Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity

Molecular and Biochemical Parasitology

Volumn 162, Issue 2, 2008, Pages 105-111

  Erdman, Laura K ^a   Finney, Constance A M ^a   Liles, W Conrad ^a,b   Kain, Kevin C ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b Tropical Disease Unit   (Canada)

Author keywords

Complement; Histamine; Inflammation; Malaria; Toll like receptor; Uric acid

Indexed keywords

ALLOPURINOL; ANTIHISTAMINIC AGENT; CARBON MONOXIDE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; COMPLEMENT COMPONENT C5A; FEBUXOSTAT; HEME OXYGENASE 1; HISTAMINE; QUINOLINE; RECOMBINANT PEGYLATED URICASE; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; URIC ACID;

ADAPTIVE IMMUNITY; ADJUVANT THERAPY; ANTIINFLAMMATORY ACTIVITY; CHEMICAL STRUCTURE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; GENE THERAPY; HISTAMINE RELEASE; HUMAN; INNATE IMMUNITY; MALARIA; MAST CELL; NONHUMAN; PLASMODIUM; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION;

HUMANS; IMMUNITY, INNATE; INFLAMMATION; MALARIA; MODELS, BIOLOGICAL; TOLL-LIKE RECEPTORS;

EID: 54149084132     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2008.08.006     Document Type: Review

References (66)

1. White N.J. Not much progress in treatment of cerebral malaria. Lancet 352 9128 (1998) 594-595
2. Hunt N.H., and Grau G.E. Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 24 9 (2003) 491-499
3. Coban C., Ishii K.J., Horii T., and Akira S. Manipulation of host innate immune responses by the malaria parasite. Trends Microbiol 15 6 (2007) 271-278
4. Trinchieri G., and Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7 3 (2007) 179-190
5. Lee M.S., and Kim Y.J. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76 (2007) 447-480
6. Gowda D.C. TLR-mediated cell signaling by malaria GPIs. Trends Parasitol 23 12 (2007) 596-604
7. Carneiro L.A., Magalhaes J.G., Tattoli I., Philpott D.J., and Travassos L.H. Nod-like proteins in inflammation and disease. J Pathol 214 2 (2008) 136-148
8. Ockenhouse C.F., Hu W.C., Kester K.E., et al. Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria. Infect Immun 74 10 (2006) 5561-5573
9. Herskovits A.A., Auerbuch V., and Portnoy D.A. Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog 3 3 (2007) e51
10. Kufer T.A., and Sansonetti P.J. Sensing of bacteria: NOD a lonely job. Curr Opin Microbiol 10 1 (2007) 62-69
11. Berman P.A., Human L., and Freese J.A. Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro. J Clin Invest 88 6 (1991) 1848-1855
12. Orengo J.M., Evans J.E., Bettiol E., Leliwa-Sytek A., Day K., and Rodriguez A. Plasmodium-induced inflammation by uric acid. PLoS Pathog 4 3 (2008) e1000013
13. Iwalokun B.A., Bamiro S.B., and Ogunledun A. Levels and interactions of plasma xanthine oxidase, catalase and liver function parameters in Nigerian children with Plasmodium falciparum infection. Apmis 114 12 (2006) 842-850
14. Das B.S., Patnaik J.K., Mohanty S., et al. Plasma antioxidants and lipid peroxidation products in falciparum malaria. Am J Trop Med Hyg 49 6 (1993) 720-725
15. Sarma P.S., Mandal A.K., and Khamis H.J. Allopurinol as an additive to quinine in the treatment of acute complicated falciparum malaria. Am J Trop Med Hyg 58 4 (1998) 454-457
16. Marr J.J. Purine analogs as chemotherapeutic agents in leishmaniasis and American trypanosomiasis. J Lab Clin Med 118 2 (1991) 111-119
17. Bungener W. Influence of allopurinol on the multiplication of rodent malaria parasites. Tropenmed Parasitol 25 3 (1974) 309-312
18. Martinon F., Petrilli V., Mayor A., Tardivel A., and Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 7081 (2006) 237-241
19. Liu-Bryan R., Scott P., Sydlaske A., Rose D.M., and Terkeltaub R. Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum 52 9 (2005) 2936-2946
20. Shi Y., Evans J.E., and Rock K.L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425 6957 (2003) 516-521
21. Creagh E.M., and O'Neill L.A. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 27 8 (2006) 352-357
22. Russell I.J., Mansen C., Kolb L.M., and Kolb W.P. Activation of the fifth component of human complement (C5) induced by monosodium urate crystals: C5 convertase assembly on the crystal surface. Clin Immunol Immunopathol 24 2 (1982) 239-250
23. Ward P.A. The dark side of C5a in sepsis. Nat Rev Immunol 4 2 (2004) 133-142
24. Guo R.F., and Ward P.A. Role of C5a in inflammatory responses. Annu Rev Immunol 23 (2005) 821-852
25. Helegbe G.K., Goka B.Q., Kurtzhals J.A., et al. Complement activation in Ghanaian children with severe Plasmodium falciparum malaria. Malar J 6 (2007) 165
26. Wenisch C., Spitzauer S., Florris-Linau K., et al. Complement activation in severe Plasmodium falciparum malaria. Clin Immunol Immunopathol 85 2 (1997) 166-171
27. Patel S.N., Berghout J., Lovegrove F.E., et al. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 2005 5 (2008) 1133-1143
28. Roestenberg M., McCall M., Mollnes T.E., et al. Complement activation in experimental human malaria infection. Trans R Soc Trop Med Hyg 101 7 (2007) 643-649
29. Riedemann N.C., Guo R.F., Hollmann T.J., et al. Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis. Faseb J 18 2 (2004) 370-372
30. Hoogerwerf J.J., de Vos A.F., Bresser P., et al. Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans. Am J Respir Crit Care Med (2008)
31. Beghdadi W., Porcherie A., Schneider B.S., et al. Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease. J Exp Med 205 2 (2008) 395-408
32. Bradding P., and Holgate S.T. Immunopathology and human mast cell cytokines. Crit Rev Oncol Hematol 31 2 (1999) 119-133
33. Srichaikul T., Archararit N., Siriasawakul T., and Viriyapanich T. Histamine changes in Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg 70 1 (1976) 36-38
34. Talreja J., Kabir M.H.M.B.F., Stechschulte D.J., and Dileepan K.N. Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. Immunology 113 2 (2004) 224-233
35. Wu L., Feng B.S., He S.H., Zheng P.Y., Croitoru K., and Yang P.C. Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: the role of TLR2 and NOD2. Immunol Cell Biol 85 7 (2007) 538-545
36. Feng B.S., He S.H., Zheng P.Y., Wu L., and Yang P.C. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171 2 (2007) 537-547
37. MacDonald S.M., Bhisutthibhan J., Shapiro T.A., et al. Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo. Proc Natl Acad Sci USA 98 19 (2001) 10829-10832
38. Bieneman A.P., Chichester K.L., Chen Y.H., and Schroeder J.T. Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J Allergy Clin Immunol 115 2 (2005) 295-301
39. Perlmann H., Helmby H., Hagstedt M., et al. IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin Exp Immunol 97 2 (1994) 284-292
40. McGregor I.A. Thoughts on malaria in pregnancy with consideration of some factors which influence remedial strategies. Parassitologia 29 2-3 (1987) 153-163
41. Pamplona A., Ferreira A., Balla J., et al. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med 13 6 (2007) 703-710
42. Abraham N.G., and Kappas A. Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 60 1 (2008) 79-127
43. Ryter S.W., Alam J., and Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86 2 (2006) 583-650
44. Cunnington A.J., Kendrick S.F., Wamola B., Lowe B., and Newton C.R. Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria. Am J Trop Med Hyg 71 1 (2004) 43-47
45. Clark I.A., Awburn M.M., Harper C.G., Liomba N.G., and Molyneux M.E. Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis. Malar J 2 1 (2003) 41
46. Takeda M., Kikuchi M., Ubalee R., et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar. Jpn J Infect Dis 58 5 (2005) 268-271
47. Epiphanio S., Mikolajczak S.A., Goncalves L.A., et al. Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Cell Host Microbe 3 5 (2008) 331-338
48. Nakahira K., Kim H.P., Geng X.H., et al. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med 203 10 (2006) 2377-2389
49. Figueiredo R.T., Fernandez P.L., Mourao-Sa D.S., et al. Characterization of heme as activator of Toll-like receptor 4. J Biol Chem 282 28 (2007) 20221-20229
50. Vannacci A., Di Felice A., Giannini L., et al. The effect of a carbon monoxide-releasing molecule on the immunological activation of guinea-pig mast cells and human basophils. Inflamm Res 53 Suppl 1 (2004) S9-S10
51. Kang D.H., Park S.K., Lee I.K., and Johnson R.J. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol 16 12 (2005) 3553-3562
52. Durante W., Kroll M.H., Christodoulides N., Peyton K.J., and Schafer A.I. Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ Res 80 4 (1997) 557-564
53. van Hensbroek M.B., Palmer A., Onyiorah E., et al. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis 174 5 (1996) 1091-1097
54. Woodruff A.W., and Dickinson C.J. Use of dexamethasone in cerebral malaria. Br Med J 3 5609 (1968) 31-32
55. Jacobs P., Radzioch D., and Stevenson M.M. A Th1-associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood-stage malaria in mice. Infect Immun 64 2 (1996) 535-541
56. Clark I.A., Budd A.C., Alleva L.M., and Cowden W.B. Human malarial disease: a consequence of inflammatory cytokine release. Malar J 5 (2006) 85
57. Coban C., Ishii K.J., Uematsu S., et al. Pathological role of Toll-like receptor signaling in cerebral malaria. Int Immunol 19 1 (2007) 67-79
58. Griffith J.W., O'Connor C., Bernard K., Town T., Goldstein D.R., and Bucala R. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis 196 10 (2007) 1553-1564
59. Hisaeda H., Tetsutani K., Imai T., et al. Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. J Immunol 180 4 (2008) 2496-2503
60. Stamp L.K., O'Donnell J.L., and Chapman P.T. Emerging therapies in the long-term management of hyperuricaemia and gout. Intern Med J 37 4 (2007) 258-266
61. Guo R.F., and Ward P.A. C5a, a therapeutic target in sepsis. Recent Patents Anti-Infect Drug Disc 1 1 (2006) 57-65
62. Borders C.W., Courtney A., Ronen K., et al. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate. Scand J Immunol 62 2 (2005) 123-130
63. Nakornchai S., and Konthiang P. Potentiation of antimalarial drug action by chlorpheniramine against multidrug-resistant Plasmodium falciparum in vitro. Parasitol Int 55 3 (2006) 195-199
64. Mayr F.B., Spiel A., Leitner J., et al. Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med 171 4 (2005) 354-360
65. Motterlini R. Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities. Biochem Soc Trans 35 Pt 5 (2007) 1142-1146
66. Finney C.A.M., Liles W.C., and Kain K.C. Severe malaria and host response: time for a paradigm shift in therapeutic strategies to improve clinical outcome. Drug Discov Today Dis Mech 4 4 (2007) 207-214