The 21-aminosteroid U74389G enhances hepatic blood flow and preserves sinusoidal endothelial cell function and structure in endotoxin-shocked dogs

Journal of Surgical Research

Volumn 86, Issue 2, 1999, Pages 183-191

  Spapen, Herbert ^a   Zhang, Haibo ^a   Wisse, Eddie ^b   Baekeland, Marijke ^b   Seynaeve, Carine ^b   Eddouks, Mohammed ^b   Vincent, Jean Louis ^a  

^a ERASME HOSPITAL   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

21 aminosteroids; Endothelium; Liver; Nitric oxide; Sepsis

Indexed keywords

21 AMINOSTEROID; 21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; ENDOTHELIUM CELL; HISTOPATHOLOGY; INTRAVENOUS DRUG ADMINISTRATION; LIVER BLOOD FLOW; LIVER INJURY; LIVER PROTECTION; LIVER SINUSOID; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK;

EID: 0032700430     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1999.5717     Document Type: Article

References (35)

1. Bone, R. C. The pathogenesis of sepsis. Ann. Intern. Med. 115: 457, 1991.
2. Galley, H. F., Davies, M. J., and Webster, N. R. Xanthine oxidase activity and free radical generation in patients with sepsis syndrome. Crit. Care. Med. 24: 1649, 1996.
3. Southorn, P. A., and Powis, G. Free radicals in medicine. I. Chemical nature and biological reactions. Mayo Clin. Proc. 63: 381, 1988.
4. Braughler, J. M., Pregenzer, J. F., Chase, R. L., Duncan, L. A., Jacobsen, E. J., and McCall, J. M. Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation. J. Biol. Chem. 262: 10438, 1987.
5. Spapen, H., Zhang, H., and Vincent, J.-L. Potential therapeutic value of lazaroids in endotoxemia and other forms of sepsis. Shock 8: 321, 1997.
6. Pastor, C. M., Billiar, T. R., Losser, M.-R., and Payen, D. M. Liver injury during sepsis. J. Crit. Care 10: 183, 1995.
7. Matuschak, G. M., Pinsky, M. R., Klein, E. C., Van Thiel, D. H., and Rinaldo, J. E. Effect of D-galactosamine-induced acute liver injury on mortality and pulmonary responses to E. coli lipopolysaccharide: Modulation by arachidonic acid metabolites. Am. Rev. Respir. Dis. 141: 1296, 1990.
8. McGuire, G. M., Liu, P., and Jaeschke, H. Neutrophil-induced lung damage after hepatic ischemia and endotoxemia. Free Radical Biol. Med. 20: 189, 1996.
9. Liu, P., Vonderfecht, S. L., McGuire, G. M., Fisher, M. A., Farhood, A., and Jaeschke, H. The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. J. Pharmacol. Exp. Ther. 271: 438, 1994.
10. Zhang, H., Spapen, H., Manikis, P., Rogiers, P., Metz, G., Buurman, W. A., and Vincent, J.-L. Tirilazad mesylate (U-74006F) inhibits effects of endotoxin in dogs. Am. J. Physiol. 268: H1847, 1995.
11. Spapen, H., Zhang, H., Vincent, J.-L., Thoné, F., and Borgers, M. Intrahepatocellular erythrocyte inclusions and increased calcium precipitation in canine endotoxic shock. J. Hepatol. 27: 1096, 1997.
12. Boler, R. K., and Bibighaus, A. J., III.. Ultrastructural alterations of dog livers during endotoxin shock. Lab. Invest. 17: 537, 1967.
13. Zhang, H., Smail, N., Cabral, A., Rogiers, P., and Vincent, J.-L. Effects of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock. Am. J. Respir. Crit. Care Med. 155: 1965, 1997.
14. Navaratnam, R. L., Morris, S. E., Traber, D. L., Flynn, J., Woodson, L., Linares, H., and Herndon, D. N. Endotoxin (LPS) increases mesenteric vascular resistance (MVR) and bacterial translocation (BT). J. Trauma 30: 1104, 1990.
15. Wylam, M. E., Samsel, R. W., Umans, J. G., Mitchell, R. W., Leff, A. R., and Schumacker, P. T. Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro. Am. Rev. Respir. Dis. 142: 1263, 1990.
16. Rubanyi, G. M., and Vanhoutte, P. M. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am. J. Physiol. 250: H822, 1986.
17. Aoki, N., Siegfried, M., and Lefer, A. M. Anti-EDRF effect of tumor necrosis factor in isolated perfused cat carotid arteries. Am. J. Physiol. 256: H1509, 1989.
18. Thomas, P. D., Mao, G. D., Rabinovitch, A., and Poznansky, M. J. Inhibition of superoxide-generating NADPH oxidase of human neutrophils by lazaroids (21-aminosteroids and 2-methylaminochromans). Biochem. Pharmacol. 45: 241, 1993.
19. Squadrito, F., Altavilla, D., Ammendolia, L., Squadrito, G., Campo, G. M., Sperandeo, A., Canale, P., Ioculano, M., Saitta, A., and Caputi, A. P. Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid U-74389G in splanchnic ischaemia-reperfusion injury in the rat. Br. J. Pharmacol. 115: 395, 1995.
20. Siegfried, M. R., Ma, X-l., and Lefer, A. M. Splanchnic vascular endothelial dysfunction in rat endotoxemia: Role of superoxide radicals. Eur. J. Pharmacol. 212: 171, 1992.
21. Lehmann, C. H., Egerer, K., Georgiew, A., Weber, M., and Kox, W. J. Inhibition of tumour necrosis factor-α release in rat experimental endotoxaemia by treatment with the 21-aminosteroid U-74389G. Intensive Care. Med. 22(Suppl. 3): S338, 1996.
22. Dahn, M. S., Wilson, R. F., Lange, P., Stone, A., and Jacobs, L. A. Hepatic parenchymal oxygen tension following injury and sepsis. Arch. Surg. 125: 441, 1990.
23. Tighe, D., Moss, R., Heywood, G., Al-Saady, N., Webb, A., and Bennett, D. Goal-directed therapy with dopexamine, dobutamine, and volume expansion: Effects of systemic oxygen transport on hepatic ultrastructure in porcine sepsis. Crit. Care. Med. 23: 1997, 1995.
24. Pagani, R., Portoles, M. T., Arahuetes, R., Ainaga, M. J., Machin, C., and Rua, C. Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells. Histol. Histopathol. 11: 597, 1996.
25. Asaka, S., Shibayama, Y., and Nakata, K. Pathogenesis of focal and random hepatocellular necrosis in endotoxemia: Microscopic observation in vivo. Liver 16: 183, 1996.
26. Doi, F., Goya, T., and Torisu, M. Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis. Hepatology 17: 1086, 1993.
27. Deaciuc, I. V., Bagby, G. J., Lang, C. H., Skrepnik, N., and Spitzer, J. J. Gram-negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver. Hepatology 18: 173, 1993.
28. Eversole, R. R., Smith, S. L., Beuving, L. J., and Hall, E. D. Protective effect of the 21-aminosteroid lipid peroxidation inhibitor tirilazad mesylate (U-74006F) on hepatic endothelium in experimental hemorrhagic shock. Circ. Shock 40: 125, 1993.
29. Fisher, M. A., Eversole, R. R., Beuving, L. J., and Hall, E. D. Sinusoidal endothelial cell and parenchymal cell injury during endotoxemia and hepatic ischemia-reperfusion: Protection by the 21-aminosteroid tirilazad mesylate. Int. Hepat. Commun. 6: 121, 1997.
30. Moncada, S., Palmer, R. M. J., and Higgs, E. A. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109, 1991.
31. Nishida, J., McCuskey, R. S., McDonnell, D., and Fox, E. S. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am. J. Physiol. 267: G1135, 1994.
32. 3 levels. J. Surg. Res. 66: 13, 1996.
33. Audus, K. L., Guillot, F. L., and Braughler, J. M. Evidence for 21-aminosteroid association with the hydrophobic domains of brain microvessel endothelial cells. Free Radical Biol. Med. 11: 361, 1991.
34. Wang, Y., Mathews, R., Guido, D. M., and Jaeschke, H. The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation. J. Pharmacol. Exp. Ther. 277: 714, 1996.
35. Kitt, T. M., Luderer, J. R., Shappell, S. B., Mitchell, J. R, Taylor, A. A., and Smith, C. W. The effect of U74006F, a novel aminosteroid on human neutrophil function. FASEB J. 3: A595, 1989.