94 (1998) 395-402
22. Kang H.S., Blink S.E., Chin R.K., et al. Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation. J Exp Med 198 (2003) 1643-1652
23. Roach D.R., Briscoe H., Saunders B., et al. Secreted lymphotoxinalpha is essential for the control of an intracellular bacterial infection. J Exp Med 193 (2001) 239-246
24. Engwerda C.R., Mynott T.L., Sawhney S., et al. Locally upregulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria. J Exp Med 195 (2002) 1371-1377
25. Ozaki K., Ohnishi Y., Iida A., et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 32 (2002) 650-654
26. Ozaki K., Inoue K., Sato H., et al. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. Nature 429 (2004) 72-75
27. Moffatt M.F., and Cookson W.O. Tumour necrosis factor haplotypes and asthma. Hum Mol Genet 6 (1997) 551-554
28. Wang T.N., Chen W.Y., Wang T.H., et al. Gene-gene synergistic effect on atopic asthma: TNF-α-308 and lymphotoxin-α-NcoI in Taiwan's children. Clin Exp Allergy 34 (2004) 184-188
29. Mochizuki H., Shigeta M., Tokuyama K., et al. Difference in airway reactivity in children with atopic vs. non-atopic asthma. Chest 116 (1999) 619-624
30. Trabetti E., Patuzzo C., Malerba G., et al. Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families. J Med Genet 36 (1999) 323-325
31. Lin Y.C., Lu C.C., Su H.J., et al. The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents. Allergy 57 (2002) 831-834
32. Hansen G., Berry G., Dekruyff R.H., et al. Allergen-specific Th1 cells fails to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 103 (1999) 175-183
33. Randolph D.A., Carruthers C.J., Szabo S.J., et al. Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. J Immunol 162 (1999) 2375-2383
34. Virchow J.C., Walker C., Hafner D., et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 151 (1995) 960-968
35. Broide D.H., Lotz M., Cuomo A.J., et al. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 89 (1992) 958-967
36. Malerba G., Trabetti E., Patuzzo C., et al. Candidate genes and a genome-wide search in Italian families with atopic asthmatic children. Clin Exp Allergy 29 (1999) 27-30
37. Noguchi E., Yokouchi Y., Shibasaki M., et al. Association between TNFA polymorphism and the development of asthma in the Japanese population. Am J Respir Crit Care Med 166 (2002) 43-46
38. Mogita O., Noguchi E., Shibasaki M., et al. Haplotype analysis of a 100 kb region spanning TNF-LTA polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. Clin Exp Allergy 35 (2005) 790-796